CN1360941A - Nanometer women's Qianjin Medicine and its prepn - Google Patents
Nanometer women's Qianjin Medicine and its prepn Download PDFInfo
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- CN1360941A CN1360941A CN 00136937 CN00136937A CN1360941A CN 1360941 A CN1360941 A CN 1360941A CN 00136937 CN00136937 CN 00136937 CN 00136937 A CN00136937 A CN 00136937A CN 1360941 A CN1360941 A CN 1360941A
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- 239000003814 drug Substances 0.000 title claims abstract description 45
- 229940079593 drug Drugs 0.000 title claims description 21
- 239000000463 material Substances 0.000 claims abstract description 20
- 241000756943 Codonopsis Species 0.000 claims abstract description 10
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 238000002360 preparation method Methods 0.000 claims description 19
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 14
- 239000010931 gold Substances 0.000 claims description 13
- 229910052737 gold Inorganic materials 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 11
- 241000746375 Andrographis Species 0.000 claims description 9
- 241000213006 Angelica dahurica Species 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 5
- 239000012528 membrane Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 230000033001 locomotion Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 2
- 239000003390 Chinese drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 9
- 241001022083 Flemingia Species 0.000 abstract 1
- 241001278833 Rosa laevigata Species 0.000 abstract 1
- 235000000661 Rosa laevigata Nutrition 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 230000000704 physical effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 description 5
- 239000002671 adjuvant Substances 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 208000004145 Endometritis Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000029082 Pelvic Inflammatory Disease Diseases 0.000 description 2
- 208000006374 Uterine Cervicitis Diseases 0.000 description 2
- 206010008323 cervicitis Diseases 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000004035 construction material Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 229940040145 liniment Drugs 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The nano women's Qianjin medicine is prepared with nano philippine flemingia root, nano cherokee rose root, nano Herba Andrographitis, nano Caulis mahoniae, nano Codonopsis Pilosulae and other three kinds of nano Chinese medicinal materials in certain proportion as material. It has a grain fineness of 1200-1500 mesh, grain size of 0.1-200 nm and mostly below 100 nm, and new physical property. It is prepared through microwave extraction, decompressing concentration, spray drying in supersonic jet and other steps. It has high biological utilization and high treating effect.
Description
The present invention relates to a kind of removing damp-heat, benefiting vital QI and blood, cure mainly nanometer women a thousand pieces of gold preparation medicine of gynecological inflammation, the invention still further relates to the method for this medication preparation.
FUKE QIANJIN PIAN is a kind of classical Chinese patent medicine, mainly contains effects such as removing damp-heat, benefiting vital QI and blood, is used for leukorrheal diseases, damp invasion of lower energizer, insufficiency of vital energy and blood, pelvic inflammatory disease, endometritis, cervicitis etc.But traditional FUKE QIANJIN PIAN disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully nanometer women a thousand pieces of gold preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer women a thousand pieces of gold preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Very heavy group of 5-50 part of nanometer Radix Rosae Laevigatae 5-40 part nanometer Caulis Spatholobi 5-60 part nanometer
Nanometer Caulis Mahoniae 5-40 part nanometer Fructus Zanthoxyli Dissiti 5-60 part nanometer Herba Andrographis 10-60 part
Nanometer Radix Codonopsis 5-60 part nano Chinese angelica 10-100 part
The formula optimization weight proportion scope of medicine of the present invention is:
Very heavy group of 20-40 part of nanometer Radix Rosae Laevigatae 10-30 part nanometer Caulis Spatholobi 10-40 part nanometer
Nanometer Caulis Mahoniae 15-25 part nanometer Fructus Zanthoxyli Dissiti 20-40 part nanometer Herba Andrographis 25-50 part
Nanometer Radix Codonopsis 20-40 part nano Chinese angelica 30-70 part
The best important proportioning of medicine of the present invention is:
25 parts of nanometers of 20 parts of nanometer Caulis Spatholobis of nanometer Radix Rosae Laevigatae are very heavy dials 30 parts
35 parts of 30 parts of nanometer Herba Andrographis of 25 parts of nanometer Fructus Zanthoxyli Dissiti of nanometer Caulis Mahoniae
50 parts of 30 parts of nano Chinese angelicas of nanometer Radix Codonopsis
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction-----material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get gynecological's a thousand pieces of gold preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer women a thousand pieces of gold preparation medicine is identical.
A kind of important feature of the present invention is, the made drug material of the present invention has reached nanoscale, common FUKE QIANJIN PIAN preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, and the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is, solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorbs fully, and the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, suppository, membrane, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nanometer women a thousand pieces of gold preparation medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as pelvic inflammatory disease, endometritis, cervicitis, and clinical efficacy significantly is better than traditional FUKE QIANJIN PIAN.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
25 parts of nanometers of 20 parts of nanometer Caulis Spatholobis of nanometer Radix Rosae Laevigatae are very heavy dials 30 parts
35 parts of 30 parts of nanometer Herba Andrographis of 25 parts of nanometer Fructus Zanthoxyli Dissiti of nanometer Caulis Mahoniae
50 parts of 30 parts of nano Chinese angelicas of nanometer Radix Codonopsis
Production method is as follows:
In the GMP cleaning shop, the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio after, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulatedly with the fully-automatic capsule racking machine, make capsule.Every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
25 parts of nanometers of 20 parts of nanometer Caulis Spatholobis of nanometer Radix Rosae Laevigatae are very heavy dials 30 parts
35 parts of 30 parts of nanometer Herba Andrographis of 25 parts of nanometer Fructus Zanthoxyli Dissiti of nanometer Caulis Mahoniae
50 parts of 30 parts of nano Chinese angelicas of nanometer Radix Codonopsis
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer women a thousand pieces of gold powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Implement sharp 3:
Prepare nano raw material by preceding method:
25 parts of nanometers of 20 parts of nanometer Caulis Spatholobis of nanometer Radix Rosae Laevigatae are very heavy dials 30 parts
35 parts of 30 parts of nanometer Herba Andrographis of 25 parts of nanometer Fructus Zanthoxyli Dissiti of nanometer Caulis Mahoniae
50 parts of 30 parts of nano Chinese angelicas of nanometer Radix Codonopsis
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer women a thousand pieces of gold liniment, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part.
Claims (6)
1, a kind of nanometer women a thousand pieces of gold preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Very heavy group of 5-50 part of nanometer Radix Rosae Laevigatae 5-40 part nanometer Caulis Spatholobi 5-60 part nanometer
Nanometer Caulis Mahoniae 5-40 part nanometer Fructus Zanthoxyli Dissiti 5-60 part nanometer Herba Andrographis 10-60 part
Nanometer Radix Codonopsis 5-60 part nano Chinese angelica 10-100 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer women a thousand pieces of gold preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Very heavy group of 20-40 part of nanometer Radix Rosae Laevigatae 10-30 part nanometer Caulis Spatholobi 10-40 part nanometer
Nanometer Caulis Mahoniae 15-25 part nanometer Fructus Zanthoxyli Dissiti 20-40 part nanometer Herba Andrographis 25-50 part
Nanometer Radix Codonopsis 20-40 part nano Chinese angelica 30-70 part
3, nanometer women a thousand pieces of gold preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
25 parts of nanometers of 20 parts of nanometer Caulis Spatholobis of nanometer Radix Rosae Laevigatae are very heavy dials 30 parts
35 parts of 30 parts of nanometer Herba Andrographis of 25 parts of nanometer Fructus Zanthoxyli Dissiti of nanometer Caulis Mahoniae
50 parts of 30 parts of nano Chinese angelicas of nanometer Radix Codonopsis
4, according to claim 1 or 2 or 3 described nanometer women a thousand pieces of gold preparation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer women a thousand pieces of gold preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00136937 CN1360941A (en) | 2000-12-29 | 2000-12-29 | Nanometer women's Qianjin Medicine and its prepn |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00136937 CN1360941A (en) | 2000-12-29 | 2000-12-29 | Nanometer women's Qianjin Medicine and its prepn |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1360941A true CN1360941A (en) | 2002-07-31 |
Family
ID=4597602
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00136937 Pending CN1360941A (en) | 2000-12-29 | 2000-12-29 | Nanometer women's Qianjin Medicine and its prepn |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1360941A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1330335C (en) * | 2004-06-18 | 2007-08-08 | 株洲千金药业股份有限公司 | Method for preparing a gynecopathy treating medicine |
-
2000
- 2000-12-29 CN CN 00136937 patent/CN1360941A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1330335C (en) * | 2004-06-18 | 2007-08-08 | 株洲千金药业股份有限公司 | Method for preparing a gynecopathy treating medicine |
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