CN1363331A - Nano storax medicine and its preparing process - Google Patents
Nano storax medicine and its preparing process Download PDFInfo
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- CN1363331A CN1363331A CN 01100769 CN01100769A CN1363331A CN 1363331 A CN1363331 A CN 1363331A CN 01100769 CN01100769 CN 01100769 CN 01100769 A CN01100769 A CN 01100769A CN 1363331 A CN1363331 A CN 1363331A
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- 239000003814 drug Substances 0.000 title claims abstract description 46
- 235000019382 gum benzoic Nutrition 0.000 title claims abstract description 25
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- 235000001361 Styrax officinalis Nutrition 0.000 title claims abstract description 24
- 238000000034 method Methods 0.000 title claims description 12
- 239000000463 material Substances 0.000 claims abstract description 20
- 241000402754 Erythranthe moschata Species 0.000 claims abstract description 10
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 5
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 21
- 241000717739 Boswellia sacra Species 0.000 claims description 9
- 235000008534 Capsicum annuum var annuum Nutrition 0.000 claims description 9
- 241000209020 Cornus Species 0.000 claims description 9
- 241000234653 Cyperus Species 0.000 claims description 9
- 235000019510 Long pepper Nutrition 0.000 claims description 9
- 240000003455 Piper longum Species 0.000 claims description 9
- 244000223014 Syzygium aromaticum Species 0.000 claims description 9
- 235000016639 Syzygium aromaticum Nutrition 0.000 claims description 9
- 241001534869 Terminalia Species 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000004863 Frankincense Substances 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 239000003390 Chinese drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 9
- 235000000126 Styrax benzoin Nutrition 0.000 abstract description 6
- 239000011858 nanopowder Substances 0.000 abstract description 3
- ISAOCJYIOMOJEB-UHFFFAOYSA-N benzoin Chemical compound C=1C=CC=CC=1C(O)C(=O)C1=CC=CC=C1 ISAOCJYIOMOJEB-UHFFFAOYSA-N 0.000 abstract 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- 244000028419 Styrax benzoin Species 0.000 abstract 1
- 235000008411 Sumatra benzointree Nutrition 0.000 abstract 1
- 229960002130 benzoin Drugs 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 description 8
- 235000015511 Liquidambar orientalis Nutrition 0.000 description 5
- 241000736148 Styrax Species 0.000 description 5
- 239000004870 Styrax Substances 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 3
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- 206010008190 Cerebrovascular accident Diseases 0.000 description 2
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
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- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 206010019345 Heat stroke Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 206010047139 Vasoconstriction Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 230000000702 anti-platelet effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 210000003445 biliary tract Anatomy 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
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- 238000010276 construction Methods 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
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- 230000005764 inhibitory process Effects 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
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- 208000026435 phlegm Diseases 0.000 description 1
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A nano medicine "Suhexiang" is prepared from the nano powders of 15 Chinese-medicinal materials including storax, benzoin, borneol, musk, etc through proportioning, microwave extracting, vacuum concentrating and supersonic-jet spray drying. Its advantages include high biological utilization rate and high curative effect.
Description
The present invention relates to a kind of causing resuscitation with aromatic drugs, promoting the circulation of QI to relieve pain, warming the interior cold expelling, resolving depression refreshment, ward off the turbid nano storax medicine of dirtyization, the invention still further relates to the method for this medication preparation.
Styrax Pilulae is a kind of classical Chinese patent medicine, mainly contains effects such as antiplatelet aggregation, protection cardiac muscle, inhibition vasoconstriction, is used for apoplexy, heatstroke, coma due to phlegm syncope, heart peratodynia, angina pectoris.But traditional Styrax Pilulae absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano storax medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano storax medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano storax 30-70 part nanometer Benzoinum 60-140 part nanometer Borneolum Syntheticum 30-70 part
Nano musk 50-100 part nanometer terminalia flesh 60-140 part nanometer Lignum Santali Albi 60-140 part
Nanometer Lignum Aquilariae Resinatum 60-140 part nano clove 60-140 part nano cyperus tuber 60-140 part
Nanometer Radix Aucklandiae 60-140 part nanometer Olibanum 60-140 part nanometer Long Pepper 60-140 part
Nanometer Rhizoma Atractylodis Macrocephalae 60-140 part nanometer Cinnabaris 60-140 part
Nanometer Pulvis Cornus Bubali Concentratus 120-280 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano storax 40-60 part nanometer Benzoinum 80-120 part nanometer Borneolum Syntheticum 40-60 part
Nano musk 60-90 part nanometer terminalia flesh 80-120 part nanometer Lignum Santali Albi 80-120 part
Nanometer Lignum Aquilariae Resinatum 80-120 part nano clove 80-120 part nano cyperus tuber 80-120 part
Nanometer Radix Aucklandiae 80-120 part nanometer Olibanum 80-120 part nanometer Long Pepper 80-120 part
Nanometer Rhizoma Atractylodis Macrocephalae 80-120 part nanometer Cinnabaris 80-120 part
Nanometer Pulvis Cornus Bubali Concentratus 160-240 part
The optimum weight proportioning of medicine of the present invention is:
50 parts of 100 parts of nanometer Borneolum Syntheticums of 50 parts of nanometer Benzoinumes of nano storax
100 parts in 100 parts of nanometer Lignum Santali Albis of 75 parts of nanometer terminalia flesh of nano musk
100 parts of 100 parts of nano cyperus tubers of 100 parts of nano cloves of nanometer Lignum Aquilariae Resinatum
100 parts of 100 parts of nanometer Long Peppers of 100 parts of nanometer Olibanums of the nanometer Radix Aucklandiae
100 parts in 100 parts of nanometer Cinnabaris of the nanometer Rhizoma Atractylodis Macrocephalae
200 parts of nanometer Pulvis Cornus Bubali Concentratuss
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get Styrax preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano storax medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common Styrax Pilulae preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that suppository, granule, membrane, microcapsule, drop pill, aerosol, injection, medicated wine, syrup, oral solution of nano storax medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as the painful biliary tract ascarid of apoplexy constipation due to cold pathogen, coma and trusted subordinate, and clinical efficacy significantly is better than traditional Styrax Pilulae.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
50 parts of 100 parts of nanometer Borneolum Syntheticums of 50 parts of nanometer Benzoinumes of nano storax
100 parts in 100 parts of nanometer Lignum Santali Albis of 75 parts of nanometer terminalia flesh of nano musk
100 parts of 100 parts of nano cyperus tubers of 100 parts of nano cloves of nanometer Lignum Aquilariae Resinatum
100 parts of 100 parts of nanometer Long Peppers of 100 parts of nanometer Olibanums of the nanometer Radix Aucklandiae
100 parts in 100 parts of nanometer Cinnabaris of the nanometer Rhizoma Atractylodis Macrocephalae
200 parts of nanometer Pulvis Cornus Bubali Concentratuss
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes 1-4 time every day, each 1-5 grain.
Embodiment 2:
Prepare nano raw material by preceding method:
50 parts of 100 parts of nanometer Borneolum Syntheticums of 50 parts of nanometer Benzoinumes of nano storax
100 parts in 100 parts of nanometer Lignum Santali Albis of 75 parts of nanometer terminalia flesh of nano musk
100 parts of 100 parts of nano cyperus tubers of 100 parts of nano cloves of nanometer Lignum Aquilariae Resinatum
100 parts of 100 parts of nanometer Long Peppers of 100 parts of nanometer Olibanums of the nanometer Radix Aucklandiae
100 parts in 100 parts of nanometer Cinnabaris of the nanometer Rhizoma Atractylodis Macrocephalae
200 parts of nanometer Pulvis Cornus Bubali Concentratuss
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make the nano storax powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
50 parts of 100 parts of nanometer Borneolum Syntheticums of 50 parts of nanometer Benzoinumes of nano storax
100 parts in 100 parts of nanometer Lignum Santali Albis of 75 parts of nanometer terminalia flesh of nano musk
100 parts of 100 parts of nano cyperus tubers of 100 parts of nano cloves of nanometer Lignum Aquilariae Resinatum
100 parts of 100 parts of nanometer Long Peppers of 100 parts of nanometer Olibanums of the nanometer Radix Aucklandiae
100 parts in 100 parts of nanometer Cinnabaris of the nanometer Rhizoma Atractylodis Macrocephalae
200 parts of nanometer Pulvis Cornus Bubali Concentratuss
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make the nano storax membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano storax medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano storax 30-70 part nanometer Benzoinum 60-140 part nanometer Borneolum Syntheticum 30-70 part
Nano musk 50-100 part nanometer terminalia flesh 60-140 part nanometer Lignum Santali Albi 60-140 part
Nanometer Lignum Aquilariae Resinatum 60-140 part nano clove 60-140 part nano cyperus tuber 60-140 part
Nanometer Radix Aucklandiae 60-140 part nanometer Olibanum 60-140 part nanometer Long Pepper 60-140 part
Nanometer Rhizoma Atractylodis Macrocephalae 60-140 part nanometer Cinnabaris 60-140 part
Nanometer Pulvis Cornus Bubali Concentratus 120-280 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
2, nano storax medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nano storax 40-60 part nanometer Benzoinum 80-120 part nanometer Borneolum Syntheticum 40-60 part
Nano musk 60-90 part nanometer terminalia flesh 80-120 part nanometer Lignum Santali Albi 80-120 part
Nanometer Lignum Aquilariae Resinatum 80-120 part nano clove 80-120 part nano cyperus tuber 80-120 part
Nanometer Radix Aucklandiae 80-120 part nanometer Olibanum 80-120 part nanometer Long Pepper 80-120 part
Nanometer Rhizoma Atractylodis Macrocephalae 80-120 part nanometer Cinnabaris 80-120 part
Nanometer Pulvis Cornus Bubali Concentratus 160-240 part
3, nano storax medicine according to claim 1, wherein the weight proportion of each nano raw material is:
50 parts of 100 parts of nanometer Borneolum Syntheticums of 50 parts of nanometer Benzoinumes of nano storax
100 parts in 100 parts of nanometer Lignum Santali Albis of 75 parts of nanometer terminalia flesh of nano musk
100 parts of 100 parts of nano cyperus tubers of 100 parts of nano cloves of nanometer Lignum Aquilariae Resinatum
100 parts of 100 parts of nanometer Long Peppers of 100 parts of nanometer Olibanums of the nanometer Radix Aucklandiae
100 parts in 100 parts of nanometer Cinnabaris of the nanometer Rhizoma Atractylodis Macrocephalae
200 parts of nanometer Pulvis Cornus Bubali Concentratuss
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano storax medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano storax medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100769 CN1363331A (en) | 2001-01-09 | 2001-01-09 | Nano storax medicine and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100769 CN1363331A (en) | 2001-01-09 | 2001-01-09 | Nano storax medicine and its preparing process |
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| Publication Number | Publication Date |
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| CN1363331A true CN1363331A (en) | 2002-08-14 |
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|---|---|---|---|
| CN 01100769 Pending CN1363331A (en) | 2001-01-09 | 2001-01-09 | Nano storax medicine and its preparing process |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102846899A (en) * | 2012-09-13 | 2013-01-02 | 李承平 | Storax tablet combination |
| CN113116997A (en) * | 2021-04-30 | 2021-07-16 | 贵州汉方药业有限公司 | Preparation method of storax pills |
-
2001
- 2001-01-09 CN CN 01100769 patent/CN1363331A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102846899A (en) * | 2012-09-13 | 2013-01-02 | 李承平 | Storax tablet combination |
| CN113116997A (en) * | 2021-04-30 | 2021-07-16 | 贵州汉方药业有限公司 | Preparation method of storax pills |
| CN113116997B (en) * | 2021-04-30 | 2022-10-21 | 贵州汉方药业有限公司 | Preparation method of storax pills |
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