BG107556A - Съединения, съдържащи сулфонамидна група, и фармацевтични състави, които ги съдържат - Google Patents

Съединения, съдържащи сулфонамидна група, и фармацевтични състави, които ги съдържат Download PDF

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Publication number: BG107556A
Authority: BG; Bulgaria
Prior art keywords: group; compound; active ingredient; erythrocytes; quinine
Prior art date: 2000-05-31

Application number

BG107556A

Other languages

Bulgarian (bg)

English (en)

Inventor

Walter Elger

Alexander Hillisch

Annemarie Hedden

Sigfrid Schwarz

Klaus Schollkope

Original Assignee

Schering Aktiengesellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-31

Filing date

2003-02-14

Publication date

2004-01-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7644802&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG107556(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-02-14 Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft

2004-01-30 Publication of BG107556A publication Critical patent/BG107556A/bg

Links

150000001875 compounds Chemical class 0.000 title claims abstract description 64
239000008194 pharmaceutical composition Substances 0.000 title description 3
FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical group NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 title 1
210000003743 erythrocyte Anatomy 0.000 claims abstract description 52
125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 26
239000000651 prodrug Substances 0.000 claims abstract description 24
229940002612 prodrug Drugs 0.000 claims abstract description 24
125000000217 alkyl group Chemical group 0.000 claims abstract description 20
125000002252 acyl group Chemical group 0.000 claims abstract description 13
125000003118 aryl group Chemical group 0.000 claims abstract description 6
125000004093 cyano group Chemical group *C#N 0.000 claims abstract description 5
125000000753 cycloalkyl group Chemical group 0.000 claims abstract description 5
125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 5
239000004480 active ingredient Substances 0.000 claims description 56
125000000524 functional group Chemical group 0.000 claims description 53
125000002947 alkylene group Chemical group 0.000 claims description 26
125000006850 spacer group Chemical group 0.000 claims description 25
125000000732 arylene group Chemical group 0.000 claims description 19
-1 acyl radical Chemical class 0.000 claims description 18
LOUPRKONTZGTKE-WZBLMQSHSA-N Quinine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-WZBLMQSHSA-N 0.000 claims description 13
LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 claims description 12
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239000000262 estrogen Substances 0.000 claims description 12
229910006074 SO2NH2 Inorganic materials 0.000 claims description 11
239000003098 androgen Substances 0.000 claims description 9
VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims description 6
235000001258 Cinchona calisaya Nutrition 0.000 claims description 6
MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims description 6
229960005309 estradiol Drugs 0.000 claims description 6
229930182833 estradiol Natural products 0.000 claims description 6
125000000623 heterocyclic group Chemical group 0.000 claims description 6
239000000583 progesterone congener Substances 0.000 claims description 6
229960000948 quinine Drugs 0.000 claims description 6
150000003254 radicals Chemical class 0.000 claims description 6
229910052717 sulfur Inorganic materials 0.000 claims description 6
NNKXWRRDHYTHFP-HZQSTTLBSA-N (r)-[(2s,4s,5r)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;hydron;dichloride Chemical compound Cl.Cl.C([C@H]([C@H](C1)C=C)C2)CN1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 NNKXWRRDHYTHFP-HZQSTTLBSA-N 0.000 claims description 5
229910052760 oxygen Inorganic materials 0.000 claims description 5
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230000036470 plasma concentration Effects 0.000 claims description 5
229960005179 primaquine Drugs 0.000 claims description 5
INDBQLZJXZLFIT-UHFFFAOYSA-N primaquine Chemical compound N1=CC=CC2=CC(OC)=CC(NC(C)CCCN)=C21 INDBQLZJXZLFIT-UHFFFAOYSA-N 0.000 claims description 5
239000003263 anabolic agent Substances 0.000 claims description 4
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VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims description 4
239000003814 drug Substances 0.000 claims description 4
238000002360 preparation method Methods 0.000 claims description 4
125000000565 sulfonamide group Chemical group 0.000 claims description 4
WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 claims description 3
XEEQGYMUWCZPDN-DOMZBBRYSA-N (-)-(11S,2'R)-erythro-mefloquine Chemical compound C([C@@H]1[C@@H](O)C=2C3=CC=CC(=C3N=C(C=2)C(F)(F)F)C(F)(F)F)CCCN1 XEEQGYMUWCZPDN-DOMZBBRYSA-N 0.000 claims description 3
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239000001096 (4-ethenyl-1-azabicyclo[2.2.2]octan-7-yl)-(6-methoxyquinolin-4-yl)methanol hydrochloride Substances 0.000 claims description 3
AKYHKWQPZHDOBW-UHFFFAOYSA-N (5-ethenyl-1-azabicyclo[2.2.2]octan-7-yl)-(6-methoxyquinolin-4-yl)methanol Chemical compound OS(O)(=O)=O.C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 AKYHKWQPZHDOBW-UHFFFAOYSA-N 0.000 claims description 3
WHTVZRBIWZFKQO-AWEZNQCLSA-N (S)-chloroquine Chemical compound ClC1=CC=C2C(N[C@@H](C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-AWEZNQCLSA-N 0.000 claims description 3
XHKUDCCTVQUHJQ-BILMMMPYSA-N (r)-[(2s,4s,5r)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C([C@H]([C@H](C1)C=C)C2)CN1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 XHKUDCCTVQUHJQ-BILMMMPYSA-N 0.000 claims description 3
MAYUSTFJKJSJNC-DSXUQNDKSA-N (r)-[(2s,4s,5r)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;2-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=CC=C1O.C([C@H]([C@H](C1)C=C)C2)CN1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 MAYUSTFJKJSJNC-DSXUQNDKSA-N 0.000 claims description 3
LKUVXQMSYPYURB-DSXUQNDKSA-N (r)-[(2s,4s,5r)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;formic acid Chemical compound OC=O.C([C@H]([C@H](C1)C=C)C2)CN1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 LKUVXQMSYPYURB-DSXUQNDKSA-N 0.000 claims description 3
229940121891 Dopamine receptor antagonist Drugs 0.000 claims description 3
239000001576 FEMA 2977 Substances 0.000 claims description 3
229940124323 amoebicide Drugs 0.000 claims description 3
230000002280 anti-androgenic effect Effects 0.000 claims description 3
239000000051 antiandrogen Substances 0.000 claims description 3
229940030495 antiandrogen sex hormone and modulator of the genital system Drugs 0.000 claims description 3
229940124538 antidiuretic agent Drugs 0.000 claims description 3
229960000981 artemether Drugs 0.000 claims description 3
FIHJKUPKCHIPAT-AHIGJZGOSA-N artesunate Chemical compound C([C@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4[C@@]31[C@@H]2O[C@@H](OC(=O)CCC(O)=O)[C@@H]4C FIHJKUPKCHIPAT-AHIGJZGOSA-N 0.000 claims description 3
229960004991 artesunate Drugs 0.000 claims description 3
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 3
229960003677 chloroquine Drugs 0.000 claims description 3
WHTVZRBIWZFKQO-UHFFFAOYSA-N chloroquine Natural products ClC1=CC=C2C(NC(C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-UHFFFAOYSA-N 0.000 claims description 3
AZFLJNIPTRTECV-FUMNGEBKSA-N dienogest Chemical compound C1CC(=O)C=C2CC[C@@H]([C@H]3[C@@](C)([C@](CC3)(O)CC#N)CC3)C3=C21 AZFLJNIPTRTECV-FUMNGEBKSA-N 0.000 claims description 3
229960003309 dienogest Drugs 0.000 claims description 3
SXYIRMFQILZOAM-HVNFFKDJSA-N dihydroartemisinin methyl ether Chemical compound C1C[C@H]2[C@H](C)CC[C@H]3[C@@H](C)[C@@H](OC)O[C@H]4[C@]32OO[C@@]1(C)O4 SXYIRMFQILZOAM-HVNFFKDJSA-N 0.000 claims description 3
METQSPRSQINEEU-UHFFFAOYSA-N dihydrospirorenone Natural products CC12CCC(C3(CCC(=O)C=C3C3CC33)C)C3C1C1CC1C21CCC(=O)O1 METQSPRSQINEEU-UHFFFAOYSA-N 0.000 claims description 3
239000003210 dopamine receptor blocking agent Substances 0.000 claims description 3
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METQSPRSQINEEU-HXCATZOESA-N drospirenone Chemical compound C([C@]12[C@H]3C[C@H]3[C@H]3[C@H]4[C@@H]([C@]5(CCC(=O)C=C5[C@@H]5C[C@@H]54)C)CC[C@@]31C)CC(=O)O2 METQSPRSQINEEU-HXCATZOESA-N 0.000 claims description 3
PROQIPRRNZUXQM-ZXXIGWHRSA-N estriol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H]([C@H](O)C4)O)[C@@H]4[C@@H]3CCC2=C1 PROQIPRRNZUXQM-ZXXIGWHRSA-N 0.000 claims description 3
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239000003862 glucocorticoid Substances 0.000 claims description 3
XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims description 3
XXSMGPRMXLTPCZ-UHFFFAOYSA-N hydroxychloroquine Chemical compound ClC1=CC=C2C(NC(C)CCCN(CCO)CC)=CC=NC2=C1 XXSMGPRMXLTPCZ-UHFFFAOYSA-N 0.000 claims description 3
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VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical group O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 claims description 3
230000003071 parasitic effect Effects 0.000 claims description 3
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SSOLNOMRVKKSON-UHFFFAOYSA-N proguanil Chemical compound CC(C)\N=C(/N)N=C(N)NC1=CC=C(Cl)C=C1 SSOLNOMRVKKSON-UHFFFAOYSA-N 0.000 claims description 3
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229960003604 testosterone Drugs 0.000 claims description 3
GKRXTXTYZVRRAI-HZQSTTLBSA-N (r)-[(2s,4s,5r)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;dihydrobromide Chemical compound Br.Br.C([C@H]([C@H](C1)C=C)C2)CN1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 GKRXTXTYZVRRAI-HZQSTTLBSA-N 0.000 claims description 2
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 2
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PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical group C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
229960000611 pyrimethamine Drugs 0.000 description 1
WKSAUQYGYAYLPV-UHFFFAOYSA-N pyrimethamine Chemical compound CCC1=NC(N)=NC(N)=C1C1=CC=C(Cl)C=C1 WKSAUQYGYAYLPV-UHFFFAOYSA-N 0.000 description 1
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
229940081974 saccharin Drugs 0.000 description 1
235000019204 saccharin Nutrition 0.000 description 1
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
238000000926 separation method Methods 0.000 description 1
ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
239000004208 shellac Substances 0.000 description 1
235000013874 shellac Nutrition 0.000 description 1
229940113147 shellac Drugs 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000007858 starting material Substances 0.000 description 1
239000000021 stimulant Substances 0.000 description 1
IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid Chemical class NS(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 description 1
125000004434 sulfur atom Chemical group 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000002700 tablet coating Substances 0.000 description 1
238000009492 tablet coating Methods 0.000 description 1
239000000454 talc Substances 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
229960003813 terlipressin Drugs 0.000 description 1
BENFXAYNYRLAIU-QSVFAHTRSA-N terlipressin Chemical compound NCCCC[C@@H](C(=O)NCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)CN)CSSC1 BENFXAYNYRLAIU-QSVFAHTRSA-N 0.000 description 1
IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 description 1
125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
229960002180 tetracycline Drugs 0.000 description 1
235000019364 tetracycline Nutrition 0.000 description 1
229930101283 tetracycline Natural products 0.000 description 1
150000003522 tetracyclines Chemical class 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
229930192474 thiophene Natural products 0.000 description 1
235000010215 titanium dioxide Nutrition 0.000 description 1
239000004408 titanium dioxide Substances 0.000 description 1
125000005425 toluyl group Chemical group 0.000 description 1
230000000472 traumatic effect Effects 0.000 description 1
MEHHPFQKXOUFFV-OWSLCNJRSA-N trenbolone Chemical compound C1CC(=O)C=C2CC[C@@H]([C@H]3[C@@](C)([C@H](CC3)O)C=C3)C3=C21 MEHHPFQKXOUFFV-OWSLCNJRSA-N 0.000 description 1
229960000312 trenbolone Drugs 0.000 description 1
229910052722 tritium Inorganic materials 0.000 description 1
231100000397 ulcer Toxicity 0.000 description 1
229960003726 vasopressin Drugs 0.000 description 1
238000005406 washing Methods 0.000 description 1
238000001262 western blot Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0044—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an estrane or gonane skeleton, including 18-substituted derivatives and derivatives where position 17-beta is substituted by a carbon atom not directly bonded to another carbon atom and not being part of an amide group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Tropical Medicine & Parasitology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Cephalosporin Compounds (AREA)
Medicinal Preparation (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

BG107556A 2000-05-31 2003-02-14 Съединения, съдържащи сулфонамидна група, и фармацевтични състави, които ги съдържат BG107556A (bg)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10027887A DE10027887A1 (de)	2000-05-31	2000-05-31	Verbindungen mit einer Sulfonamidgruppe und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
PCT/EP2001/005169 WO2001091797A2 (de)	2000-05-31	2001-05-08	Verbindungen mit einer sulfonamidgruppe und diese verbindungen enthaltende pharmazeutische zusammensetzungen

Publications (1)

Publication Number	Publication Date
BG107556A true BG107556A (bg)	2004-01-30

Family

ID=7644802

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG107556A BG107556A (bg)	2000-05-31	2003-02-14	Съединения, съдържащи сулфонамидна група, и фармацевтични състави, които ги съдържат

Country Status (29)

Country	Link
US (2)	US7507725B2 (es)
EP (1)	EP1294402B2 (es)
JP (1)	JP2003534386A (es)
KR (3)	KR20030017524A (es)
CN (1)	CN1441678A (es)
AT (1)	ATE315407T1 (es)
AU (2)	AU2001265933B2 (es)
BG (1)	BG107556A (es)
BR (1)	BR0111294A (es)
CA (1)	CA2410630A1 (es)
CZ (1)	CZ2003621A3 (es)
DE (2)	DE10027887A1 (es)
DK (1)	DK1294402T4 (es)
EA (1)	EA006432B1 (es)
ES (1)	ES2256256T5 (es)
HR (1)	HRP20021038B1 (es)
HU (1)	HUP0301949A3 (es)
IL (2)	IL152932A0 (es)
ME (1)	MEP14608A (es)
MX (1)	MXPA02011844A (es)
NO (1)	NO20025739L (es)
NZ (1)	NZ535201A (es)
PL (1)	PL206462B1 (es)
PT (1)	PT1294402E (es)
SK (1)	SK2912003A3 (es)
UA (1)	UA76953C2 (es)
WO (1)	WO2001091797A2 (es)
YU (1)	YU90102A (es)
ZA (1)	ZA200209490B (es)

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2000
- 2000-05-31 DE DE10027887A patent/DE10027887A1/de not_active Ceased
2001
- 2001-05-08 NZ NZ535201A patent/NZ535201A/en unknown
- 2001-05-08 CA CA002410630A patent/CA2410630A1/en not_active Abandoned
- 2001-05-08 CN CN01810337A patent/CN1441678A/zh active Pending
- 2001-05-08 DK DK01943329T patent/DK1294402T4/da active
- 2001-05-08 PL PL361426A patent/PL206462B1/pl not_active IP Right Cessation
- 2001-05-08 AU AU2001265933A patent/AU2001265933B2/en not_active Ceased
- 2001-05-08 PT PT01943329T patent/PT1294402E/pt unknown
- 2001-05-08 ES ES01943329T patent/ES2256256T5/es not_active Expired - Lifetime
- 2001-05-08 KR KR1020027016148A patent/KR20030017524A/ko not_active Ceased
- 2001-05-08 SK SK291-2003A patent/SK2912003A3/sk not_active Application Discontinuation
- 2001-05-08 KR KR1020087009746A patent/KR20080038460A/ko not_active Abandoned
- 2001-05-08 MX MXPA02011844A patent/MXPA02011844A/es active IP Right Grant
- 2001-05-08 HU HU0301949A patent/HUP0301949A3/hu unknown
- 2001-05-08 YU YU90102A patent/YU90102A/sh unknown
- 2001-05-08 KR KR1020097014971A patent/KR20090090398A/ko not_active Ceased
- 2001-05-08 US US10/296,973 patent/US7507725B2/en not_active Expired - Fee Related
- 2001-05-08 DE DE50108674T patent/DE50108674D1/de not_active Expired - Lifetime
- 2001-05-08 IL IL15293201A patent/IL152932A0/xx active IP Right Grant
- 2001-05-08 EA EA200201201A patent/EA006432B1/ru not_active IP Right Cessation
- 2001-05-08 ME MEP-146/08A patent/MEP14608A/xx unknown
- 2001-05-08 WO PCT/EP2001/005169 patent/WO2001091797A2/de not_active Ceased
- 2001-05-08 CZ CZ2003621A patent/CZ2003621A3/cs unknown
- 2001-05-08 JP JP2001587809A patent/JP2003534386A/ja active Pending
- 2001-05-08 HR HR20021038A patent/HRP20021038B1/xx not_active IP Right Cessation
- 2001-05-08 EP EP01943329A patent/EP1294402B2/de not_active Expired - Lifetime
- 2001-05-08 AT AT01943329T patent/ATE315407T1/de not_active IP Right Cessation
- 2001-05-08 BR BR0111294-5A patent/BR0111294A/pt not_active Application Discontinuation
- 2001-05-08 AU AU6593301A patent/AU6593301A/xx active Pending
- 2001-08-05 UA UA20021210409A patent/UA76953C2/uk unknown
2002
- 2002-11-19 IL IL152932A patent/IL152932A/en not_active IP Right Cessation
- 2002-11-21 ZA ZA200209490A patent/ZA200209490B/en unknown
- 2002-11-29 NO NO20025739A patent/NO20025739L/no not_active Application Discontinuation
2003
- 2003-02-14 BG BG107556A patent/BG107556A/bg unknown
2008
- 2008-06-19 US US12/142,332 patent/US20090023896A1/en not_active Abandoned

Also Published As

Publication number	Publication date
PL206462B1 (pl)	2010-08-31
JP2003534386A (ja)	2003-11-18
PL361426A1 (pl)	2004-10-04
YU90102A (sh)	2006-05-25
HRP20021038B1 (hr)	2008-08-31
HUP0301949A2 (hu)	2003-09-29
BR0111294A (pt)	2003-06-10
KR20030017524A (ko)	2003-03-03
WO2001091797A3 (de)	2002-06-20
AU2001265933B2 (en)	2007-10-18
IL152932A (en)	2007-07-04
HRP20021038A2 (en)	2004-10-31
EA006432B1 (ru)	2005-12-29
KR20090090398A (ko)	2009-08-25
CA2410630A1 (en)	2002-11-28
CN1441678A (zh)	2003-09-10
EP1294402B2 (de)	2009-08-12
DK1294402T4 (da)	2009-11-23
MEP14608A (bs)	2010-06-10
NO20025739D0 (no)	2002-11-29
AU6593301A (en)	2001-12-11
KR20080038460A (ko)	2008-05-06
ES2256256T5 (es)	2009-12-11
NZ535201A (en)	2007-01-26
SK2912003A3 (en)	2003-09-11
US20090023896A1 (en)	2009-01-22
DE50108674D1 (de)	2006-04-06
EP1294402A2 (de)	2003-03-26
EP1294402B1 (de)	2006-01-11
PT1294402E (pt)	2006-05-31
US7507725B2 (en)	2009-03-24
ATE315407T1 (de)	2006-02-15
ZA200209490B (en)	2005-03-10
MXPA02011844A (es)	2004-05-17
DK1294402T3 (da)	2006-05-22
WO2001091797A2 (de)	2001-12-06
ES2256256T3 (es)	2006-07-16
US20040014781A1 (en)	2004-01-22
UA76953C2 (en)	2006-10-16
HUP0301949A3 (en)	2010-01-28
DE10027887A1 (de)	2001-12-13
EA200201201A1 (ru)	2003-06-26
CZ2003621A3 (cs)	2003-12-17
IL152932A0 (en)	2003-06-24
NO20025739L (no)	2002-11-29

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