CN1360928A - Nanometer Fuyanping medicine and its prepn - Google Patents
Nanometer Fuyanping medicine and its prepn Download PDFInfo
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- CN1360928A CN1360928A CN 00136924 CN00136924A CN1360928A CN 1360928 A CN1360928 A CN 1360928A CN 00136924 CN00136924 CN 00136924 CN 00136924 A CN00136924 A CN 00136924A CN 1360928 A CN1360928 A CN 1360928A
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- 239000003814 drug Substances 0.000 title claims abstract description 45
- 239000000463 material Substances 0.000 claims abstract description 20
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 5
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 20
- 239000000843 powder Substances 0.000 claims description 19
- 238000002360 preparation method Methods 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 11
- 239000002775 capsule Substances 0.000 claims description 10
- 235000010338 boric acid Nutrition 0.000 claims description 9
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 229940093265 berberine Drugs 0.000 claims description 5
- QISXPYZVZJBNDM-UHFFFAOYSA-N berberine Natural products COc1ccc2C=C3N(Cc2c1OC)C=Cc4cc5OCOc5cc34 QISXPYZVZJBNDM-UHFFFAOYSA-N 0.000 claims description 5
- -1 berberine hydrochlorides Chemical class 0.000 claims description 5
- 125000005619 boric acid group Chemical class 0.000 claims description 5
- 239000008187 granular material Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- VKJGBAJNNALVAV-UHFFFAOYSA-M Berberine chloride (TN) Chemical compound [Cl-].C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 VKJGBAJNNALVAV-UHFFFAOYSA-M 0.000 claims description 4
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 4
- 239000004327 boric acid Substances 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 230000033001 locomotion Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 2
- 239000006188 syrup Substances 0.000 claims description 2
- 235000020357 syrup Nutrition 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 239000003390 Chinese drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 9
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- DFOCUWZXJBAUSQ-URLMMPGGSA-N Berbamine Chemical compound C([C@@H]1N(C)CCC=2C=C(C(OC=3C(OC)=C(OC)C=C4CCN(C)[C@@H](C=34)CC=3C=C(C(=CC=3)O)O3)=CC=21)OC)C1=CC=C3C=C1 DFOCUWZXJBAUSQ-URLMMPGGSA-N 0.000 abstract 1
- DFOCUWZXJBAUSQ-UHFFFAOYSA-N Berbamine Natural products O1C(C(=CC=2)O)=CC=2CC(C=23)N(C)CCC3=CC(OC)=C(OC)C=2OC(=CC=23)C(OC)=CC=2CCN(C)C3CC2=CC=C1C=C2 DFOCUWZXJBAUSQ-UHFFFAOYSA-N 0.000 abstract 1
- 241000212948 Cnidium Species 0.000 abstract 1
- 235000009694 Quassia amara Nutrition 0.000 abstract 1
- 240000003085 Quassia amara Species 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 230000000704 physical effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 description 5
- 208000003251 Pruritus Diseases 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 208000004926 Bacterial Vaginosis Diseases 0.000 description 2
- 208000004145 Endometritis Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000006374 Uterine Cervicitis Diseases 0.000 description 2
- 206010008323 cervicitis Diseases 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000009545 invasion Effects 0.000 description 2
- 230000007803 itching Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 244000045947 parasite Species 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 208000002003 vulvitis Diseases 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 206010046914 Vaginal infection Diseases 0.000 description 1
- 201000008100 Vaginitis Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000004035 construction material Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The nano Fuyanping medicine is prepared with nano Radix Sophorae Flavescentis, nano Cnidium mormieri, nano indian quassiawood, nano borneol, nano berbamine and other four kinds of nano Chinese medicinal materials in certain proportion as material. It has a grain fineness of 1200-1500 mesh, grain size of 0.1-200 nm and mostly below 100 nm, and new physical property. It is prepared through microwave extraction, decompressing concentration, spray drying in supersonic jet and other steps. It has high biological utilization and high treating effect.
Description
The present invention relates to a kind of heat-clearing and toxic substances removing, dampness leukorrhagia stopping, killing parasites for relieving itching, cure mainly the nanometer FUYANPING preparation medicine of vaginitis, cervicitis, endometritis, the invention still further relates to the method for this medication preparation.
Fuyanping capsules is a kind of classical Chinese patent medicine, mainly contains effects such as heat-clearing and toxic substances removing, dampness leukorrhagia stopping, killing parasites for relieving itching, is used for that damp invasion of lower energizer, dai channel are failed to keep an appointment, leucorrhea with red and white discharge, pudendal pruritus swell and ache, and infusorian, mycete, bacterial vaginitis, vulvitis etc.But traditional fuyanping capsules disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer FUYANPING preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer FUYANPING preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Radix Sophorae Flavescentis 200-300 part nano-pearl layer powder 1-5 part nano berberine hydrochloride 10-30 part
Nanometer Ramulus Et Folium Picrasmae 160-240 part nanometer Borneolum Syntheticum 1-10 part nano boric acid 10-50 part
Nanometer Fructus Cnidii 160-240 part nanometer Mentholum 1-3 part nanometer dried Alumen 30-70 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Radix Sophorae Flavescentis 220-270 part nano-pearl layer powder 2-3 part nano berberine hydrochloride 15-25 part
Nanometer Ramulus Et Folium Picrasmae 180-220 part nanometer Borneolum Syntheticum 3-7 part nano boric acid 20-40 part
Nanometer Fructus Cnidii 180-220 part nanometer Mentholum 1.5-2.5 part nanometer dried Alumen 40-60 part
The best important proportioning of medicine of the present invention is:
20 parts of 2.5 parts of nano berberine hydrochlorides of 250 parts of nano-pearl layers of nanometer Radix Sophorae Flavescentis powder
30 parts of 5 parts of nano boric acids of 200 parts of nanometer Borneolum Syntheticums of nanometer Ramulus Et Folium Picrasmae
50 parts of 2 parts of nanometer dried Alumens of 200 parts of nanometer Mentholums of nanometer Fructus Cnidii
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction-----material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get FUYANPING preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer FUYANPING preparation medicine is identical.
A kind of important feature of the present invention is, the made drug material of the present invention has reached nanoscale, common fuyanping capsules preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, and the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is, solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorbs fully, and the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, suppository, membrane, microcapsule, drop pill, aerosol, injection, oral solution of nanometer FUYANPING preparation medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for that damp invasion of lower energizer, dai channel are failed to keep an appointment, leucorrhea with red and white discharge, pudendal pruritus swell and ache, and treatment of conditions such as infusorian, mycete, bacterial vaginitis, vulvitis, endometritis, cervicitis, clinical efficacy significantly is better than traditional fuyanping capsules.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
20 parts of 2.5 parts of nano berberine hydrochlorides of 250 parts of nano-pearl layers of nanometer Radix Sophorae Flavescentis powder
30 parts of 5 parts of nano boric acids of 200 parts of nanometer Borneolum Syntheticums of nanometer Ramulus Et Folium Picrasmae
50 parts of 2 parts of nanometer dried Alumens of 200 parts of nanometer Mentholums of nanometer Fructus Cnidii
Production method is as follows:
In the GMP cleaning shop, the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio after, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulatedly with the fully-automatic capsule racking machine, make capsule.Every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
20 parts of 2.5 parts of nano berberine hydrochlorides of 250 parts of nano-pearl layers of nanometer Radix Sophorae Flavescentis powder
30 parts of 5 parts of nano boric acids of 200 parts of nanometer Borneolum Syntheticums of nanometer Ramulus Et Folium Picrasmae
50 parts of 2 parts of nanometer dried Alumens of 200 parts of nanometer Mentholums of nanometer Fructus Cnidii
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer FUYANPING powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Implement sharp 3:
Prepare nano raw material by preceding method:
20 parts of 2.5 parts of nano berberine hydrochlorides of 250 parts of nano-pearl layers of nanometer Radix Sophorae Flavescentis powder
30 parts of 5 parts of nano boric acids of 200 parts of nanometer Borneolum Syntheticums of nanometer Ramulus Et Folium Picrasmae
50 parts of 2 parts of nanometer dried Alumens of 200 parts of nanometer Mentholums of nanometer Fructus Cnidii
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer FUYANPING membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part.
Claims (6)
1, a kind of nanometer FUYANPING preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Radix Sophorae Flavescentis 200-300 part nano-pearl layer powder 1-5 part nano berberine hydrochloride 10-30 part
Nanometer Ramulus Et Folium Picrasmae 160-240 part nanometer Borneolum Syntheticum 1-10 part nano boric acid 10-50 part
Nanometer Fructus Cnidii 160-240 part nanometer Mentholum 1-3 part nanometer dried Alumen 30-70 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer FUYANPING preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Radix Sophorae Flavescentis 220-270 part nano-pearl layer powder 2-3 part nano berberine hydrochloride 15-25 part
Nanometer Ramulus Et Folium Picrasmae 180-220 part nanometer Borneolum Syntheticum 3-7 part nano boric acid 20-40 part
Nanometer Fructus Cnidii 180-220 part nanometer Mentholum 1.5-2.5 part nanometer dried Alumen 40-60 part
3, nanometer FUYANPING preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
20 parts of 2.5 parts of nano berberine hydrochlorides of 250 parts of nano-pearl layers of nanometer Radix Sophorae Flavescentis powder
30 parts of 5 parts of nano boric acids of 200 parts of nanometer Borneolum Syntheticums of nanometer Ramulus Et Folium Picrasmae
50 parts of 2 parts of nanometer dried Alumens of 200 parts of nanometer Mentholums of nanometer Fructus Cnidii
4, according to claim 1 or 2 or 3 described nanometer FUYANPING preparation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer FUYANPING preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00136924 CN1360928A (en) | 2000-12-29 | 2000-12-29 | Nanometer Fuyanping medicine and its prepn |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00136924 CN1360928A (en) | 2000-12-29 | 2000-12-29 | Nanometer Fuyanping medicine and its prepn |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1360928A true CN1360928A (en) | 2002-07-31 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00136924 Pending CN1360928A (en) | 2000-12-29 | 2000-12-29 | Nanometer Fuyanping medicine and its prepn |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1360928A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101455715B (en) * | 2008-11-13 | 2011-02-16 | 陕西东泰制药有限公司 | Suppository for treating gynecologic diseases and preparation method thereof |
-
2000
- 2000-12-29 CN CN 00136924 patent/CN1360928A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101455715B (en) * | 2008-11-13 | 2011-02-16 | 陕西东泰制药有限公司 | Suppository for treating gynecologic diseases and preparation method thereof |
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