BRPI0713565A2 - composição farmacêutica contendo ácido tetrahidrofólico - Google Patents
composição farmacêutica contendo ácido tetrahidrofólico Download PDFInfo
- Publication number
- BRPI0713565A2 BRPI0713565A2 BRPI0713565-3A BRPI0713565A BRPI0713565A2 BR PI0713565 A2 BRPI0713565 A2 BR PI0713565A2 BR PI0713565 A BRPI0713565 A BR PI0713565A BR PI0713565 A2 BRPI0713565 A2 BR PI0713565A2
- Authority
- BR
- Brazil
- Prior art keywords
- tetrahydrofolic acid
- composition containing
- pharmaceutical composition
- estrogen
- progestogen
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Abstract
COMPOSIçãO FARMACêUTICA CONTENDO áCIDO TETRAHIDROFóLICO. A presente invenção refere-se a composições farmacêuticas sólidas, em particular a contraceptivos orais, compreendendo um progestogênio, tal como drospirenona; um estrogênio, tal como etinilestradiol; um ácido tetrahidrofólico ou um sal farmaceuticamente aceitável do mesmo, tal como 5-metil-(6S)-tetrahidrofolato de cálcio; e pelo menos um veículo ou excipiente farmaceuticamente aceitável do mesmo. As composições da invenção provêem boa estabilidade do ácido tetrahidrofólico mediante armazenamento enquanto ainda assegura uma rápida de confiável liberação do estrogênio e do progestogênio presentes na composição.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06014002.7 | 2006-07-06 | ||
| EP06014002 | 2006-07-06 | ||
| PCT/EP2007/005764 WO2008003432A1 (en) | 2006-07-06 | 2007-06-29 | Pharmaceutical composition containing a tetrahydrofolic acid |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0713565A2 true BRPI0713565A2 (pt) | 2012-03-20 |
| BRPI0713565B1 BRPI0713565B1 (pt) | 2021-02-02 |
| BRPI0713565B8 BRPI0713565B8 (pt) | 2021-05-25 |
Family
ID=36763829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0713565A BRPI0713565B8 (pt) | 2006-07-06 | 2007-06-29 | processo para fabricação de uma forma de dosagem oral sólida |
Country Status (31)
| Country | Link |
|---|---|
| EP (2) | EP2422774B1 (pt) |
| JP (1) | JP2009542591A (pt) |
| KR (2) | KR20090033889A (pt) |
| CN (3) | CN101489563A (pt) |
| AR (2) | AR061958A1 (pt) |
| AU (1) | AU2007271449B2 (pt) |
| BR (1) | BRPI0713565B8 (pt) |
| CA (2) | CA2856344C (pt) |
| CL (1) | CL2007001962A1 (pt) |
| CO (1) | CO6150125A2 (pt) |
| CR (1) | CR10549A (pt) |
| CU (1) | CU20090004A7 (pt) |
| EC (1) | ECSP099030A (pt) |
| ES (1) | ES2626838T5 (pt) |
| GT (1) | GT200900001A (pt) |
| IL (3) | IL196027A0 (pt) |
| MA (1) | MA30598B1 (pt) |
| MX (1) | MX2009000079A (pt) |
| MY (1) | MY169516A (pt) |
| NO (1) | NO347567B1 (pt) |
| NZ (1) | NZ573766A (pt) |
| PE (3) | PE20150287A1 (pt) |
| PH (1) | PH12012501774A1 (pt) |
| RU (2) | RU2479306C2 (pt) |
| SG (1) | SG188869A1 (pt) |
| TN (1) | TNSN08543A1 (pt) |
| TW (2) | TW201538161A (pt) |
| UA (2) | UA105078C2 (pt) |
| UY (1) | UY30462A1 (pt) |
| WO (1) | WO2008003432A1 (pt) |
| ZA (4) | ZA200900868B (pt) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8617597B2 (en) | 2006-07-06 | 2013-12-31 | Bayer Intellectual Property Gmbh | Pharmaceutical composition containing a tetrahydrofolic acid |
| CN101489563A (zh) | 2006-07-06 | 2009-07-22 | 拜耳先灵医药股份有限公司 | 用于避孕和预防先天性畸形风险的药物制剂 |
| US20100317635A1 (en) | 2009-06-16 | 2010-12-16 | Endorecherche, Inc. | Treatment of hot flushes, vasomotor symptoms, and night sweats with sex steroid precursors in combination with selective estrogen receptor modulators |
| UY32836A (es) * | 2009-08-12 | 2011-03-31 | Bayer Schering Pharma Ag | Partículas estabilizadas que comprenden 5-metil-(6s)-tetrahidrofolato |
| CN102985070A (zh) | 2010-04-15 | 2013-03-20 | 拜耳知识产权有限责任公司 | 用于hrt的极低剂量的固体口服剂型 |
| AR081670A1 (es) | 2010-06-29 | 2012-10-10 | Leon Farma Sa Lab | Composicion farmaceutica que comprende drospirenona y kit anticonceptivo |
| US11351122B1 (en) | 2010-07-28 | 2022-06-07 | Laboratorios Leon Farma Sa | Synthetic progestogens and pharmaceutical compositions comprising the same |
| US10849857B2 (en) | 2010-07-28 | 2020-12-01 | Laboratorios Leon Farma Sa | Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same |
| US9603860B2 (en) | 2010-07-28 | 2017-03-28 | Laboratorios Leon Farma Sa | Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same |
| CN102516247A (zh) * | 2010-12-15 | 2012-06-27 | 连云港金康医药科技有限公司 | A型l-5-甲基四氢叶酸钙盐多晶型及其制备方法 |
| EP2383279A1 (en) | 2011-07-19 | 2011-11-02 | Pantarhei Bioscience B.V. | Process for the preparation of estetrol |
| EP2781214A1 (en) * | 2013-03-22 | 2014-09-24 | Chemo Research, S.L. | Formulation of amorphous calcium L-5-methyltetrahydrofolate (L-5-MTHF-Ca) |
| EP2878600B1 (en) | 2013-12-02 | 2018-06-27 | Cerbios-Pharma S.A. | Stable complexes of an alkaline earth metal salt of N5-methyl-tetrahydrofolic acid and a polyol |
| CN104490887A (zh) * | 2014-09-04 | 2015-04-08 | 连云港金康和信药业有限公司 | (6s)-5-甲基-四氢叶酸钙盐的稳定药物组合物 |
| EP3310346B1 (en) | 2015-06-18 | 2021-03-24 | Estetra SPRL | Orodispersible tablet containing estetrol |
| PL3310333T3 (pl) | 2015-06-18 | 2020-07-13 | Estetra Sprl | Ulegająca rozpadowi w jamie ustnej jednostka dawkowana zawierająca składnik estetrolowy |
| WO2016203009A1 (en) | 2015-06-18 | 2016-12-22 | Mithra Pharmaceuticals S.A. | Orodispersible tablet containing estetrol |
| US20160367567A1 (en) | 2015-06-18 | 2016-12-22 | Mithra Pharmaceuticals S.A. | Orodispersible dosage unit containing an estetrol component |
| CN105030779A (zh) * | 2015-07-21 | 2015-11-11 | 福格森（武汉）生物科技股份有限公司 | 一种(6s)-5-甲基四氢叶酸钙口服营养补充剂及其制备方法 |
| CA3178291A1 (en) | 2016-08-05 | 2018-04-12 | Estetra Srl | Method for the management of dysmenorrhea and menstrual pain |
| CN106336444A (zh) * | 2016-08-23 | 2017-01-18 | 国家卫生计生委科学技术研究所 | 一种新晶型炔雌醇 |
| CN107446458A (zh) * | 2017-08-04 | 2017-12-08 | 合众（佛山）化工有限公司 | 一种高耐水性的丙烯酸改性聚氨酯杂化树脂水性涂料 |
| TWI801561B (zh) | 2018-04-19 | 2023-05-11 | 比利時商依思特拉私人有限責任公司 | 化合物及其用於緩解絕經相關症狀的用途 |
| JOP20200260A1 (ar) | 2018-04-19 | 2019-10-19 | Estetra Sprl | مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث |
| CN110237046B (zh) * | 2019-03-29 | 2021-07-30 | 福格森（武汉）生物科技股份有限公司 | 一种l-5-甲基四氢叶酸微囊的制备方法 |
| CN110548034A (zh) * | 2019-07-12 | 2019-12-10 | 广州莎蔓生物科技有限公司 | 一种怀孕阻断药物 |
| TWI893101B (zh) | 2020-04-16 | 2025-08-11 | 比利時商埃斯特拉有限責任公司 | 具有降低之副作用之避孕組成物 |
| IT202100008834A1 (it) * | 2021-04-08 | 2022-10-08 | Ind Chimica Srl | Processo per la preparazione di drospirenone come polvere fine tramite duplice cambio di forma cristallina |
| CN114569567B (zh) * | 2021-12-20 | 2023-03-14 | 南通联亚药业股份有限公司 | 一种稳定的双醋炔诺酮炔雌醇复方片及其制备方法 |
| CN115813937B (zh) * | 2022-12-01 | 2025-04-11 | 南通联亚药业股份有限公司 | 一种稳定的包含屈螺酮和雌二醇的药物组合物及其制备方法 |
| IT202300027360A1 (it) * | 2023-12-20 | 2025-06-20 | Lesaffre Et Cie | Formulazioni solide di folati |
| CN117771389A (zh) * | 2023-12-28 | 2024-03-29 | 浙江圣达生物药业股份有限公司 | L-5-甲基四氢叶酸钙-γ-环糊精包合物及其制备方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3347125A1 (de) | 1983-12-22 | 1985-07-11 | Schering AG, 1000 Berlin und 4709 Bergkamen | Mehrstufenkombinationspraeparat und seine verwendung zur oralen kontrazeption |
| FR2676927B1 (fr) * | 1991-05-29 | 1995-06-23 | Ibf | Microspheres utilisables pour les occlusions vasculaires therapeutiques et solutions injectables les contenant. |
| TW390813B (en) * | 1994-04-29 | 2000-05-21 | Merck & Co Inc | Wet granulation formulation for bisphosphonic acids |
| DE4426709A1 (de) | 1994-07-20 | 1996-01-25 | Schering Ag | Steroidale Sexualhormone enthaltende feste Arzneiformen |
| ATE236639T1 (de) | 1994-09-22 | 2003-04-15 | Akzo Nobel Nv | Verfahren zur herstellung von dosierungsformen durch feuchtgranulierung |
| RU2073529C1 (ru) * | 1995-05-16 | 1997-02-20 | Центральный научно-исследовательский рентгенорадиологический институт | Композиция для эмболизации кровеносных сосудов |
| CH693255A5 (de) | 1997-06-13 | 2003-05-15 | Eprova Ag | Verwendung von Tetrahydrofolaten in der natürlichenstereoisomeren Form zur Herstellung einer pharmazeutischenZubereitung geeignet zur Beeinflussung des Homocystein-Spiegels. |
| WO1999053910A2 (en) | 1998-04-17 | 1999-10-28 | Ortho-Mcneil Pharmaceutical, Inc. | Folic acid-containing pharmaceutical compositions, and related methods and delivery systems |
| US6214815B1 (en) * | 1998-12-23 | 2001-04-10 | Ortho-Mcneil Pharmaceuticals, Inc. | Triphasic oral contraceptive |
| CH693905A5 (de) * | 1999-04-15 | 2004-04-15 | Eprova Ag | Stabile kristalline Salze von 5-Methyltetrahydrofolsäure. |
| DE122009000007I2 (de) * | 1999-08-31 | 2011-07-21 | Bayer Schering Pharma | Pharmazeutische kombination von ethinylestradiol und drospirenone als empfangnisverhutendes mittel. |
| CN1223350C (zh) * | 1999-08-31 | 2005-10-19 | 先灵公司 | 用作避孕剂的炔雌醇和屈螺酮的药物联合形式 |
| NZ520630A (en) * | 2000-01-18 | 2004-09-24 | Schering Ag | Drospirenone for hormone replacement therapy |
| US6550482B1 (en) * | 2000-04-21 | 2003-04-22 | Vascular Control Systems, Inc. | Methods for non-permanent occlusion of a uterine artery |
| US6864774B2 (en) | 2000-10-19 | 2005-03-08 | Matsushita Electric Industrial Co., Ltd. | Inductance component and method of manufacturing the same |
| EP1216712A1 (en) | 2000-12-20 | 2002-06-26 | Schering Aktiengesellschaft | Cyclodextrin-drospirenone inclusion complexes |
| EP1216713A1 (en) * | 2000-12-20 | 2002-06-26 | Schering Aktiengesellschaft | Compositions of estrogen-cyclodextrin complexes |
| US6537569B2 (en) * | 2001-02-14 | 2003-03-25 | Microvention, Inc. | Radiation cross-linked hydrogels |
| EP1478373B1 (en) * | 2002-02-21 | 2006-10-04 | Schering Aktiengesellschaft | Pharmaceutical compositions comprising one or more steroids one or more tetrahydrofolate components and vitamin b12 |
| CA2503949C (en) * | 2002-10-29 | 2012-10-23 | Toray Industries, Inc. | Embolization material |
| UY29527A1 (es) * | 2005-05-13 | 2006-12-29 | Schering Ag | Composicinn farmaccutica que contienen gestrgenos y/o estrngenos y 5-metil - (6s) - tetrhidrofolato. |
| CN101489563A (zh) | 2006-07-06 | 2009-07-22 | 拜耳先灵医药股份有限公司 | 用于避孕和预防先天性畸形风险的药物制剂 |
| JP2009542588A (ja) * | 2006-07-06 | 2009-12-03 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | 避妊及び先天的異常の危険性の予防のための医薬製剤 |
| RU62008U1 (ru) * | 2006-10-13 | 2007-03-27 | Закрытое акционерное общество "ААА-КОМПАНИ" | Средство для эмболизации сосудов |
| RU61120U1 (ru) * | 2006-10-13 | 2007-02-27 | Закрытое акционерное общество "ААА-КОМПАНИ" | Средство для эмболизации сосудов |
| US8916188B2 (en) * | 2008-04-18 | 2014-12-23 | Abbott Cardiovascular Systems Inc. | Block copolymer comprising at least one polyester block and a poly (ethylene glycol) block |
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2007
- 2007-05-05 CN CNA2007800254913A patent/CN101489563A/zh active Pending
- 2007-06-21 MY MYPI20070991A patent/MY169516A/en unknown
- 2007-06-25 TW TW104122823A patent/TW201538161A/zh unknown
- 2007-06-25 TW TW096122889A patent/TWI508730B/zh active
- 2007-06-29 NZ NZ573766A patent/NZ573766A/en unknown
- 2007-06-29 RU RU2009103649/15A patent/RU2479306C2/ru active
- 2007-06-29 SG SG2013017165A patent/SG188869A1/en unknown
- 2007-06-29 UA UAA201207425A patent/UA105078C2/uk unknown
- 2007-06-29 JP JP2009517003A patent/JP2009542591A/ja active Pending
- 2007-06-29 MX MX2009000079A patent/MX2009000079A/es active IP Right Grant
- 2007-06-29 EP EP11190550.1A patent/EP2422774B1/en not_active Revoked
- 2007-06-29 NO NO20090578A patent/NO347567B1/no unknown
- 2007-06-29 AU AU2007271449A patent/AU2007271449B2/en active Active
- 2007-06-29 ES ES07764936T patent/ES2626838T5/es active Active
- 2007-06-29 CA CA2856344A patent/CA2856344C/en not_active Expired - Fee Related
- 2007-06-29 KR KR1020097002386A patent/KR20090033889A/ko not_active Ceased
- 2007-06-29 EP EP07764936.6A patent/EP2040683B2/en active Active
- 2007-06-29 WO PCT/EP2007/005764 patent/WO2008003432A1/en not_active Ceased
- 2007-06-29 UA UAA200900637A patent/UA100228C2/uk unknown
- 2007-06-29 CN CN2007800255704A patent/CN101484143B/zh active Active
- 2007-06-29 BR BRPI0713565A patent/BRPI0713565B8/pt active IP Right Grant
- 2007-06-29 CN CN201210143925.2A patent/CN102813663B/zh active Active
- 2007-06-29 KR KR1020137006954A patent/KR20130042638A/ko not_active Ceased
- 2007-06-29 CA CA2656131A patent/CA2656131C/en not_active Expired - Fee Related
- 2007-07-04 UY UY30462A patent/UY30462A1/es not_active Application Discontinuation
- 2007-07-05 CL CL2007001962A patent/CL2007001962A1/es unknown
- 2007-07-05 PE PE2014002543A patent/PE20150287A1/es active IP Right Grant
- 2007-07-05 PE PE2007000867A patent/PE20080273A1/es not_active Application Discontinuation
- 2007-07-05 PE PE2011002146A patent/PE20120375A1/es active IP Right Grant
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