CN1364514A - Nano eight ingredient motherwort medicine and its preparing method - Google Patents
Nano eight ingredient motherwort medicine and its preparing method Download PDFInfo
- Publication number
- CN1364514A CN1364514A CN 01100499 CN01100499A CN1364514A CN 1364514 A CN1364514 A CN 1364514A CN 01100499 CN01100499 CN 01100499 CN 01100499 A CN01100499 A CN 01100499A CN 1364514 A CN1364514 A CN 1364514A
- Authority
- CN
- China
- Prior art keywords
- nano
- nanometer
- motherwort
- parts
- chinese
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 46
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 title claims abstract description 26
- 241000207925 Leonurus Species 0.000 title claims abstract description 26
- 235000000802 Leonurus cardiaca ssp. villosus Nutrition 0.000 title claims abstract description 26
- 239000004615 ingredient Substances 0.000 title claims abstract description 14
- 238000000034 method Methods 0.000 title claims description 12
- 239000000463 material Substances 0.000 claims abstract description 20
- 241000213006 Angelica dahurica Species 0.000 claims abstract description 10
- 241000756943 Codonopsis Species 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 7
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 5
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 20
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 241000202807 Glycyrrhiza Species 0.000 claims description 5
- 239000006187 pill Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 2
- 229940100688 oral solution Drugs 0.000 claims description 2
- 239000006188 syrup Substances 0.000 claims description 2
- 235000020357 syrup Nutrition 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 239000003390 Chinese drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 9
- 238000002360 preparation method Methods 0.000 abstract description 8
- 230000006837 decompression Effects 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 230000000704 physical effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010003549 asthenia Diseases 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 206010021067 Hypopituitarism Diseases 0.000 description 1
- 208000019255 Menstrual disease Diseases 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 206010036297 Postpartum hypopituitarism Diseases 0.000 description 1
- 206010037549 Purpura Diseases 0.000 description 1
- 241001672981 Purpura Species 0.000 description 1
- 201000009895 Sheehan syndrome Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000000916 dilatatory effect Effects 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 210000000865 mononuclear phagocyte system Anatomy 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000000242 pagocytic effect Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
The nano eight ingredient and motherwort medicine is prepared with nano motherwort, nano Codonopsis Pilosulae, nano prepared remannia rhizome, nano Chinese angelica, nano Radix Paeoniae Alba and other four kinds of nano Chinese medicinal materials in certain proportion as raw material. The new medicine preparation has a grain fineness of 1200-1500 mesh, rain size of 0.1-200 nm, mostly below 100 nm, and new physical property. It is prepared through microwave extraction, decompression concentration, spray drying in supersonic jet and other steps. It has high biological utilization and obvious treating effect.
Description
The present invention relates to a kind of menstruation that fills blood, transfers, cure mainly the nano eight ingredient motherwort medicine that asthenia of qi and blood loses, the invention still further relates to the method for this medication preparation.
BAZHEN YIMU PIAN is a kind of classical Chinese patent medicine, mainly contains effects such as blood vessel dilating, anticoagulant, stimulation reticuloendothelial system phagocytic function, excited uterus, is used for women's QI and blood deficiency, unable, the menoxenia of asthenia.But traditional BAZHEN YIMU PIAN disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano eight ingredient motherwort medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano eight ingredient motherwort medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer motherwort 150-350 part nanometer Radix Codonopsis 40-80 part nanometer Radix Rehmanniae Preparata 80-170 part
Nano Chinese angelica 80-170 part nanometer Radix Paeoniae Alba 40-80 part nano Poria 40-80 part
Nanometer Rhizoma Atractylodis Macrocephalae 40-80 part nanometer Rhizoma Chuanxiong 40-80 part nanometer Radix Glycyrrhizae 10-50 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer motherwort 200-300 part nanometer Radix Codonopsis 50-70 part nanometer Radix Rehmanniae Preparata 100-150 part
Nano Chinese angelica 100-150 part nanometer Radix Paeoniae Alba 50-70 part nano Poria 50-70 part
Nanometer Rhizoma Atractylodis Macrocephalae 50-70 part nanometer Rhizoma Chuanxiong 50-70 part nanometer Radix Glycyrrhizae 20-40 part
The optimum weight proportioning of medicine of the present invention is:
123 parts of 61 parts of nanometer Radix Rehmanniae Preparata of 245 parts of nanometer Radix Codonopsis of nanometer motherwort
61 parts of 61 parts of nano Porias of 123 parts of nanometer Radix Paeoniae Albas of nano Chinese angelica
31 parts in 61 parts of nanometer Radix Glycyrrhizaes of 61 parts of nanometer Rhizoma Chuanxiongs of the nanometer Rhizoma Atractylodis Macrocephalae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the eight ingredient motherwort nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano eight ingredient motherwort medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common BAZHEN YIMU PIAN preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection of nano eight ingredient motherwort medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as Sheehan syndrome, pigment purpura, and clinical efficacy significantly is better than traditional BAZHEN YIMU PIAN.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
123 parts of 61 parts of nanometer Radix Rehmanniae Preparata of 245 parts of nanometer Radix Codonopsis of nanometer motherwort
61 parts of 61 parts of nano Porias of 123 parts of nanometer Radix Paeoniae Albas of nano Chinese angelica
31 parts in 61 parts of nanometer Radix Glycyrrhizaes of 61 parts of nanometer Rhizoma Chuanxiongs of the nanometer Rhizoma Atractylodis Macrocephalae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes 1-4 time every day, each 1-5 grain.
Embodiment 2:
Prepare nano raw material by preceding method:
123 parts of 61 parts of nanometer Radix Rehmanniae Preparata of 245 parts of nanometer Radix Codonopsis of nanometer motherwort
61 parts of 61 parts of nano Porias of 123 parts of nanometer Radix Paeoniae Albas of nano Chinese angelica
31 parts in 61 parts of nanometer Radix Glycyrrhizaes of 61 parts of nanometer Rhizoma Chuanxiongs of the nanometer Rhizoma Atractylodis Macrocephalae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make nanometer eight delicacies with motherwort powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
123 parts of 61 parts of nanometer Radix Rehmanniae Preparata of 245 parts of nanometer Radix Codonopsis of nanometer motherwort
61 parts of 61 parts of nano Porias of 123 parts of nanometer Radix Paeoniae Albas of nano Chinese angelica
31 parts in 61 parts of nanometer Radix Glycyrrhizaes of 61 parts of nanometer Rhizoma Chuanxiongs of the nanometer Rhizoma Atractylodis Macrocephalae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make nanometer eight delicacies with motherwort membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part.
Claims (6)
1, a kind of nano eight ingredient motherwort medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer motherwort 150-350 part nanometer Radix Codonopsis 40-80 part nanometer Radix Rehmanniae Preparata 80-170 part
Nano Chinese angelica 80-170 part nanometer Radix Paeoniae Alba 40-80 part nano Poria 40-80 part
Nanometer Rhizoma Atractylodis Macrocephalae 40-80 part nanometer Rhizoma Chuanxiong 40-80 part nanometer Radix Glycyrrhizae 10-50 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
2, nano eight ingredient motherwort medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer motherwort 200-300 part nanometer Radix Codonopsis 50-70 part nanometer Radix Rehmanniae Preparata 100-150 part
Nano Chinese angelica 100-150 part nanometer Radix Paeoniae Alba 50-70 part nano Poria 50-70 part
Nanometer Rhizoma Atractylodis Macrocephalae 50-70 part nanometer Rhizoma Chuanxiong 50-70 part nanometer Radix Glycyrrhizae 20-40 part
3, nano eight ingredient motherwort medicine according to claim 1, wherein the weight proportion of each nano raw material is:
123 parts of 61 parts of nanometer Radix Rehmanniae Preparata of 245 parts of nanometer Radix Codonopsis of nanometer motherwort
61 parts of 61 parts of nano Porias of 123 parts of nanometer Radix Paeoniae Albas of nano Chinese angelica
31 parts in 61 parts of nanometer Radix Glycyrrhizaes of 61 parts of nanometer Rhizoma Chuanxiongs of the nanometer Rhizoma Atractylodis Macrocephalae
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano eight ingredient motherwort medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano eight ingredient motherwort medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100499 CN1364514A (en) | 2001-01-16 | 2001-01-16 | Nano eight ingredient motherwort medicine and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100499 CN1364514A (en) | 2001-01-16 | 2001-01-16 | Nano eight ingredient motherwort medicine and its preparing method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1364514A true CN1364514A (en) | 2002-08-21 |
Family
ID=4651639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100499 Pending CN1364514A (en) | 2001-01-16 | 2001-01-16 | Nano eight ingredient motherwort medicine and its preparing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1364514A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102824457A (en) * | 2012-06-04 | 2012-12-19 | 江西南昌桑海制药厂 | Eight-treasure motherwort active site and preparation process of capsules |
-
2001
- 2001-01-16 CN CN 01100499 patent/CN1364514A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102824457A (en) * | 2012-06-04 | 2012-12-19 | 江西南昌桑海制药厂 | Eight-treasure motherwort active site and preparation process of capsules |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1363287A (en) | Nano Wuling medicine and its preparing process | |
| CN1364514A (en) | Nano eight ingredient motherwort medicine and its preparing method | |
| CN1364558A (en) | Nano wet and heat astralgia treating medicine and its preparing method | |
| CN1366895A (en) | Nano supplement both qi and blood preparation medicine and preparation method thereof | |
| CN1364482A (en) | Nano wild jujube seed mecicine and its preparing method | |
| CN1363341A (en) | Nano medicine 'Jiuwei Qianghuo' and its preparing process | |
| CN1364605A (en) | Nano compound sichuan fritillary bulb medicine and its preparing method | |
| CN1366966A (en) | Nano pinellia preparation medicine and preparation method | |
| CN1362232A (en) | Nano medicine of cinnamoni, Aconiti preparata and rehmannia and its preparation | |
| CN1362220A (en) | Nano Anemarrhenae, phellodendri and Rehmanniae medicine and its preparation | |
| CN1364602A (en) | Nano powerful tonic medicine and its preparing method | |
| CN1362128A (en) | Nano tranquilizing and brain nourishing medicine and its preparation | |
| CN1360938A (en) | Nanometer rhinitis-treaitng Qianbai medicine and its prepn | |
| CN1368184A (en) | Nano medicine 'Shujin Huoluo' and its preparing process | |
| CN1364506A (en) | Nano seven ingredient grape medicine and its preparing method | |
| CN1362179A (en) | Nano eight-ingredient medicine and its preparation | |
| CN1362178A (en) | Nano rehmannia medicine with six ingredients and its preparation | |
| CN1362104A (en) | Nano Angelicae Pubescentis and Loranthis medicine and its preparation | |
| CN1362195A (en) | Nano Jinkuishenqi medicine for invigorating kidney essence and its preparation | |
| CN1360917A (en) | Nanoemter alopecia treating medicine and its prepn | |
| CN1362222A (en) | Nanometer blood-nourishing and transquilizing medicine and its preparation | |
| CN1360926A (en) | Nanometer menstruction regulation Chinese angelica medicine and its prepn | |
| CN1362157A (en) | Nano Sanjiuweitai medicine and its preparation | |
| CN1362229A (en) | Nano Maiwei Rehmannine Praeparatae medicine and its preparation | |
| CN1364582A (en) | Nano children heat clearing away and cough arresting medicine and its preparing method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |