[go: up one dir, main page]

BRPI0815210A2 - Derivados de indol 5-amino-4,6-dissubstituído e indolina 5-amino-4,6-dissubstituída como moduladores de canais de potássio - Google Patents

Derivados de indol 5-amino-4,6-dissubstituído e indolina 5-amino-4,6-dissubstituída como moduladores de canais de potássio

Info

Publication number
BRPI0815210A2
BRPI0815210A2 BRPI0815210A BRPI0815210A2 BR PI0815210 A2 BRPI0815210 A2 BR PI0815210A2 BR PI0815210 A BRPI0815210 A BR PI0815210A BR PI0815210 A2 BRPI0815210 A2 BR PI0815210A2
Authority
BR
Brazil
Prior art keywords
amino
disubstituted
derivatives
potassium channel
channel modulators
Prior art date
Application number
Other languages
English (en)
Inventor
Jean-Michel Vernier
Huanming Chen
Jianlan Song
Original Assignee
Valeant Pharmaceuticals Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Valeant Pharmaceuticals Int filed Critical Valeant Pharmaceuticals Int
Publication of BRPI0815210A2 publication Critical patent/BRPI0815210A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
BRPI0815210 2007-08-13 2008-08-12 Derivados de indol 5-amino-4,6-dissubstituído e indolina 5-amino-4,6-dissubstituída como moduladores de canais de potássio BRPI0815210A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96452607P 2007-08-13 2007-08-13
US12/189,709 US7786146B2 (en) 2007-08-13 2008-08-11 Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators
PCT/US2008/072926 WO2009023677A1 (en) 2007-08-13 2008-08-12 Derivatives of 5-amino-4, 6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators

Publications (1)

Publication Number Publication Date
BRPI0815210A2 true BRPI0815210A2 (pt) 2015-03-31

Family

ID=40029251

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0815210 BRPI0815210A2 (pt) 2007-08-13 2008-08-12 Derivados de indol 5-amino-4,6-dissubstituído e indolina 5-amino-4,6-dissubstituída como moduladores de canais de potássio

Country Status (16)

Country Link
US (2) US7786146B2 (pt)
EP (1) EP2190534B1 (pt)
JP (1) JP2010536771A (pt)
KR (1) KR20100075436A (pt)
CN (1) CN101795727A (pt)
AU (1) AU2008286919B2 (pt)
BR (1) BRPI0815210A2 (pt)
CA (1) CA2696012C (pt)
ES (1) ES2531335T3 (pt)
HU (1) HUE025928T2 (pt)
MX (1) MX2010001712A (pt)
PL (1) PL2190534T3 (pt)
RU (1) RU2483060C2 (pt)
SG (1) SG183725A1 (pt)
TW (1) TW200927096A (pt)
WO (1) WO2009023677A1 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050089559A1 (en) * 2003-10-23 2005-04-28 Istvan Szelenyi Combinations of potassium channel openers and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains
US8722929B2 (en) * 2006-10-10 2014-05-13 Valeant Pharmaceuticals International N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators
US8563566B2 (en) * 2007-08-01 2013-10-22 Valeant Pharmaceuticals International Naphthyridine derivatives as potassium channel modulators
US7786146B2 (en) * 2007-08-13 2010-08-31 Valeant Pharmaceuticals International Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators
CN102241608A (zh) * 2011-05-12 2011-11-16 天津市汉康医药生物技术有限公司 瑞替加滨化合物及其组合物
WO2013159095A1 (en) * 2012-04-20 2013-10-24 Anderson Gaweco Ror modulators and their uses
CN103508960B (zh) * 2012-06-29 2017-12-12 江苏先声药业有限公司 苯并杂环衍生物
CN107098844B (zh) * 2017-05-17 2019-07-30 许昌学院 一种c-5位硝基取代的酰基吲哚啉类化合物的合成方法
CN112010808B (zh) * 2019-05-31 2021-11-30 上海挚盟医药科技有限公司 作为钾通道调节剂的四氢-1h-苯氮杂卓类化合物及其制备和应用
CN114539120A (zh) * 2022-03-09 2022-05-27 台州学院 一种吲哚类钾离子通道激动剂的制备方法
WO2025231340A1 (en) * 2024-05-03 2025-11-06 Xenon Pharmaceuticals Inc. Azaindole and azaindoline compounds and uses thereof
WO2025231323A1 (en) * 2024-05-03 2025-11-06 Xenon Pharmaceuticals Inc. Bicyclic heteroaryl compounds and uses thereof

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4181803A (en) 1973-12-14 1980-01-01 Eisai Co., Ltd. Propiophenone derivatives and preparation thereof
DE3337593A1 (de) 1982-10-27 1984-05-03 Degussa Ag, 6000 Frankfurt 2-amino-3-acylamino-6-benzylamino-pyridin-derivate mit antiepileptischer wirkung
EP0110091B1 (de) 1982-10-27 1987-01-21 Degussa Aktiengesellschaft 2-Amino-3-Acylamino-6-benzylamino-pyridin-Derivate mit anti-epileptischer Wirkung
EP0189788B1 (de) 1985-01-23 1989-09-13 ASTA Pharma Aktiengesellschaft Synergistische Kombination von Flupirtin und nicht-steroidalen Antiphlogistika
DE3604575A1 (de) 1985-02-23 1986-08-28 Degussa Ag, 6000 Frankfurt Kombination von flupirtin und anticholinergisch wirkenden spasmolytika
ATE43789T1 (de) 1985-02-23 1989-06-15 Asta Pharma Ag Kombination von flupirtin und anticholinergisch wirkenden spasmolytika.
JP2583067B2 (ja) 1987-08-04 1997-02-19 住友化学工業株式会社 モノアゾ化合物およびそれを用いて疎水性繊維材料を染色または捺染する方法
GB8800199D0 (en) 1988-01-06 1988-02-10 Beecham Group Plc Pharmaceutical preparation
MC2029A1 (fr) 1988-05-16 1990-04-25 Asta Pharma Ag (n-heterocyclyl)-3 diamino-2,6 pyridines substituees et leurs n-oxydes,preparation de ces composes et leur application comme medicaments
US5629307A (en) 1989-10-20 1997-05-13 Olney; John W. Use of ibogaine in reducing excitotoxic brain damage
US6004945A (en) 1990-05-10 1999-12-21 Fukunaga; Atsuo F. Use of adenosine compounds to relieve pain
IN172468B (pt) 1990-07-14 1993-08-14 Asta Medica Ag
US5643921A (en) 1990-09-26 1997-07-01 E.R. Squibb & Sons, Inc. Cardiopulmonary bypass and organ transplant using a potassium channel activator
US5234947A (en) 1991-11-07 1993-08-10 New York University Potassium channel activating compounds and methods of use thereof
DE4200259A1 (de) 1992-01-08 1993-07-15 Asta Medica Ag Neue 1,2,4-triaminobenzol-derivate und verfahren zu deren herstellung
US5262419A (en) 1992-06-11 1993-11-16 E. R. Squibb & Sons, Inc. Method for the prophylaxis and/or treatment of ulcerative gastrointestinal conditions using a potassium channel activator
CA2115792C (en) 1993-03-05 2005-11-01 David J. Mayer Method for the treatment of pain
US5428039A (en) 1994-02-20 1995-06-27 The Center For Innovative Technology Method for electively achieving reversible hyperpolarized cardiac arrest
JPH10503501A (ja) 1994-08-03 1998-03-31 アスタ メディカ アクチエンゲゼルシャフト 抗喘息、抗アレルギー、抗炎症及び免疫修飾作用を有するインドール、インダゾール、ピリドピロール及びピリドピラゾール誘導体
ES2268686T3 (es) 1994-09-22 2007-03-16 Richard Alan Smith Combinacion de dextrometorfano con quinidina o sulfato de quinina para tratar diversos trastornos de dificil cura.
US5679706A (en) 1994-09-30 1997-10-21 Bristol-Myers Squibb Company Combination of a potassium channel activator and an antiarrhythmic agent
EP1609477B1 (en) 1994-12-12 2011-11-09 Omeros Corporation Irrigation solution and use thereof for the perioperative inhibition of pain/inflammation and/or spasm at a vascular structure
DE19539861A1 (de) 1995-10-26 1997-04-30 Asta Medica Ag Verwendung von 4-Amino-4-(4-fluorbenzylamino)-1-ethoxy-carbonylaminobenzen zur Prophylaxe und Behandlung der Folgen der akuten und chronischen zerebralen Minderdurchblutung sowie neurodegenerativer Erkrankungen
DE19701694A1 (de) 1997-01-20 1998-07-23 Asta Medica Ag Neue Modifikationen des 2-Amino-4-(4-fluorbenzylamino)-l-ethoxycarbonyl-aminobenzen sowie Verfahren zu ihrer Herstellung
US5800285A (en) * 1997-03-19 1998-09-01 Sturm, Ruger & Company, Inc. Method of fabricating golf club parts carrying artwork etched after fabrication and parts with such artwork
EP0977743A1 (en) 1997-04-25 2000-02-09 Smithkline Beecham Protease inhibitors
US5760007A (en) 1997-07-16 1998-06-02 Ortho Pharmaceutical Corporation Anticonvulsant derivatives useful in treating neuropathic pain
ATE308342T1 (de) 1997-08-08 2005-11-15 Chugai Pharmaceutical Co Ltd Arzneimittel gegen diabetes-komplikationen
US6265417B1 (en) 1997-12-18 2001-07-24 Abbott Laboratories Potassium channel openers
US6593335B1 (en) 1997-12-18 2003-07-15 Abbott Laboratories Potassium channel openers
US6211171B1 (en) 1998-05-19 2001-04-03 Dalhousie University Use of antidepressants for local analgesia
JP3441970B2 (ja) 1998-06-30 2003-09-02 株式会社サミー 豆腐の製造方法及び製造装置
CN1149983C (zh) 1998-12-14 2004-05-19 赛勒吉药物股份有限公司 用于治疗肛门直肠病的组合物和方法
US6281211B1 (en) 1999-02-04 2001-08-28 Euro-Celtique S.A. Substituted semicarbazides and the use thereof
GB9903476D0 (en) 1999-02-17 1999-04-07 Zeneca Ltd Therapeutic agents
AU3216600A (en) 1999-03-10 2000-09-28 Warner-Lambert Company Analgesic compositions comprising anti-epileptic compounds and methods of using same
AU766648B2 (en) 1999-03-17 2003-10-23 Axys Pharmaceuticals, Inc. Compounds and methods for modulation of estrogen receptors
AT409083B (de) 1999-04-01 2002-05-27 Sanochemia Pharmazeutika Ag Pharmazeutische, tolperison enthaltende zubereitung zur oralen verabreichung
GB9915414D0 (en) 1999-07-01 1999-09-01 Glaxo Group Ltd Medical use
HUP0202253A3 (en) 1999-07-06 2003-12-29 Lilly Co Eli Selective iglur5 receptor antagonists for the treatment of migraine
US6472165B1 (en) 1999-08-03 2002-10-29 Arzneimittelwerk Dresden Gmbh Modulatory binding site in potassium channels for screening and finding new active ingredients
US6495550B2 (en) 1999-08-04 2002-12-17 Icagen, Inc. Pyridine-substituted benzanilides as potassium ion channel openers
NZ516743A (en) 1999-08-04 2004-02-27 Icagen Inc Methods for treating or preventing pain and anxiety
ATE380176T1 (de) 1999-08-04 2007-12-15 Icagen Inc Benzanilide als öffner des kaliumkanals
US6117900A (en) 1999-09-27 2000-09-12 Asta Medica Aktiengesellschaft Use of retigabine for the treatment of neuropathic pain
US6383511B1 (en) 1999-10-25 2002-05-07 Epicept Corporation Local prevention or amelioration of pain from surgically closed wounds
US6538004B2 (en) 2000-03-03 2003-03-25 Abbott Laboratories Tricyclic dihydropyrazolone and tricyclic dihydroisoxazolone potassium channel openers
US20020015730A1 (en) 2000-03-09 2002-02-07 Torsten Hoffmann Pharmaceutical formulations and method for making
US6348486B1 (en) 2000-10-17 2002-02-19 American Home Products Corporation Methods for modulating bladder function
US6589986B2 (en) 2000-12-20 2003-07-08 Wyeth Methods of treating anxiety disorders
US6469042B1 (en) 2001-02-20 2002-10-22 Bristol-Myers Squibb Company Fluoro oxindole derivatives as modulators if KCNQ potassium channels
WO2002080898A2 (en) 2001-04-04 2002-10-17 Wyeth Methods for treating hyperactive gastric motility
GB0121214D0 (en) 2001-08-31 2001-10-24 Btg Int Ltd Synthetic method
US6831087B2 (en) 2001-11-09 2004-12-14 Hoffmann-La Roche Inc. Pyridine substituted isoquinoline derivatives
PE20030762A1 (es) * 2001-12-18 2003-09-05 Schering Corp Compuestos heterociclicos como antagonistas nk1
WO2003068769A1 (en) 2002-02-12 2003-08-21 Pfizer Inc. Non-peptide compounds affecting the action of gonadotropin-releasing hormone (gnrh)
WO2003097586A1 (en) 2002-05-17 2003-11-27 Janssen Pharmaceutica N.V. Aminotetralin-derived urea modulators of vanilloid vr1 receptor
BR0311338A (pt) 2002-05-29 2005-03-22 Hoffmann La Roche Derivados de n-acilaminobenzeno como inibidores seletivos da monoamina oxidade b
WO2003106454A1 (en) 2002-06-12 2003-12-24 Orchid Chemicals & Pharmaceuticals Ltd 1h-isoquinoline-oxazolidinone derivaties and their use as antibacterial agents
AUPS312602A0 (en) 2002-06-21 2002-07-18 James Cook University Organ arrest, protection, preservation and recovery
US7419981B2 (en) 2002-08-15 2008-09-02 Pfizer Inc. Synergistic combinations of an alpha-2-delta ligand and a cGMP phosphodieterse 5 inhibitor
AU2003294441A1 (en) 2002-11-22 2004-06-18 Bristol-Myers Squibb Company 1-aryl-2-hydroxyethyl amides as potassium channel openers
CA2505195C (en) 2002-12-23 2012-07-10 Icagen, Inc. Quinazolinones as potassium channel modulators
CA2511502A1 (en) 2002-12-27 2004-07-15 H. Lundbeck A/S 1,2,4-triaminobenzene derivatives,useful for treating disorders of the central nervous system
AR043507A1 (es) 2003-03-14 2005-08-03 Lundbeck & Co As H Derivados de anilina sustituidos y composiciones farmaceuticas
MXPA05009282A (es) 2003-03-14 2005-10-05 Lundbeck & Co As H Derivados de anilina sustituidos.
US7906537B2 (en) 2003-03-21 2011-03-15 H. Lundbeck A/S Substituted p-diaminobenzene derivatives
MXPA05010174A (es) * 2003-04-25 2005-11-08 Lundbeck & Co As H Derivados de indol e indolina sustituidos.
EP1644043A1 (en) 2003-05-27 2006-04-12 ALTANA Pharma AG Pharmaceutical combinations of a proton pump inhibitor and a compound which modifies gastrointestinal motility
JP4786147B2 (ja) * 2003-06-26 2011-10-05 武田薬品工業株式会社 カンナビノイド受容体調節剤
US20050014786A1 (en) 2003-07-11 2005-01-20 Chongqing Sun Tetrahydroquinoline derivatives as cannabinoid receptor modulators
JP2007505142A (ja) 2003-09-10 2007-03-08 セダーズ−シナイ メディカル センター 血液脳関門を通過する薬剤のカリウムチャネル媒介性送達
US20050089559A1 (en) 2003-10-23 2005-04-28 Istvan Szelenyi Combinations of potassium channel openers and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains
DE10359335A1 (de) 2003-10-23 2005-05-25 Viatris Gmbh & Co. Kg Kombinationen aus Kaliumkanalöffnern und Natriumkanalinhibitoren oder Natriumkanal beeinflussenden Wirkstoffen zur Behandlung von Schmerzzuständen
ES2235626B1 (es) 2003-11-10 2006-11-01 Almirall Prodesfarma, S.A. Formas de administracion masticables, no comprimidas dosificadas individualmente.
TWI349666B (en) 2004-03-12 2011-10-01 Lundbeck & Co As H Substituted morpholine and thiomorpholine derivatives
AU2005233642A1 (en) 2004-04-13 2005-10-27 Astellas Pharma Inc. Polycyclic pyridines as potassium ion channel modulators
US20050277579A1 (en) 2004-05-03 2005-12-15 Ranga Krishnan Compositions for affecting weight loss
UA89503C2 (uk) 2004-09-13 2010-02-10 Х. Луннбек А/С Заміщені похідні аніліну
JPWO2006054513A1 (ja) 2004-11-19 2008-05-29 キッセイ薬品工業株式会社 神経因性疼痛の予防又は治療剤
EP1688141A1 (en) 2005-01-31 2006-08-09 elbion AG The use of flupirtine for the treatment of overactive bladder and associated diseases, and for the treatment of irritable bowel syndrome
MX2007010547A (es) 2005-03-03 2007-10-03 Lundbeck & Co As H Derivados de piridina sustituidos.
CN101258133A (zh) * 2005-09-09 2008-09-03 H.隆德贝克有限公司 嘧啶衍生物和它们作为kcnq钾通道开放剂的用途
US7683058B2 (en) 2005-09-09 2010-03-23 H. Lundbeck A/S Substituted pyrimidine derivatives
JP2009256208A (ja) 2006-08-17 2009-11-05 Dainippon Sumitomo Pharma Co Ltd フタリド誘導体またはその薬学的に許容される塩
CA2661462C (en) 2006-08-23 2015-09-29 Valeant Pharmaceuticals International Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators
ES2375417T3 (es) * 2006-11-28 2012-02-29 Valeant Pharmaceuticals International Análogos 1,4-diamino bicíclicos de retigabina como moduladores de los canales de potasio.
JP5414540B2 (ja) * 2007-02-23 2014-02-12 オプテイカル・エア・データ・システムズ，エルエルシー 航空機の着陸及び離陸の間の航空機の位置及び情況を決定及び表示する光学システム
US8367684B2 (en) * 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
US8563566B2 (en) 2007-08-01 2013-10-22 Valeant Pharmaceuticals International Naphthyridine derivatives as potassium channel modulators
US7786146B2 (en) * 2007-08-13 2010-08-31 Valeant Pharmaceuticals International Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators
CA2765678A1 (en) 2009-06-22 2010-12-29 Christopher Blackburn Substituted hydroxamic acids and uses thereof

Also Published As

Publication number Publication date
US7786146B2 (en) 2010-08-31
KR20100075436A (ko) 2010-07-02
AU2008286919B2 (en) 2014-05-29
US8211918B2 (en) 2012-07-03
ES2531335T3 (es) 2015-03-13
RU2483060C2 (ru) 2013-05-27
EP2190534A1 (en) 2010-06-02
PL2190534T3 (pl) 2015-11-30
WO2009023677A1 (en) 2009-02-19
RU2010109388A (ru) 2011-09-20
MX2010001712A (es) 2010-07-28
US20110118318A1 (en) 2011-05-19
CN101795727A (zh) 2010-08-04
CA2696012A1 (en) 2009-02-19
SG183725A1 (en) 2012-09-27
HUE025928T2 (en) 2016-05-30
US20090137635A1 (en) 2009-05-28
EP2190534B1 (en) 2015-02-18
TW200927096A (en) 2009-07-01
JP2010536771A (ja) 2010-12-02
AU2008286919A1 (en) 2009-02-19
CA2696012C (en) 2017-10-31

Similar Documents

Publication Publication Date Title
BRPI0815210A2 (pt) Derivados de indol 5-amino-4,6-dissubstituído e indolina 5-amino-4,6-dissubstituída como moduladores de canais de potássio
BRPI0920354A2 (pt) derivados de indol e benzomorfolina como moduladores de receptores de glutamato metabotrópicos
BRPI0921333A2 (pt) derivados de indol e benzoxazina como moduladores de receptores de glutamato metabotrópicos
ES2643164T3 (es) Indol 7-sustituido como inhibidores de Mcl-1
BRPI0715324A2 (pt) Composto de indol
DK2144897T3 (da) 8-Oxy-quinolinderivater som bradykinin B2-receptormodulatorer
DK2598503T3 (da) Cis-tetrahydro-spiro(cyclohexan-1,1'-pyrido[3,4-b]indol)-4-amin-derivat
BRPI0918055A2 (pt) derivados de 3-azabiciclo[3,1,0]hexila como moduladores de receptores metabotrópicos de glutamato.
CR9868A (es) Derivados de indol 1,3-disustituido para su uso como moduladores de ppar
IL207684A0 (en) Substituted indole derivatives
EP2255129B8 (en) Lighting system, light source and electrode device
BRPI0912394A2 (pt) moduladores do receptor de androgênio à base de tetra-hidrociclopenta[b]indol
BRPI0910585A2 (pt) indóis como moduladores de receptor de aceticolina nicotínica do subtipo alfa-7
CR9906A (es) Modulacion de la expresion del receptor glucocorticoide
DK2176220T3 (da) Pyrrolidin-2-on-derivater som androgenreceptormodulatorer.
DK2094658T3 (da) Tetrahydrocyclopenta[B]indolforbindelser som androgenreceptormodulatorer
BRPI0822058A2 (pt) Derivados de 5-oxo-3-pirrolidinacarboxamida como moduladores de p2x7
BRPI0915887A2 (pt) derivados de indol macrocíclicos úteis como inibidores do vírus da hepatite c
CU23870B1 (es) Derivados de ciclopropilamida como moduladores h3
NO344044B1 (no) Nye triazindionderivater som GABA-B-reseptormodulatorer
BRPI0812564A2 (pt) Derivados de 4-(n-azacicloalquil) anilidas como moduladores de canal de potássio
BRPI0908893A2 (pt) Modulação enzimática e de receptores
ZA200905265B (en) Indole derivatives
ATE512137T1 (de) Benzoylpiperidinderivate als doppelmodulatoren des 5-ht2a- und des d3-rezeptors
BRPI0915627A2 (pt) compostos derivados de indol, composições farmacêuticas que os contêm, e seus usos

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B11D Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time