CN1362075A - Nano blood stasis dispersing medicine and its preparation - Google Patents
Nano blood stasis dispersing medicine and its preparation Download PDFInfo
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- CN1362075A CN1362075A CN 01100040 CN01100040A CN1362075A CN 1362075 A CN1362075 A CN 1362075A CN 01100040 CN01100040 CN 01100040 CN 01100040 A CN01100040 A CN 01100040A CN 1362075 A CN1362075 A CN 1362075A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- 239000008280 blood Substances 0.000 title claims abstract description 16
- 210000004369 blood Anatomy 0.000 title claims abstract description 16
- 239000003814 drug Substances 0.000 title claims description 44
- 239000000463 material Substances 0.000 claims abstract description 21
- 241000213006 Angelica dahurica Species 0.000 claims abstract description 10
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 11
- 239000000843 powder Substances 0.000 claims description 10
- 241000202726 Bupleurum Species 0.000 claims description 9
- 244000020518 Carthamus tinctorius Species 0.000 claims description 9
- 235000003255 Carthamus tinctorius Nutrition 0.000 claims description 9
- 210000000582 semen Anatomy 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 241000202807 Glycyrrhiza Species 0.000 claims description 5
- 239000000284 extract Substances 0.000 claims description 5
- 239000008187 granular material Substances 0.000 claims description 5
- 239000006187 pill Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 2
- 229940100688 oral solution Drugs 0.000 claims description 2
- 239000006188 syrup Substances 0.000 claims description 2
- 235000020357 syrup Nutrition 0.000 claims description 2
- 239000003390 Chinese drug Substances 0.000 claims 2
- 239000002245 particle Substances 0.000 abstract description 6
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 241000112528 Ligusticum striatum Species 0.000 abstract 1
- 241000405414 Rehmannia Species 0.000 abstract 1
- 230000006837 decompression Effects 0.000 abstract 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract 1
- 235000011477 liquorice Nutrition 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 4
- 239000010056 xuefu Substances 0.000 description 4
- 206010019233 Headaches Diseases 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 231100000869 headache Toxicity 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 206010008479 Chest Pain Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 208000029028 brain injury Diseases 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The invention discloses a nano preparation for dispelling blood stasis. It comprises materials such as nanopeach seed, nano Chinese angelica, nano ligusticum wallichii, nano radixbupleuri, nanored flower, nano radix achyranthis bidentatae, nano radix paeoniae rubrathe, nano glutinous rehmannia, nano radix platycodi, nano liquorice, and makes up in accordance with proportion then fabricates into a new medical preparation. Its particle fineness reaches 1200-1500 mesh, and particle size 0.1-200nm, most of the particle size is less than 100nm and haw new material properties. It is fabricated through steps such as microwave extraction, decompression and concentration, supersonic jet and spray drying.
Description
The present invention relates to a kind of blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, cure mainly the nano blood stasis dispersing preparation medicine of headache or chest pain, the invention still further relates to the method for this medication preparation.
XUEFU ZHUYU JIAONANG is a kind of classical Chinese patent medicine, mainly contain anticoagulant, improve cardiac function, arrhythmia improves hemorheological property and microcirculation, anti-hypoxia, effects such as antiinflammatory are used for that blood-stasis internal-depression, headache or chest pain, interior-heat are felt oppressed, insomnia and dreamful sleep, cardiopalmus severe palpitation, the anxious susceptible to get angry of making an uproar, but traditional XUEFU ZHUYU JIAONANG absorbs not exclusively, bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano blood stasis dispersing preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano blood stasis dispersing preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Semen Persicae 10-50 part nano Chinese angelica 8-60 part nanometer Fructus Aurantii 10-70 part
Nanometer Rhizoma Chuanxiong 8-60 part nano bupleurum 10-60 part nano safflower 8-60 part
Nanometer Radix Achyranthis Bidentatae 8-50 part nanometer Radix Paeoniae Rubra 8-60 part nanometer Radix Rehmanniae 10-60 part
Nanometer Radix Platycodonis 5-50 part nanometer Radix Glycyrrhizae 5-30 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Semen Persicae 20-40 part nano Chinese angelica 15-50 part nanometer Fructus Aurantii 20-50 part
Nanometer Rhizoma Chuanxiong 15-50 part nano bupleurum 20-50 part nano safflower 15-50 part
Nanometer Radix Achyranthis Bidentatae 10-30 part nanometer Radix Paeoniae Rubra 15-50 part nanometer Radix Rehmanniae 20-50 part
Nanometer Radix Platycodonis 15-40 part nanometer Radix Glycyrrhizae 8-25 part
The optimum weight proportioning of medicine of the present invention is:
30 parts of 25 parts of nanometer Fructus Aurantiis of 30 parts of nano Chinese angelicas of nanometer Semen Persicae
25 parts of 30 parts of nano safflowers of 25 parts of nano bupleurums of nanometer Rhizoma Chuanxiong
30 parts of 35 parts of nanometer Radix Rehmanniae of 20 parts of nanometer Radix Paeoniae Rubra of nanometer Radix Achyranthis Bidentatae
15 parts in 25 parts of nanometer Radix Glycyrrhizaes of nanometer Radix Platycodonis
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get 'Xue Fu Zhu Yu ' preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the nano blood stasis dispersing preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common XUEFU ZHUYU JIAONANG preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention solid dispersion in water is good, absorb fully, and the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, membrane, microcapsule, drop pill, aerosol, injection of nano blood stasis dispersing preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as headache, dizzy, brain injury sequela, angina pectoris, and clinical efficacy significantly is better than traditional XUEFU ZHUYU JIAONANG.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
30 parts of 25 parts of nanometer Fructus Aurantiis of 30 parts of nano Chinese angelicas of nanometer Semen Persicae
25 parts of 30 parts of nano safflowers of 25 parts of nano bupleurums of nanometer Rhizoma Chuanxiong
30 parts of 35 parts of nanometer Radix Rehmanniae of 20 parts of nanometer Radix Paeoniae Rubra of nanometer Radix Achyranthis Bidentatae
15 parts in 25 parts of nanometer Radix Glycyrrhizaes of nanometer Radix Platycodonis
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes 1-4 time every day, each 1-5 grain.
Embodiment 2:
Prepare nano raw material by preceding method:
30 parts of 25 parts of nanometer Fructus Aurantiis of 30 parts of nano Chinese angelicas of nanometer Semen Persicae
25 parts of 30 parts of nano safflowers of 25 parts of nano bupleurums of nanometer Rhizoma Chuanxiong
30 parts of 35 parts of nanometer Radix Rehmanniae of 20 parts of nanometer Radix Paeoniae Rubra of nanometer Radix Achyranthis Bidentatae
15 parts in 25 parts of nanometer Radix Glycyrrhizaes of nanometer Radix Platycodonis
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make the nano blood stasis dispersing powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
30 parts of 25 parts of nanometer Fructus Aurantiis of 30 parts of nano Chinese angelicas of nanometer Semen Persicae
25 parts of 30 parts of nano safflowers of 25 parts of nano bupleurums of nanometer Rhizoma Chuanxiong
30 parts of 35 parts of nanometer Radix Rehmanniae of 20 parts of nanometer Radix Paeoniae Rubra of nanometer Radix Achyranthis Bidentatae
15 parts in 25 parts of nanometer Radix Glycyrrhizaes of nanometer Radix Platycodonis
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make the nano blood stasis dispersing membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest.
Claims (6)
1, a kind of nano blood stasis dispersing preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Semen Persicae 10-50 part nano Chinese angelica 8-60 part nanometer Fructus Aurantii 10-70 part
Nanometer Rhizoma Chuanxiong 8-60 part nano bupleurum 10-60 part nano safflower 8-60 part
Nanometer Radix Achyranthis Bidentatae 8-50 part nanometer Radix Paeoniae Rubra 8-60 part nanometer Radix Rehmanniae 10-60 part
Nanometer Radix Platycodonis 5-50 part nanometer Radix Glycyrrhizae 5-30 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
2, nano blood stasis dispersing preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Semen Persicae 20-40 part nano Chinese angelica 15-50 part nanometer Fructus Aurantii 20-50 part
Nanometer Rhizoma Chuanxiong 15-50 part nano bupleurum 20-50 part nano safflower 15-50 part
Nanometer Radix Achyranthis Bidentatae 10-30 part nanometer Radix Paeoniae Rubra 15-50 part nanometer Radix Rehmanniae 20-50 part
Nanometer Radix Platycodonis 15-40 part nanometer Radix Glycyrrhizae 8-25 part
3, nano blood stasis dispersing preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
30 parts of 25 parts of nanometer Fructus Aurantiis of 30 parts of nano Chinese angelicas of nanometer Semen Persicae
25 parts of 30 parts of nano safflowers of 25 parts of nano bupleurums of nanometer Rhizoma Chuanxiong
30 parts of 35 parts of nanometer Radix Rehmanniae of 20 parts of nanometer Radix Paeoniae Rubra of nanometer Radix Achyranthis Bidentatae
15 parts in 25 parts of nanometer Radix Glycyrrhizaes of nanometer Radix Platycodonis
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano blood stasis dispersing preparation medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano blood stasis dispersing preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100040 CN1362075A (en) | 2001-01-05 | 2001-01-05 | Nano blood stasis dispersing medicine and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100040 CN1362075A (en) | 2001-01-05 | 2001-01-05 | Nano blood stasis dispersing medicine and its preparation |
Publications (1)
| Publication Number | Publication Date |
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| CN1362075A true CN1362075A (en) | 2002-08-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 01100040 Pending CN1362075A (en) | 2001-01-05 | 2001-01-05 | Nano blood stasis dispersing medicine and its preparation |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100444860C (en) * | 2004-02-25 | 2008-12-24 | 浙江大学 | A kind of compound traditional Chinese medicine extract composition and preparation method thereof |
| CN103083490A (en) * | 2013-02-18 | 2013-05-08 | 柳少逸 | Traditional Chinese medicine for treating post-traumatic brain syndrome |
| CN103356796A (en) * | 2013-06-24 | 2013-10-23 | 广州中医药大学 | Blood stasis removing particles and preparation method thereof |
-
2001
- 2001-01-05 CN CN 01100040 patent/CN1362075A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100444860C (en) * | 2004-02-25 | 2008-12-24 | 浙江大学 | A kind of compound traditional Chinese medicine extract composition and preparation method thereof |
| CN103083490A (en) * | 2013-02-18 | 2013-05-08 | 柳少逸 | Traditional Chinese medicine for treating post-traumatic brain syndrome |
| CN103356796A (en) * | 2013-06-24 | 2013-10-23 | 广州中医药大学 | Blood stasis removing particles and preparation method thereof |
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