BE2019C523I2 - - Google Patents
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- Publication number
- BE2019C523I2 BE2019C523I2 BE2019C523C BE2019C523C BE2019C523I2 BE 2019C523 I2 BE2019C523 I2 BE 2019C523I2 BE 2019C523 C BE2019C523 C BE 2019C523C BE 2019C523 C BE2019C523 C BE 2019C523C BE 2019C523 I2 BE2019C523 I2 BE 2019C523I2
- Authority
- BE
- Belgium
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62727704P | 2004-11-12 | 2004-11-12 | |
| PCT/US2005/041205 WO2006053299A2 (fr) | 2004-11-12 | 2005-11-14 | Modification du facteur fviii en fonction du site |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE2019C523I2 true BE2019C523I2 (fr) | 2025-02-10 |
Family
ID=36337298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE2019C523C BE2019C523I2 (fr) | 2004-11-12 | 2019-05-07 |
Country Status (32)
| Country | Link |
|---|---|
| US (4) | US7632921B2 (fr) |
| EP (9) | EP3323829B1 (fr) |
| JP (5) | JP2008524117A (fr) |
| KR (7) | KR101483917B1 (fr) |
| CN (6) | CN105148287B (fr) |
| AU (1) | AU2005304622B2 (fr) |
| BE (1) | BE2019C523I2 (fr) |
| BR (2) | BRPI0517795B8 (fr) |
| CA (1) | CA2586379C (fr) |
| CY (3) | CY1119292T1 (fr) |
| DK (3) | DK2371856T3 (fr) |
| ES (4) | ES2821832T3 (fr) |
| FR (1) | FR19C1031I2 (fr) |
| HN (1) | HN2007015683A (fr) |
| HR (2) | HRP20070268B1 (fr) |
| HU (5) | HUE059193T2 (fr) |
| IL (3) | IL182903A (fr) |
| LT (5) | LT1824988T (fr) |
| LU (1) | LUC00118I2 (fr) |
| MA (1) | MA29663B1 (fr) |
| MX (3) | MX350293B (fr) |
| NL (1) | NL300989I2 (fr) |
| NO (3) | NO345800B1 (fr) |
| NZ (1) | NZ555032A (fr) |
| PH (2) | PH12014500352B1 (fr) |
| PL (3) | PL1824988T3 (fr) |
| PT (4) | PT2363414T (fr) |
| RU (1) | RU2423380C2 (fr) |
| SI (4) | SI2363414T1 (fr) |
| UA (1) | UA95225C2 (fr) |
| WO (1) | WO2006053299A2 (fr) |
| ZA (1) | ZA200703696B (fr) |
Families Citing this family (107)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2338333B1 (fr) | 2003-04-09 | 2017-09-06 | ratiopharm GmbH | Méthode de glycopegylation et proteines/peptides produits au moyen de ces méthodes |
| US9005625B2 (en) | 2003-07-25 | 2015-04-14 | Novo Nordisk A/S | Antibody toxin conjugates |
| US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
| ES2390082T5 (es) * | 2004-06-30 | 2018-01-19 | Nektar Therapeutics | Conjugados de resto de Factor IX y polímeros |
| WO2006010143A2 (fr) | 2004-07-13 | 2006-01-26 | Neose Technologies, Inc. | Remodelage de peg ramifie et glycosylation de peptide-1 semblable a glucagon [glp-1] |
| HUE026826T2 (en) | 2004-10-29 | 2016-07-28 | Ratiopharm Gmbh | Modeling and glycopegylation of fibroblast growth factor (FGF) |
| ES2821832T3 (es) | 2004-11-12 | 2021-04-27 | Bayer Healthcare Llc | Modificación de FVIII dirigida al sitio |
| EP2514757A3 (fr) | 2005-01-10 | 2014-03-05 | ratiopharm GmbH | Facteur de stimulation de colonies de granulocytes glycopegylé |
| EP2386571B1 (fr) | 2005-04-08 | 2016-06-01 | ratiopharm GmbH | Compositions et méthodes utilisées pour la préparation de mutants par glycosylation de l'hormone de croissance humaine résistant à la protéase |
| EP1893632B1 (fr) | 2005-06-17 | 2015-08-12 | Novo Nordisk Health Care AG | Reduction et derivation séléctives de proteines facteur vii comprenant au moins une cysteine non native |
| US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
| US7855279B2 (en) | 2005-09-27 | 2010-12-21 | Amunix Operating, Inc. | Unstructured recombinant polymers and uses thereof |
| US20090048440A1 (en) | 2005-11-03 | 2009-02-19 | Neose Technologies, Inc. | Nucleotide Sugar Purification Using Membranes |
| AU2007253264A1 (en) * | 2006-05-24 | 2007-11-29 | Novo Nordisk Health Care Ag | Factor IX analogues having prolonged in vivo half life |
| US20080280818A1 (en) | 2006-07-21 | 2008-11-13 | Neose Technologies, Inc. | Glycosylation of peptides via o-linked glycosylation sequences |
| WO2008057683A2 (fr) | 2006-10-03 | 2008-05-15 | Novo Nordisk A/S | Méthodes de purification de conjugués de polypeptides |
| EP2101821B1 (fr) | 2006-12-15 | 2014-08-13 | Baxter International Inc. | Conjugué du facteur viia et de l'acide (poly)sialique présentant une demi-vie in vivo prolongée |
| PL2144923T3 (pl) | 2007-04-03 | 2013-12-31 | Biogenerix Ag | Sposoby leczenia z użyciem glikopegilowanego G-CSF |
| US9493499B2 (en) | 2007-06-12 | 2016-11-15 | Novo Nordisk A/S | Process for the production of purified cytidinemonophosphate-sialic acid-polyalkylene oxide (CMP-SA-PEG) as modified nucleotide sugars via anion exchange chromatography |
| US8173597B2 (en) * | 2007-11-09 | 2012-05-08 | Baxter International Inc. | Modified recombinant factor VIII and von Willebrand factor and methods of use |
| EP2257311B1 (fr) * | 2008-02-27 | 2014-04-16 | Novo Nordisk A/S | Molécules de facteur viii conjuguées |
| JP5997443B2 (ja) | 2008-05-16 | 2016-09-28 | バイエル・ヘルスケア・エルエルシーBayer HealthCare LLC | 標的化凝固因子およびそれを使用する方法 |
| AU2009256093A1 (en) * | 2008-06-04 | 2009-12-10 | Bayer Healthcare Llc | FVIII muteins for treatment of von Willebrand disease |
| EP2291523B1 (fr) | 2008-06-24 | 2014-12-17 | CSL Behring GmbH | Facteur VIII, facteur von Willebrand ou complexes associés avec demi-vie in vivo prolongée |
| WO2010019263A2 (fr) * | 2008-08-15 | 2010-02-18 | Genzyme Corporation | Produits de construction de flt soluble pour traiter des cancers |
| SMT201800486T1 (it) * | 2008-10-17 | 2018-11-09 | Baxalta Inc | Fattori sanguigni modificati comprendenti un grado basso di polimero solubile in acqua |
| JP2012508172A (ja) * | 2008-11-03 | 2012-04-05 | バイエル・ヘルスケア・エルエルシー | 血友病の治療方法 |
| JP2012510060A (ja) * | 2008-11-24 | 2012-04-26 | バイエル・ヘルスケア・エルエルシー | シリカをベースとする活性化部分トロンボプラスチン時間アッセイにおけるpeg化血液凝固因子の活性の測定方法 |
| CA2748662A1 (fr) * | 2009-01-19 | 2010-07-22 | Bayer Healthcare Llc | Conjugue proteique ayant une fraction bio-protectrice pouvant etre clivee par une endopeptidase |
| CN108530543B (zh) | 2009-02-03 | 2023-06-23 | 阿穆尼克斯制药公司 | 延伸重组多肽和包含该延伸重组多肽的组合物 |
| US20110306551A1 (en) * | 2009-02-19 | 2011-12-15 | Novo Nordisk A/S | Modification of Factor VIII |
| WO2010107256A2 (fr) * | 2009-03-20 | 2010-09-23 | Hanmi Pharm. Co., Ltd. | Procédé de préparation d'un conjugué de polypeptide physiologiquement actif et spécifique d'un site |
| CN102427823A (zh) * | 2009-03-24 | 2012-04-25 | 拜耳医药保健有限公司 | 因子viii变体及使用方法 |
| US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| CN104530182A (zh) | 2009-07-27 | 2015-04-22 | 利普森技术有限公司 | 非凝血蛋白的糖基多唾液酸化 |
| US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| SG178051A1 (en) | 2009-07-27 | 2012-03-29 | Lipoxen Technologies Ltd | Glycopolysialylation of non-blood coagulation proteins |
| RU2595442C2 (ru) | 2009-07-27 | 2016-08-27 | Баксалта Инкорпорейтед | Конъюгаты белков свертывания крови |
| US9062299B2 (en) | 2009-08-24 | 2015-06-23 | Amunix Operating Inc. | Coagulation factor IX compositions and methods of making and using same |
| HRP20180135T1 (hr) | 2009-12-06 | 2018-04-06 | Bioverativ Therapeutics Inc. | Kimerni i hibridni polipeptidi čimbenika viii-fc, te postupci njihove upotrebe |
| WO2011075185A1 (fr) | 2009-12-18 | 2011-06-23 | Oligasis | Conjugués de polymère de phosphorylcholine à médicament ciblé |
| WO2011101242A1 (fr) | 2010-02-16 | 2011-08-25 | Novo Nordisk A/S | Molécules de facteur viii avec liaison réduite au vwf |
| PT2536399T (pt) * | 2010-02-21 | 2020-02-06 | Bayer Healthcare Llc | Método para ativação e conjugação de biomoléculas |
| WO2011130694A2 (fr) | 2010-04-15 | 2011-10-20 | Oligasis | Polymères de haut poids moléculaire contenant des zwitterions |
| GB201007357D0 (en) * | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIII |
| GB201007356D0 (en) | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIIa |
| EP3508573A1 (fr) | 2010-07-09 | 2019-07-10 | Bioverativ Therapeutics Inc. | Systèmes de traitement de facteur viii et procédés associés |
| CA2816575C (fr) * | 2010-11-05 | 2019-06-11 | Baxter Healthcare S.A. | Un nouveau variant du facteur viii anti-hemophile ayant une activite specifique accrue |
| CN103282045A (zh) * | 2010-12-16 | 2013-09-04 | 诺沃—诺迪斯克有限公司 | 因子viii水溶液 |
| CA2822591C (fr) | 2010-12-22 | 2020-12-29 | Baxter International Inc. | Materiels et methodes pour la conjugaison d'un derive d'acide gras soluble dans l'eau a une proteine |
| EP3808378A1 (fr) * | 2011-05-27 | 2021-04-21 | Baxalta GmbH | Protéines thérapeutiques présentant une demi-vie accrue et leurs procédés de préparation |
| DK2717898T3 (en) | 2011-06-10 | 2019-03-25 | Bioverativ Therapeutics Inc | COAGULATING COMPOUNDS AND PROCEDURES FOR USE THEREOF |
| HK1199889A1 (en) | 2011-07-01 | 2015-07-24 | Bayer Intellectual Property Gmbh | Relaxin fusion polypeptides and uses thereof |
| CN107261122A (zh) | 2011-07-08 | 2017-10-20 | 比奥贝拉蒂治疗公司 | 因子viii嵌合和杂合多肽及其使用方法 |
| AR088161A1 (es) | 2011-09-23 | 2014-05-14 | Novo Nordisk As | Analogos de glucagon |
| KR20130049671A (ko) * | 2011-11-04 | 2013-05-14 | 한미사이언스 주식회사 | 생리활성 폴리펩타이드 결합체 제조 방법 |
| BR112014019901A8 (pt) | 2012-02-15 | 2018-01-02 | Biogen Idec Inc | Proteínas de fator viii recombinante |
| EP3564260B1 (fr) | 2012-02-15 | 2022-10-19 | Bioverativ Therapeutics Inc. | Compositions de facteur viii et leurs procédés de fabrication et d'utilisation |
| US9458223B2 (en) | 2012-02-15 | 2016-10-04 | Csl Behring Gmbh | Von willebrand factor variants having improved factor VIII binding affinity |
| EP2666782A1 (fr) | 2012-05-22 | 2013-11-27 | Imnate Sarl | Facteur VIII de coagulation avec immunogénicité réduite |
| CN104519897A (zh) | 2012-06-08 | 2015-04-15 | 比奥根艾迪克Ma公司 | 促凝血化合物 |
| EP3404105A1 (fr) | 2012-07-06 | 2018-11-21 | Bioverativ Therapeutics Inc. | Lignée cellulaire exprimant des polypeptides du facteur viii à chaîne unique et ses utilisations |
| CA2888806A1 (fr) | 2012-10-18 | 2014-04-24 | Biogen Idec Ma Inc. | Procedes d'utilisation d'une dose fixe d'un facteur de coagulation |
| EP3943102A1 (fr) | 2012-10-30 | 2022-01-26 | Bioverativ Therapeutics Inc. | Procédé d'utilisation de polypeptide du facteur viii |
| EP2970430A4 (fr) * | 2013-03-15 | 2017-01-11 | Bayer HealthCare LLC | Formulations de facteur viii recombinant |
| HUE047933T2 (hu) | 2013-03-15 | 2020-05-28 | Bioverativ Therapeutics Inc | Faktor VIII polipeptid készítmények |
| JP6387392B2 (ja) | 2013-03-15 | 2018-09-05 | バイオベラティブ セラピューティクス インコーポレイテッド | 第ix因子ポリペプチド製剤 |
| SI2986313T1 (sl) | 2013-04-18 | 2019-09-30 | Novo Nordisk A/S | Stabilni koagonisti GLP-1 / glukagonskega receptorja z dolgotrajnim učinkom za medicinsko uporabo |
| DK2796145T3 (da) | 2013-04-22 | 2018-01-29 | Csl Ltd | Et kovalent kompleks af von Willebrand-faktor og faktor VIII linket af en disulfidbro |
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| EP4108254A1 (fr) | 2013-08-14 | 2022-12-28 | Bioverativ Therapeutics Inc. | Protéines de facteur viii de recombinaison |
| PT3041513T (pt) | 2013-09-08 | 2020-09-07 | Kodiak Sciences Inc | Conjugados de polímeros zwiteriónicos com fator viii |
| AU2014339034A1 (en) * | 2013-10-22 | 2016-05-19 | Dbv Technologies | Method of treating haemophilia by inducing tolerance to blood factors |
| US10584147B2 (en) | 2013-11-08 | 2020-03-10 | Biovertiv Therapeutics Inc. | Procoagulant fusion compound |
| RU2546297C1 (ru) * | 2013-11-19 | 2015-04-10 | Федеральное государственное бюджетное учреждение "Научно-исследовательский институт фармакологии" Сибирского отделения Российской академии медицинских наук | Средство, улучшающее реологические свойства крови |
| EP4332839A3 (fr) | 2013-12-06 | 2024-06-05 | Bioverativ Therapeutics Inc. | Outils pharmacocinétiques de population et leurs utilisations |
| US10822393B2 (en) | 2014-01-20 | 2020-11-03 | Octapharma Ag | Process for manufacturing factor VIII having an improved ratio of FVIII:C/FVIII/AG |
| WO2015120056A1 (fr) | 2014-02-04 | 2015-08-13 | Biogen Ma Inc. | Chromatographie par échange cationique utilisée dans le mode de fixation par écoulement pour enrichir les modifications post-traductionnelles |
| EP3114138B1 (fr) * | 2014-03-05 | 2021-11-17 | Pfizer Inc. | Mutéines améliorées du facteur viii de coagulation |
| WO2015148444A1 (fr) | 2014-03-24 | 2015-10-01 | Biogen Ma Inc. | Formulations de facteur ix lyophilisées |
| CA2944909A1 (fr) * | 2014-04-04 | 2015-10-08 | Bloodworks | Laboratoire ordinaire et analyse hors laboratoire de l'hemostase |
| KR20160144429A (ko) | 2014-04-10 | 2016-12-16 | 바이엘 헬쓰케어 엘엘씨 | 배합된 배지 분말 제형 및 세포 배양을 위한 액체 배지의 제조 방법 |
| CN106536547A (zh) | 2014-06-04 | 2017-03-22 | 诺和诺德股份有限公司 | 用于医疗用途的glp‑1/胰高血糖素受体共激动剂 |
| KR20170026580A (ko) | 2014-07-02 | 2017-03-08 | 씨에스엘 리미티드 | 변형된 폰 빌레브란트 인자 |
| MA40864A (fr) | 2014-10-31 | 2017-09-05 | Biogen Ma Inc | Hypotaurine, gaba, bêta-alanine et choline pour la régulation de l'accumulation de sous-produits résiduaires dans des procédés de culture de cellules mammifères |
| CN107406493B (zh) | 2015-03-06 | 2021-08-13 | 康诺贝林伦瑙有限公司 | 具有改善的半衰期的经修饰的血管性血友病因子 |
| WO2016188907A1 (fr) | 2015-05-22 | 2016-12-01 | Csl Behring Recombinant Facility Ag | Polypeptides du facteur von willebrand tronqué pour le traitement de l'hémophilie |
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