BRPI0815154A2 - Compostos de indol, composição para a prevenção ou tratamento de necrose e doenças associadas com a necrose, e, método de preparação da mesma - Google Patents
Compostos de indol, composição para a prevenção ou tratamento de necrose e doenças associadas com a necrose, e, método de preparação da mesmaInfo
- Publication number
- BRPI0815154A2 BRPI0815154A2 BRPI0815154A BRPI0815154A2 BR PI0815154 A2 BRPI0815154 A2 BR PI0815154A2 BR PI0815154 A BRPI0815154 A BR PI0815154A BR PI0815154 A2 BRPI0815154 A2 BR PI0815154A2
- Authority
- BR
- Brazil
- Prior art keywords
- necrosis
- prevention
- preparation
- treatment
- composition
- Prior art date
Links
- 206010028851 Necrosis Diseases 0.000 title 2
- 230000017074 necrotic cell death Effects 0.000 title 2
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 150000002475 indoles Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
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- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| KR20070082687 | 2007-08-17 | ||
| KR10-2007-0082687 | 2007-08-17 | ||
| PCT/KR2008/004783 WO2009025477A1 (en) | 2007-08-17 | 2008-08-18 | Indole compounds as an inhibitor of cellular necrosis |
Publications (2)
| Publication Number | Publication Date |
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| BRPI0815154A2 true BRPI0815154A2 (pt) | 2015-03-31 |
| BRPI0815154B1 BRPI0815154B1 (pt) | 2024-01-30 |
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| BRPI0815154-7A BRPI0815154B1 (pt) | 2007-08-17 | 2008-08-18 | Compostos de indol, composição, e, método de preparação da mesma |
Family Applications Before (1)
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| BRPI0814958A BRPI0814958B8 (pt) | 2007-08-17 | 2008-08-18 | compostos de indol, e, composição |
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| EP (2) | EP2178870B1 (pt) |
| JP (2) | JP5517935B2 (pt) |
| KR (2) | KR20090018593A (pt) |
| CN (2) | CN101784543B (pt) |
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| SI (1) | SI2178870T1 (pt) |
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Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2178870T1 (sl) * | 2007-08-17 | 2018-11-30 | Lg Chem, Ltd. | Indolne in indazolne spojine kot inhibitor celične nekroze |
| US20090142832A1 (en) | 2007-11-29 | 2009-06-04 | James Dalton | Indoles, Derivatives, and Analogs Thereof and Uses Therefor |
| EP2220081A4 (en) * | 2007-12-20 | 2011-08-24 | Lg Life Sciences Ltd | GLUCCOAINEACTIVATORS AND THESE PHARMACEUTICAL COMPOSITIONS CONTAINING ACTIVE SUBSTANCES |
| RU2460525C2 (ru) * | 2008-01-04 | 2012-09-10 | Эл Джи Лайф Сайенсиз Лтд. | Производные индола и индазола, обладающие консервирующим действием по отношению к клеткам, тканям и органам |
| MX2010011138A (es) * | 2008-04-10 | 2010-11-12 | Takeda Pharmaceutical | Compuestos de anillo fusionados y uso de los mismos. |
| JPWO2010076884A1 (ja) | 2008-12-29 | 2012-06-21 | 武田薬品工業株式会社 | 新規縮合環化合物およびその用途 |
| TWI535440B (zh) * | 2009-10-26 | 2016-06-01 | Lg生命科學有限公司 | 包括吲哚化合物之醫藥組成物 |
| KR101304772B1 (ko) * | 2011-04-11 | 2013-09-05 | 인제대학교 산학협력단 | NecroX―5를 유효성분으로 포함하는 미토콘드리아 기능 조절용 조성물 |
| CN102766083B (zh) * | 2011-05-03 | 2014-10-22 | 中国科学院上海有机化学研究所 | 2-氨基-3-全氟乙酰吲哚类化合物及其衍生物、制备方法和应用 |
| KR101404151B1 (ko) * | 2011-11-25 | 2014-06-05 | 가톨릭대학교 산학협력단 | 안과 질환의 예방 및 치료용 약학 조성물 |
| KR101941004B1 (ko) * | 2013-03-25 | 2019-01-23 | 주식회사 엘지화학 | 조절 t 세포로의 분화 유도 및 증식 촉진을 통한 면역 반응 억제용 약학 조성물 |
| KR102139339B1 (ko) * | 2013-06-24 | 2020-07-29 | 주식회사 엘지생활건강 | 인돌 화합물을 포함하는 용해도가 개선된 화장료 조성물 |
| KR102139338B1 (ko) * | 2013-06-24 | 2020-07-29 | 주식회사 엘지생활건강 | 인돌 화합물을 포함하는 용해도가 개선된 화장료 조성물 |
| KR101985886B1 (ko) * | 2013-06-24 | 2019-06-04 | 주식회사 엘지생활건강 | 인돌 화합물 및 판테놀을 포함하는 자외선에 의한 피부손상 예방 및 개선용 조성물 |
| CN105636956B (zh) * | 2013-08-22 | 2019-07-09 | 株式会社Lg化学 | 作为细胞坏死阻碍剂的吲哚化合物 |
| CN105658625B (zh) * | 2013-08-22 | 2019-05-03 | 株式会社Lg化学 | 作为细胞坏死阻碍剂的吲哚酰胺化合物 |
| CN103601662B (zh) * | 2013-11-21 | 2016-04-06 | 深圳市药品检验所 | 一种褪黑素半抗原、褪黑素完全抗原及其制备方法和应用 |
| WO2015111947A1 (en) * | 2014-01-24 | 2015-07-30 | Lg Life Sciences Ltd. | Composition for preventing or treating acute lung injury and acute respiratory distress syndrome |
| ES2851006T3 (es) * | 2014-04-18 | 2021-09-02 | Lg Chemical Ltd | Composición para prevenir o tratar esteatosis hepáticas |
| TW201707707A (zh) * | 2015-03-26 | 2017-03-01 | Lg生命科學股份有限公司 | 包含吲哚化合物之製劑及其製備方法 |
| US10968185B2 (en) * | 2015-04-07 | 2021-04-06 | Ela Pharma Ltd. | Substituted thiazoles for preventing and/or treating cell or tissue necrosis |
| KR102446529B1 (ko) * | 2017-01-10 | 2022-09-23 | 에테하 취리히 | 세포 보호 화합물 및 이의 용도 |
| JOP20210131A1 (ar) | 2018-12-17 | 2023-01-30 | Vertex Pharma | مثبطات apol1 وطرق استخدامها |
| CN109884212A (zh) * | 2019-03-27 | 2019-06-14 | 清华大学深圳研究生院 | 基于化学衍生化与hplc-ms的不饱和脂肪酸定量方法 |
| CN114080382B (zh) * | 2019-06-19 | 2024-05-24 | 株式会社Lg化学 | 制备吲哚或吲唑化合物的方法 |
| KR102389717B1 (ko) | 2019-06-19 | 2022-04-25 | 주식회사 엘지화학 | 인돌 또는 인다졸 화합물의 제조방법 |
| KR102397752B1 (ko) | 2019-06-19 | 2022-05-16 | 주식회사 엘지화학 | 인돌 또는 인다졸 화합물의 제조방법 |
| US12358879B2 (en) | 2019-10-18 | 2025-07-15 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| BR112022010561A2 (pt) | 2019-12-02 | 2022-11-16 | Storm Therapeutics Ltd | Compostos poli-heterocíclicos como inibidores de mettl3 |
| EP4097083A1 (en) | 2020-01-29 | 2022-12-07 | Vertex Pharmaceuticals Incorporated | Inhibitors of apol1 and methods of using same |
| WO2021154902A1 (en) * | 2020-01-30 | 2021-08-05 | Anima Biotech Inc. | Collagen 1 translation inhibitors and methods of use thereof |
| EP4114385A1 (en) | 2020-03-06 | 2023-01-11 | Vertex Pharmaceuticals Incorporated | Methods of treating apol-1 dependent focal segmental glomerulosclerosis |
| WO2021201609A1 (ko) | 2020-03-31 | 2021-10-07 | 주식회사 엘지화학 | 췌도 이식 보호용 조성물 |
| EP4165023A1 (en) * | 2020-06-12 | 2023-04-19 | Vertex Pharmaceuticals Incorporated | Inhibitors of apol1 and use of the same |
| AU2021286728A1 (en) | 2020-06-12 | 2023-01-19 | Vertex Pharmaceuticals Incorporated | Inhibitors of APOL1 and use of the same |
| WO2022039506A1 (ko) | 2020-08-19 | 2022-02-24 | 주식회사 미토이뮨테라퓨틱스 | Mabc-r 감염에 의한 병적 염증 치료제로서의 미토콘드리아 표적 항산화제 |
| IL318169A (en) | 2020-08-26 | 2025-03-01 | Vertex Pharma | Apol1 inhibitors and methods of use are the same |
| EP4382106A4 (en) * | 2021-04-12 | 2025-04-02 | MitoImmune Therapeutics Inc. | Composition for inhibiting inflammation or ageing of stem cells and method for inhibiting inflammation or ageing therewith |
| US20240199598A1 (en) * | 2021-04-12 | 2024-06-20 | Mitoimmune Therapeutics Inc. | Sulfate of 5-[(1,1-dioxido-4-thiomorpholinyl)methyl]-2-phenyl-n-(tetrahydro-2h-pyran-4-yl)-1h-indole-7-amine, and novel crystal form thereof |
| EP4324830A4 (en) * | 2021-04-12 | 2025-04-16 | MitoImmune Therapeutics Inc. | NEW CRYSTAL FORM OF 5-[(1,1-DIOXIDO-4-THIOMORPHOLINYL)METHYL)-2-PHENYL-N-(TETRAHYDRO-2H-PYRAN-4-YL)-1H-INDOLE-7-AMINE |
| DE102021207925A1 (de) * | 2021-07-23 | 2023-01-26 | Continental Reifen Deutschland Gmbh | Verbindung, Verfahren zu deren Herstellung sowie Verwendung der Verbindung als Alterungsschutzmittel und/oder Ozonschutzmittel und/oder Farbstoff |
| CA3227666A1 (en) | 2021-08-02 | 2023-02-09 | Soon Ha Kim | Novel indole derivatives, pharmaceutical compositions comprising the same, and use thereof |
| US20250289785A1 (en) | 2021-08-02 | 2025-09-18 | Mitoimmune Therapeutics Inc. | Indole derivative, method for preparing same, and use thereof |
| WO2023106973A1 (ru) * | 2021-12-10 | 2023-06-15 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Новые гепатопротекторные средства |
| AU2023213494A1 (en) | 2022-01-27 | 2024-08-08 | Mitoimmune Therapeutics Inc. | Ovarian anti-aging pharmaceutical composition and use thereof |
| WO2023182840A1 (ko) | 2022-03-25 | 2023-09-28 | 주식회사 미토이뮨테라퓨틱스 | 항바이러스용 약학적 조성물 및 이의 용도 |
| WO2024158205A1 (ko) * | 2023-01-25 | 2024-08-02 | 주식회사 미토이뮨테라퓨틱스 | 치환기를 가지는 인돌 유도체, 및 약학적 용도 |
| KR20240118677A (ko) | 2023-01-27 | 2024-08-05 | 주식회사 미토이뮨테라퓨틱스 | 페롭토시스 억제제로서 인돌 화합물의 용도 |
| WO2024191106A1 (ko) | 2023-03-13 | 2024-09-19 | 주식회사 미토이뮨테라퓨틱스 | 뇌전증 예방 또는 치료용 약학적 조성물 |
| WO2025188159A1 (ko) | 2024-03-06 | 2025-09-12 | 주식회사 미토이뮨테라퓨틱스 | 신장 섬유증 예방 또는 치료용 약학적 조성물 |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB599834A (en) * | 1943-04-08 | 1948-03-22 | Francolor Sa | Improvements in or relating to the manufacture of azodyestuffs |
| US3755332A (en) * | 1971-07-01 | 1973-08-28 | Ciba Geigy Corp | Substituted 4 indazolaminoquinolines |
| BE792078A (fr) * | 1971-12-01 | 1973-05-29 | Wander Ag Dr A | Nouveaux derives de l'indazole, leur preparation et leur application comme medicaments |
| DE2653005A1 (de) * | 1975-12-03 | 1977-06-08 | Sandoz Ag | Neue organische verbindungen, ihre verwendung und herstellung |
| JPS6160648A (ja) * | 1984-08-31 | 1986-03-28 | Teikoku Hormone Mfg Co Ltd | 2−(3,5−ジアルキル−4−ヒドロキシフエニル)インド−ル誘導体 |
| US5254135A (en) * | 1989-10-20 | 1993-10-19 | L'oreal | Methods for dyeing keratinous fibres with aminoindoles, compositions and devices for use |
| FR2659552B2 (fr) * | 1989-10-20 | 1994-11-04 | Oreal | Procede de teinture des fibres keratiniques avec des aminoindoles, composition et dispositif de mise en óoeuvre. |
| AU8225991A (en) * | 1990-07-31 | 1992-03-02 | Teikoku Hormone Mfg. Co., Ltd. | 2-phenylindole derivative |
| FI944602A7 (fi) * | 1992-04-03 | 1994-10-03 | Upjohn Co | Farmaseuttisesti aktiiviset bisyklis-heterosykliset amiinit |
| EP0676967A4 (en) | 1992-12-30 | 1996-10-02 | Fmc Corp | RELEASED, EXTENDED, EASY TO PRODUCE EXCIPIENT, BASED ON KONJAC GLUCOMANNANE. |
| JP3545461B2 (ja) * | 1993-09-10 | 2004-07-21 | エーザイ株式会社 | 二環式ヘテロ環含有スルホンアミド誘導体 |
| DK0673937T3 (da) | 1993-09-10 | 2004-03-22 | Eisai Co Ltd | Bicyclisk heterocyclisk sulfonamid og sulfonsyreesterderivater |
| KR20000057137A (ko) | 1996-11-19 | 2000-09-15 | 스티븐 엠. 오드레 | 아릴 및 헤테로아릴로 치환된 융합 피롤 항염증제 |
| FR2767475A1 (fr) * | 1997-08-25 | 1999-02-26 | Oreal | Compositions de teinture des fibres keratiniques contenant des derives d'indazoles et procede |
| US6858577B1 (en) * | 1999-06-29 | 2005-02-22 | Ortho-Mcneil Pharmaceutical, Inc. | Indole peptidomimetics as thrombin receptor antagonists |
| US6660744B1 (en) * | 1999-09-17 | 2003-12-09 | Abbott Gmbh & Co. Kg | Pyrazolopyrimidines as therapeutic agents |
| US7217722B2 (en) * | 2000-02-01 | 2007-05-15 | Kirin Beer Kabushiki Kaisha | Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same |
| RU2240826C2 (ru) * | 2000-02-03 | 2004-11-27 | Эйсай Ко., Лтд. | Ингибитор экспрессии интегрина |
| AU2001280187A1 (en) * | 2000-08-28 | 2002-03-13 | Toray Industries, Inc. | Cyclic amine derivatives |
| KR20090090406A (ko) * | 2000-12-18 | 2009-08-25 | 가부시키가이샤 이야쿠 분지 셋케이 겐쿠쇼 | 염증성 사이토카인 생산 유리 억제제 |
| US6982274B2 (en) * | 2001-04-16 | 2006-01-03 | Eisai Co., Ltd. | 1H-indazole compound |
| WO2002100833A1 (en) * | 2001-06-12 | 2002-12-19 | Sumitomo Pharmaceuticals Company, Limited | Rho KINASE INHIBITORS |
| ITMI20012060A1 (it) * | 2001-10-05 | 2003-04-05 | Recordati Chem Pharm | Nuovi eterocilcli n-acilati |
| TW200306819A (en) * | 2002-01-25 | 2003-12-01 | Vertex Pharma | Indazole compounds useful as protein kinase inhibitors |
| DE10228103A1 (de) | 2002-06-24 | 2004-01-15 | Bayer Cropscience Ag | Fungizide Wirkstoffkombinationen |
| WO2004009557A1 (en) * | 2002-07-19 | 2004-01-29 | Memory Pharmaceuticals Corporation | 6-amino-1h-indazole and 4-aminobenzofuran compounds as phosphodiesterase 4 inhibitors |
| RS51752B (sr) * | 2002-07-29 | 2011-12-31 | Rigel Pharmaceuticals | Metode tretiranja i prevencije autoimunih oboljenja jedinjenjima 2,4-pirimidindiamina |
| DE10237722A1 (de) * | 2002-08-17 | 2004-08-19 | Aventis Pharma Deutschland Gmbh | Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase |
| US20040110802A1 (en) | 2002-08-23 | 2004-06-10 | Atli Thorarensen | Antibacterial benzoic acid derivatives |
| CA2499128C (en) * | 2002-09-25 | 2012-07-31 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof |
| MXPA05007857A (es) | 2003-01-22 | 2005-10-18 | Lilly Co Eli | Moduladores derivados de indol de receptores nucleares de hormonas esteroideas. |
| US7563748B2 (en) * | 2003-06-23 | 2009-07-21 | Cognis Ip Management Gmbh | Alcohol alkoxylate carriers for pesticide active ingredients |
| JP4110324B2 (ja) * | 2003-10-15 | 2008-07-02 | 宇部興産株式会社 | 新規インダゾール誘導体 |
| WO2005092854A1 (en) * | 2004-03-03 | 2005-10-06 | Eli Lilly And Company | Bicyclic substituted indole-derivative steroid hormone nuclear receptor modulators |
| EP1769092A4 (en) | 2004-06-29 | 2008-08-06 | Europ Nickel Plc | IMPROVED LIXIVIATION OF BASE METALS |
| EP1632491A1 (en) * | 2004-08-30 | 2006-03-08 | Laboratorios Del Dr. Esteve, S.A. | Substituted indole compounds and their use as 5-HT6 receptor modulators |
| WO2006058338A2 (en) * | 2004-11-29 | 2006-06-01 | Janssen Pharmaceutica N.V. | 4 - piperidinecarboxamide derivatives as modulators of vanilloid vr1 receptor |
| WO2006062982A2 (en) * | 2004-12-07 | 2006-06-15 | Locus Pharmaceuticals, Inc. | Urea inhibitors of map kinases |
| WO2006112549A1 (ja) * | 2005-04-20 | 2006-10-26 | Takeda Pharmaceutical Company Limited | 縮合複素環化合物 |
| WO2007076161A2 (en) * | 2005-12-27 | 2007-07-05 | Myriad Genetics, Inc | Compounds with therapeutic activity |
| TW200736232A (en) * | 2006-01-26 | 2007-10-01 | Astrazeneca Ab | Pyrimidine derivatives |
| WO2008050821A1 (en) * | 2006-10-19 | 2008-05-02 | Takeda Pharmaceutical Company Limited | Indole compound |
| SI2178870T1 (sl) * | 2007-08-17 | 2018-11-30 | Lg Chem, Ltd. | Indolne in indazolne spojine kot inhibitor celične nekroze |
| EP2220081A4 (en) * | 2007-12-20 | 2011-08-24 | Lg Life Sciences Ltd | GLUCCOAINEACTIVATORS AND THESE PHARMACEUTICAL COMPOSITIONS CONTAINING ACTIVE SUBSTANCES |
| RU2460525C2 (ru) * | 2008-01-04 | 2012-09-10 | Эл Джи Лайф Сайенсиз Лтд. | Производные индола и индазола, обладающие консервирующим действием по отношению к клеткам, тканям и органам |
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- 2008-08-18 DK DK08793298.4T patent/DK2178870T3/en active
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