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CL2017000902A1 - Dihidropirrolopiridinas inhibidoras de ror-gamma - Google Patents

Dihidropirrolopiridinas inhibidoras de ror-gamma

Info

Publication number
CL2017000902A1
CL2017000902A1 CL2017000902A CL2017000902A CL2017000902A1 CL 2017000902 A1 CL2017000902 A1 CL 2017000902A1 CL 2017000902 A CL2017000902 A CL 2017000902A CL 2017000902 A CL2017000902 A CL 2017000902A CL 2017000902 A1 CL2017000902 A1 CL 2017000902A1
Authority
CL
Chile
Prior art keywords
dihydropyrrolopyridines
ror
gamma inhibitor
formula
diseases
Prior art date
Application number
CL2017000902A
Other languages
English (en)
Inventor
David A Claremon
Lawrence Wayne Dillard
Chengguo Dong
Yi Fan
Lanqi Jia
Stephen D Lotesta
Andrew Marcus
Suresh B Singh
Colin M Tice
Jing Yuan
Wei Zhao
Yajun Zheng
Linghang Zhuang
Original Assignee
Vitae Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vitae Pharmaceuticals Inc filed Critical Vitae Pharmaceuticals Inc
Publication of CL2017000902A1 publication Critical patent/CL2017000902A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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Abstract

<p>SE PROVEEN COMPUESTOS NOVEDOSOS DE FÓRMULA (I): SALES FARMACÉUTICAMENTE ACEPTABLES DE LOS MISMOS, Y COMPOSICIONES FARMACÉUTICAS DE LOS MISMOS, QUE SON ÚTILES EN EL TRATAMIENTO DE ENFERMEDADES Y TRASTORNOS MEDIADOS POR ROR-GAMMA. TAMBIÉN SE PROVEEN COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN LOS COMPUESTOS NOVEDOSOS DE FÓRMULA (I) Y MÉTODOS PARA SU USO EN EL TRATAMIENTO DE UNA O MÁS ENFERMEDADES INFLAMATORIAS, METABÓLICAS, AUTOINMUNES Y OTRAS ENFERMEDADES O TRASTORNOS.</p>
CL2017000902A 2014-10-14 2017-04-12 Dihidropirrolopiridinas inhibidoras de ror-gamma CL2017000902A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462063912P 2014-10-14 2014-10-14
US201462074406P 2014-11-03 2014-11-03

Publications (1)

Publication Number Publication Date
CL2017000902A1 true CL2017000902A1 (es) 2017-09-29

Family

ID=54352515

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2017000902A CL2017000902A1 (es) 2014-10-14 2017-04-12 Dihidropirrolopiridinas inhibidoras de ror-gamma

Country Status (28)

Country Link
US (3) US9796710B2 (es)
EP (1) EP3207043B3 (es)
JP (1) JP6564029B2 (es)
KR (1) KR20170066628A (es)
CN (1) CN107074852B (es)
AU (1) AU2015333610B2 (es)
BR (1) BR112017007460A2 (es)
CA (1) CA2963140A1 (es)
CL (1) CL2017000902A1 (es)
CO (1) CO2017004525A2 (es)
CY (1) CY1121413T1 (es)
DK (1) DK3207043T6 (es)
EA (1) EA031967B1 (es)
EC (1) ECSP17029371A (es)
ES (1) ES2715458T7 (es)
HU (1) HUE042335T2 (es)
IL (1) IL251584B (es)
MX (1) MX371304B (es)
MY (1) MY182454A (es)
PH (1) PH12017500583B1 (es)
PL (1) PL3207043T6 (es)
PT (1) PT3207043T (es)
SG (1) SG11201702362SA (es)
SI (1) SI3207043T1 (es)
TW (1) TWI675032B (es)
UA (1) UA118989C2 (es)
WO (1) WO2016061160A1 (es)
ZA (1) ZA201702237B (es)

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TWI757266B (zh) 2016-01-29 2022-03-11 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
JP2020059651A (ja) * 2016-12-26 2020-04-16 科研製薬株式会社 ピラゾール誘導体及びそれを含有する医薬
JP7157755B2 (ja) 2017-03-16 2022-10-20 エフ．ホフマン－ラ ロシュ アーゲー 二重ａｔｘ／ｃａ阻害剤として有用な複素環式化合物
JP7090099B2 (ja) 2017-03-16 2022-06-23 エフ．ホフマン－ラ ロシュ アーゲー Ａｔｘインヒビターとしての新規二環式化合物
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