CN1364478A - Nano wanyingding medicine and its prepairng method - Google Patents
Nano wanyingding medicine and its prepairng method Download PDFInfo
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- CN1364478A CN1364478A CN 01100252 CN01100252A CN1364478A CN 1364478 A CN1364478 A CN 1364478A CN 01100252 CN01100252 CN 01100252 CN 01100252 A CN01100252 A CN 01100252A CN 1364478 A CN1364478 A CN 1364478A
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- 239000003814 drug Substances 0.000 title claims abstract 20
- 238000000034 method Methods 0.000 title claims 4
- 239000000463 material Substances 0.000 claims abstract 7
- 238000002360 preparation method Methods 0.000 claims abstract 6
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract 4
- 241000402754 Erythranthe moschata Species 0.000 claims abstract 4
- 239000002994 raw material Substances 0.000 claims abstract 4
- 238000001694 spray drying Methods 0.000 claims abstract 3
- 229940079593 drug Drugs 0.000 claims 9
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 claims 3
- 244000080767 Areca catechu Species 0.000 claims 3
- 235000006226 Areca catechu Nutrition 0.000 claims 3
- 206010004542 Bezoar Diseases 0.000 claims 3
- 244000247747 Coptis groenlandica Species 0.000 claims 3
- 235000002991 Coptis groenlandica Nutrition 0.000 claims 3
- 239000003390 Chinese drug Substances 0.000 claims 2
- 239000012141 concentrate Substances 0.000 claims 2
- 235000008504 concentrate Nutrition 0.000 claims 2
- 238000001035 drying Methods 0.000 claims 2
- 238000000605 extraction Methods 0.000 claims 2
- 230000008676 import Effects 0.000 claims 2
- 238000002156 mixing Methods 0.000 claims 2
- 239000006187 pill Substances 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 239000000443 aerosol Substances 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000006196 drop Substances 0.000 claims 1
- 239000000796 flavoring agent Substances 0.000 claims 1
- 235000019634 flavors Nutrition 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 239000003094 microcapsule Substances 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 229940100688 oral solution Drugs 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
- 239000006188 syrup Substances 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- 241001483116 Neopicrorhiza scrophulariiflora Species 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 230000000704 physical effect Effects 0.000 abstract 1
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- Medicinal Preparation (AREA)
Abstract
The nano Wanyingding medicine is prepared with nano figwortflower picrorhiza rhizome, nano Rhizoma Coptidis, nano borneol, nano bear gall, nano musk and other four kinds of nano Chinese medicinal materials in certain proportion as raw material. The new medicine preparation has a grain fineness of 1200-1500 mesh, grain size of 0.1-200 nm, mostly below 100 nm, and new physical property. It is prepared through microwave extraction, decompressing concentration, spray drying in supersonic jet and other steps. it has high biological utilization and obvious treating effect.
Description
The present invention relates to a kind of heat clearing away, relieving convulsion, detoxifcation, cure mainly in the evil poison of children's and accumulate, the hyperpyrexia agitation, easily frightened, aphtha of the mouth and tongue, the nanometer wanying troche preparation medicine of gingiva, laryngopharynx swelling and pain the invention still further relates to the method for this medication preparation.
Wanying troche is a kind of classical Chinese patent medicine, mainly contains effects such as heat clearing away, relieving convulsion, detoxifcation, be used for accumulateing in the evil poison of children's, and the hyperpyrexia agitation, easily frightened, aphtha of the mouth and tongue, gingiva, laryngopharynx swelling and pain.But traditional wanying troche disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer wanying troche preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer wanying troche preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Rhizoma Picrorhizae 70-150 part nanometer coptis 70-150 part nanometer catechu 70-150 part
Nanometer Borneolum Syntheticum 4-9 part nanometer XIANGMO(sic) 120-300 part nanometer Fel Ursi 10-30 part
Nano musk 3-8 part nano bezoar 3-8 part nanometer Fel Bovis seu Bubali 100-200 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Rhizoma Picrorhizae 80-120 part nanometer coptis 80-120 part nanometer catechu 80-120 part
Nanometer Borneolum Syntheticum 5-8 part nanometer XIANGMO(sic) 150-250 part nanometer Fel Ursi 15-25 part
Nano musk 4-6 part nano bezoar 4-6 part nanometer Fel Bovis seu Bubali 120-180 part
The optimum weight proportioning of medicine of the present invention is:
100 parts in 100 portions of nanometer catechu of 100 parts of nanometer coptis of nanometer Rhizoma Picrorhizae
20 parts of 200 parts of nanometer Fel Ursis of 6 parts of nanometer XIANGMO(sic) of nanometer Borneolum Syntheticum
160 parts of 5 parts of nanometer Fel Bovis seu Bubali of 5 parts of nano bezoars of nano musk
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get wanying troche preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer wanying troche preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common wanying troche preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nanometer wanying troche preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for accumulateing in the evil poison of children's, and the hyperpyrexia agitation is easily frightened, aphtha of the mouth and tongue, and treatment of conditions such as gingiva, laryngopharynx swelling and pain, clinical efficacy significantly is better than traditional wanying troche.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
100 parts in 100 portions of nanometer catechu of 100 parts of nanometer coptis of nanometer Rhizoma Picrorhizae
20 parts of 200 parts of nanometer Fel Ursis of 6 parts of nanometer XIANGMO(sic) of nanometer Borneolum Syntheticum
160 parts of 5 parts of nanometer Fel Bovis seu Bubali of 5 parts of nano bezoars of nano musk
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
100 parts in 100 portions of nanometer catechu of 100 parts of nanometer coptis of nanometer Rhizoma Picrorhizae
20 parts of 200 parts of nanometer Fel Ursis of 6 parts of nanometer XIANGMO(sic) of nanometer Borneolum Syntheticum
160 parts of 5 parts of nanometer Fel Bovis seu Bubali of 5 parts of nano bezoars of nano musk
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer wanying troche powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
100 parts in 100 portions of nanometer catechu of 100 parts of nanometer coptis of nanometer Rhizoma Picrorhizae
20 parts of 200 parts of nanometer Fel Ursis of 6 parts of nanometer XIANGMO(sic) of nanometer Borneolum Syntheticum
160 parts of 5 parts of nanometer Fel Bovis seu Bubali of 5 parts of nano bezoars of nano musk
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer wanying troche membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nanometer wanying troche preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Rhizoma Picrorhizae 70-150 part nanometer coptis 70-150 part nanometer catechu 70-150 part
Nanometer Borneolum Syntheticum 4-9 part nanometer XIANGMO(sic) 120-300 part nanometer Fel Ursi 10-30 part
Nano musk 3-8 part nano bezoar 3-8 part nanometer Fel Bovis seu Bubali 100-200 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer wanying troche preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Rhizoma Picrorhizae 80-120 part nanometer coptis 80-120 part nanometer catechu 80-120 part
Nanometer Borneolum Syntheticum 5-8 part nanometer XIANGMO(sic) 150-250 part nanometer Fel Ursi 15-25 part
Nano musk 4-6 part nano bezoar 4-6 part nanometer Fel Bovis seu Bubali 120-180 part
3, nanometer wanying troche preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
100 parts in 100 portions of nanometer catechu of 100 parts of nanometer coptis of nanometer Rhizoma Picrorhizae
20 parts of 200 parts of nanometer Fel Ursis of 6 parts of nanometer XIANGMO(sic) of nanometer Borneolum Syntheticum
160 parts of 5 parts of nanometer Fel Bovis seu Bubali of 5 parts of nano bezoars of nano musk
4, according to claim 1 or 2 or 3 described nanometer wanying troche preparation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer wanying troche preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100252 CN1364478A (en) | 2001-01-12 | 2001-01-12 | Nano wanyingding medicine and its prepairng method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100252 CN1364478A (en) | 2001-01-12 | 2001-01-12 | Nano wanyingding medicine and its prepairng method |
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| CN1364478A true CN1364478A (en) | 2002-08-21 |
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| CN 01100252 Pending CN1364478A (en) | 2001-01-12 | 2001-01-12 | Nano wanyingding medicine and its prepairng method |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105748696A (en) * | 2014-12-19 | 2016-07-13 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Traditional Chinese medicinal composition for clearing heat and cooling blood, and preparation method thereof |
| CN111686167A (en) * | 2020-07-16 | 2020-09-22 | 成都杨天万应制药有限公司 | Preparation method and application of antibacterial and anti-inflammatory ointment |
| CN111714560A (en) * | 2020-07-16 | 2020-09-29 | 成都杨天万应制药有限公司 | Skin mucosa disinfection ointment and preparation method and application thereof |
| CN115192652A (en) * | 2021-09-01 | 2022-10-18 | 成都杨天万应制药有限公司 | Wanying granules and preparation method thereof |
| CN115463175A (en) * | 2022-05-23 | 2022-12-13 | 成都杨天万应制药有限公司 | Wanying capsule for clearing away heat and toxic material and its preparation process |
-
2001
- 2001-01-12 CN CN 01100252 patent/CN1364478A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105748696A (en) * | 2014-12-19 | 2016-07-13 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Traditional Chinese medicinal composition for clearing heat and cooling blood, and preparation method thereof |
| CN111686167A (en) * | 2020-07-16 | 2020-09-22 | 成都杨天万应制药有限公司 | Preparation method and application of antibacterial and anti-inflammatory ointment |
| CN111714560A (en) * | 2020-07-16 | 2020-09-29 | 成都杨天万应制药有限公司 | Skin mucosa disinfection ointment and preparation method and application thereof |
| CN115192652A (en) * | 2021-09-01 | 2022-10-18 | 成都杨天万应制药有限公司 | Wanying granules and preparation method thereof |
| CN115192652B (en) * | 2021-09-01 | 2023-05-23 | 成都杨天万应制药有限公司 | Universal granule and preparation method thereof |
| CN115463175A (en) * | 2022-05-23 | 2022-12-13 | 成都杨天万应制药有限公司 | Wanying capsule for clearing away heat and toxic material and its preparation process |
| CN115463175B (en) * | 2022-05-23 | 2023-11-21 | 成都杨天万应制药有限公司 | Universal capsule for clearing heat and detoxicating and its preparing process |
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