CN1364558A - Nano wet and heat astralgia treating medicine and its preparing method - Google Patents
Nano wet and heat astralgia treating medicine and its preparing method Download PDFInfo
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- CN1364558A CN1364558A CN 01100825 CN01100825A CN1364558A CN 1364558 A CN1364558 A CN 1364558A CN 01100825 CN01100825 CN 01100825 CN 01100825 A CN01100825 A CN 01100825A CN 1364558 A CN1364558 A CN 1364558A
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- 239000003814 drug Substances 0.000 title claims abstract description 46
- 238000000034 method Methods 0.000 title claims description 12
- 239000000463 material Substances 0.000 claims abstract description 20
- 241000972673 Phellodendron amurense Species 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 241000361919 Metaphire sieboldi Species 0.000 claims abstract description 5
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 20
- 239000000843 powder Substances 0.000 claims description 10
- 241000903946 Clematidis Species 0.000 claims description 9
- 239000008187 granular material Substances 0.000 claims description 9
- 210000000582 semen Anatomy 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 7
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 241000241550 Cyathula Species 0.000 claims description 5
- 241000245240 Lonicera Species 0.000 claims description 5
- 241000545442 Radix Species 0.000 claims description 5
- 241001233061 earthworms Species 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 2
- 239000003390 Chinese drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 9
- 238000002360 preparation method Methods 0.000 abstract description 8
- 241000205585 Aquilegia canadensis Species 0.000 abstract 1
- 241000555682 Forsythia x intermedia Species 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 230000000704 physical effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 description 5
- 208000006820 Arthralgia Diseases 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 231100000862 numbness Toxicity 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
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Abstract
The nano wet and heat astralgia treating medicine is prepared with nano Rhizoma, Atractylodis, nano honey-suckle stem, nano earthworm, nano forsythia fruit, nano phellodendron bark and other seven kinds of nano Chinese medicinal materials in certain proportion as raw material. The new medicine preparation has a grain fineness of 1200-1500 mesh, grain size of 0.1-200 nm, mostly below 100 nm, and new physical property. It is prepared through microwave extraction, decompressing concentration, spray drying in supersonic jet and other steps. It has high biological utilization and obvious treating effect.
Description
The present invention relates to the nano wet and heat astralgia treating medicine of a kind of expelling wind and removing dampness, clearing heat for detumescence, dredging collateral to stop pain, the invention still further relates to the method for this medication preparation.
Damp and hot arthralgia eliminating granule is a kind of classical Chinese patent medicine, mainly contains effects such as expelling wind and removing dampness, clearing heat for detumescence, dredging collateral to stop pain, is used for diseases such as damp and hot arthromyodynia.But traditional damp and hot arthralgia eliminating granule absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano wet and heat astralgia treating medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano wet and heat astralgia treating medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Rhizoma Atractylodis 10-50 part nanometer Caulis Lonicerae 8-50 part nanometer earthworm 10-50 part
Nanometer Fructus Forsythiae 5-40 part nano phellodendron bark 8-50 part nanometer Semen Coicis 8-50 part
Nanometer Radix Saposhnikoviae 8-50 part nanometer Radix Cyathulae 10-50 part nanometric Hypoglaucous Collett Yam Rhizome 5-40 part
Nanometer Ramulus Mori 8-50 part nanometer Radix Stephaniae Tetrandrae 5-40 part nanometer Radix Clematidis 8-50 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Rhizoma Atractylodis 20-40 part nanometer Caulis Lonicerae 15-40 part nanometer earthworm 20-40 part
Nanometer Fructus Forsythiae 10-30 part nano phellodendron bark 15-40 part nanometer Semen Coicis 15-40 part
Nanometer Radix Saposhnikoviae 15-40 part nanometer Radix Cyathulae 20-40 part nanometric Hypoglaucous Collett Yam Rhizome 10-30 part
Nanometer Ramulus Mori 15-40 part nanometer Radix Stephaniae Tetrandrae 10-30 part nanometer Radix Clematidis 15-40 part
The optimum weight proportioning of medicine of the present invention is:
28 parts of 25 parts of nanometer earthworms of 30 parts of nanometer Caulis Loniceraes of nanometer Rhizoma Atractylodis
23 parts of 25 parts of nanometer Semen Coiciss of 20 parts of nano phellodendron barks of nanometer Fructus Forsythiae
20 parts of 30 parts of nanometric Hypoglaucous Collett Yam Rhizomes of 25 parts of nanometer Radix Cyathulaes of nanometer Radix Saposhnikoviae
25 parts of 20 parts of nanometer Radix Clematidis of 26 parts of nanometer Radixs Stephaniae Tetrandrae of nanometer Ramulus Mori
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the wet and heat astralgia treating nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano wet and heat astralgia treating medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common damp and hot arthralgia eliminating granule preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, tablet, suppository, membrane, capsule, microcapsule, drop pill, aerosol, injection, medicated wine, syrup, oral solution of nano wet and heat astralgia treating medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as damp and hot arthromyodynia, and clinical efficacy significantly is better than traditional damp and hot arthralgia eliminating granule.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
28 parts of 25 parts of nanometer earthworms of 30 parts of nanometer Caulis Loniceraes of nanometer Rhizoma Atractylodis
23 parts of 25 parts of nanometer Semen Coiciss of 20 parts of nano phellodendron barks of nanometer Fructus Forsythiae
20 parts of 30 parts of nanometric Hypoglaucous Collett Yam Rhizomes of 25 parts of nanometer Radix Cyathulaes of nanometer Radix Saposhnikoviae
25 parts of 20 parts of nanometer Radix Clematidis of 26 parts of nanometer Radixs Stephaniae Tetrandrae of nanometer Ramulus Mori
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is a 0.1-0.6 gram, and the patient takes 1-4 time every day, every day the 1-5 grain.
Embodiment 2:
Prepare nano raw material by preceding method:
28 parts of 25 parts of nanometer earthworms of 30 parts of nanometer Caulis Loniceraes of nanometer Rhizoma Atractylodis
23 parts of 25 parts of nanometer Semen Coiciss of 20 parts of nano phellodendron barks of nanometer Fructus Forsythiae
20 parts of 30 parts of nanometric Hypoglaucous Collett Yam Rhizomes of 25 parts of nanometer Radix Cyathulaes of nanometer Radix Saposhnikoviae
25 parts of 20 parts of nanometer Radix Clematidis of 26 parts of nanometer Radixs Stephaniae Tetrandrae of nanometer Ramulus Mori
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make the damp and hot numbness powder needle injection of nanometer, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
28 parts of 25 parts of nanometer earthworms of 30 parts of nanometer Caulis Loniceraes of nanometer Rhizoma Atractylodis
23 parts of 25 parts of nanometer Semen Coiciss of 20 parts of nano phellodendron barks of nanometer Fructus Forsythiae
20 parts of 30 parts of nanometric Hypoglaucous Collett Yam Rhizomes of 25 parts of nanometer Radix Cyathulaes of nanometer Radix Saposhnikoviae
25 parts of 20 parts of nanometer Radix Clematidis of 26 parts of nanometer Radixs Stephaniae Tetrandrae of nanometer Ramulus Mori
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make the damp and hot numbness membrane of nanometer, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: the affected part.
Claims (6)
1, a kind of nano wet and heat astralgia treating medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Rhizoma Atractylodis 10-50 part nanometer Caulis Lonicerae 8-50 part nanometer earthworm 10-50 part
Nanometer Fructus Forsythiae 5-40 part nano phellodendron bark 8-50 part nanometer Semen Coicis 8-50 part
Nanometer Radix Saposhnikoviae 8-50 part nanometer Radix Cyathulae 10-50 part nanometric Hypoglaucous Collett Yam Rhizome 5-40 part
Nanometer Ramulus Mori 8-50 part nanometer Radix Stephaniae Tetrandrae 5-40 part nanometer Radix Clematidis 8-50 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano wet and heat astralgia treating medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Rhizoma Atractylodis 20-40 part nanometer Caulis Lonicerae 15-40 part nanometer earthworm 20-40 part
Nanometer Fructus Forsythiae 10-30 part nano phellodendron bark 15-40 part nanometer Semen Coicis 15-40 part
Nanometer Radix Saposhnikoviae 15-40 part nanometer Radix Cyathulae 20-40 part nanometric Hypoglaucous Collett Yam Rhizome 10-30 part
Nanometer Ramulus Mori 15-40 part nanometer Radix Stephaniae Tetrandrae 10-30 part nanometer Radix Clematidis 15-40 part
3, nano wet and heat astralgia treating medicine according to claim 1, wherein the weight proportion of each nano raw material is:
28 parts of 25 parts of nanometer earthworms of 30 parts of nanometer Caulis Loniceraes of nanometer Rhizoma Atractylodis
23 parts of 25 parts of nanometer Semen Coiciss of 20 parts of nano phellodendron barks of nanometer Fructus Forsythiae
20 parts of 30 parts of nanometric Hypoglaucous Collett Yam Rhizomes of 25 parts of nanometer Radix Cyathulaes of nanometer Radix Saposhnikoviae
25 parts of 20 parts of nanometer Radix Clematidis of 26 parts of nanometer Radixs Stephaniae Tetrandrae of nanometer Ramulus Mori
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano wet and heat astralgia treating medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano wet and heat astralgia treating medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100825 CN1364558A (en) | 2001-01-11 | 2001-01-11 | Nano wet and heat astralgia treating medicine and its preparing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100825 CN1364558A (en) | 2001-01-11 | 2001-01-11 | Nano wet and heat astralgia treating medicine and its preparing method |
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| Publication Number | Publication Date |
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| CN1364558A true CN1364558A (en) | 2002-08-21 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 01100825 Pending CN1364558A (en) | 2001-01-11 | 2001-01-11 | Nano wet and heat astralgia treating medicine and its preparing method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100391521C (en) * | 2005-10-25 | 2008-06-04 | 辽宁本溪三药有限公司 | A kind of traditional Chinese medicine for treating damp-heat arthralgia and preparation method thereof |
| CN101850063A (en) * | 2010-04-02 | 2010-10-06 | 贵阳春科药业技术研发有限公司 | Medicinal preparation for preventing and treating gout and preparation method |
| CN118078926A (en) * | 2024-03-13 | 2024-05-28 | 辽宁上药好护士药业（集团）有限公司 | Application of a pharmaceutical composition in the preparation of a drug for treating gouty arthritis |
-
2001
- 2001-01-11 CN CN 01100825 patent/CN1364558A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100391521C (en) * | 2005-10-25 | 2008-06-04 | 辽宁本溪三药有限公司 | A kind of traditional Chinese medicine for treating damp-heat arthralgia and preparation method thereof |
| CN101850063A (en) * | 2010-04-02 | 2010-10-06 | 贵阳春科药业技术研发有限公司 | Medicinal preparation for preventing and treating gout and preparation method |
| CN118078926A (en) * | 2024-03-13 | 2024-05-28 | 辽宁上药好护士药业（集团）有限公司 | Application of a pharmaceutical composition in the preparation of a drug for treating gouty arthritis |
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