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BRPI0814958B8 - compostos de indol, e, composição - Google Patents

compostos de indol, e, composição

Info

Publication number
BRPI0814958B8
BRPI0814958B8 BRPI0814958A BRPI0814958A BRPI0814958B8 BR PI0814958 B8 BRPI0814958 B8 BR PI0814958B8 BR PI0814958 A BRPI0814958 A BR PI0814958A BR PI0814958 A BRPI0814958 A BR PI0814958A BR PI0814958 B8 BRPI0814958 B8 BR PI0814958B8
Authority
BR
Brazil
Prior art keywords
composition
indole compounds
necrosis
indazole
prevention
Prior art date
Application number
BRPI0814958A
Other languages
English (en)
Inventor
Woong Chung Chul
Ook Seo Dong
Park Eok
Sul Park Heui
Shin Kwak Hyo
Jin Kim Hyoung
Hyun Yoon Seung
Ha Kim Soon
Young Koo Sun
Bae Lee Sung
Original Assignee
Lg Chemical Ltd
Lg Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Chemical Ltd, Lg Life Sciences Ltd filed Critical Lg Chemical Ltd
Publication of BRPI0814958A2 publication Critical patent/BRPI0814958A2/pt
Publication of BRPI0814958B1 publication Critical patent/BRPI0814958B1/pt
Publication of BRPI0814958B8 publication Critical patent/BRPI0814958B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
    • A—HUMAN NECESSITIES
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    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract

compostos de indazol ou indol, composição, e, método para preparar uma composição a presente invenção diz respeito aos compostos de indazol ou indol, sais farmaceuticamente aceitáveis ou isômeros dos mesmos que são úteis para a prevenção ou tratamento da necrose celular e doenças associadas com a necrose. a presente invenção também diz respeito a um método e uma composição para a prevenção ou tratamento da necrose celular e doenças associadas com a necrose, que compreende os ditos compostos de indazol ou indol como um ingrediente ativo.
BRPI0814958A 2007-08-17 2008-08-18 compostos de indol, e, composição BRPI0814958B8 (pt)

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KR20070082687 2007-08-17
KR10-2007-0082687 2007-08-17
PCT/KR2008/004784 WO2009025478A1 (en) 2007-08-17 2008-08-18 Indole and indazole compounds as an inhibitor of cellular necrosis

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BRPI0814958B1 BRPI0814958B1 (pt) 2021-05-11
BRPI0814958B8 true BRPI0814958B8 (pt) 2021-05-25

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US20100210647A1 (en) 2010-08-19
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KR101098584B1 (ko) 2011-12-26
US8569307B2 (en) 2013-10-29
EP2178870B1 (en) 2018-09-19
BRPI0815154B1 (pt) 2024-01-30
RU2437883C1 (ru) 2011-12-27
ES2426641T3 (es) 2013-10-24
CN101784543A (zh) 2010-07-21
KR20090018593A (ko) 2009-02-20
US8222414B2 (en) 2012-07-17
RU2010109898A (ru) 2011-09-27
US20100197673A1 (en) 2010-08-05
CN101784543B (zh) 2013-10-16
US20120252798A1 (en) 2012-10-04
JP5323834B2 (ja) 2013-10-23
BRPI0815154A2 (pt) 2015-03-31
CN101801965A (zh) 2010-08-11
KR20090018594A (ko) 2009-02-20
EP2178869A1 (en) 2010-04-28
DK2178870T3 (en) 2018-10-22
BRPI0814958B1 (pt) 2021-05-11
SI2178870T1 (sl) 2018-11-30
JP2010536845A (ja) 2010-12-02
EP2178869B1 (en) 2013-06-12
MX368368B (es) 2019-09-30
WO2009025477A1 (en) 2009-02-26
US8889691B2 (en) 2014-11-18
PT2178870T (pt) 2018-11-09
BRPI0814958A2 (pt) 2015-02-03
CN101801965B (zh) 2014-07-30
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US9000028B2 (en) 2015-04-07
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US20140024618A1 (en) 2014-01-23
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