CN1362072A - Nano heart nourishing medicine and its preparation - Google Patents
Nano heart nourishing medicine and its preparation Download PDFInfo
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- CN1362072A CN1362072A CN 01100037 CN01100037A CN1362072A CN 1362072 A CN1362072 A CN 1362072A CN 01100037 CN01100037 CN 01100037 CN 01100037 A CN01100037 A CN 01100037A CN 1362072 A CN1362072 A CN 1362072A
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- 239000003814 drug Substances 0.000 title claims abstract description 47
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 238000000034 method Methods 0.000 claims abstract description 12
- 241000213006 Angelica dahurica Species 0.000 claims abstract description 10
- 244000247747 Coptis groenlandica Species 0.000 claims abstract description 10
- 235000002991 Coptis groenlandica Nutrition 0.000 claims abstract description 10
- 241000218176 Corydalis Species 0.000 claims abstract description 10
- 241000222336 Ganoderma Species 0.000 claims abstract description 10
- 239000008187 granular material Substances 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 20
- 239000000463 material Substances 0.000 claims description 19
- 239000000843 powder Substances 0.000 claims description 10
- 241000208340 Araliaceae Species 0.000 claims description 9
- 241001061264 Astragalus Species 0.000 claims description 9
- 241000756943 Codonopsis Species 0.000 claims description 9
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 9
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 9
- 240000007164 Salvia officinalis Species 0.000 claims description 9
- 235000006533 astragalus Nutrition 0.000 claims description 9
- 235000008434 ginseng Nutrition 0.000 claims description 9
- 235000005412 red sage Nutrition 0.000 claims description 9
- 210000004233 talus Anatomy 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 239000003390 Chinese drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 9
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017443 Hedysarum boreale Nutrition 0.000 abstract 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 abstract 1
- 241000219780 Pueraria Species 0.000 abstract 1
- 239000008661 Yangxinshi Substances 0.000 abstract 1
- 229940107666 astragalus root Drugs 0.000 abstract 1
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 235000002020 sage Nutrition 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 208000029078 coronary artery disease Diseases 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 206010002383 Angina Pectoris Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000031226 Hyperlipidaemia Diseases 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 210000001367 artery Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 201000001421 hyperglycemia Diseases 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 208000010125 myocardial infarction Diseases 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The present invention discloses a nano Yangxinshi preparation medicine for nourishing heart, which uses nano astragalus root, pilose asiabell root, rod sage root, pueraria, barrenmort, may bloom remannia root, chinese angelica, coptis root, corydalis tuber, lucid ganoderma and licorice root as raw material and to prepare them according to a certain proportion through the process of microwave extraction, depressured concentration and ultrasonic jet spray drying make the medicine with the granule fineness of up to 1200-1500 mesh number, granule diameter of 0.1-200 nm is which absolute majority under 100 nm. Said medicine has high biological utilization rate and obvious therapy effect.
Description
The present invention relates to a kind of strengthening the body resistance, benefiting QI for activating blood circulation, the pain relieving of row arteries and veins, cure mainly the nano heart nourishing preparation medicine of coronary heart disease, the invention still further relates to the method for this medication preparation.
The heart nourishing sheet is a kind of classical Chinese patent medicine, mainly contains effects such as strengthening the body resistance, benefiting QI for activating blood circulation, the pain relieving of row arteries and veins, is used for coronary heart disease with qi deficiency and blood stasis, angina pectoris, myocardial infarction and merging hyperlipidemia, hyperglycemia etc.But traditional heart nourishing sheet disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano heart nourishing preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano heart nourishing preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano astragalus 10-50 part nanometer Radix Codonopsis 8-50 part nano red sage 8-50 part
Nanometer Radix Puerariae 5-40 part nanometer Herba Epimedii 5-50 part nanometer three short, bristly hair or beard 5-50 parts
Nanometer Radix Rehmanniae 5-50 part nano Chinese angelica 10-50 part nanometer coptis 5-40 part
Nanometer Rhizoma Corydalis 5-40 part nano ganoderma 5-50 part nano ginseng 5-50 part
Nanometer Radix Glycyrrhizae 5-30 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano astragalus 20-40 part nanometer Radix Codonopsis 15-40 part nano red sage 15-40 part
Nanometer Radix Puerariae 10-30 part nanometer Herba Epimedii 15-40 part nanometer three short, bristly hair or beard 15-40 parts
Nanometer Radix Rehmanniae 15-40 part nano Chinese angelica 20-40 part nanometer coptis 10-30 part
Nanometer Rhizoma Corydalis 10-30 part nano ganoderma 15-40 part nano ginseng 15-40 part
Nanometer Radix Glycyrrhizae 8-20 part
The optimum weight proportioning of medicine of the present invention is:
25 parts of 25 parts of nano red sages of 30 parts of nanometer Radix Codonopsis of nano astragalus
25 parts of 25 parts of nanometers of 20 parts of nanometer Herba Epimedii of nanometer Radix Puerariae, three short, bristly hair or beards
20 parts of 28 parts of nanometer coptis of 25 parts of nano Chinese angelicas of nanometer Radix Rehmanniae
25 parts of 25 parts of nano ginsengs of 20 parts of nano ganodermas of nanometer Rhizoma Corydalis
15 parts in nanometer Radix Glycyrrhizae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get heart nourishing preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the nano heart nourishing preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common heart nourishing tablet preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, suppository, granule, membrane, microcapsule, drop pill, aerosol, injection, medicated wine, syrup, oral solution of nano heart nourishing preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for coronary heart disease with qi deficiency and blood stasis, angina pectoris, treatment of conditions such as myocardial infarction and merging hyperlipidemia, hyperglycemia, and clinical efficacy significantly is better than traditional heart nourishing sheet.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
25 parts of 25 parts of nano red sages of 30 parts of nanometer Radix Codonopsis of nano astragalus
25 parts of 25 parts of nanometers of 20 parts of nanometer Herba Epimedii of nanometer Radix Puerariae, three short, bristly hair or beards
20 parts of 28 parts of nanometer coptis of 25 parts of nano Chinese angelicas of nanometer Radix Rehmanniae
25 parts of 25 parts of nano ginsengs of 20 parts of nano ganodermas of nanometer Rhizoma Corydalis
15 parts in nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes 1-4 time every day, each 1-5 grain.
Embodiment 2:
Prepare nano raw material by preceding method:
25 parts of 25 parts of nano red sages of 30 parts of nanometer Radix Codonopsis of nano astragalus
25 parts of 25 parts of nanometers of 20 parts of nanometer Herba Epimedii of nanometer Radix Puerariae, three short, bristly hair or beards
20 parts of 28 parts of nanometer coptis of 25 parts of nano Chinese angelicas of nanometer Radix Rehmanniae
25 parts of 25 parts of nano ginsengs of 20 parts of nano ganodermas of nanometer Rhizoma Corydalis
15 parts in nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make the nano heart nourishing powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
25 parts of 25 parts of nano red sages of 30 parts of nanometer Radix Codonopsis of nano astragalus
25 parts of 25 parts of nanometers of 20 parts of nanometer Herba Epimedii of nanometer Radix Puerariae, three short, bristly hair or beards
20 parts of 28 parts of nanometer coptis of 25 parts of nano Chinese angelicas of nanometer Radix Rehmanniae
25 parts of 25 parts of nano ginsengs of 20 parts of nano ganodermas of nanometer Rhizoma Corydalis
15 parts in nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make the nano heart nourishing membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: chest.
Claims (6)
1, a kind of nano heart nourishing preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano astragalus 10-50 part nanometer Radix Codonopsis 8-50 part nano red sage 8-50 part
Nanometer Radix Puerariae 5-40 part nanometer Herba Epimedii 5-50 part nanometer three short, bristly hair or beard 5-50 parts
Nanometer Radix Rehmanniae 5-50 part nano Chinese angelica 10-50 part nanometer coptis 5-40 part
Nanometer Rhizoma Corydalis 5-40 part nano ganoderma 5-50 part nano ginseng 5-50 part
Nanometer Radix Glycyrrhizae 5-30 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
2, nano heart nourishing preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nano astragalus 20-40 part nanometer Radix Codonopsis 15-40 part nano red sage 15-40 part
Nanometer Radix Puerariae 10-30 part nanometer Herba Epimedii 15-40 part nanometer three short, bristly hair or beard 15-40 parts
Nanometer Radix Rehmanniae 15-40 part nano Chinese angelica 20-40 part nanometer coptis 10-30 part
Nanometer Rhizoma Corydalis 10-30 part nano ganoderma 15-40 part nano ginseng 15-40 part
Nanometer Radix Glycyrrhizae 8-20 part
3, nano heart nourishing preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
25 parts of 25 parts of nano red sages of 30 parts of nanometer Radix Codonopsis of nano astragalus
25 parts of 25 parts of nanometers of 20 parts of nanometer Herba Epimedii of nanometer Radix Puerariae, three short, bristly hair or beards
20 parts of 28 parts of nanometer coptis of 25 parts of nano Chinese angelicas of nanometer Radix Rehmanniae
25 parts of 25 parts of nano ginsengs of 20 parts of nano ganodermas of nanometer Rhizoma Corydalis
15 parts in nanometer Radix Glycyrrhizae
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano heart nourishing preparation medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano heart nourishing preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100037 CN1362072A (en) | 2001-01-05 | 2001-01-05 | Nano heart nourishing medicine and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100037 CN1362072A (en) | 2001-01-05 | 2001-01-05 | Nano heart nourishing medicine and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1362072A true CN1362072A (en) | 2002-08-07 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100037 Pending CN1362072A (en) | 2001-01-05 | 2001-01-05 | Nano heart nourishing medicine and its preparation |
Country Status (1)
| Country | Link |
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| CN (1) | CN1362072A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100441217C (en) * | 2005-05-19 | 2008-12-10 | 北京燕京中科生物技术有限公司 | A medicine for treating angina pectoris |
-
2001
- 2001-01-05 CN CN 01100037 patent/CN1362072A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100441217C (en) * | 2005-05-19 | 2008-12-10 | 北京燕京中科生物技术有限公司 | A medicine for treating angina pectoris |
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