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BR9810870A - Regulação de expressão de quinolato fosforibosil transferase - Google Patents

Regulação de expressão de quinolato fosforibosil transferase

Info

Publication number
BR9810870A
BR9810870A BR9810870-0A BR9810870A BR9810870A BR 9810870 A BR9810870 A BR 9810870A BR 9810870 A BR9810870 A BR 9810870A BR 9810870 A BR9810870 A BR 9810870A
Authority
BR
Brazil
Prior art keywords
regulation
phosphoribosyl transferase
quinolate phosphoribosyl
expression
transferase expression
Prior art date
Application number
BR9810870-0A
Other languages
English (en)
Other versions
BRPI9810870B1 (pt
Inventor
Mark A Conkling
Nandini Mendu
Wen Song
Original Assignee
Univ North Carolina State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21960004&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9810870(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ North Carolina State filed Critical Univ North Carolina State
Publication of BR9810870A publication Critical patent/BR9810870A/pt
Publication of BRPI9810870B1 publication Critical patent/BRPI9810870B1/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • C12N9/1077Pentosyltransferases (2.4.2)
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01HNEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H5/00Angiosperms, i.e. flowering plants, characterised by their plant parts; Angiosperms characterised otherwise than by their botanic taxonomy
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Nutrition Science (AREA)
  • Medicinal Chemistry (AREA)
  • Physiology (AREA)
  • Botany (AREA)
  • Developmental Biology & Embryology (AREA)
  • Environmental Sciences (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Manufacture Of Tobacco Products (AREA)

Abstract

Patente de Invenção: <B>"REGULAçãO DE EXPRESSãO DE QUINOLATO FOSFORIBOSIL TRANSFERASE"<D>. DNA codificando uma enzima de quinolato fosforibosil transferase de planta (QPRTase), e construtos compreendendo tal DNA, são fornecidos. Processos de alteração de expressão de quinolato fosforibosil transferase são fornecidos.
BRPI9810870-0A 1997-06-12 1998-06-10 Molécula e construto de dna, processos de preparação de uma célula de planta transformada e de produção de uma planta de tabaco transgênica, bem como processo para redução de expressão de um gene de quinolato fosforibosil transferase em uma célula de planta BRPI9810870B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4947197P 1997-06-12 1997-06-12
US60/049,471 1997-06-12
PCT/US1998/011893 WO1998056923A1 (en) 1997-06-12 1998-06-10 Regulation of quinolate phosphoribosyl transferase expression

Publications (2)

Publication Number Publication Date
BR9810870A true BR9810870A (pt) 2000-11-14
BRPI9810870B1 BRPI9810870B1 (pt) 2021-06-01

Family

ID=21960004

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9810870-0A BRPI9810870B1 (pt) 1997-06-12 1998-06-10 Molécula e construto de dna, processos de preparação de uma célula de planta transformada e de produção de uma planta de tabaco transgênica, bem como processo para redução de expressão de um gene de quinolato fosforibosil transferase em uma célula de planta

Country Status (37)

Country Link
US (9) US6586661B1 (pt)
EP (3) EP1457562B1 (pt)
JP (4) JP4095678B2 (pt)
KR (1) KR100365969B1 (pt)
CN (2) CN1304576C (pt)
AP (1) AP1169A (pt)
AT (1) ATE262039T1 (pt)
AU (1) AU748514B2 (pt)
BG (1) BG64319B1 (pt)
BR (1) BRPI9810870B1 (pt)
CA (2) CA2287776C (pt)
CU (1) CU23174A3 (pt)
CZ (1) CZ297379B6 (pt)
DE (2) DE991766T1 (pt)
DK (1) DK0991766T3 (pt)
EA (2) EA004652B1 (pt)
EE (1) EE04595B1 (pt)
ES (1) ES2154624T3 (pt)
GE (1) GEP20032871B (pt)
GR (1) GR20010300003T1 (pt)
HU (1) HU225888B1 (pt)
ID (1) ID29311A (pt)
IL (3) IL132184A0 (pt)
LT (1) LT4706B (pt)
LV (1) LV12507B (pt)
NO (1) NO324872B1 (pt)
NZ (1) NZ500963A (pt)
OA (1) OA11219A (pt)
PL (1) PL201266B1 (pt)
PT (1) PT991766E (pt)
RO (1) RO121968B1 (pt)
RS (1) RS49677B (pt)
SI (1) SI20215B (pt)
SK (1) SK161899A3 (pt)
TR (1) TR199902728T2 (pt)
UA (1) UA72187C2 (pt)
WO (1) WO1998056923A1 (pt)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6586661B1 (en) 1997-06-12 2003-07-01 North Carolina State University Regulation of quinolate phosphoribosyl transferase expression by transformation with a tobacco quinolate phosphoribosyl transferase nucleic acid
US20100251425A9 (en) * 1998-05-15 2010-09-30 University Of Central Florida Expression of human interferon in transgenic chloroplasts
DE19926216A1 (de) * 1999-06-09 2001-02-22 Metallgesellschaft Ag Verfahren zur Herstellung von Bariumsulfat, Bariumsulfat und Verwendung des Bariumsulfats
ES2267809T3 (es) * 2000-08-30 2007-03-16 North Carolina State University Plantas transgenicas que contienen señuelos moleculares de proteinas en su interior.
CA2427825A1 (en) * 2000-11-07 2002-05-16 North Carolina State University Putrescine-n-methyltransferase promoter
WO2002037990A2 (en) 2000-11-10 2002-05-16 Vector Tobacco Ltd. Method and product for removing carcinogens from tobacco smoke
DE10055870A1 (de) * 2000-11-10 2002-05-29 Degussa Neue für das nadC-Gen kodierende Nukleotidsequenzen
CN1954688A (zh) * 2001-06-06 2007-05-02 二十二世纪有限责任公司 烟草生物质的用途
WO2005103296A2 (en) * 2004-03-30 2005-11-03 Vector Tobacco, Ltd. Global gene expression analysis of human bronchial epithelial cells exposed to cigarette smoke, smoke condensates, or components thereof
CN1638655A (zh) * 2001-06-08 2005-07-13 韦克多烟草有限公司 修饰烟草中烟碱和亚硝胺的水平
US20060157072A1 (en) * 2001-06-08 2006-07-20 Anthony Albino Method of reducing the harmful effects of orally or transdermally delivered nicotine
US6730832B1 (en) 2001-09-10 2004-05-04 Luis Mayan Dominguez High threonine producing lines of Nicotiana tobacum and methods for producing
WO2003041521A2 (en) * 2001-11-09 2003-05-22 Vector Tobacco Inc. Method and composition for mentholation of charcoal filtered cigarettes
JP2005512555A (ja) * 2001-12-19 2005-05-12 ベクター・タバコ・インコーポレーテッド シガレットのメントール化する方法及び組成物
JP2005512554A (ja) * 2001-12-19 2005-05-12 ベクター・タバコ・インコーポレーテッド タバコ製品に清涼効果を付与する方法および組成物
JP2005522201A (ja) * 2002-04-09 2005-07-28 ベクター、タバコ、リミテッド ニコチンおよびニトロソアミンを減少させたタバコ
KR20060128821A (ko) 2003-08-19 2006-12-14 22엔디 센츄리 리미티드, 엘엘씨 감소된 노출 담배 제품
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
WO2005041151A2 (en) * 2003-10-02 2005-05-06 Vector Tobacco Ltd. Tobacco product labeling system
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
US7538071B2 (en) 2003-11-21 2009-05-26 Carl Berger Methods of reducing the nicotine content of tobacco plants and tobacco plants obtained thereby
US8792955B2 (en) 2004-05-03 2014-07-29 Dexcom, Inc. Transcutaneous analyte sensor
US7654956B2 (en) 2004-07-13 2010-02-02 Dexcom, Inc. Transcutaneous analyte sensor
CA2992898A1 (en) 2005-02-28 2006-10-19 22Nd Century Limited, Llc Reducing levels of nicotinic alkaloids in plants
AU2012203977B2 (en) * 2005-02-28 2015-01-29 22Nd Century Limited, Llc Reducing levels of nicotinic alkaloids in plants
NZ564025A (en) * 2005-05-11 2012-03-30 Vector Tobacco Inc Reduced risk tobacco products and methods of making same
FR2889003A1 (fr) * 2005-07-22 2007-01-26 St Microelectronics Sa Adaptation automatique d'une source video a un recepteur
CN104894158B (zh) 2006-06-19 2018-05-25 22世纪有限责任公司 编码n-甲基腐胺氧化酶之核酸及其应用
US9551003B2 (en) * 2006-09-13 2017-01-24 22Nd Century Limited, Llc Increasing levels of nicotinic alkaloids in plants
EP3578661A1 (en) 2006-09-13 2019-12-11 22nd Century Limited, LLC Increasing levels of nicotinic alkaloids
US9102948B2 (en) 2006-11-17 2015-08-11 22Nd Century Limited, Llc Regulating alkaloids
US9106606B1 (en) 2007-02-05 2015-08-11 F5 Networks, Inc. Method, intermediate device and computer program code for maintaining persistency
CN102171344B (zh) 2007-05-25 2016-03-16 22世纪有限责任公司 编码调节生物碱合成之转录因子的核酸序列及其在改良植物代谢中的应用
US20100206317A1 (en) * 2007-09-28 2010-08-19 Vector Tobacco, Inc. Reduced risk tobacco products and use thereof
CN104131030A (zh) 2007-12-13 2014-11-05 菲利普莫里斯生产公司 就减少的镉转运进行修饰的转基因植物、衍生产物和相关方法
US9493776B2 (en) 2009-11-19 2016-11-15 National University Corporation Okayama University System for increasing gene expression and vector comprising the system
JP5631410B2 (ja) 2009-12-11 2014-11-26 テルモ ビーシーティー、インコーポレーテッド シールド付きの抽出ポート及び光学的制御を有する血液分離システム
EP2537929B1 (en) 2010-02-17 2017-04-12 Japan Tobacco, Inc. Plant component regulation factor, and use thereof
US9862923B2 (en) 2010-03-26 2018-01-09 Philip Morris Usa Inc. Cultured tobacco cells as a matrix for consumable products
EP2565265A1 (en) 2011-09-02 2013-03-06 Philip Morris Products S.A. Isopropylmalate synthase from Nicotiana tabacum and methods and uses thereof
US8716571B2 (en) 2011-09-21 2014-05-06 Reynolds Technologies, Inc. Tobacco having reduced amounts of amino acids and methods for producing such lines
US9137958B2 (en) 2012-02-08 2015-09-22 Reynolds Technologies, Inc. Tobacco having altered amounts of environmental contaminants
US10563215B2 (en) * 2012-12-21 2020-02-18 Philip Morris Products S.A. Tobacco specific nitrosamine reduction in plants
CN103173488B (zh) * 2013-03-14 2014-09-03 浙江省农业科学院 新的融合标签进行水稻转基因快速筛选的方法
US10375910B2 (en) 2013-03-15 2019-08-13 Altria Client Services Llc Development of tobacco varieties with no or significantly reduced anatabine content
BR112017023719A2 (pt) * 2015-05-05 2018-07-17 Univ North Carolina State planta de tabaco, parte de planta e/ou célula de planta, semente, cultura de planta, produto de tabaco, método para reduzir pon e/ou nnk, método de produção de uma planta e método para produzir um produto de tabaco
US10405571B2 (en) 2015-06-26 2019-09-10 Altria Client Services Llc Compositions and methods for producing tobacco plants and products having altered alkaloid levels
EP3480314A1 (en) 2017-11-03 2019-05-08 Philip Morris Products S.A. Regulation of alkaloid content
US10897925B2 (en) 2018-07-27 2021-01-26 Joseph Pandolfino Articles and formulations for smoking products and vaporizers
US20200035118A1 (en) 2018-07-27 2020-01-30 Joseph Pandolfino Methods and products to facilitate smokers switching to a tobacco heating product or e-cigarettes
EP4041899A1 (en) * 2019-10-10 2022-08-17 Altria Client Services LLC Compositions and methods based on qpt engineering for producing tobacco plants and products having altered alkaloid levels
CN113528537A (zh) * 2021-08-11 2021-10-22 云南省烟草农业科学研究院 一种降低烟叶烟碱含量的NtQPT2基因突变体及其应用
CN116983432A (zh) * 2023-07-07 2023-11-03 深圳先进技术研究院 用于治疗类风湿性关节炎的药物

Family Cites Families (216)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US299541A (en) 1884-06-03 heae-n
US254285A (en) 1882-02-28 David w
US38123A (en) * 1863-04-07 Improvement in harvesters
US819751A (en) * 1905-01-04 1906-05-08 Giuseppe Gianoli Process of charging silk.
US2479526A (en) 1940-12-11 1949-08-16 Wurton Machine Company Apparatus for curing green tobacco
US2728803A (en) * 1951-12-28 1955-12-27 Standard Oil Co Separation of ethylbenzene from other c8 aromatic hydrocarbons by extraction with hf-bf3
US2728603A (en) 1954-12-13 1955-12-27 James H Stagg Lawn and garden sprinkler
DE1917552U (de) 1964-01-31 1965-06-10 Fritz Tautenhahn Flaechig-ornamentales gitterwerk.
US3693631A (en) 1971-04-28 1972-09-26 Reynolds Leasing Corp Tobacco expansion process
US3840025A (en) 1972-08-14 1974-10-08 Industrial Nucleonics Corp Tobacco moisture control system and method
US3905123A (en) 1973-10-15 1975-09-16 Industrial Nucleonics Corp Method and apparatus for controlling a tobacco dryer
US4319587A (en) 1975-06-09 1982-03-16 Irving S. Moser Smoking article
DE2531285C2 (de) 1975-07-12 1982-10-28 Deutsche Benkert Gmbh & Co Kg, 4690 Herne Filterzigarette
US4192323A (en) 1977-09-21 1980-03-11 Gas-Fired Products, Inc. Apparatus and method for automatically controlling curing conditions in a tobacco curing barn
US4557280A (en) 1978-06-15 1985-12-10 Brown & Williamson Tobacco Corporation Process for reduction of nitrate and nicotine content of tobacco by microbial treatment
US4243056A (en) 1979-01-12 1981-01-06 Philip Morris Incorporated Method for uniform incorporation of additives into tobacco
FR2478958A1 (fr) 1980-04-01 1981-10-02 Decoufle Dispositif d'alimentation en encre des appareils d'imprimerie pour machines a confectionner les cigarettes
US4499911A (en) 1980-12-09 1985-02-19 Johnson William H Energy efficient curing and drying system
GB2092149B (en) * 1981-02-03 1985-01-03 Searle & Co Imidazoline hydrazone and hydrazine derivatives production thereof and use in medicine
US4459355A (en) 1982-07-12 1984-07-10 International Paper Company Method for transforming plant cells
US4762785A (en) 1982-08-12 1988-08-09 Calgene, Inc. Novel method and compositions for introducting alien DNA in vivo
NL8203963A (nl) 1982-10-14 1984-05-01 Naarden International Nv Werkwijze voor het aromatiseren van droog plantaardig materiaal.
EP0116718B2 (en) 1983-01-13 1996-05-08 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Process for the introduction of expressible genes into plant cell genomes and agrobacterium strains carrying hybrid Ti plasmid vectors useful for this process
US6051757A (en) 1983-01-14 2000-04-18 Washington University Regeneration of plants containing genetically engineered T-DNA
DE3484215D1 (de) 1983-01-17 1991-04-11 Monsanto Co Chimaerische gene geeignet zur expression in pflanzenzellen.
US6174724B1 (en) 1983-01-17 2001-01-16 Monsanto Company Chimeric genes suitable for expression in plant cells
US5034322A (en) 1983-01-17 1991-07-23 Monsanto Company Chimeric genes suitable for expression in plant cells
EP0131620B1 (en) 1983-01-17 1991-08-21 Monsanto Company Genetically transformed plants
US5352605A (en) 1983-01-17 1994-10-04 Monsanto Company Chimeric genes for transforming plant cells using viral promoters
WO1984002919A1 (en) 1983-01-17 1984-08-02 Monsanto Co Plasmids for transforming plant cells
NL8300698A (nl) 1983-02-24 1984-09-17 Univ Leiden Werkwijze voor het inbouwen van vreemd dna in het genoom van tweezaadlobbige planten; agrobacterium tumefaciens bacterien en werkwijze voor het produceren daarvan; planten en plantecellen met gewijzigde genetische eigenschappen; werkwijze voor het bereiden van chemische en/of farmaceutische produkten.
NL8300699A (nl) 1983-02-24 1984-09-17 Univ Leiden Werkwijze voor het inbouwen van vreemd dna in het genoom van tweezaadlobbige planten; werkwijze voor het produceren van agrobacterium tumefaciens bacterien; stabiele cointegraat plasmiden; planten en plantecellen met gewijzigde genetische eigenschappen; werkwijze voor het bereiden van chemische en/of farmaceutische produkten.
US4751348A (en) 1983-07-16 1988-06-14 Cold Spring Harbor Laboratory Nicotiana plants with both altered polyamine levels and flower structures and method for obtaining these plants
US4766855A (en) * 1983-07-20 1988-08-30 Cummins Engine Co., Inc. Plasma jet ignition apparatus
DE3486053T3 (de) 1983-10-20 2004-01-08 The Research Foundation Of State University Of New York Regulierung von Gen-Expression durch Translationshemmung unter Verwendung von m-RNS hinderndem Komplementär-RNS.
US5190931A (en) 1983-10-20 1993-03-02 The Research Foundation Of State University Of New York Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA
US5208149A (en) 1983-10-20 1993-05-04 The Research Foundation Of State University Of New York Nucleic acid constructs containing stable stem and loop structures
US5272065A (en) 1983-10-20 1993-12-21 Research Foundation Of State University Of New York Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA
US4885248A (en) 1984-02-15 1989-12-05 Lubrizol Genetics, Inc. Transfer vector
US4771002A (en) 1984-02-24 1988-09-13 Lubrizol Genetics, Inc. Transcription in plants and bacteria
US5149645A (en) 1984-06-04 1992-09-22 Rijksuniversiteit Leiden Process for introducing foreign DNA into the genome of plants
NL8401780A (nl) 1984-06-04 1986-01-02 Rijksuniversiteit Leiden En Pr Werkwijze voor het inbouwen van vreemd dna in het genoom van planten.
US5100792A (en) 1984-11-13 1992-03-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues
US4945050A (en) 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US5036006A (en) 1984-11-13 1991-07-30 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
DE3587548T2 (de) 1984-12-28 1993-12-23 Bayer Ag Rekombinante DNA, die in pflanzliche Zellen eingebracht werden kann.
US4943674A (en) 1987-05-26 1990-07-24 Calgene, Inc. Fruit specific transcriptional factors
US6281410B1 (en) 1986-07-31 2001-08-28 Calgene Llc Methods and compositions for regulated transcription and expression of heterologous genes
US5753475A (en) 1985-01-17 1998-05-19 Calgene, Inc. Methods and compositions for regulated transcription and expression of heterologous genes
US6617496B1 (en) 1985-10-16 2003-09-09 Monsanto Company Effecting virus resistance in plants through the use of negative strand RNAs
NL8502948A (nl) 1985-10-29 1987-05-18 Rijksuniversiteit Leiden En Pr Werkwijze voor het inbouwen van "vreemd dna" in het genoom van dicotyle planten.
US4795855A (en) 1985-11-14 1989-01-03 Joanne Fillatti Transformation and foreign gene expression with woody species
GB8529851D0 (en) 1985-12-04 1986-01-15 Rothmans Of Pall Mall Linear layered cigarette
US5453566A (en) 1986-03-28 1995-09-26 Calgene, Inc. Antisense regulation of gene expression in plant/cells
US5107065A (en) 1986-03-28 1992-04-21 Calgene, Inc. Anti-sense regulation of gene expression in plant cells
IL81737A (en) 1986-03-28 1992-11-15 Calgene Inc Regulation of gene expression in plant cells
US4700725A (en) 1986-04-17 1987-10-20 Philip Morris Incorporated Adjustable filter cigarette
US4699158A (en) 1986-04-17 1987-10-13 Philip Morris Incorporated Adjustable filter cigarette with tactile indicator
ATE39600T1 (de) 1986-04-23 1989-01-15 Reynolds Tobacco Gmbh Verfahren zur behandlung von tabak und aehnlichen organischen materialien.
US4766911A (en) 1986-06-23 1988-08-30 R. J. Reynolds Tobacco Company Method for tracing smoking articles
US4962028A (en) 1986-07-09 1990-10-09 Dna Plant Technology Corporation Plant promotors
US5229292A (en) 1986-07-28 1993-07-20 Stine Seed Farm, Inc. Biological control of insects using pseudomonas strains transformed with bacillus thuringiensis insect toxingene
EP0265556A1 (en) 1986-10-31 1988-05-04 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Stable binary agrobacterium vectors and their use
US5268463A (en) 1986-11-11 1993-12-07 Jefferson Richard A Plant promoter α-glucuronidase gene construct
US5015580A (en) 1987-07-29 1991-05-14 Agracetus Particle-mediated transformation of soybean plants and lines
US4966916A (en) 1987-02-12 1990-10-30 Abood Leo G Agonists and antagonists to nicotine as smoking deterrents
US4835162A (en) 1987-02-12 1989-05-30 Abood Leo G Agonists and antagonists to nicotine as smoking deterents
US5356799A (en) 1988-02-03 1994-10-18 Pioneer Hi-Bred International, Inc. Antisense gene systems of pollination control for hybrid seed production
US5922602A (en) 1988-02-26 1999-07-13 Biosource Technologies, Inc. Cytoplasmic inhibition of gene expression
US5179022A (en) 1988-02-29 1993-01-12 E. I. Du Pont De Nemours & Co. Biolistic apparatus for delivering substances into cells and tissues in a non-lethal manner
US4954442A (en) 1988-08-31 1990-09-04 Purdue Research Foundation Opine enhancement of vir gene induction
US5023179A (en) 1988-11-14 1991-06-11 Eric Lam Promoter enhancer element for gene expression in plant roots
GB8827592D0 (en) 1988-11-25 1988-12-29 Taniguchi T Improvements in & relating to regulation of expression
US5223419A (en) 1989-03-14 1993-06-29 The Rockefeller University Alteration of gene expression in plants
US4990607A (en) 1989-03-14 1991-02-05 The Rockefeller University Alteration of gene expression in plants
US5231020A (en) 1989-03-30 1993-07-27 Dna Plant Technology Corporation Genetic engineering of novel plant phenotypes
US5034323A (en) 1989-03-30 1991-07-23 Dna Plant Technology Corporation Genetic engineering of novel plant phenotypes
GB8916213D0 (en) 1989-07-14 1989-08-31 Ici Plc Dna constructs,cells and plants derived therefrom
US6203976B1 (en) 1989-07-18 2001-03-20 Osi Pharmaceuticals, Inc. Methods of preparing compositions comprising chemicals capable of transcriptional modulation
US5580722A (en) 1989-07-18 1996-12-03 Oncogene Science, Inc. Methods of determining chemicals that modulate transcriptionally expression of genes associated with cardiovascular disease
AU660405B2 (en) 1989-07-18 1995-06-29 Osi Pharmaceuticals, Inc. Method of transcriptionally modulating gene expression and of discovering chemicals capable of functioning as gene expression modulators
US5776502A (en) 1989-07-18 1998-07-07 Oncogene Science, Inc. Methods of transcriptionally modulating gene expression
US5665543A (en) 1989-07-18 1997-09-09 Oncogene Science, Inc. Method of discovering chemicals capable of functioning as gene expression modulators
NL8901931A (nl) 1989-07-26 1991-02-18 Mogen International N V En Rij Werkwijze voor het plaatsgericht introduceren van vreemd dna in het genoom van planten.
US5501967A (en) 1989-07-26 1996-03-26 Mogen International, N.V./Rijksuniversiteit Te Leiden Process for the site-directed integration of DNA into the genome of plants
US5097025A (en) 1989-08-01 1992-03-17 The Rockefeller University Plant promoters
US5062434A (en) 1989-09-22 1991-11-05 Brown & Williamson Tobacco Corporation Cigarette paper
GB8923716D0 (en) 1989-10-20 1989-12-06 Ici Plc Dna,constructs,cells and plants derived therefrom
US5177308A (en) 1989-11-29 1993-01-05 Agracetus Insecticidal toxins in plants
ATE130371T1 (de) 1989-12-19 1995-12-15 Ciba Geigy Ag Verfahren und vorrichtung zur genetischen transformation von zellen.
JPH0673478B2 (ja) * 1990-01-11 1994-09-21 旭化成工業株式会社 L―カルニチンの高感度測定法および測定用組成物
WO1991011535A1 (en) 1990-01-30 1991-08-08 Childrens Hospital Of Los Angeles Inhibition of transcription by double-stranded oligonucleotides
CA2036935A1 (en) 1990-02-26 1991-08-27 Paul Christou Plant transformation process with early identification of germ line transformation events
GB9005945D0 (en) 1990-03-16 1990-05-09 Cambridge Advanced Tech Plant promoter
WO1991014790A1 (en) 1990-03-27 1991-10-03 New England Medical Center Hospitals, Inc. Inhibitors of transcription activation activity of papillomaviruses
US5109876A (en) 1990-04-19 1992-05-05 R. J. Reynolds Tobacco Company Cigarette paper and cigarette incorporating same
US5204253A (en) 1990-05-29 1993-04-20 E. I. Du Pont De Nemours And Company Method and apparatus for introducing biological substances into living cells
US5668295A (en) 1990-11-14 1997-09-16 Philip Morris Incorporated Protein involved in nicotine synthesis, DNA encoding, and use of sense and antisense DNAs corresponding thereto to affect nicotine content in transgenic tobacco cells and plants
US5932782A (en) 1990-11-14 1999-08-03 Pioneer Hi-Bred International, Inc. Plant transformation method using agrobacterium species adhered to microprojectiles
US5260205A (en) 1990-11-14 1993-11-09 Philip Morris Incorporated Method of purifying putrescine N-methyltransferase from tobacco plant extract with a polyamine
US5035252A (en) 1990-12-14 1991-07-30 Mondre Steven J Nicotine-containing dental floss
US5459252A (en) 1991-01-31 1995-10-17 North Carolina State University Root specific gene promoter
JPH04265569A (ja) * 1991-02-19 1992-09-21 Canon Inc 音声信号記録装置及び再生装置
EP0575518A1 (en) 1991-03-06 1993-12-29 Board Of Regents, The University Of Texas System Methods and compositions for the selective inhibition of gene expression
US5683985A (en) 1991-04-18 1997-11-04 The Salk Institute For Biological Studies Oligonucleotide decoys and methods relating thereto
FR2675803B1 (fr) 1991-04-25 1996-09-06 Genset Sa Oligonucleotides fermes, antisens et sens et leurs applications.
GB9109063D0 (en) 1991-04-26 1991-06-12 Ici Plc Modification of lignin synthesis in plants
WO1993000546A1 (en) 1991-06-20 1993-01-07 Reinforced Plastics/Composites Pty Ltd A connecting system
CA2112130C (en) 1991-06-27 1996-08-06 Cynthia A. Edwards Screening assay for the detection of dna-binding molecules
US5994629A (en) 1991-08-28 1999-11-30 Novartis Ag Positive selection
DK152291D0 (da) 1991-08-28 1991-08-28 Danisco Fremgangsmaade og kemiske forbindelser
GB9304200D0 (en) 1993-03-02 1993-04-21 Sandoz Ltd Improvements in or relating to organic compounds
WO1993005646A1 (en) * 1991-09-13 1993-04-01 Technology Management Services, S.A. Reduction of nicotine levels in tobacco
AU3584993A (en) 1992-01-27 1993-09-01 Trustees Of The University Of Pennsylvania, The Methods and compositions for neutralizing intracellular nucleic acid-binding protein biological activity in a cell, including methods and compositions useful to regulate gene function
WO1993017116A1 (en) 1992-02-26 1993-09-02 Mogen International N.V. Agrobacterium strains capable of site-specific recombination
EP0633940B1 (en) 1992-04-02 2002-12-04 SemBioSys Genetics Inc. Oil-body protein cis-elements as regulatory signals
US5780051A (en) 1992-04-02 1998-07-14 Dynagen, Inc. Methods and articles of manufacture for nicotine cessation and monitoring nicotine use
US5626152A (en) 1992-08-26 1997-05-06 Molins Plc Cigarette making machine
US5469871A (en) 1992-09-17 1995-11-28 R. J. Reynolds Tobacco Company Cigarette and method of making same
EP0746803B1 (en) 1992-11-27 2000-02-02 Voxel Methods and apparatus for making holograms
JPH08503853A (ja) 1992-11-30 1996-04-30 チューア,ナム−ハイ 植物における組織−及び発生−特異的な発現を付与する発現モチーフ
IL108367A0 (en) 1993-01-27 1994-04-12 Hektoen Inst For Medical Resea Antisense polynzcleotide inhibition of human growth factor-sensitive cancer cells
ATE203772T1 (de) 1993-05-13 2001-08-15 Aventis Cropscience Nv Markiergen
CN1127530A (zh) * 1993-06-01 1996-07-24 菲利普莫里斯生产公司 腐胺n-甲基转移酶,编码腐胺n-甲基转移酶的重组dna分子,生物碱含量减少的转基因烟草植物
US5540242A (en) 1993-07-07 1996-07-30 Brown & Williamson Tobacco Corporation Cigarette paper having reduced sidestream properties
US5377697A (en) 1993-08-27 1995-01-03 Hoechst Celanese Corporation Cigarette filter test apparatus and associated method for measuring filter hot collapse and tobacco consumption
US5810020A (en) 1993-09-07 1998-09-22 Osmotek, Inc. Process for removing nitrogen-containing anions and tobacco-specific nitrosamines from tobacco products
EP0732929B1 (en) 1993-10-29 2008-05-14 The Brigham And Women's Hospital, Inc. Therapeutic use of cis-element decoys in vivo
US6399376B1 (en) 1993-11-05 2002-06-04 Isis Pharmaceuticals, Inc. Modulation of vascular cell adhesive molecule expression through oligonucleotide interactions
ES2287933T3 (es) 1993-12-08 2007-12-16 Japan Tobacco Inc. Procedimiento de transformacion de plantas y vector para ello.
US5394894A (en) 1994-02-22 1995-03-07 Zade; Ismail Y. Method and apparatus for elimination of smoking
US5858774A (en) 1994-05-12 1999-01-12 The Research Foundation Of State University Of New York Antisense DNA constructs for expression of hybrid MRNAs driven by inducible, tissue-specific promoters
ES2081257B1 (es) 1994-05-12 1996-07-16 Sagrera Jorge Martinez Instalacion y procedimiento para el curado de tabaco.
US5750870A (en) 1994-06-17 1998-05-12 Agritope, Inc. Plant genetic transformation methods and transgenic plants
JP3235934B2 (ja) 1994-08-04 2001-12-04 三菱レイヨン株式会社 ロドコッカス属細菌由来カナマイシン耐性遺伝子
IT1275697B1 (it) 1994-12-20 1997-10-17 Olmo Giancarlo Dell Metodo per stampare direttamente su carta microincisioni di ologrammi,chinogrammi,reticoli di diffrazione o microincisioni
US5733744A (en) 1995-01-13 1998-03-31 Cornell Research Foundation, Inc. Binary BAC vector
EP0817856A1 (en) 1995-03-22 1998-01-14 Novo Nordisk A/S Introduction of dna into bacillus strains by conjugation
US6028250A (en) 1995-03-30 2000-02-22 Takara Shuzo Co, Ltd. Plant promoter and method for gene expression using said promoter
JP3474879B2 (ja) 1995-05-12 2003-12-08 アンジェスエムジー株式会社 NF−κBに起因する疾患の治療および予防剤
US5837876A (en) * 1995-07-28 1998-11-17 North Carolina State University Root cortex specific gene promoter
GB9517263D0 (en) 1995-08-23 1995-10-25 Cancer Res Campaign Tech Expression systems
ES2262158T3 (es) 1995-09-25 2006-11-16 Syngenta Participations Ag Integracion mejorada de adn exogeno suministrado a celulas vegetales.
US6051409A (en) 1995-09-25 2000-04-18 Novartis Finance Corporation Method for achieving integration of exogenous DNA delivered by non-biological means to plant cells
US6198827B1 (en) * 1995-12-26 2001-03-06 Rocktron Corporation 5-2-5 Matrix system
US5693512A (en) 1996-03-01 1997-12-02 The Ohio State Research Foundation Method for transforming plant tissue by sonication
AU2678097A (en) 1996-04-16 1997-11-07 Immusol Incorporated Targeted viral vectors
US5851804A (en) 1996-05-06 1998-12-22 Apollon, Inc. Chimeric kanamycin resistance gene
US5713376A (en) 1996-05-13 1998-02-03 Berger; Carl Non-addictive tobacco products
DE69738454D1 (de) 1996-05-20 2008-02-21 Us Gov Health & Human Serv Oligonukleotide welche spezifisch retrovirale nukleokapsid-proteine binden
US6022863A (en) 1996-05-21 2000-02-08 Yale University Regulation of gene expression
US5834236A (en) 1996-06-27 1998-11-10 The Salk Institute For Biological Studies AATT repeat transcription enhancer element
USRE38123E1 (en) 1996-06-28 2003-05-27 Regent Court Technologies, Llc. Tobacco products having reduced nitrosamine content
US5803081A (en) 1996-06-28 1998-09-08 Regent Court Technologies Tobacco and related products
US6135121A (en) 1996-06-28 2000-10-24 Regent Court Technologies Tobacco products having reduced nitrosamine content
US5845647A (en) 1996-06-28 1998-12-08 Regent Court Technologies Tobacco and related products
US6037525A (en) 1996-08-01 2000-03-14 North Carolina State University Method for reducing expression variability of transgenes in plant cells
US5830318A (en) 1996-10-25 1998-11-03 Schweitzer-Mauduit International, Inc. High opacity tipping paper
US5929306A (en) 1996-11-15 1999-07-27 University Of Kentucky Research Foundation KYRT1, a disarmed version of a highly tumorigenic Agrobacterium tumefaciens strain identified as Chry5
US6202649B1 (en) 1996-12-02 2001-03-20 Regent Court Technologies Method of treating tobacco to reduce nitrosamine content, and products produced thereby
US6096947A (en) 1997-01-14 2000-08-01 Pioneer Hi-Bred International, Inc. Methods for improving transformation efficiency
AU5918398A (en) 1997-01-28 1998-08-18 Ribozyme Pharmaceuticals, Inc. Compositions and method for modulation of alkaloid biosynthesis and flower formation in plants
US6166032A (en) 1997-02-07 2000-12-26 Synapse Pharmaceuticals International, Inc. Method for controlling tobacco use and alleviating withdrawal symptoms due to cessation of tobacco use
ES1036967Y (es) * 1997-04-15 1998-05-01 Techpack Espana S L Cazoleta perfeccionada para estuche de lapiz de labios.
US6163521A (en) * 1997-04-16 2000-12-19 Matsushita Electric Industrial Co., Ltd. Disk having read-only and read-write areas
US6020989A (en) * 1997-05-14 2000-02-01 Affinity Co., Ltd. Laminated bodies and windows using them
US6586661B1 (en) 1997-06-12 2003-07-01 North Carolina State University Regulation of quinolate phosphoribosyl transferase expression by transformation with a tobacco quinolate phosphoribosyl transferase nucleic acid
UY25037A1 (es) 1997-06-13 1998-12-11 Shell Int Research Un proceso para producir material vegetal modificado geneticamente que comprende una o mas secuencias de adn de interes establemente incorporadas
US6020969A (en) 1997-07-11 2000-02-01 Philip Morris Incorporated Cigarette making machine including band inspection
US6391547B1 (en) 1997-09-09 2002-05-21 Center For The Application Of Molecular Biology To International Agriculture Microbial β-glucuronidase genes, gene products and uses thereof
US6641996B1 (en) 1997-09-09 2003-11-04 Cambia Microbial β-glucuronidase genes, gene products and uses thereof
JP2001514009A (ja) 1997-08-25 2001-09-11 ヌンヘムス・ザーデン・ベー・ヴェー 植物の改良されたアグロバクテリウム−媒介形質転換法
ZA988332B (en) 1997-09-12 1999-03-23 Performance Plants Inc In planta transformation of plants
CA2248622A1 (en) 1997-09-23 1999-03-23 Joe Celeste Biolistic apparatus for delivering substances into cells and tissues
CN1155410C (zh) 1997-10-03 2004-06-30 卡里药品公司 治疗尼古丁成瘾的含有尼古丁受体拮抗剂和抗抑郁药或抗焦虑药的组合物
US6077992A (en) 1997-10-24 2000-06-20 E. I. Du Pont De Nemours And Company Binary viral expression system in plants
AU757672B2 (en) 1997-11-18 2003-02-27 Pioneer Hi-Bred International, Inc. A method for directional stable transformation of eukaryotic cells
US6060310A (en) 1997-11-24 2000-05-09 The United States Of America As Represented By The Department Of Health And Human Services Transcription factor decoy and tumor growth inhibitor
US6153811A (en) 1997-12-22 2000-11-28 Dekalb Genetics Corporation Method for reduction of transgene copy number
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
US6265538B1 (en) * 1998-02-27 2001-07-24 The Regents Of The University Of California Inhibitor of the inflammatory response induced by the TNFA and IL-1
ES2374534T3 (es) 1998-03-20 2012-02-17 Commonwealth Scientific And Industrial Research Organisation Control de la expresión de genes.
JP3444191B2 (ja) 1998-03-31 2003-09-08 日本製紙株式会社 フェニルプロパノイド生合成経路を制御する転写因子
US6136799A (en) 1998-04-08 2000-10-24 Abbott Laboratories Cosolvent formulations
WO1999053050A1 (en) 1998-04-08 1999-10-21 Commonwealth Scientific And Industrial Research Organisation Methods and means for obtaining modified phenotypes
US5938017A (en) 1998-05-04 1999-08-17 Wik; Dennis O. Article for assisting persons to quit smoking and method for same
AR020078A1 (es) 1998-05-26 2002-04-10 Syngenta Participations Ag Metodo para alterar la expresion de un gen objetivo en una celula de planta
US6350479B1 (en) 1998-06-05 2002-02-26 Regent Court Technologies Treating depression with alcohol extracts of tobacco
US6271031B1 (en) 1998-08-12 2001-08-07 E.I. Du Pont De Nemours And Company Quinolinate metabolism enzymes
BR9913651A (pt) 1998-08-31 2001-09-25 Monsanto Co Análise de transgene usando transformação de agrobacterium rhizogenes estável
WO2000018939A1 (en) 1998-10-01 2000-04-06 Pioneer Hi-Bred International, Inc. Method of plant transformation
DE19847767A1 (de) 1998-10-16 2000-04-20 Decoufle Sarl Anordnung zum Zuführen von fließfähiger Druckfarbe zu einem Druckwerk für einen Zigarettenpapierstreifen
DE19852757A1 (de) 1998-11-16 2000-05-18 Eth Zuerich Zuerich Promotoren zur Genexpression in Wurzeln von Pflanzen
MXPA01006457A (es) 1998-12-22 2002-04-24 Nat Research Council Plantas transgenicas que comprenden un gen condicionalmente letal. .
AU2594300A (en) 1998-12-23 2000-07-12 Samuel Roberts Noble Foundation, Inc., The Plant transformation process
JP2002541853A (ja) 1999-04-19 2002-12-10 ロビオ 植物の形質転換方法
WO2000067558A1 (en) 1999-05-06 2000-11-16 Michael Timko Regulation of gene expression in tobacco for manipulation of plant growth and secondary metabolism
US6603061B1 (en) 1999-07-29 2003-08-05 Monsanto Company Agrobacterium-mediated plant transformation method
US6314964B1 (en) 1999-09-15 2001-11-13 Schweitzer-Mauduit International, Inc. Cigarette paper containing carbon fibers for improved ash characteristics
EP1250447B1 (en) 1999-11-29 2011-12-21 Midwest Oilseeds, Inc. Methods, media and apparatus for the introduction of molecules into plant cells and bacteria using aerosol beams
ES2335614T3 (es) 1999-12-16 2010-03-30 Cropdesign N.V. Transferencia optimizada de t-dna y vestores asociados.
WO2001049844A1 (en) 1999-12-30 2001-07-12 Rutgers, The State University Of New Jersey Compositions and methods for gene silencing
AU2778801A (en) 2000-01-07 2001-07-24 Baylor University Antisense compositions and methods
WO2001068836A2 (en) 2000-03-16 2001-09-20 Genetica, Inc. Methods and compositions for rna interference
WO2001077350A2 (en) 2000-04-07 2001-10-18 Large Scale Biology Corporation Compositions and methods for inhibiting gene expression
WO2002000926A2 (en) 2000-06-30 2002-01-03 Epigenomics Ag Diagnosis of diseases associated with signal transduction
ES2267809T3 (es) 2000-08-30 2007-03-16 North Carolina State University Plantas transgenicas que contienen señuelos moleculares de proteinas en su interior.
CA2427825A1 (en) 2000-11-07 2002-05-16 North Carolina State University Putrescine-n-methyltransferase promoter
CN1954688A (zh) 2001-06-06 2007-05-02 二十二世纪有限责任公司 烟草生物质的用途
CN1638655A (zh) 2001-06-08 2005-07-13 韦克多烟草有限公司 修饰烟草中烟碱和亚硝胺的水平
US20060157072A1 (en) 2001-06-08 2006-07-20 Anthony Albino Method of reducing the harmful effects of orally or transdermally delivered nicotine
US6557560B2 (en) 2001-06-18 2003-05-06 Ctc Canada Inc. Cigarette making machine
KR20060128821A (ko) 2003-08-19 2006-12-14 22엔디 센츄리 리미티드, 엘엘씨 감소된 노출 담배 제품
CA2992898A1 (en) 2005-02-28 2006-10-19 22Nd Century Limited, Llc Reducing levels of nicotinic alkaloids in plants
CN104894158B (zh) 2006-06-19 2018-05-25 22世纪有限责任公司 编码n-甲基腐胺氧化酶之核酸及其应用
CA2666383C (en) 2006-10-13 2015-12-22 North Carolina State University Alteration of tobacco alkaloid content through modification of specific cytochrome p450 genes

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