BG62955B1 - Лекарствени форми на циклоспорин за орално прилагане с висока биоактивност и метод за получаванетоим - Google Patents

Лекарствени форми на циклоспорин за орално прилагане с висока биоактивност и метод за получаванетоим Download PDF

Info

Publication number: BG62955B1
Authority: BG; Bulgaria
Prior art keywords: cyclosporin; solution; preparation; parts; ethanol
Prior art date: 1994-11-03

Application number

BG101117A

Other languages

Bulgarian (bg)

English (en)

Other versions

BG101117A (en

Inventor

Matthias Olbrich

Heinrich Poetter

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-11-03

Filing date

1997-01-06

Publication date

2000-12-29

1997-01-06 Application filed by Novartis Ag filed Critical Novartis Ag

1997-08-29 Publication of BG101117A publication Critical patent/BG101117A/xx

2000-12-29 Publication of BG62955B1 publication Critical patent/BG62955B1/bg

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title claims abstract description 38
108010036949 Cyclosporine Proteins 0.000 title claims abstract description 37
229960001265 ciclosporin Drugs 0.000 title claims abstract description 37
229930182912 cyclosporin Natural products 0.000 title claims abstract description 27
229930105110 Cyclosporin A Natural products 0.000 title claims abstract description 23
238000002360 preparation method Methods 0.000 title claims description 10
238000000034 method Methods 0.000 title claims description 8
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 25
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 24
239000002775 capsule Substances 0.000 claims abstract description 9
108010036941 Cyclosporins Proteins 0.000 claims abstract description 6
150000001298 alcohols Chemical class 0.000 claims abstract description 6
239000002202 Polyethylene glycol Substances 0.000 claims abstract description 5
229920001223 polyethylene glycol Polymers 0.000 claims abstract description 5
ZMKGDQSIRSGUDJ-VSROPUKISA-N (3s,6s,9s,12r,15s,18s,21s,24s,30s,33s)-33-[(e,1r,2r)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-30-propyl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,1 Chemical compound CCC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O ZMKGDQSIRSGUDJ-VSROPUKISA-N 0.000 claims abstract description 4
ZMKGDQSIRSGUDJ-UHFFFAOYSA-N NVa2 cyclosporine Natural products CCCC1NC(=O)C(C(O)C(C)CC=CC)N(C)C(=O)C(C(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)N(C)C(=O)C(C(C)C)NC(=O)C(CC(C)C)N(C)C(=O)CN(C)C1=O ZMKGDQSIRSGUDJ-UHFFFAOYSA-N 0.000 claims abstract description 4
108010019249 cyclosporin G Proteins 0.000 claims abstract description 4
229920006395 saturated elastomer Polymers 0.000 claims abstract description 4
239000004480 active ingredient Substances 0.000 claims description 8
238000003756 stirring Methods 0.000 claims description 8
239000002552 dosage form Substances 0.000 claims description 7
239000002904 solvent Substances 0.000 claims description 6
235000014113 dietary fatty acids Nutrition 0.000 claims description 4
239000000194 fatty acid Substances 0.000 claims description 4
229930195729 fatty acid Natural products 0.000 claims description 4
230000037406 food intake Effects 0.000 claims 1
239000000203 mixture Substances 0.000 abstract description 13
229960004063 propylene glycol Drugs 0.000 abstract 2
235000013772 propylene glycol Nutrition 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
238000013019 agitation Methods 0.000 abstract 1
238000004090 dissolution Methods 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
239000000243 solution Substances 0.000 description 11
239000004094 surface-active agent Substances 0.000 description 6
238000009472 formulation Methods 0.000 description 5
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
239000004615 ingredient Substances 0.000 description 4
239000003921 oil Substances 0.000 description 4
235000019198 oils Nutrition 0.000 description 4
-1 hydroxyl fatty acids Chemical class 0.000 description 3
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
235000005687 corn oil Nutrition 0.000 description 2
239000002285 corn oil Substances 0.000 description 2
239000012895 dilution Substances 0.000 description 2
238000010790 dilution Methods 0.000 description 2
230000035622 drinking Effects 0.000 description 2
230000002209 hydrophobic effect Effects 0.000 description 2
230000002906 microbiologic effect Effects 0.000 description 2
239000006186 oral dosage form Substances 0.000 description 2
239000008194 pharmaceutical composition Substances 0.000 description 2
OIQOAYVCKAHSEJ-UHFFFAOYSA-N 2-[2,3-bis(2-hydroxyethoxy)propoxy]ethanol;hexadecanoic acid;octadecanoic acid Chemical compound OCCOCC(OCCO)COCCO.CCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O OIQOAYVCKAHSEJ-UHFFFAOYSA-N 0.000 description 1
AFENDNXGAFYKQO-UHFFFAOYSA-N 2-hydroxybutyric acid Chemical class CCC(O)C(O)=O AFENDNXGAFYKQO-UHFFFAOYSA-N 0.000 description 1
208000023275 Autoimmune disease Diseases 0.000 description 1
108010069514 Cyclic Peptides Proteins 0.000 description 1
102000001189 Cyclic Peptides Human genes 0.000 description 1
206010029164 Nephrotic syndrome Diseases 0.000 description 1
201000004681 Psoriasis Diseases 0.000 description 1
235000019486 Sunflower oil Nutrition 0.000 description 1
206010052779 Transplant rejections Diseases 0.000 description 1
206010046851 Uveitis Diseases 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
229910052782 aluminium Inorganic materials 0.000 description 1
230000003110 anti-inflammatory effect Effects 0.000 description 1
230000002141 anti-parasite Effects 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
239000008280 blood Substances 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
238000010322 bone marrow transplantation Methods 0.000 description 1
239000006184 cosolvent Substances 0.000 description 1
230000037029 cross reaction Effects 0.000 description 1
231100000673 dose–response relationship Toxicity 0.000 description 1
239000003814 drug Substances 0.000 description 1
230000000694 effects Effects 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
238000011049 filling Methods 0.000 description 1
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
238000002650 immunosuppressive therapy Methods 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
238000002955 isolation Methods 0.000 description 1
239000007788 liquid Substances 0.000 description 1
239000008297 liquid dosage form Substances 0.000 description 1
239000006193 liquid solution Substances 0.000 description 1
239000004530 micro-emulsion Substances 0.000 description 1
238000002156 mixing Methods 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
239000004006 olive oil Substances 0.000 description 1
235000008390 olive oil Nutrition 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
238000012856 packing Methods 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
239000000843 powder Substances 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
238000000746 purification Methods 0.000 description 1
239000002600 sunflower oil Substances 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
150000003626 triacylglycerols Chemical class 0.000 description 1
238000002604 ultrasonography Methods 0.000 description 1
150000004670 unsaturated fatty acids Chemical class 0.000 description 1
235000021122 unsaturated fatty acids Nutrition 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Dispersion Chemistry (AREA)
Molecular Biology (AREA)
Transplantation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Peptides Or Proteins (AREA)

BG101117A 1994-11-03 1997-01-06 Лекарствени форми на циклоспорин за орално прилагане с висока биоактивност и метод за получаванетоим BG62955B1 (bg)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE4438861		1994-11-03
PCT/DE1995/000951 WO1996014079A1 (de)	1994-11-03	1995-07-19	Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung

Publications (2)

Publication Number	Publication Date
BG101117A BG101117A (en)	1997-08-29
BG62955B1 true BG62955B1 (bg)	2000-12-29

Family

ID=6532126

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG101117A BG62955B1 (bg)	1994-11-03	1997-01-06	Лекарствени форми на циклоспорин за орално прилагане с висока биоактивност и метод за получаванетоим

Country Status (27)

Country	Link
US (1)	US6486124B2 (et)
EP (1)	EP0789580B1 (et)
JP (1)	JP3833248B2 (et)
KR (1)	KR970704464A (et)
CN (1)	CN1121238C (et)
AT (1)	ATE218359T1 (et)
AU (1)	AU715165B2 (et)
BG (1)	BG62955B1 (et)
BR (1)	BR9509550A (et)
CA (1)	CA2231404C (et)
CZ (1)	CZ287806B6 (et)
DE (2)	DE59510233D1 (et)
DK (1)	DK0789580T3 (et)
EE (1)	EE03425B1 (et)
ES (1)	ES2177652T3 (et)
FI (1)	FI118722B (et)
HU (1)	HUT77283A (et)
LT (1)	LT4306B (et)
LV (1)	LV11884B (et)
NO (1)	NO970741D0 (et)
PL (1)	PL183579B1 (et)
PT (1)	PT789580E (et)
RU (1)	RU2158601C2 (et)
SK (1)	SK164796A3 (et)
TR (1)	TR199501361A2 (et)
TW (1)	TW492876B (et)
WO (1)	WO1996014079A1 (et)

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EP0789580B1 (de)	1994-11-03	2002-06-05	Novartis AG	Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung
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US5962019A (en) *	1995-08-25	1999-10-05	Sangstat Medical Corporation	Oral cyclosporin formulations
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DE19544507B4 (de) *	1995-11-29	2007-11-15	Novartis Ag	Cyclosporin enthaltende Präparate
KR20000069900A (ko) *	1997-01-30	2000-11-25	한스 루돌프 하우스, 헨리테 브룬너, 베아트리체 귄터	오일을 함유하지 않은 사이클로스포린 ａ 함유 제약 조성물
AU762247B2 (en) *	1997-01-30	2003-06-19	Novartis Ag	Oil-free pharmaceutical compositions containing cyclosporin A
DE19821951A1 (de) *	1998-05-15	1999-11-18	Basf Ag	Cyclosporin-Zubereitungen
AUPP627498A0 (en)	1998-10-02	1998-10-22	University Of Queensland, The	Novel peptides - i
NZ512599A (en)	1998-12-30	2003-10-31	Dexcel Ltd	Formulation for cyclosporin administration featuring a hydrophilic solvent and a surfactant with a HLB of less than 5
US6656504B1 (en)	1999-09-09	2003-12-02	Elan Pharma International Ltd.	Nanoparticulate compositions comprising amorphous cyclosporine and methods of making and using such compositions
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US7851444B2 (en)	2002-12-02	2010-12-14	Xenome Ltd.	χ-conotoxin peptides (-1)
WO2004050688A1 (en)	2002-12-02	2004-06-17	Xenome Ltd	NOVEL χ-CONOTOXIN PEPTIDES (-II)
SE0301119D0 (sv) *	2003-04-14	2003-04-14	Astrazeneca Ab	New non-ionic surfactants for solubilizing poorly soluble molecules
CN102552917A (zh)	2003-08-13	2012-07-11	比奥孔有限公司	用于治疗剂的微-粒子脂肪酸盐固体剂量制剂
US20050059583A1 (en) *	2003-09-15	2005-03-17	Allergan, Inc.	Methods of providing therapeutic effects using cyclosporin components
RU2272643C2 (ru) *	2004-06-11	2006-03-27	Маргарита Васильевна Бибикова	Высокоактивный кристаллический препарат циклоспорина а и способ его получения
US7151085B2 (en)	2004-11-15	2006-12-19	Allergan, Inc.	Therapeutic methods using cyclosporine components
US7135455B2 (en) *	2004-11-15	2006-11-14	Allergan, Inc	Methods for the therapeutic use of cyclosporine components
JP2008535921A (ja)	2005-04-12	2008-09-04	エラン・ファルマ・インターナショナル・リミテッド	シクロスポリンを含むナノ粒子および放出調節された組成物
US7202209B2 (en)	2005-07-13	2007-04-10	Allergan, Inc.	Cyclosporin compositions
US7288520B2 (en)	2005-07-13	2007-10-30	Allergan, Inc.	Cyclosporin compositions
US20070015691A1 (en) *	2005-07-13	2007-01-18	Allergan, Inc.	Cyclosporin compositions
US20070015693A1 (en) *	2005-07-13	2007-01-18	Allergan, Inc.	Cyclosporin compositions
US7297679B2 (en)	2005-07-13	2007-11-20	Allergan, Inc.	Cyclosporin compositions
US7276476B2 (en) *	2005-07-13	2007-10-02	Allergan, Inc.	Cyclosporin compositions
US7501393B2 (en) *	2005-07-27	2009-03-10	Allergan, Inc.	Pharmaceutical compositions comprising cyclosporins
US9839667B2 (en)	2005-10-14	2017-12-12	Allergan, Inc.	Prevention and treatment of ocular side effects with a cyclosporin
US7745400B2 (en) *	2005-10-14	2010-06-29	Gregg Feinerman	Prevention and treatment of ocular side effects with a cyclosporin
AU2012339693B2 (en) *	2011-11-15	2017-09-07	Allergan, Inc.	Cyclosporine A Form 2 and method of making same
ES2791751T3 (es) *	2011-11-15	2020-11-05	Allergan Inc	Suspensiones de forma 2 de ciclosporina A

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1995
- 1995-07-19 EP EP95925707A patent/EP0789580B1/de not_active Expired - Lifetime
- 1995-07-19 DE DE59510233T patent/DE59510233D1/de not_active Expired - Fee Related
- 1995-07-19 KR KR1019970700361A patent/KR970704464A/ko not_active Ceased
- 1995-07-19 HU HU9702144A patent/HUT77283A/hu unknown
- 1995-07-19 EE EE9700112A patent/EE03425B1/et not_active IP Right Cessation
- 1995-07-19 CA CA002231404A patent/CA2231404C/en not_active Expired - Fee Related
- 1995-07-19 WO PCT/DE1995/000951 patent/WO1996014079A1/de not_active Ceased
- 1995-07-19 BR BR9509550A patent/BR9509550A/pt not_active Application Discontinuation
- 1995-07-19 SK SK1647-96A patent/SK164796A3/sk unknown
- 1995-07-19 ES ES95925707T patent/ES2177652T3/es not_active Expired - Lifetime
- 1995-07-19 DK DK95925707T patent/DK0789580T3/da active
- 1995-07-19 PT PT95925707T patent/PT789580E/pt unknown
- 1995-07-19 AU AU29751/95A patent/AU715165B2/en not_active Ceased
- 1995-07-19 RU RU97108682/14A patent/RU2158601C2/ru active
- 1995-07-19 AT AT95925707T patent/ATE218359T1/de not_active IP Right Cessation
- 1995-07-19 JP JP51493496A patent/JP3833248B2/ja not_active Expired - Fee Related
- 1995-07-19 CN CN95196010A patent/CN1121238C/zh not_active Expired - Fee Related
- 1995-07-19 CZ CZ19963616A patent/CZ287806B6/cs not_active IP Right Cessation
- 1995-08-08 TW TW084108225A patent/TW492876B/zh active
- 1995-10-26 DE DE19539860A patent/DE19539860A1/de not_active Withdrawn
- 1995-11-02 TR TR95/01361A patent/TR199501361A2/xx unknown
1997
- 1997-01-06 BG BG101117A patent/BG62955B1/bg unknown
- 1997-01-09 LT LT97-002A patent/LT4306B/lt not_active IP Right Cessation
- 1997-02-14 FI FI970634A patent/FI118722B/fi active IP Right Grant
- 1997-02-18 NO NO970741A patent/NO970741D0/no not_active Application Discontinuation
- 1997-05-14 LV LVP-97-94A patent/LV11884B/lv unknown
1998
- 1998-03-09 PL PL95318560A patent/PL183579B1/pl unknown
2001
- 2001-10-17 US US09/981,929 patent/US6486124B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
LV11884B (lv)	1998-03-20
CA2231404C (en)	2009-02-17
CN1121238C (zh)	2003-09-17
EE9700112A (et)	1997-12-15
DE19539860A1 (de)	1996-05-09
NO970741L (no)	1997-02-18
LT4306B (lt)	1998-03-25
CN1162265A (zh)	1997-10-15
RU2158601C2 (ru)	2000-11-10
NO970741D0 (no)	1997-02-18
EP0789580A1 (de)	1997-08-20
EE03425B1 (et)	2001-06-15
CZ361696A3 (en)	1997-07-16
CA2231404A1 (en)	1996-05-17
LT97002A (en)	1997-11-25
AU715165B2 (en)	2000-01-20
FI970634L (fi)	1997-02-14
TW492876B (en)	2002-07-01
JP3833248B2 (ja)	2006-10-11
PT789580E (pt)	2002-09-30
ES2177652T3 (es)	2002-12-16
PL318560A1 (en)	1997-06-23
US20020025927A1 (en)	2002-02-28
KR970704464A (ko)	1997-09-06
TR199501361A2 (tr)	1996-06-21
EP0789580B1 (de)	2002-06-05
HUT77283A (hu)	1998-03-30
SK164796A3 (en)	1997-06-04
BR9509550A (pt)	1997-09-16
PL183579B1 (pl)	2002-06-28
LV11884A (lv)	1997-12-20
BG101117A (en)	1997-08-29
FI970634A0 (fi)	1997-02-14
JPH10508306A (ja)	1998-08-18
AU2975195A (en)	1996-05-31
CZ287806B6 (en)	2001-02-14
US6486124B2 (en)	2002-11-26
WO1996014079A1 (de)	1996-05-17
DE59510233D1 (de)	2002-07-11
DK0789580T3 (da)	2002-09-09
ATE218359T1 (de)	2002-06-15
FI118722B (fi)	2008-02-29

Publication	Publication Date	Title
BG62955B1 (bg)	2000-12-29	Лекарствени форми на циклоспорин за орално прилагане с висока биоактивност и метод за получаванетоим
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