|
CN102924458B
(zh)
|
2004-04-02 |
2014-11-05 |
Osi制药有限责任公司 |
6,6-双环取代的杂双环蛋白激酶抑制剂
|
|
US20100279994A1
(en)
*
|
2005-06-21 |
2010-11-04 |
Inifinity Discovery, Inc. |
Ansamycin Formulations and Methods of Use Thereof
|
|
EP2865381A1
(en)
*
|
2006-05-18 |
2015-04-29 |
Pharmacyclics, Inc. |
ITK inhibitors for treating blood cell malignancies
|
|
DE602007013567D1
(de)
*
|
2006-08-16 |
2011-05-12 |
Novartis Ag |
Verfahren zur herstellung fester dispersionen von midostaurin
|
|
EA018573B1
(ru)
*
|
2006-09-22 |
2013-09-30 |
Фармасайкликс, Инк. |
Ингибиторы тирозинкиназы брутона
|
|
EP2089391B1
(en)
*
|
2006-11-03 |
2013-01-16 |
Pharmacyclics, Inc. |
Bruton's tyrosine kinase activity probe and method of using
|
|
SG10201508035TA
(en)
*
|
2007-03-28 |
2015-10-29 |
Pharmacyclics Inc |
Inhibitors of bruton's tyrosine kinase
|
|
US8809273B2
(en)
|
2007-03-28 |
2014-08-19 |
Pharmacyclics, Inc. |
Inhibitors of Bruton's tyrosine kinase
|
|
CN101677991A
(zh)
*
|
2007-04-12 |
2010-03-24 |
英菲尼蒂发现公司 |
氢醌安莎霉素制剂
|
|
US7989465B2
(en)
*
|
2007-10-19 |
2011-08-02 |
Avila Therapeutics, Inc. |
4,6-disubstituted pyrimidines useful as kinase inhibitors
|
|
TWI475996B
(zh)
*
|
2007-10-19 |
2015-03-11 |
Celgene Avilomics Res Inc |
雜芳基化合物及其用途
|
|
US20110046144A1
(en)
*
|
2008-01-18 |
2011-02-24 |
Mulvihill Mark J |
Imidazopyrazinol derivatives for the treatment of cancers
|
|
EP2283020B8
(en)
*
|
2008-05-19 |
2012-12-12 |
OSI Pharmaceuticals, LLC |
Substituted imidazopyr-and imidazotri-azines
|
|
US20090301928A1
(en)
*
|
2008-06-05 |
2009-12-10 |
United Comb & Novelty Corporation |
Packaging For Lipped Containers
|
|
US8338439B2
(en)
|
2008-06-27 |
2012-12-25 |
Celgene Avilomics Research, Inc. |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
BRPI0914682B8
(pt)
|
2008-06-27 |
2021-05-25 |
Avila Therapeutics Inc |
compostos de heteroarila e composições compreendendo os referidos compostos
|
|
US11351168B1
(en)
|
2008-06-27 |
2022-06-07 |
Celgene Car Llc |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
EP2307413B1
(en)
|
2008-07-15 |
2015-09-09 |
F. Hoffmann-La Roche AG |
Novel phenyl-imidazopyridines and pyridazines
|
|
AU2013245503B2
(en)
*
|
2008-07-16 |
2015-09-24 |
Pharmacyclics Llc |
Inhibitors of Bruton's tyrosine kinase for the treatment of solid tumors
|
|
JP5369183B2
(ja)
*
|
2008-07-16 |
2013-12-18 |
ファーマサイクリックス,インク. |
固形腫瘍の治療用のブルートンのチロシンキナーゼの阻害剤
|
|
RU2014150660A
(ru)
*
|
2008-09-05 |
2015-07-20 |
Селджен Авиломикс Рисерч, Инк. |
Алгоритм разработки необратимо действующих ингибиторов
|
|
US8778921B2
(en)
|
2008-10-15 |
2014-07-15 |
Infinity Pharmaceuticals, Inc. |
Ansamycin hydroquinone compositions
|
|
WO2010043633A1
(en)
*
|
2008-10-15 |
2010-04-22 |
Palau Pharma, S. A. |
2h-pyrazolo [4,3-d]pyrimidin-5-amine derivatives as h4 histamine receptor antagonists for the treatment of allergic, immunological and inflammatory diseases
|
|
US9095592B2
(en)
*
|
2008-11-07 |
2015-08-04 |
The Research Foundation For The State University Of New York |
Bruton's tyrosine kinase as anti-cancer drug target
|
|
US8426428B2
(en)
*
|
2008-12-05 |
2013-04-23 |
Principia Biopharma, Inc. |
EGFR kinase knockdown via electrophilically enhanced inhibitors
|
|
BRPI1016245A2
(pt)
|
2009-04-20 |
2015-09-01 |
Osi Pharmaceuticals Llc |
Preparação de c-pirazina-metilaminas.
|
|
EP2424368B1
(en)
|
2009-04-29 |
2014-12-31 |
Locus Pharmaceuticals, Inc. |
Pyrrolotriazine compounds
|
|
US9908884B2
(en)
|
2009-05-05 |
2018-03-06 |
Dana-Farber Cancer Institute, Inc. |
EGFR inhibitors and methods of treating disorders
|
|
EP2427192A1
(en)
*
|
2009-05-07 |
2012-03-14 |
OSI Pharmaceuticals, LLC |
Use of osi-906 for treating adrenocortical carcinoma
|
|
PL2473049T3
(pl)
*
|
2009-09-04 |
2019-07-31 |
Biogen Ma Inc. |
Inhibitory kinazy tyrozynowej brutona
|
|
IN2012DN03112A
(zh)
*
|
2009-09-11 |
2015-09-18 |
Cylene Pharamaceuticals Inc |
|
|
CN102713618B
(zh)
*
|
2009-09-16 |
2015-07-15 |
新基阿维罗米克斯研究公司 |
蛋白激酶复合物和抑制剂
|
|
US7965498B2
(en)
|
2009-09-30 |
2011-06-21 |
Apple Inc. |
Cover glass to housing interface system
|
|
US7718662B1
(en)
|
2009-10-12 |
2010-05-18 |
Pharmacyclics, Inc. |
Pyrazolo-pyrimidine inhibitors of bruton's tyrosine kinase
|
|
EP2937345B1
(en)
|
2009-12-29 |
2018-03-21 |
Dana-Farber Cancer Institute, Inc. |
Type ii raf kinase inhibitors
|
|
WO2011082285A1
(en)
|
2009-12-30 |
2011-07-07 |
Avila Therapeutics, Inc. |
Ligand-directed covalent modification of protein
|
|
JP2013521318A
(ja)
*
|
2010-03-08 |
2013-06-10 |
ラティオファルム ゲー・エム・ベー・ハー |
ダビガトランエテキシラートを含有する医薬組成物
|
|
WO2011133609A2
(en)
*
|
2010-04-19 |
2011-10-27 |
The Translational Genomics Research Institute |
Methods and kits to predict therapeutic outcome of btk inhibitors
|
|
ES2592152T3
(es)
|
2010-05-31 |
2016-11-28 |
Ono Pharmaceutical Co., Ltd. |
Derivado de purinona como inhibidor de Btk quinasa
|
|
US20120087915A1
(en)
*
|
2010-06-03 |
2012-04-12 |
Pharmacyclics, Inc. |
Use of inhibitors of bruton's tyrosine kinase (btk)
|
|
US20120053189A1
(en)
*
|
2010-06-28 |
2012-03-01 |
Pharmacyclics, Inc. |
Btk inhibitors for the treatment of immune mediated conditions
|
|
JP5810157B2
(ja)
*
|
2010-07-09 |
2015-11-11 |
ザ・ウォルター・アンド・エリザ・ホール・インスティテュート・オブ・メディカル・リサーチ |
プロテインキナーゼ阻害剤および処置の方法
|
|
NZ607845A
(en)
|
2010-08-10 |
2015-03-27 |
Celgene Avilomics Res Inc |
Besylate salt of a btk inhibitor
|
|
KR101541086B1
(ko)
*
|
2010-08-20 |
2015-08-03 |
허치슨 메디파르마 리미티드 |
피롤로피리미딘 화합물 및 그 용도
|
|
CN103269704B
(zh)
|
2010-11-01 |
2018-07-06 |
西建卡尔有限责任公司 |
杂环化合物和其用途
|
|
US9238629B2
(en)
|
2010-11-01 |
2016-01-19 |
Celgene Avilomics Research, Inc. |
Heteroaryl compounds and uses thereof
|
|
EP2637502B1
(en)
|
2010-11-10 |
2018-01-10 |
Celgene CAR LLC |
Mutant-selective egfr inhibitors and uses thereof
|
|
UA106692C2
(uk)
|
2011-02-23 |
2014-09-25 |
Пфайзер Інк. |
ІМІДАЗО[5,1-f][1,2,4]ТРИАЗИНИ ДЛЯ ЛІКУВАННЯ НЕВРОЛОГІЧНИХ РОЗЛАДІВ
|
|
US9580427B2
(en)
|
2011-05-17 |
2017-02-28 |
The Regents Of The University Of California |
Kinase inhibitors
|
|
US9376438B2
(en)
|
2011-05-17 |
2016-06-28 |
Principia Biopharma, Inc. |
Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors
|
|
WO2012158810A1
(en)
*
|
2011-05-17 |
2012-11-22 |
Principia Biopharma Inc. |
Tyrosine kinase inhibitors
|
|
KR102027598B1
(ko)
*
|
2011-05-17 |
2019-10-01 |
프린시피아 바이오파마, 인코퍼레이티드 |
타이로신 키나아제 저해제
|
|
WO2013003629A2
(en)
*
|
2011-06-28 |
2013-01-03 |
Pharmacyclics, Inc. |
Methods and compositions for inhibition of bone resorption
|
|
US10465247B2
(en)
|
2011-07-01 |
2019-11-05 |
Dana-Farber Cancer Institute, Inc. |
Discovery of a somatic mutation in MYD88 gene in lymphoplasmacytic lymphoma
|
|
BR112014000314A2
(pt)
|
2011-07-08 |
2017-01-10 |
Novartis Ag |
derivados de pirrolo pirimidina
|
|
CA2841080A1
(en)
|
2011-07-13 |
2013-01-17 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase
|
|
EP2548877A1
(en)
*
|
2011-07-19 |
2013-01-23 |
MSD Oss B.V. |
4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors
|
|
HRP20190135T1
(hr)
*
|
2011-07-19 |
2019-03-22 |
Merck Sharp & Dohme B.V. |
4-imidazopiridazin-1-yl-benzamidi i 4-imidazotriazin-1-yl-benzamidi kao inhibitori btk
|
|
PT3409278T
(pt)
|
2011-07-21 |
2020-12-18 |
Sumitomo Dainippon Pharma Oncology Inc |
Inibidores de proteína cinase heterocíclicos
|
|
IL317457A
(en)
*
|
2011-10-19 |
2025-02-01 |
Pharmacyclics Llc |
Use of Bruton's tyrosine kinase inhibitors
|
|
TW201325593A
(zh)
|
2011-10-28 |
2013-07-01 |
Celgene Avilomics Res Inc |
治療布魯頓(bruton’s)酪胺酸激酶疾病或病症之方法
|
|
GB2496135B
(en)
|
2011-11-01 |
2015-03-18 |
Valirx Plc |
Inhibitors of the interaction between a Src family kinase and an androgen receptor or estradiol receptor for treatment of endometriosis
|
|
UA111756C2
(uk)
*
|
2011-11-03 |
2016-06-10 |
Ф. Хоффманн-Ля Рош Аг |
Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона
|
|
BR112014010391A2
(pt)
*
|
2011-11-03 |
2017-04-18 |
Hoffmann La Roche |
composto, composição farmacêutica, processo de produção de uma composição farmacêutica, método de tratamento, kit e uso de uma composição farmacêutica
|
|
US9212381B2
(en)
*
|
2011-11-10 |
2015-12-15 |
President And Fellows Of Harvard College |
Methods and compositions for labeling polypeptides
|
|
EP3569598A1
(en)
|
2011-11-17 |
2019-11-20 |
Dana Farber Cancer Institute, Inc. |
Inhibitors of c-jun-n-terminal kinase (jnk)
|
|
JP5704252B2
(ja)
|
2011-11-29 |
2015-04-22 |
小野薬品工業株式会社 |
プリノン誘導体塩酸塩
|
|
US8377946B1
(en)
|
2011-12-30 |
2013-02-19 |
Pharmacyclics, Inc. |
Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
|
|
WO2013106414A1
(en)
|
2012-01-09 |
2013-07-18 |
X-Rx, Inc. |
Tryptoline derivatives having kinase inhibitory activity and uses thereof
|
|
WO2013113097A1
(en)
*
|
2012-01-31 |
2013-08-08 |
Beta Pharma Canada Inc. |
Cyclic molecules as bruton's tyrosine kinase inhibitors
|
|
US8501724B1
(en)
*
|
2012-01-31 |
2013-08-06 |
Pharmacyclics, Inc. |
Purinone compounds as kinase inhibitors
|
|
WO2013118817A1
(ja)
*
|
2012-02-07 |
2013-08-15 |
大鵬薬品工業株式会社 |
キノリルピロロピリミジン化合物又はその塩
|
|
HUE029343T2
(en)
*
|
2012-02-23 |
2017-02-28 |
Taiho Pharmaceutical Co Ltd |
Quinolylpyrrolo-pyrimidyl fused ring compounds and salts thereof
|
|
CN103312670A
(zh)
|
2012-03-12 |
2013-09-18 |
西安西电捷通无线网络通信股份有限公司 |
一种认证方法及系统
|
|
JP6317320B2
(ja)
|
2012-03-15 |
2018-04-25 |
セルジーン シーエーアール エルエルシー |
上皮成長因子受容体キナーゼ阻害剤の塩
|
|
CN108658873B
(zh)
|
2012-03-15 |
2021-09-14 |
西建卡尔有限责任公司 |
表皮生长因子受体激酶抑制剂的固体形式
|
|
US9365566B2
(en)
|
2012-03-27 |
2016-06-14 |
Takeda Pharmaceutical Company Limited |
Cinnoline derivatives
|
|
US9353062B2
(en)
|
2012-04-04 |
2016-05-31 |
Hangzhouderenyucheng Biotechnology Ltd |
Substituted quinolines as bruton's tyrosine kinases inhibitors
|
|
ES2681050T3
(es)
|
2012-04-11 |
2018-09-11 |
Acerta Pharma B.V. |
Inhibidores de la tirosina quinasa de Bruton para la movilización hematopoyética
|
|
US9879003B2
(en)
|
2012-04-11 |
2018-01-30 |
Dana-Farber Cancer Institute, Inc. |
Host targeted inhibitors of dengue virus and other viruses
|
|
CN103374001B
(zh)
*
|
2012-04-19 |
2015-10-28 |
山东轩竹医药科技有限公司 |
咪唑并三嗪类mTOR抑制剂
|
|
EP2855484A4
(en)
*
|
2012-05-31 |
2015-12-16 |
Pharmascience Inc |
PROTEIN KINASE INHIBITORS
|
|
MX348290B
(es)
|
2012-06-04 |
2017-06-05 |
Pharmacyclics Llc |
Formas cristalinas de un inhibidor de tirosina quinasa de bruton.
|
|
AR091273A1
(es)
|
2012-06-08 |
2015-01-21 |
Biogen Idec Inc |
Inhibidores de pirimidinil tirosina quinasa
|
|
WO2013191965A1
(en)
*
|
2012-06-18 |
2013-12-27 |
Principia Biopharma Inc. |
Reversible covalent pyrrolo- or pyrazolopyrimidines useful for the treatment cancer and autoimmune diseases
|
|
WO2014004707A1
(en)
|
2012-06-29 |
2014-01-03 |
Principia Biopharma Inc. |
Formulations comprising ibrutinib
|
|
MX2015001081A
(es)
|
2012-07-24 |
2015-10-14 |
Pharmacyclics Inc |
Mutaciones asociadas a resistencia a inhibidores de la tirosina cinasa de bruton (btk).
|
|
CN104507946A
(zh)
*
|
2012-07-30 |
2015-04-08 |
康塞特医药品有限公司 |
氘代依鲁替尼
|
|
WO2014022569A1
(en)
*
|
2012-08-03 |
2014-02-06 |
Principia Biopharma Inc. |
Treatment of dry eye
|
|
AP2015008203A0
(en)
*
|
2012-08-10 |
2015-01-31 |
Boehringer Ingelheim Int |
Heteroaromatic compounds as bruton's tyrosine kinase (BTK) inhibitors
|
|
CN103121999A
(zh)
*
|
2012-08-29 |
2013-05-29 |
苏州迪飞医药科技有限公司 |
一种酪氨酸激酶抑制剂pci-32765的合成方法
|
|
EP2890691B1
(en)
|
2012-08-31 |
2018-04-25 |
Principia Biopharma Inc. |
Benzimidazole derivatives as itk inhibitors
|
|
CN104822681B
(zh)
|
2012-09-10 |
2018-01-30 |
普林斯匹亚生物制药公司 |
作为激酶抑制剂的吡唑并嘧啶化合物
|
|
CH706997A1
(en)
|
2012-09-20 |
2014-03-31 |
Ferag Ag |
Access control on operating modules of a control unit.
|
|
EP2909194A1
(en)
|
2012-10-18 |
2015-08-26 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 (cdk7)
|
|
USRE48175E1
(en)
*
|
2012-10-19 |
2020-08-25 |
Dana-Farber Cancer Institute, Inc. |
Hydrophobically tagged small molecules as inducers of protein degradation
|
|
WO2014063054A1
(en)
|
2012-10-19 |
2014-04-24 |
Dana-Farber Cancer Institute, Inc. |
Bone marrow on x chromosome kinase (bmx) inhibitors and uses thereof
|
|
US20150291554A1
(en)
*
|
2012-11-02 |
2015-10-15 |
Pfizer Inc. |
Bruton's Tyrosine Kinase Inhibitors
|
|
AU2013337663A1
(en)
|
2012-11-02 |
2015-06-11 |
Pharmacyclics Llc |
TEC family kinase inhibitor adjuvant therapy
|
|
MA38183A1
(fr)
*
|
2012-11-15 |
2017-03-31 |
Pharmacyclics Inc |
Composés pyrrolopyrimidines en tant qu'inhibiteurs de kinase
|
|
CN104918935B
(zh)
|
2012-11-16 |
2017-07-28 |
百时美施贵宝公司 |
二氢吡唑gpr40调节剂
|
|
CN103848810A
(zh)
*
|
2012-11-30 |
2014-06-11 |
北京赛林泰医药技术有限公司 |
鲁顿酪氨酸激酶抑制剂
|
|
EP2935226A4
(en)
|
2012-12-21 |
2016-11-02 |
Celgene Avilomics Res Inc |
HETEROARYL COMPOUNDS AND USES THEREOF
|
|
SG11201504422XA
(en)
*
|
2012-12-21 |
2015-07-30 |
Teva Pharma |
Transmucosal delivery of glatiramer acetate
|
|
TW201441234A
(zh)
|
2013-01-23 |
2014-11-01 |
Merck Sharp & Dohme |
Btk抑制劑
|
|
WO2014113932A1
(en)
*
|
2013-01-23 |
2014-07-31 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
|
WO2014113942A1
(en)
*
|
2013-01-23 |
2014-07-31 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
|
CA2900012A1
(en)
|
2013-02-08 |
2014-08-14 |
Celgene Avilomics Research, Inc. |
Erk inhibitors and uses thereof
|
|
WO2014130856A2
(en)
*
|
2013-02-21 |
2014-08-28 |
Wayne Rothbaum |
Treatment of skeletal-related disorders
|
|
JP5851068B2
(ja)
|
2013-02-22 |
2016-02-03 |
大鵬薬品工業株式会社 |
三環性化合物の製造方法及び当該製造方法により得ることができる三環性化合物
|
|
JO3377B1
(ar)
|
2013-03-11 |
2019-03-13 |
Takeda Pharmaceuticals Co |
مشتقات بيريدينيل وبيريدينيل مندمج
|
|
WO2014165253A1
(en)
*
|
2013-03-12 |
2014-10-09 |
Nbip, Llc |
Compositions and methods for preventing infection of a wound and for advancing the healing process
|
|
CN103142601A
(zh)
*
|
2013-03-13 |
2013-06-12 |
杭州雷索药业有限公司 |
Pci-32765在制备抗血管生成类药物中的应用
|
|
US10202356B2
(en)
|
2013-03-14 |
2019-02-12 |
Tolero Pharmaceuticals, Inc. |
JAK2 and ALK2 inhibitors and methods for their use
|
|
US8895750B2
(en)
|
2013-03-14 |
2014-11-25 |
Boehringer Ingelheim International Gmbh |
Heteroaromatic compounds as BTK inhibitors
|
|
JP2016512549A
(ja)
*
|
2013-03-14 |
2016-04-28 |
ファーマサイクリックス エルエルシー |
ブルトン型チロシンキナーゼ阻害剤及びcyp3a4阻害剤の組み合わせ
|
|
US9156847B2
(en)
*
|
2013-03-15 |
2015-10-13 |
Janssen Pharmaceutica Nv |
Processes and intermediates for preparing a medicament
|
|
AU2014238443A1
(en)
|
2013-03-15 |
2015-07-30 |
Celgene Car Llc |
MK2 inhibitors and uses thereof
|
|
CN105026400A
(zh)
|
2013-03-15 |
2015-11-04 |
詹森药业有限公司 |
用于制备药物的方法和中间体
|
|
EP2970300B1
(en)
|
2013-03-15 |
2018-05-16 |
Boehringer Ingelheim International GmbH |
Heteroaromatic compounds as btk inhibitors
|
|
TWI654206B
(zh)
|
2013-03-16 |
2019-03-21 |
諾華公司 |
使用人類化抗-cd19嵌合抗原受體治療癌症
|
|
KR20160061911A
(ko)
|
2013-04-08 |
2016-06-01 |
데니스 엠. 브라운 |
최적하 투여된 화학 화합물의 치료 효과
|
|
MX369503B
(es)
*
|
2013-04-08 |
2019-11-11 |
Pharmacyclics Llc |
Combinaciones que comprenden ibrutinib y abt-199 para tratar trastornos proliferativos de células b y métodos de uso de las mismas.
|
|
US8957080B2
(en)
|
2013-04-09 |
2015-02-17 |
Principia Biopharma Inc. |
Tyrosine kinase inhibitors
|
|
ES2619125T3
(es)
|
2013-04-25 |
2017-06-23 |
Beigene, Ltd. |
Compuestos heterocíclicos fusionados como inhibidores de proteína cinasa
|
|
GB2513615A
(en)
|
2013-05-01 |
2014-11-05 |
Cancer Rec Tech Ltd |
Medical use
|
|
GB201309085D0
(en)
|
2013-05-20 |
2013-07-03 |
Redx Pharma Ltd |
Compounds
|
|
US9694011B2
(en)
|
2013-05-21 |
2017-07-04 |
Jiangsu Medolution Ltd |
Substituted pyrazolopyrimidines as kinases inhibitors
|
|
WO2015002894A1
(en)
*
|
2013-07-02 |
2015-01-08 |
Pharmacyclics, Inc. |
Purinone compounds as kinase inhibitors
|
|
CA2912359A1
(en)
|
2013-07-03 |
2015-01-08 |
F. Hoffmann-La Roche Ag |
Heteroaryl pyridone and aza-pyridone amide compounds
|
|
WO2015013579A1
(en)
|
2013-07-26 |
2015-01-29 |
Update Pharma Inc. |
Compositions to improve the therapeutic benefit of bisantrene
|
|
WO2015017812A1
(en)
|
2013-08-02 |
2015-02-05 |
Pharmacyclics, Inc. |
Methods for the treatment of solid tumors
|
|
EP2832358A1
(en)
|
2013-08-02 |
2015-02-04 |
Bionsil S.r.l. |
Pharmaceutical kit for use in the treatment of colon and colorectal cancer
|
|
CA2920534A1
(en)
|
2013-08-12 |
2015-02-19 |
Pharmacyclics Llc |
Methods for the treatment of her2 amplified cancer
|
|
US9492471B2
(en)
|
2013-08-27 |
2016-11-15 |
Celgene Avilomics Research, Inc. |
Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase
|
|
IL296026B2
(en)
|
2013-09-13 |
2024-10-01 |
Beigene Switzerland Gmbh |
Anti-pd1 antibodies and their use as therapeutics and diagnostics
|
|
SI3052476T1
(sl)
|
2013-09-30 |
2020-12-31 |
Guangzhou Innocare Pharma Tech Co., Ltd. |
Substituirani nikotinimidni inhibitorji BTK in njihova priprava in uporaba pri zdravljenju raka, vnetja in avtoimunske bolezni
|
|
CN105764896A
(zh)
*
|
2013-09-30 |
2016-07-13 |
药品循环有限责任公司 |
布鲁顿氏酪氨酸激酶的抑制剂
|
|
US20150105409A1
(en)
*
|
2013-10-10 |
2015-04-16 |
Acetylon Pharmaceticals, Inc. |
Hdac inhibitors, alone or in combination with btk inhibitors, for treating nonhodgkin's lymphoma
|
|
WO2015057992A1
(en)
|
2013-10-16 |
2015-04-23 |
Izumi Raquel |
Btk inhibitors for hematopoietic mobilization
|
|
WO2015069441A1
(en)
*
|
2013-10-18 |
2015-05-14 |
Medivation Technologies, Inc. |
Pyrazolo-, imidazolo- and pyrrolo-pyridine or -pyrimidine derivatives as inhibitors o brutons kinase (btk)
|
|
WO2015058084A1
(en)
|
2013-10-18 |
2015-04-23 |
Medivation Technologies, Inc. |
Heterocyclic compounds and methods of use
|
|
WO2015058140A1
(en)
|
2013-10-18 |
2015-04-23 |
Dana-Farber Cancer Institute, Inc. |
Polycyclic inhibitors of cyclin-dependent kinase 7 (cdk7)
|
|
ES2676734T3
(es)
|
2013-10-18 |
2018-07-24 |
Syros Pharmaceuticals, Inc. |
Compuestos heteroatómicos útiles para el tratamiento de enfermedades proliferativas
|
|
WO2015061752A1
(en)
*
|
2013-10-25 |
2015-04-30 |
Pharmacyclics, Inc. |
Treatment using bruton's tyrosine kinase inhibitors and immunotherapy
|
|
MX392373B
(es)
*
|
2013-10-25 |
2025-03-24 |
Pharmacyclics Llc |
Uso de ibrutinib en el tratamiento de enfermedad injerto contra huesped cronica
|
|
US9636340B2
(en)
|
2013-11-12 |
2017-05-02 |
Ayyappan K. Rajasekaran |
Kinase inhibitors
|
|
WO2015071432A1
(en)
|
2013-11-14 |
2015-05-21 |
Sandoz Ag |
Pharmaceutical compositions of ibrutinib
|
|
US20150141438A1
(en)
*
|
2013-11-15 |
2015-05-21 |
Pharmacyclics, Inc. |
Methods for delaying or preventing the onset of type 1 diabetes
|
|
CN103626774B
(zh)
*
|
2013-11-20 |
2015-11-04 |
苏州明锐医药科技有限公司 |
伊鲁替尼的制备方法
|
|
CA2833867A1
(en)
*
|
2013-11-21 |
2015-05-21 |
Pharmascience Inc. |
Protein kinase inhibitors
|
|
CN103694241A
(zh)
*
|
2013-11-27 |
2014-04-02 |
苏州晶云药物科技有限公司 |
Pci-32765的新晶型a及其制备方法
|
|
US9512084B2
(en)
|
2013-11-29 |
2016-12-06 |
Novartis Ag |
Amino pyrimidine derivatives
|
|
TWI743019B
(zh)
*
|
2013-12-02 |
2021-10-21 |
美商製藥公司 |
治療及預防異體抗體所驅動之慢性移植體對抗宿主疾病之方法
|
|
HRP20171846T1
(hr)
|
2013-12-05 |
2018-01-12 |
Pfizer Inc. |
PIROLO[2,3-d]PIRIMIDINIL-, PIROLO[2,3-b]PIRAZINIL- I PIROLO[2,3-d]PIRIDINILAKRILAMIDI
|
|
AU2014358868A1
(en)
|
2013-12-05 |
2016-06-09 |
Acerta Pharma B.V. |
Therapeutic combination of a PI3K inhibitor and a BTK inhibitor
|
|
KR101813830B1
(ko)
|
2013-12-05 |
2017-12-29 |
에프. 호프만-라 로슈 아게 |
친전자성 작용기를 갖는 헤테로아릴 피리돈 및 아자-피리돈 화합물
|
|
EP3079682A4
(en)
*
|
2013-12-13 |
2017-08-30 |
Dana-Farber Cancer Institute, Inc. |
Methods to treat lymphoplasmacytic lymphoma
|
|
JP6879740B2
(ja)
|
2013-12-13 |
2021-06-02 |
ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド |
リンパ形質細胞性リンパ腫を処置する方法
|
|
EP3082809B1
(en)
*
|
2013-12-20 |
2021-01-20 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
|
US9415049B2
(en)
|
2013-12-20 |
2016-08-16 |
Celgene Avilomics Research, Inc. |
Heteroaryl compounds and uses thereof
|
|
EP3082811B1
(en)
|
2013-12-20 |
2020-01-15 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
|
US10272083B2
(en)
|
2014-01-21 |
2019-04-30 |
Acerta Pharma B.V. |
Methods of treating chronic lymphocytic leukemia and small lymphocytic leukemia using a BTK inhibitor
|
|
EP3099674B1
(en)
|
2014-01-29 |
2018-10-24 |
Boehringer Ingelheim International Gmbh |
Pyrazole compounds as btk inhibitors
|
|
CN105949198A
(zh)
*
|
2014-01-29 |
2016-09-21 |
苏州晶云药物科技有限公司 |
依鲁替尼的新晶型及其制备方法
|
|
CA2934989C
(en)
*
|
2014-02-03 |
2017-08-08 |
Cadila Healthcare Limited |
Novel heterocyclic compounds
|
|
EP3107544B1
(en)
|
2014-02-21 |
2020-10-07 |
Principia Biopharma Inc. |
Salts and solid form of a btk inhibitor
|
|
AU2015222865B2
(en)
|
2014-02-28 |
2019-06-20 |
Takeda Pharmaceutical Company Limited |
TYK2 inhibitors and uses thereof
|
|
GB201404987D0
(en)
*
|
2014-03-20 |
2014-05-07 |
Redx Pharma Ltd |
Compounds
|
|
US9885086B2
(en)
|
2014-03-20 |
2018-02-06 |
Pharmacyclics Llc |
Phospholipase C gamma 2 and resistance associated mutations
|
|
ES2806506T3
(es)
|
2014-03-25 |
2021-02-17 |
Ono Pharmaceutical Co |
Agente profiláctico y/o agente terapéutico para el linfoma difuso de células B grandes
|
|
MX2016012419A
(es)
*
|
2014-03-27 |
2016-11-30 |
Perrigo Api Ltd |
Formas solidas de ibrutinib y procesos para la produccion de las mismas.
|
|
WO2015151006A1
(en)
*
|
2014-03-29 |
2015-10-08 |
Lupin Limited |
Substituted purine compounds as btk inhibitors
|
|
WO2015185998A2
(en)
*
|
2014-04-11 |
2015-12-10 |
Acerta Pharma B.V. |
Methods of blocking the cxcr-4/sdf-1 signaling pathway with inhibitors of bone marrow x kinase
|
|
US9937171B2
(en)
|
2014-04-11 |
2018-04-10 |
Acerta Pharma B.V. |
Methods of blocking the CXCR-4/SDF-1 signaling pathway with inhibitors of bruton's tyrosine kinase
|
|
CN105017256A
(zh)
*
|
2014-04-29 |
2015-11-04 |
浙江导明医药科技有限公司 |
多氟化合物作为布鲁顿酪氨酸激酶抑制剂
|
|
CN105085474B
(zh)
*
|
2014-05-07 |
2018-05-18 |
北京赛林泰医药技术有限公司 |
鲁顿酪氨酸激酶抑制剂
|
|
CN105085529A
(zh)
*
|
2014-05-15 |
2015-11-25 |
广东东阳光药业有限公司 |
依鲁替尼新晶型及其制备方法
|
|
CN104086551B
(zh)
*
|
2014-06-06 |
2016-09-21 |
人福医药集团股份公司 |
化合物及其制备方法和用途
|
|
GB201410430D0
(en)
*
|
2014-06-11 |
2014-07-23 |
Redx Pharma Ltd |
Compounds
|
|
WO2015193740A2
(en)
|
2014-06-17 |
2015-12-23 |
Acerta Pharma B.V. |
Therapeutic combinations of a btk inhibitor, a pi3k inhibitor and/or a jak-2 inhibitor
|
|
CN104945404B
(zh)
*
|
2014-06-25 |
2018-09-14 |
广东东阳光药业有限公司 |
一种n-丙烯羰基哌啶衍生物的制备方法
|
|
TW201613919A
(en)
*
|
2014-07-02 |
2016-04-16 |
Pharmacyclics Llc |
Inhibitors of Bruton's tyrosine kinase
|
|
CN105294571B
(zh)
*
|
2014-07-03 |
2019-04-23 |
浙江九洲药业股份有限公司 |
一种依鲁替尼中间体及其制备方法和用途
|
|
JP6526189B2
(ja)
|
2014-07-03 |
2019-06-05 |
ベイジーン リミテッド |
抗pd−l1抗体並びにその治療及び診断のための使用
|
|
US9951077B2
(en)
*
|
2014-07-07 |
2018-04-24 |
Jiangsu Hengrui Medicine Co., Ltd. |
Aminopyridazinone compounds as protein kinase inhibitors
|
|
WO2016008411A1
(en)
*
|
2014-07-18 |
2016-01-21 |
Beigene, Ltd. |
5-amino-4-carbamoyl-pyrazole compounds as selective and irreversible t790m over wt-egfr kinase inhibitors and use thereof
|
|
WO2016019237A2
(en)
*
|
2014-07-31 |
2016-02-04 |
Pharmacyclics Llc |
Inhibitors of bruton's tyrosine kinase
|
|
WO2016019233A1
(en)
*
|
2014-08-01 |
2016-02-04 |
Pharmacyclics Llc |
Inhibitors of bruton's tyrosine kinase
|
|
TW201618783A
(zh)
|
2014-08-07 |
2016-06-01 |
艾森塔製藥公司 |
以布魯頓(Bruton)氏酪胺酸激酶(BTK)佔據和BTK再合成速率為基礎之治療癌症、免疫和自體免疫疾病及發炎性疾病之方法
|
|
AU2015300798A1
(en)
|
2014-08-07 |
2017-02-02 |
Pharmacyclics Llc |
Novel formulations of a Bruton's tyrosine kinase inhibitor
|
|
CN105461720B
(zh)
*
|
2014-08-08 |
2019-08-06 |
南京圣和药业股份有限公司 |
吗啉类酪氨酸激酶抑制剂
|
|
AU2015300966A1
(en)
|
2014-08-08 |
2017-02-16 |
Janssen Pharmaceutica Nv |
Bruton's tyrosine kinase inhibitor combinations and uses thereof
|
|
WO2016024227A1
(en)
|
2014-08-11 |
2016-02-18 |
Acerta Pharma B.V. |
Btk inhibitors to treat solid tumors through modulation of the tumor microenvironment
|
|
PT3179991T
(pt)
|
2014-08-11 |
2021-11-26 |
Acerta Pharma Bv |
Combinações terapêuticas de um inibidor de btk e um inibidor de bcl-2
|
|
WO2016024232A1
(en)
|
2014-08-11 |
2016-02-18 |
Acerta Pharma B.V. |
Therapeutic combinations of a btk inhibitor, a pi3k inhibitor, a jak-2 inhibitor and/or a cdk 4/6 inhibitor
|
|
HUE059131T2
(hu)
|
2014-08-11 |
2022-10-28 |
Acerta Pharma Bv |
BTK-inhibitor, PD-1-inhibitor és/vagy PD-L1-inhibitor terápiás kombinációja
|
|
CN112430250A
(zh)
|
2014-08-12 |
2021-03-02 |
莫纳什大学 |
定向淋巴的前药
|
|
DK3179858T3
(da)
|
2014-08-13 |
2019-07-22 |
Celgene Car Llc |
Forme og sammensætninger af en ERK-inhibitor
|
|
CA2958139A1
(en)
|
2014-08-14 |
2016-02-18 |
Assia Chemical Industries Ltd. |
Solid state forms of ibrutinib
|
|
JP6507234B2
(ja)
|
2014-10-02 |
2019-04-24 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
ブルトンチロシンキナーゼ(btk)によって介入される障害の処置における使用のためのピラゾールカルボキサミド化合物
|
|
CA2965178C
(en)
|
2014-10-22 |
2023-09-26 |
Dana-Farber Cancer Institute, Inc. |
Thiazolyl-containing compounds for treating proliferative diseases
|
|
CA2965517C
(en)
|
2014-10-24 |
2023-05-02 |
Bristol-Myers Squibb Company |
Indole carboxamides compounds useful as kinase inhibitors
|
|
EP3212645B1
(en)
|
2014-10-27 |
2018-11-28 |
F.Hoffmann-La Roche Ag |
Process for making tricyclic lactam compounds
|
|
BR112017008575B1
(pt)
|
2014-10-29 |
2021-07-13 |
Bicyclerd Limited |
Ligantes de peptídeos bicíclicos específicos a mt1-mmp, conjugado de fármaco, processo para preparação de um conjugado de fármaco e composição farmacêutica
|
|
WO2016066673A1
(en)
*
|
2014-10-30 |
2016-05-06 |
Sandoz Ag |
Synthesis of substituted 1h-pyrazolo[3,4-d]pyrimidines
|
|
WO2016079693A1
(en)
*
|
2014-11-19 |
2016-05-26 |
Sun Pharmaceutical Industries Limited |
A process for the preparation of ibrutinib
|
|
WO2016079216A1
(en)
|
2014-11-20 |
2016-05-26 |
Sandoz Ag |
Physical forms of ibrutinib, a bruton's kinase inhibitor
|
|
CN104447761A
(zh)
*
|
2014-11-27 |
2015-03-25 |
广东东阳光药业有限公司 |
一种吡唑衍生物的制备方法
|
|
AR102871A1
(es)
*
|
2014-12-03 |
2017-03-29 |
Pharmacyclics Llc |
Métodos de tratamiento de fibrosis
|
|
WO2016088074A1
(en)
*
|
2014-12-03 |
2016-06-09 |
Dr. Reddy’S Laboratories Limited |
Process for the preparation of amorphous ibrutinib
|
|
CN104478884A
(zh)
*
|
2014-12-05 |
2015-04-01 |
广东东阳光药业有限公司 |
一种中间体的制备方法
|
|
WO2016087994A1
(en)
|
2014-12-05 |
2016-06-09 |
Acerta Pharma B.V. |
Btk inhibitors to treat solid tumors through modulation of the tumor microenvironment
|
|
TW201702218A
(zh)
|
2014-12-12 |
2017-01-16 |
美國杰克森實驗室 |
關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法
|
|
CN112375077A
(zh)
|
2014-12-18 |
2021-02-19 |
豪夫迈·罗氏有限公司 |
四氢-吡啶并[3,4-b]吲哚雌激素受体调节剂及其用途
|
|
CA2970723C
(en)
|
2014-12-18 |
2023-09-05 |
Principia Biopharma Inc. |
Treatment of pemphigus
|
|
AU2015371251B2
(en)
|
2014-12-23 |
2020-06-11 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 (CDK7)
|
|
WO2016106624A1
(en)
|
2014-12-31 |
2016-07-07 |
Merck Sharp & Dohme Corp. |
Tertiary alcohol imidazopyrazine btk inhibitors
|
|
WO2016106628A1
(en)
*
|
2014-12-31 |
2016-07-07 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
|
WO2016106629A1
(en)
|
2014-12-31 |
2016-07-07 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
|
WO2016106652A1
(en)
*
|
2014-12-31 |
2016-07-07 |
Merck Sharp & Dohme Corp. |
Biarylether imidazopyrazine btk inhibitors
|
|
CN105820168B
(zh)
*
|
2015-01-09 |
2018-12-04 |
上海医药工业研究院 |
一种依鲁替尼中间体的制备方法
|
|
MA41350A
(fr)
*
|
2015-01-14 |
2017-11-21 |
Janssen Pharmaceutica Nv |
Synthèse d'un inhibiteur de la tyrosine kinase de bruton
|
|
WO2016115869A1
(zh)
*
|
2015-01-21 |
2016-07-28 |
中国科学院合肥物质科学研究院 |
Flt3激酶的新型抑制剂及其用途
|
|
WO2016123504A1
(en)
*
|
2015-01-30 |
2016-08-04 |
Pharmacyclics Llc |
Btk inhibitor combinations and multidrug-resistance
|
|
CZ201584A3
(cs)
|
2015-02-09 |
2016-08-17 |
Zentiva, K.S. |
Sůl Ibrutinib sulfátu
|
|
US10214532B2
(en)
|
2015-02-12 |
2019-02-26 |
Shanghai Dude Medical Science and Technology Co., Ltd. |
Process for preparing ibrutinib
|
|
WO2016132383A1
(en)
|
2015-02-18 |
2016-08-25 |
Mylan Laboratories Limited |
Process for the preparation of ibrutinib
|
|
WO2016138352A1
(en)
|
2015-02-27 |
2016-09-01 |
Nimbus Lakshmi, Inc. |
Tyk2 inhibitors and uses thereof
|
|
IL315294A
(en)
*
|
2015-03-03 |
2024-10-01 |
Pharmacyclics Llc |
Pharmaceutical formulations of bruton's tyrosine kinase inhibitor
|
|
US10045990B2
(en)
|
2015-03-04 |
2018-08-14 |
Arizona Board Of Regents On Behalf Of Arizona State University |
ERBB4 inhibitors and methods of use thereof
|
|
US9717745B2
(en)
|
2015-03-19 |
2017-08-01 |
Zhejiang DTRM Biopharma Co. Ltd. |
Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases
|
|
CN106146508A
(zh)
*
|
2015-03-19 |
2016-11-23 |
浙江导明医药科技有限公司 |
优化的联合用药及其治疗癌症和自身免疫疾病的用途
|
|
MA41828A
(fr)
|
2015-03-27 |
2018-01-30 |
Pharmacyclics Llc |
Co-cristaux d'un inhibiteur de la tyrosine kinase de bruton
|
|
CN107427521B
(zh)
|
2015-03-27 |
2021-08-03 |
达纳-法伯癌症研究所股份有限公司 |
细胞周期蛋白依赖性激酶的抑制剂
|
|
MA41827A
(fr)
|
2015-03-27 |
2018-01-30 |
Pharmacyclics Llc |
Formes solvatées d'un inhibiteur de la tyrosine kinase de bruton
|
|
WO2016161248A1
(en)
*
|
2015-04-02 |
2016-10-06 |
Tolero Pharmaceuticals, Inc. |
Targeting pim kinases in combination with btk inhibition
|
|
EP3524606A1
(en)
|
2015-04-02 |
2019-08-14 |
ratiopharm GmbH |
Co-crystals of ibrutinib with carboxylic acids
|
|
CN106146511A
(zh)
*
|
2015-04-03 |
2016-11-23 |
安润医药科技(苏州)有限公司 |
吡唑并嘧啶衍生物、制备方法、药物组合物及用途
|
|
CN105906621A
(zh)
*
|
2015-04-06 |
2016-08-31 |
四川百利药业有限责任公司 |
用作fgfr抑制剂的乙醇类化合物
|
|
EP4272835A3
(en)
|
2015-04-06 |
2023-12-20 |
JANSSEN Pharmaceutica NV |
Compositions containing ibrutinib
|
|
AU2016245958B2
(en)
|
2015-04-08 |
2021-09-09 |
Novartis Ag |
CD20 therapies, CD22 therapies, and combination therapies with a CD19 Chimeric Antigen Receptor (CAR) - expressing cell
|
|
EP3281943B1
(en)
|
2015-04-09 |
2023-06-28 |
ONO Pharmaceutical Co., Ltd. |
Process for producing purinone derivative
|
|
CN106146512B
(zh)
*
|
2015-04-09 |
2018-07-17 |
北京睿创康泰医药研究院有限公司 |
依鲁替尼的制备方法
|
|
KR20170134462A
(ko)
|
2015-04-13 |
2017-12-06 |
다이이찌 산쿄 가부시키가이샤 |
Mdm2 저해제와 btk 저해제의 병용 치료법
|
|
CN106146482B
(zh)
*
|
2015-04-14 |
2020-06-23 |
宁波文达医药科技有限公司 |
布鲁顿酪氨酸激酶抑制剂
|
|
WO2016170545A1
(en)
*
|
2015-04-22 |
2016-10-27 |
Msn Laboratories Private Limited |
Process for the preparation of 1-[(3r)-3-[4-amino-3-(4-phenoxyphenvl)-1h- pvrazolo[3,4-d]pyriniidin-1-y1]-1-piperidinvl]-2-propen-1-one and its polymorphs thereof
|
|
EP3195865A1
(de)
|
2016-01-25 |
2017-07-26 |
Bayer Pharma Aktiengesellschaft |
Kombinationen von irak4 inhibitoren und btk inhibitoren
|
|
US20180289685A1
(en)
|
2015-04-30 |
2018-10-11 |
Bayer Pharma Aktiengesellschaft |
Combinations of inhibitors of irak4 with inhibitors of btk
|
|
EP3302550B1
(en)
|
2015-05-26 |
2019-08-28 |
MorphoSys AG |
Combination of an anti-cd19 antibody and a bruton's tyrosine kinase inhibitor and uses thereof
|
|
MX395007B
(es)
*
|
2015-06-03 |
2025-03-24 |
Principia Biopharma Inc |
Inhibidores de tirosina-cinasas
|
|
US10702527B2
(en)
|
2015-06-12 |
2020-07-07 |
Dana-Farber Cancer Institute, Inc. |
Combination therapy of transcription inhibitors and kinase inhibitors
|
|
US9394312B1
(en)
*
|
2015-06-14 |
2016-07-19 |
Mark Quang Nguyen |
Ibrutinib prodrugs, pharmaceutical compositions thereof, and methods of use
|
|
WO2016208595A1
(ja)
|
2015-06-22 |
2016-12-29 |
小野薬品工業株式会社 |
Brk阻害化合物
|
|
EP3313839A1
(en)
|
2015-06-24 |
2018-05-02 |
Principia Biopharma Inc. |
Tyrosine kinase inhibitors
|
|
CZ2015442A3
(cs)
*
|
2015-06-26 |
2017-01-04 |
Zentiva, K.S. |
Ibrutinib hemisulfát
|
|
WO2016207172A1
(en)
*
|
2015-06-26 |
2016-12-29 |
Sandoz Gmbh |
Preparation of pure amorphous ibrutinib
|
|
WO2017004134A1
(en)
|
2015-06-29 |
2017-01-05 |
Nimbus Iris, Inc. |
Irak inhibitors and uses thereof
|
|
EP4585597A1
(en)
|
2015-07-02 |
2025-07-16 |
F. Hoffmann-La Roche AG |
Benzoxazepin oxazolidinone compounds and methods of use
|
|
WO2017002095A1
(en)
|
2015-07-02 |
2017-01-05 |
Acerta Pharma B.V. |
Solid forms and formulations of (s)-4-(8-amino-3-(1 -(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-n-(pyridin-2-yl)benzamide
|
|
CN111848643A
(zh)
|
2015-07-02 |
2020-10-30 |
豪夫迈·罗氏有限公司 |
苯并氧氮杂*噁唑烷酮化合物及其使用方法
|
|
ITUB20152576A1
(it)
*
|
2015-07-29 |
2017-01-29 |
Laboratorio Chimico Int S P A |
Procedimento per la preparazione di ibrutinib e nuovo intermedio di sintesi.
|
|
EP3337485B1
(en)
|
2015-08-19 |
2021-03-17 |
Sun Pharmaceutical Industries Ltd |
Crystalline forms of ibrutinib
|
|
WO2017033113A1
(en)
|
2015-08-21 |
2017-03-02 |
Acerta Pharma B.V. |
Therapeutic combinations of a mek inhibitor and a btk inhibitor
|
|
HK1257338A1
(zh)
|
2015-08-31 |
2019-10-18 |
Pharmacyclics Llc |
用於治疗多发性骨髓瘤的btk抑制剂组合
|
|
EP3344624B8
(en)
|
2015-09-02 |
2023-11-29 |
Takeda Pharmaceutical Company Limited |
Tyk2 inhibitors and uses thereof
|
|
CN118063537A
(zh)
|
2015-09-08 |
2024-05-24 |
莫纳什大学 |
定向淋巴的前药
|
|
CA2996978A1
(en)
|
2015-09-09 |
2017-03-16 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinases
|
|
WO2017044720A1
(en)
|
2015-09-11 |
2017-03-16 |
Navitor Pharmaceuticals, Inc. |
Rapamycin analogs and uses thereof
|
|
CN105753863B
(zh)
*
|
2015-09-11 |
2018-07-31 |
东莞市真兴贝特医药技术有限公司 |
氧代二氢咪唑并吡啶类化合物及其应用
|
|
CA2904270A1
(en)
*
|
2015-09-11 |
2017-03-11 |
Pharmascience Inc. |
Protein kinase inhibitors
|
|
WO2017046746A1
(en)
|
2015-09-15 |
2017-03-23 |
Acerta Pharma B.V. |
Therapeutic combinations of a btk inhibitor and a gitr binding molecule, a 4-1bb agonist, or an ox40 agonist
|
|
MA44909A
(fr)
|
2015-09-15 |
2018-07-25 |
Acerta Pharma Bv |
Association thérapeutique d'un inhibiteur du cd19 et d'un inhibiteur de la btk
|
|
US10611766B2
(en)
|
2015-09-16 |
2020-04-07 |
Loxo Oncology Inc. |
Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer
|
|
JP2018530550A
(ja)
|
2015-10-01 |
2018-10-18 |
ギリアド サイエンシズ, インコーポレイテッド |
癌を治療するためのbtk阻害剤とチェックポイント阻害剤との組合せ
|
|
CN106608877B
(zh)
*
|
2015-10-21 |
2018-11-13 |
新发药业有限公司 |
一种依鲁替尼中间体4-氨基-3-(4-苯氧基)苯基-1H-吡唑并[3,4-d]嘧啶的制备方法
|
|
US10100066B2
(en)
|
2015-10-23 |
2018-10-16 |
Navitor Pharmaceuticals, Inc. |
Modulators of sestrin-GATOR2 interaction and uses thereof
|
|
TWI642671B
(zh)
*
|
2015-10-28 |
2018-12-01 |
台灣神隆股份有限公司 |
依魯替尼之製備方法及其中間體
|
|
ES2964946T3
(es)
*
|
2015-11-17 |
2024-04-10 |
Merck Patent Gmbh |
Métodos para tratar esclerosis múltiple usando compuestos de pirimidina con actividad inhibidora de tirosina cinasa de bruton
|
|
CN105294696A
(zh)
*
|
2015-11-19 |
2016-02-03 |
上海创诺医药集团有限公司 |
依鲁替尼新晶型及其制备方法
|
|
ES2901795T3
(es)
|
2015-12-04 |
2022-03-23 |
Juno Therapeutics Inc |
Métodos y composiciones relacionadas con la toxicidad asociada con la terapia celular
|
|
ES2959692T3
(es)
|
2015-12-04 |
2024-02-27 |
Alexion Pharma Inc |
Cerdulatinib y venetoclax para tratar linfoma no Hodgkin
|
|
JO3793B1
(ar)
|
2015-12-10 |
2021-01-31 |
Janssen Pharmaceutica Nv |
مثبطات تيروزين كاينيز بروتون وأساليب استخدامها
|
|
JO3794B1
(ar)
|
2015-12-10 |
2021-01-31 |
Janssen Pharmaceutica Nv |
المركبات متعددة الحلقات كمثبطات لتيروزين كيناز بروتون
|
|
WO2017106352A1
(en)
|
2015-12-14 |
2017-06-22 |
Raze Therapeutics, Inc. |
Caffeine inhibitors of mthfd2 and uses thereof
|
|
CN114573510B
(zh)
|
2015-12-16 |
2025-02-25 |
洛克索肿瘤学股份有限公司 |
可用作激酶抑制剂的化合物
|
|
EA034561B1
(ru)
|
2015-12-16 |
2020-02-20 |
Бёрингер Ингельхайм Интернациональ Гмбх |
Бипиразолильные производные, пригодные для лечения аутоиммунных заболеваний
|
|
JP6916185B2
(ja)
|
2016-01-13 |
2021-08-11 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Btk阻害剤としてのイソキノロン類
|
|
EP3402503B1
(en)
|
2016-01-13 |
2020-10-21 |
Acerta Pharma B.V. |
Therapeutic combinations of an antifolate and a btk inhibitor
|
|
KR20180101521A
(ko)
|
2016-01-19 |
2018-09-12 |
얀센 파마슈티카 엔.브이. |
Btk 저해제를 포함하는 제형/조성물
|
|
US20190290650A1
(en)
|
2016-01-19 |
2019-09-26 |
Janssen Pharmaceutic Nv |
Formulations/compositions comprising a btk inhibitor
|
|
US10793566B2
(en)
|
2016-01-21 |
2020-10-06 |
Zibo Biopolar Changsheng Pharmaceutical Co. Ltd. |
Bruton's tyrosine kinase inhibitors
|
|
EA201891626A1
(ru)
|
2016-01-21 |
2019-04-30 |
Зибо Биополар Чангшенг Фармасьютикал Ко. Лтд. |
Ингибиторы тирозинкиназы брутона
|
|
CN106995446B
(zh)
*
|
2016-01-22 |
2021-07-02 |
山东新时代药业有限公司 |
布鲁顿酪氨酸激酶抑制剂制备方法
|
|
CN105732638B
(zh)
*
|
2016-01-22 |
2018-01-30 |
成都倍特药业有限公司 |
一种具有螺环或桥环结构的布鲁顿酪氨酸激酶抑制剂及其制备方法
|
|
US10626117B2
(en)
|
2016-02-01 |
2020-04-21 |
Natco Pharma Limited |
Process for the preparation of Ibrutinib
|
|
WO2017134685A2
(en)
*
|
2016-02-02 |
2017-08-10 |
Sun Pharma Advanced Research Company Limited |
Novel hydrazino compounds as btk inhibitors
|
|
WO2017134588A1
(en)
|
2016-02-04 |
2017-08-10 |
Shilpa Medicare Limited |
Process for the preparation of ibrutinib
|
|
CN108602834B
(zh)
*
|
2016-02-05 |
2021-01-08 |
北京盛诺基医药科技股份有限公司 |
一种布鲁顿酪氨酸激酶抑制剂
|
|
GB2558514A
(en)
*
|
2016-02-09 |
2018-07-18 |
Azad Pharmaceutical Ingredients Ag |
Process for the synthesis of stable amorphous ibrutinib
|
|
WO2017143294A1
(en)
|
2016-02-18 |
2017-08-24 |
Privo Technologies, Inc. |
Two-stage microparticle-based therapeutic delivery system and method
|
|
CN105646498A
(zh)
*
|
2016-03-01 |
2016-06-08 |
孙霖 |
依鲁替尼晶型f及制备方法
|
|
CN105646499A
(zh)
*
|
2016-03-01 |
2016-06-08 |
孙霖 |
依鲁替尼晶型g及制备方法
|
|
WO2017156179A1
(en)
|
2016-03-09 |
2017-09-14 |
Raze Therapeutics, Inc. |
3-phosphoglycerate dehydrogenase inhibitors and uses thereof
|
|
ES2965264T3
(es)
|
2016-03-09 |
2024-04-11 |
Raze Therapeutics Inc |
Inhibidores de la 3-fosfoglicerato deshidrogenasa y sus usos
|
|
US10870652B2
(en)
|
2016-03-11 |
2020-12-22 |
Corvus Pharmaceuticals, Inc. |
Compounds and methods for modulating bruton's tyrosine kinase
|
|
WO2017163257A1
(en)
*
|
2016-03-21 |
2017-09-28 |
Ind-Swift Laboratories Limited |
Process for preparing pure lh-pyrazolo[3,4-d] pyrimidine derivative
|
|
PL3436447T3
(pl)
|
2016-03-31 |
2021-12-27 |
Takeda Pharmaceutical Company Limited |
Kompleksy triazolonu izochinolinylowego
|
|
CZ2016196A3
(cs)
|
2016-04-06 |
2017-10-18 |
Zentiva, K.S. |
Pevné formy Ibrutinibu
|
|
CN109153722A
(zh)
|
2016-04-08 |
2019-01-04 |
X4 制药有限公司 |
用于治疗癌症的方法
|
|
PT3442535T
(pt)
|
2016-04-15 |
2022-09-05 |
Cancer Research Tech Ltd |
Compostos heterocíclicos como inibidores da ret quinase
|
|
HUE056135T2
(hu)
|
2016-04-15 |
2022-01-28 |
Cancer Research Tech Ltd |
RET kináz inhibitor heterociklusos vegyületek
|
|
EP3445364A4
(en)
|
2016-04-19 |
2019-11-27 |
Acetylon Pharmaceuticals, Inc. |
HDAC INHIBITORS, ONLY OR IN COMBINATION WITH BTK INHIBITORS, FOR THE TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA
|
|
CA3019182A1
(en)
*
|
2016-04-29 |
2017-11-02 |
Dana-Farber Cancer Institute, Inc. |
Hck as a therapeutic target in myd88 mutated diseases
|
|
CZ2016276A3
(cs)
|
2016-05-11 |
2017-11-22 |
Zentiva, K.S. |
Pevné formy volné báze ibrutinibu
|
|
US11400155B2
(en)
|
2016-05-20 |
2022-08-02 |
Biohaven Therapeutics Ltd. |
Use of riluzole, riluzole prodrugs or riluzole analogs with immunotherapies to treat cancers
|
|
CN105859728B
(zh)
*
|
2016-05-26 |
2018-06-08 |
江苏中邦制药有限公司 |
一种依鲁替尼的制备方法
|
|
SG11201810333UA
(en)
|
2016-05-27 |
2018-12-28 |
Tg Therapeutics Inc |
Combination of anti-cd20 antibody, p13 kinase-delta selective inhibitor, and btk inhibitor to treat b-cell proliferative disorders
|
|
EP3472162B1
(en)
|
2016-06-16 |
2021-11-17 |
F. Hoffmann-La Roche AG |
Heteroaryl estrogen receptor modulators and uses thereof
|
|
JP2019521983A
(ja)
|
2016-06-16 |
2019-08-08 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
テトラヒドロ−ピリド[3,4−b]インドールエストロゲン受容体モジュレーター及びその使用
|
|
IL263429B
(en)
*
|
2016-06-20 |
2022-08-01 |
Novartis Ag |
Crystalline forms of triazolopyrimidine compound
|
|
WO2017223239A1
(en)
|
2016-06-21 |
2017-12-28 |
X4 Pharmaceuticals, Inc. |
Cxcr4 inhibitors and uses thereof
|
|
CA3027500A1
(en)
|
2016-06-21 |
2017-12-28 |
X4 Pharmaceuticals, Inc. |
Cxcr4 inhibitors and uses thereof
|
|
CN109640988A
(zh)
|
2016-06-21 |
2019-04-16 |
X4 制药有限公司 |
Cxcr4抑制剂及其用途
|
|
WO2018000250A1
(zh)
*
|
2016-06-29 |
2018-01-04 |
上海创诺医药集团有限公司 |
依鲁替尼新晶型及其制备方法
|
|
IL293621B2
(en)
|
2016-06-29 |
2023-09-01 |
Principia Biopharma Inc |
Modified release formulations of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[4,3-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4 -Methyl-4-[4-(oxane-3-yl)piperazine-1-yl)penta-2-ananitrile
|
|
CN106117214A
(zh)
*
|
2016-06-29 |
2016-11-16 |
上海创诺医药集团有限公司 |
依鲁替尼新晶型及其制备方法
|
|
WO2018002958A1
(en)
|
2016-06-30 |
2018-01-04 |
Sun Pharma Advanced Research Company Limited |
Novel hydrazide containing compounds as btk inhibitors
|
|
ES2977557T3
(es)
|
2016-06-30 |
2024-08-26 |
Daewoong Pharmaceutical Co Ltd |
Derivados de pirazolopirimidina como inhibidores de cinasas
|
|
WO2018007885A1
(en)
|
2016-07-05 |
2018-01-11 |
Beigene, Ltd. |
COMBINATION OF A PD-l ANTAGONIST AND A RAF INHIBITOR FOR TREATING CANCER
|
|
WO2018009017A1
(en)
|
2016-07-07 |
2018-01-11 |
Daewoong Pharmaceutical Co., Ltd. |
NOVEL 4-AMINOPYRAZOLO[3,4-d]PYRIMIDINYLAZABICYCLO DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
|
|
CN107641123A
(zh)
*
|
2016-07-20 |
2018-01-30 |
南京亿华药业有限公司 |
一种依鲁替尼及其关键中间体的制备新方法
|
|
WO2018017153A1
(en)
|
2016-07-21 |
2018-01-25 |
Biogen Ma Inc. |
Succinate forms and compositions of bruton's tyrosine kinase inhibitors
|
|
SG11201901141WA
(en)
|
2016-08-16 |
2019-03-28 |
Beigene Ltd |
Crystalline form of (s)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof
|
|
CN108368119B
(zh)
*
|
2016-08-17 |
2019-04-23 |
深圳市塔吉瑞生物医药有限公司 |
用于抑制酪氨酸激酶活性的稠合双环类化合物
|
|
PT3500299T
(pt)
|
2016-08-19 |
2024-02-21 |
Beigene Switzerland Gmbh |
Combinação de zanubrutinib com um anticorpo anti-cd20 ou anti-pd-1 para utilização no tratamento do cancro
|
|
EP3515414B1
(en)
|
2016-09-19 |
2022-11-30 |
MEI Pharma, Inc. |
Combination therapy
|
|
US20200039981A1
(en)
*
|
2016-10-06 |
2020-02-06 |
Janssen Pharmaceutica Nv |
Processes and intermediates for preparing a btk inhibitor
|
|
CN115448916A
(zh)
|
2016-10-14 |
2022-12-09 |
林伯士拉克许米公司 |
Tyk2抑制剂及其用途
|
|
CN109843329A
(zh)
|
2016-10-17 |
2019-06-04 |
第一三共株式会社 |
使用mdm2抑制剂和dna甲基转移酶抑制剂的组合治疗方法
|
|
CN110300590A
(zh)
|
2016-10-21 |
2019-10-01 |
林伯士拉克许米公司 |
Tyk2抑制剂及其用途
|
|
PT3532098T
(pt)
|
2016-10-28 |
2021-06-17 |
Morphosys Ag |
Combinação de anticorpo anti cd19 com um inibidor bcl-2 e suas utilizações
|
|
MX2019005029A
(es)
|
2016-11-03 |
2019-10-24 |
Juno Therapeutics Inc |
Terapia de combinación de una terapia de células t y un inhibidor de tirosina cinasa de bruton (btk).
|
|
US10414727B2
(en)
|
2016-11-08 |
2019-09-17 |
Navitor Pharmaceuticals, Inc. |
Phenyl amino piperidine mTORC inhibitors and uses thereof
|
|
JP6782855B2
(ja)
*
|
2016-11-15 |
2020-11-11 |
杭州和正医薬有限公司 |
選択性ブルトン型チロシンキナーゼ阻害剤及びその使用
|
|
CN108101905A
(zh)
*
|
2016-11-24 |
2018-06-01 |
中国科学院上海药物研究所 |
嘧啶并[5,4-b]吲嗪或嘧啶并[5,4-b]吡呤化合物、其制备方法及用途
|
|
AU2017368050A1
(en)
|
2016-11-29 |
2019-06-20 |
Puretech Lyt, Inc. |
Exosomes for delivery of therapeutic agents
|
|
US10183024B2
(en)
|
2016-12-02 |
2019-01-22 |
Apotex Inc. |
Crystalline forms of ibrutinib
|
|
MX2019006288A
(es)
|
2016-12-03 |
2020-10-01 |
Juno Therapeutics Inc |
Metodos y composiciones para el uso de celulas t terapeuticas en combinacion con inhibidores de quinasa.
|
|
US11091451B2
(en)
|
2016-12-05 |
2021-08-17 |
Raze Therapeutics, Inc. |
SHMT inhibitors and uses thereof
|
|
JP7022131B2
(ja)
*
|
2016-12-21 |
2022-02-17 |
アセルタ ファーマ ビー.ブイ. |
ブルトン型チロシンキナーゼのイミダゾピラジン阻害剤
|
|
WO2018115203A1
(en)
|
2016-12-23 |
2018-06-28 |
Bicyclerd Limited |
Peptide derivatives having novel linkage structures
|
|
ES2985986T3
(es)
|
2017-01-06 |
2024-11-08 |
Bicyclerd Ltd |
Conjugado biciclo para tratar el cáncer
|
|
CN110461847B
(zh)
|
2017-01-25 |
2022-06-07 |
百济神州有限公司 |
(S)-7-(1-(丁-2-炔酰基)哌啶-4-基)-2-(4-苯氧基苯基)-4,5,6,7-四氢吡唑并[1,5-a]嘧啶-3-甲酰胺的结晶形式、其制备及用途
|
|
US20180235899A1
(en)
|
2017-02-17 |
2018-08-23 |
Privo Technologies, Inc. |
Particle-based multi-layer therapeutic delivery device and method
|
|
CN110312720A
(zh)
|
2017-02-24 |
2019-10-08 |
吉利德科学公司 |
布鲁顿氏酪氨酸激酶的抑制剂
|
|
US10314844B2
(en)
|
2017-02-24 |
2019-06-11 |
Gilead Sciences, Inc. |
Inhibitors of Bruton's tyrosine kinase
|
|
TWI868528B
(zh)
|
2017-03-08 |
2025-01-01 |
日商武田藥品工業股份有限公司 |
Tyk2抑制劑之生產方法
|
|
CN108570036A
(zh)
*
|
2017-03-09 |
2018-09-25 |
北京赛林泰医药技术有限公司 |
一种btk抑制剂的多晶型物及其制备方法
|
|
GB201703876D0
(en)
|
2017-03-10 |
2017-04-26 |
Berlin-Chemie Ag |
Pharmaceutical combinations
|
|
EP3595777A4
(en)
*
|
2017-03-14 |
2021-01-20 |
Dana-Farber Cancer Institute, Inc. |
LOW MOLECULAR SENSITIVITY OF BAX ACTIVATION FOR INDUCING CELL DEATH
|
|
EP3375784A1
(en)
|
2017-03-14 |
2018-09-19 |
Artax Biopharma Inc. |
Aza-dihydro-acridone derivatives
|
|
EP3375778A1
(en)
|
2017-03-14 |
2018-09-19 |
Artax Biopharma Inc. |
Aryl-piperidine derivatives
|
|
MX2019011116A
(es)
*
|
2017-03-22 |
2020-02-05 |
Liao Xibin |
Inhibidores de la tirosina quinasa de bruton.
|
|
US11339144B2
(en)
|
2017-04-10 |
2022-05-24 |
Navitor Pharmaceuticals, Inc. |
Heteroaryl Rheb inhibitors and uses thereof
|
|
GB201705971D0
(en)
|
2017-04-13 |
2017-05-31 |
Cancer Res Tech Ltd |
Inhibitor compounds
|
|
US10800787B2
(en)
|
2017-04-20 |
2020-10-13 |
Apotex Inc. |
Process for the preparation of acalabrutinib
|
|
CN107043366B
(zh)
*
|
2017-04-25 |
2020-05-26 |
中国药科大学 |
4-氨基嘧啶类化合物、其制备方法及医药用途
|
|
AU2018258355B2
(en)
|
2017-04-26 |
2024-05-30 |
Navitor Pharmaceuticals, Inc. |
Modulators of sestrin-gator2 interaction and uses thereof
|
|
WO2018197893A1
(en)
|
2017-04-27 |
2018-11-01 |
Bicycletx Limited |
Bicyclic peptide ligands and uses thereof
|
|
US10478403B1
(en)
|
2017-05-03 |
2019-11-19 |
Privo Technologies, Inc. |
Intraoperative topically-applied non-implantable rapid release patch
|
|
WO2018223101A1
(en)
|
2017-06-02 |
2018-12-06 |
Juno Therapeutics, Inc. |
Articles of manufacture and methods for treatment using adoptive cell therapy
|
|
CN111201438A
(zh)
|
2017-06-02 |
2020-05-26 |
朱诺治疗学股份有限公司 |
与和细胞疗法相关的毒性有关的制品和方法
|
|
CN109111446B
(zh)
|
2017-06-22 |
2021-11-30 |
上海度德医药科技有限公司 |
一种具有药物活性的杂芳基化合物
|
|
JP7301757B2
(ja)
|
2017-06-26 |
2023-07-03 |
バイスクルアールディー・リミテッド |
検出可能部分を持つ二環式ペプチドリガンドおよびその使用
|
|
TWI877099B
(zh)
|
2017-06-26 |
2025-03-21 |
英屬開曼群島商百濟神州有限公司 |
抗pd-1抗體或其抗原結合片段在製備治療用於患有肝細胞癌(hcc)之藥物的用途
|
|
CN111050545A
(zh)
|
2017-06-29 |
2020-04-21 |
朱诺治疗学股份有限公司 |
评估与免疫疗法相关的毒性的小鼠模型
|
|
KR102384924B1
(ko)
*
|
2017-07-12 |
2022-04-08 |
주식회사 대웅제약 |
신규한 1h-피라졸로피리딘 유도체 및 이를 포함하는 약학 조성물
|
|
WO2019013562A1
(ko)
|
2017-07-12 |
2019-01-17 |
주식회사 대웅제약 |
신규한 1h-피라졸로피리딘 유도체 및 이를 포함하는 약학 조성물
|
|
ES2994013T3
(en)
|
2017-07-28 |
2025-01-15 |
Takeda Pharmaceuticals Co |
Tyk2 inhibitors and uses thereof
|
|
US11261214B2
(en)
|
2017-08-04 |
2022-03-01 |
Bicycletx Limited |
Bicyclic peptide ligand specific for CD137
|
|
WO2019034009A1
(en)
|
2017-08-12 |
2019-02-21 |
Beigene, Ltd. |
BTK INHIBITOR WITH ENHANCED DOUBLE SELECTIVITY
|
|
US20200291096A1
(en)
|
2017-08-14 |
2020-09-17 |
Bicyclerd Limited |
Bicyclic peptide ligand sting conjugates and uses thereof
|
|
US20200283482A1
(en)
|
2017-08-14 |
2020-09-10 |
Bicyclerd Limited |
Bicyclic peptide ligand prr-a conjugates and uses thereof
|
|
US11883497B2
(en)
|
2017-08-29 |
2024-01-30 |
Puretech Lyt, Inc. |
Lymphatic system-directing lipid prodrugs
|
|
AU2018324037A1
(en)
|
2017-08-29 |
2020-04-16 |
Monash University |
Lymphatic system-directing lipid prodrugs
|
|
EP3676403A1
(en)
|
2017-09-01 |
2020-07-08 |
Juno Therapeutics, Inc. |
Gene expression and assessment of risk of developing toxicity following cell therapy
|
|
EP3684366A4
(en)
|
2017-09-22 |
2021-09-08 |
Kymera Therapeutics, Inc. |
Crbn ligands and uses thereof
|
|
MX2020003190A
(es)
|
2017-09-22 |
2020-11-11 |
Kymera Therapeutics Inc |
Degradadores de proteinas y usos de los mismos.
|
|
EA037031B1
(ru)
*
|
2017-10-06 |
2021-01-28 |
Асерта Фарма Б.В. |
Имидазопиразиновые ингибиторы тирозинкиназы брутона
|
|
KR102613433B1
(ko)
*
|
2017-10-11 |
2023-12-13 |
주식회사 대웅제약 |
신규한 페닐피리딘 유도체 및 이를 포함하는 약학 조성물
|
|
TW201922256A
(zh)
|
2017-10-27 |
2019-06-16 |
中國大陸商浙江導明醫藥科技有限公司 |
治療淋巴樣惡性疾病之方法
|
|
WO2019089848A1
(en)
|
2017-11-01 |
2019-05-09 |
Juno Therapeutics, Inc. |
Methods associated with tumor burden for assessing response to a cell therapy
|
|
WO2019108795A1
(en)
|
2017-11-29 |
2019-06-06 |
Beigene Switzerland Gmbh |
Treatment of indolent or aggressive b-cell lymphomas using a combination comprising btk inhibitors
|
|
CZ2017787A3
(cs)
|
2017-12-08 |
2019-06-19 |
Zentiva, K.S. |
Farmaceutické kompozice obsahující ibrutinib
|
|
US11304954B2
(en)
|
2017-12-19 |
2022-04-19 |
Puretech Lyt, Inc. |
Lipid prodrugs of mycophenolic acid and uses thereof
|
|
WO2019126378A1
(en)
|
2017-12-19 |
2019-06-27 |
Ariya Therapeutics, Inc. |
Lipid prodrugs of mycophenolic acid and uses thereof
|
|
US11608345B1
(en)
|
2017-12-19 |
2023-03-21 |
Puretech Lyt, Inc. |
Lipid prodrugs of rapamycin and its analogs and uses thereof
|
|
TWI825046B
(zh)
|
2017-12-19 |
2023-12-11 |
英商拜西可泰克斯有限公司 |
Epha2特用之雙環胜肽配位基
|
|
GB201721265D0
(en)
|
2017-12-19 |
2018-01-31 |
Bicyclerd Ltd |
Bicyclic peptide ligands specific for EphA2
|
|
IL315310A
(en)
|
2017-12-26 |
2024-10-01 |
Kymera Therapeutics Inc |
Irak degraders and uses thereof
|
|
WO2019127008A1
(zh)
*
|
2017-12-26 |
2019-07-04 |
清华大学 |
一种靶向降解btk的化合物及其应用
|
|
CN108220261B
(zh)
*
|
2017-12-29 |
2021-05-14 |
安徽联创生物医药股份有限公司 |
酮还原酶、核酸、重组表达载体、重组表达菌株及应用
|
|
EP3737675A4
(en)
|
2018-01-12 |
2022-01-05 |
Kymera Therapeutics, Inc. |
Crbn ligands and uses thereof
|
|
EP3737666A4
(en)
|
2018-01-12 |
2022-01-05 |
Kymera Therapeutics, Inc. |
PROTEIN DEGRADATION AGENTS AND ASSOCIATED USES
|
|
CA3089537A1
(en)
|
2018-01-20 |
2019-07-25 |
Natco Pharma Limited |
Pharmaceutical compositions comprising ibrutinib
|
|
MX2020007797A
(es)
|
2018-01-29 |
2020-09-18 |
Merck Patent Gmbh |
Inhibidores de la cinasa 2 de control general no desrepresible (gcn2) y usos de los mismos.
|
|
US10988477B2
(en)
|
2018-01-29 |
2021-04-27 |
Merck Patent Gmbh |
GCN2 inhibitors and uses thereof
|
|
CA3091775A1
(en)
|
2018-02-23 |
2019-08-29 |
Bicycletx Limited |
Multimeric bicyclic peptide ligands
|
|
AU2019229258B2
(en)
|
2018-02-27 |
2023-09-14 |
Artax Biopharma Inc. |
Chromene derivatives as inhibitors of TCR-Nck interaction
|
|
JP2021524835A
(ja)
|
2018-04-05 |
2021-09-16 |
スミトモ ダイニッポン ファーマ オンコロジー, インコーポレイテッド |
Axlキナーゼ阻害剤およびその使用
|
|
MX2020010556A
(es)
|
2018-04-13 |
2021-03-02 |
Sumitomo Pharma Oncology Inc |
Inhibidores de cinasa de insercion proviral en linfomas murinos (pim) para el tratamiento de neoplasias mieloproliferativas y fibrosis asociadas con cancer.
|
|
WO2019209759A1
(en)
|
2018-04-24 |
2019-10-31 |
Merck Patent Gmbh |
Antiproliferation compounds and uses thereof
|
|
IL278122B2
(en)
|
2018-04-24 |
2024-01-01 |
Vertex Pharma |
Pteridinone compounds and uses thereof
|
|
US20210113568A1
(en)
|
2018-04-27 |
2021-04-22 |
Ono Pharmaceutical Co., Ltd. |
PREVENTIVE AND/OR THERAPEUTIC AGENT FOR AUTOIMMUNE DISEASE COMPRISING COMPOUND HAVING Btk INHIBITORY ACTIVITY AS ACTIVE INGREDIENT
|
|
KR102106821B1
(ko)
|
2018-04-27 |
2020-05-06 |
재단법인대구경북과학기술원 |
이브루티닙을 유효성분으로 포함하는 퇴행성 뇌질환의 예방 또는 치료용 약학적 조성물
|
|
BR112020022185A2
(pt)
|
2018-05-03 |
2021-02-02 |
Juno Therapeutics Inc |
terapia de combinação de uma terapia de células t do receptor de antígeno quimérico (car) e um inibidor de quinase
|
|
US10865198B2
(en)
|
2018-05-04 |
2020-12-15 |
Alexion Pharmaceuticals, Inc. |
Solid forms of cerdulatinib
|
|
EP3575300A1
(en)
|
2018-05-31 |
2019-12-04 |
Apotex Inc. |
Novel crystalline forms of ibrutinib
|
|
IL259810A
(en)
|
2018-06-04 |
2018-07-31 |
Yeda Res & Dev |
Mitogen-activated protein kinase kinase 7 inhibitors
|
|
RU2711106C2
(ru)
*
|
2018-06-06 |
2020-01-15 |
Общество с ограниченной ответственностью "АКСЕЛЬФАРМ" |
Кристаллическая μ-модификация 1-[(3R)-3-[4-амино-3-(4-фенокси-фенил)-1Н-пиразоло[3,4-d]пиримидин-1-ил]-1-пиперидил]-2-пропенил-1-она, способ её получения и фармацевтическая композиция на её основе
|
|
CN118512397A
(zh)
|
2018-06-15 |
2024-08-20 |
詹森药业有限公司 |
包含依鲁替尼的配制品/组合物
|
|
EP4302827A3
(en)
|
2018-06-15 |
2024-03-13 |
JANSSEN Pharmaceutica NV |
Rapamycin analogs and uses thereof
|
|
IL279489B2
(en)
|
2018-06-22 |
2025-10-01 |
Bicycletx Ltd |
Bicyclic peptide ligands specific for nectin-4, a drug conjugate containing the peptide ligands and a pharmaceutical composition containing the drug conjugate
|
|
GB201810316D0
(en)
|
2018-06-22 |
2018-08-08 |
Bicyclerd Ltd |
Peptide ligands for binding to EphA2
|
|
JP7590185B2
(ja)
|
2018-06-25 |
2024-11-26 |
ダナ-ファーバー キャンサー インスティテュート, インコーポレイテッド |
Taireファミリーキナーゼインヒビターおよびそれらの使用
|
|
US11292792B2
(en)
|
2018-07-06 |
2022-04-05 |
Kymera Therapeutics, Inc. |
Tricyclic CRBN ligands and uses thereof
|
|
US12454520B2
(en)
|
2018-07-06 |
2025-10-28 |
Kymera Therapeutics, Inc. |
Protein degraders and uses thereof
|
|
JP2021530554A
(ja)
|
2018-07-26 |
2021-11-11 |
スミトモ ダイニッポン ファーマ オンコロジー, インコーポレイテッド |
異常なacvr1発現を伴う疾患を処置するための方法およびそこで使用するためのacvr1阻害剤
|
|
WO2020028258A1
(en)
|
2018-07-31 |
2020-02-06 |
Loxo Oncology, Inc. |
Spray-dried dispersions and formulations of (s)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoro propan-2-yl)-1h-pyrazole-4-carboxamide
|
|
WO2020045941A1
(ko)
|
2018-08-27 |
2020-03-05 |
주식회사 대웅제약 |
신규한 헤테로사이클릭아민 유도체 및 이를 포함하는 약학 조성물
|
|
KR102328682B1
(ko)
|
2018-08-27 |
2021-11-18 |
주식회사 대웅제약 |
신규한 헤테로사이클릭아민 유도체 및 이를 포함하는 약학 조성물
|
|
IL280880B2
(en)
|
2018-08-27 |
2025-04-01 |
Regeneron Pharma |
Using Raman Spectroscopy in Downstream Purification
|
|
CA3111126A1
(en)
|
2018-08-31 |
2020-03-05 |
Stichting Katholieke Universiteit |
Synergistic combinations of amino acid depletion agent sensitizers (aadas) and amino acid depletion agents (aada), and therapeutic methods of use thereof
|
|
US10548889B1
(en)
|
2018-08-31 |
2020-02-04 |
X4 Pharmaceuticals, Inc. |
Compositions of CXCR4 inhibitors and methods of preparation and use
|
|
JP2022500499A
(ja)
|
2018-09-07 |
2022-01-04 |
ピク セラピューティクス, インコーポレイテッド |
Eif4e阻害剤およびその使用
|
|
CN110964016B
(zh)
*
|
2018-09-29 |
2021-05-28 |
南京药捷安康生物科技有限公司 |
氨基降茨烷衍生物及其制备方法与应用
|
|
AU2019360941B2
(en)
|
2018-10-15 |
2025-02-27 |
Takeda Pharmaceutical Company Limited |
TYK2 inhibitors and uses thereof
|
|
US10919937B2
(en)
|
2018-10-23 |
2021-02-16 |
Bicycletx Limited |
Bicyclic peptide ligands and uses thereof
|
|
AU2019364542B2
(en)
|
2018-10-24 |
2025-08-28 |
Navitor Pharmaceuticals, Inc. |
Polymorphic compounds and uses thereof
|
|
CN111170986A
(zh)
|
2018-11-13 |
2020-05-19 |
北京睿熙生物科技有限公司 |
布鲁顿酪氨酸激酶的抑制剂
|
|
CN109293630A
(zh)
*
|
2018-11-15 |
2019-02-01 |
山东大学 |
含取代吡唑类化合物及其制备方法与应用
|
|
CN109369654A
(zh)
*
|
2018-11-20 |
2019-02-22 |
山东大学 |
1,3-二取代-4-氨基吡唑并嘧啶类化合物及其制备方法和应用
|
|
US11053241B2
(en)
|
2018-11-30 |
2021-07-06 |
Nimbus Lakshmi, Inc. |
TYK2 inhibitors and uses thereof
|
|
BR112021010484A2
(pt)
|
2018-11-30 |
2021-08-24 |
Kymera Therapeutics, Inc. |
Degradadores de irak e usos dos mesmos
|
|
IL283298B2
(en)
|
2018-11-30 |
2025-03-01 |
Juno Therapeutics Inc |
Methods for dosing and treating B-cell malignancies with adoptive cell therapy
|
|
CA3120869A1
(en)
|
2018-11-30 |
2020-06-04 |
Juno Therapeutics, Inc. |
Methods for treatment using adoptive cell therapy
|
|
GB201820295D0
(en)
|
2018-12-13 |
2019-01-30 |
Bicyclerd Ltd |
Bicyclic peptide ligands specific for MT1-MMP
|
|
GB201820325D0
(en)
|
2018-12-13 |
2019-01-30 |
Bicyclerd Ltd |
Bicyclic peptide ligands specific for psma
|
|
GB201820288D0
(en)
|
2018-12-13 |
2019-01-30 |
Bicycle Tx Ltd |
Bicycle peptide ligaands specific for MT1-MMP
|
|
EP3670659A1
(en)
|
2018-12-20 |
2020-06-24 |
Abivax |
Biomarkers, and uses in treatment of viral infections, inflammations, or cancer
|
|
EP3897631A4
(en)
|
2018-12-20 |
2022-11-23 |
C4 Therapeutics, Inc. |
TARGETED PROTEIN BREAKDOWN
|
|
US20220040324A1
(en)
|
2018-12-21 |
2022-02-10 |
Daiichi Sankyo Company, Limited |
Combination of antibody-drug conjugate and kinase inhibitor
|
|
EP3669867A1
(en)
|
2018-12-21 |
2020-06-24 |
Synthon B.V. |
Pharmaceutical composition comprising ibrutinib
|
|
US10688050B1
(en)
|
2018-12-21 |
2020-06-23 |
Synthon B.V. |
Pharmaceutical composition comprising ibrutinib
|
|
CN113474045A
(zh)
|
2018-12-21 |
2021-10-01 |
拜斯科技术开发有限公司 |
Pd-l1特异性的双环肽配体
|
|
AU2019413694B2
(en)
|
2018-12-28 |
2025-03-20 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 and uses thereof
|
|
JP2022521452A
(ja)
|
2019-01-09 |
2022-04-08 |
イェダ リサーチ アンド ディベロップメント カンパニー リミテッド |
Pin1活性のモジュレータおよびその使用
|
|
CN111454268B
(zh)
*
|
2019-01-18 |
2023-09-08 |
明慧医药(上海)有限公司 |
作为布鲁顿酪氨酸激酶抑制剂的环状分子
|
|
AU2020212001A1
(en)
|
2019-01-23 |
2021-07-22 |
Takeda Pharmaceutical Company Limited |
TYK2 inhibitors and uses thereof
|
|
CA3127502A1
(en)
|
2019-02-12 |
2020-08-20 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Formulations comprising heterocyclic protein kinase inhibitors
|
|
WO2020165600A1
(en)
|
2019-02-14 |
2020-08-20 |
Bicycletx Limited |
Bicyclic peptide ligand sting conjugates and uses thereof
|
|
WO2020170270A1
(en)
*
|
2019-02-19 |
2020-08-27 |
Msn Laboratories Private Limited, R&D Center |
Novel crystalline polymorphs of 1-[(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one and process for preparation thereof
|
|
CN114364798A
(zh)
|
2019-03-21 |
2022-04-15 |
欧恩科斯欧公司 |
用于治疗癌症的Dbait分子与激酶抑制剂的组合
|
|
WO2020201753A1
(en)
|
2019-04-02 |
2020-10-08 |
Bicycletx Limited |
Bicycle toxin conjugates and uses thereof
|
|
CA3135802A1
(en)
|
2019-04-05 |
2020-10-08 |
Kymera Therapeutics, Inc. |
Stat degraders and uses thereof
|
|
CN120136774A
(zh)
|
2019-05-21 |
2025-06-13 |
詹森药业有限公司 |
用于制备btk抑制剂的方法和中间体
|
|
CN113874378A
(zh)
*
|
2019-05-21 |
2021-12-31 |
詹森药业有限公司 |
用于制备btk抑制剂的方法和中间体
|
|
JP7150289B2
(ja)
*
|
2019-05-28 |
2022-10-11 |
ペイジ.エーアイ インコーポレイテッド |
デジタル病理学のための処理された画像に関するスライドを調製するために画像を処理するためのシステムおよび方法
|
|
AU2020282759A1
(en)
|
2019-05-31 |
2021-12-23 |
Ikena Oncology, Inc. |
TEAD inhibitors and uses thereof
|
|
TWI856111B
(zh)
|
2019-06-10 |
2024-09-21 |
瑞士商百濟神州瑞士有限責任公司 |
一種含有布魯頓氏酪胺酸激酶抑制劑的口服固體錠劑及其製備方法
|
|
US12521438B2
(en)
|
2019-06-10 |
2026-01-13 |
Kymera Therapeutics, Inc. |
SMARCA degraders and uses thereof
|
|
TWI862640B
(zh)
|
2019-07-30 |
2024-11-21 |
英商拜西可泰克斯有限公司 |
異質雙環肽複合物
|
|
WO2021038540A1
(en)
|
2019-08-31 |
2021-03-04 |
Sun Pharma Advanced Research Company Limited |
Cycloalkylidene carboxylic acids and derivatives as btk inhibitors
|
|
JP2022548594A
(ja)
|
2019-09-11 |
2022-11-21 |
ビンシア・バイオサイエンシーズ・インコーポレイテッド |
Usp30阻害剤及びその使用
|
|
AU2020347274A1
(en)
|
2019-09-13 |
2022-03-31 |
Nimbus Saturn, Inc. |
HPK1 antagonists and uses thereof
|
|
IL291994A
(en)
|
2019-10-14 |
2022-06-01 |
Principia Biopharma Inc |
Methods for treating immune thrombocytopenia by administering (r)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine- 1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile
|
|
WO2021087432A1
(en)
|
2019-11-01 |
2021-05-06 |
Navitor Pharmaceuticals, Inc. |
Methods of treatment using an mtorc1 modulator
|
|
JP2023500906A
(ja)
|
2019-11-08 |
2023-01-11 |
インサーム(インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル) |
キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法
|
|
MX2022006807A
(es)
|
2019-12-05 |
2022-09-12 |
Anakuria Therapeutics Inc |
Análogos de rapamicina y usos de estos.
|
|
AU2020395318A1
(en)
|
2019-12-06 |
2022-06-09 |
Juno Therapeutics, Inc. |
Methods related to toxicity and response associated with cell therapy for treating B cell malignancies
|
|
CN115052627A
(zh)
|
2019-12-17 |
2022-09-13 |
凯麦拉医疗公司 |
Irak降解剂和其用途
|
|
WO2021127283A2
(en)
|
2019-12-17 |
2021-06-24 |
Kymera Therapeutics, Inc. |
Irak degraders and uses thereof
|
|
EP4081308A4
(en)
|
2019-12-23 |
2024-01-24 |
Kymera Therapeutics, Inc. |
SMARCA DEGRADERS AND USES THEREOF
|
|
US11969418B2
(en)
|
2020-01-20 |
2024-04-30 |
Genzyme Corporation |
Therapeutic tyrosine kinase inhibitors for relapsing multiple sclerosis (RMS)
|
|
WO2021148581A1
(en)
|
2020-01-22 |
2021-07-29 |
Onxeo |
Novel dbait molecule and its use
|
|
CN115461341A
(zh)
|
2020-01-22 |
2022-12-09 |
普林斯匹亚生物制药公司 |
2-[3-[4-氨基-3-(2-氟-4-苯氧基-苯基)-1h-吡唑并[3,4-d]嘧啶-1-基]哌啶-1-羰基]-4-甲基-4-[4-(氧杂环丁烷-3-基)哌嗪-1-基]戊-2-烯腈的晶型
|
|
WO2021159021A1
(en)
|
2020-02-05 |
2021-08-12 |
Puretech Lyt, Inc. |
Lipid prodrugs of neurosteroids
|
|
CN113336760B
(zh)
*
|
2020-02-18 |
2022-11-04 |
深圳市塔吉瑞生物医药有限公司 |
取代的酰胺衍生物及其组合物及用途
|
|
US20230094404A1
(en)
|
2020-02-26 |
2023-03-30 |
Daewoong Pharmaceutical Co., Ltd. |
Method for preparation of heterocyclicamine derivatives
|
|
MX2022010944A
(es)
|
2020-03-03 |
2022-11-09 |
Pic Therapeutics Inc |
Inhibidores del factor de iniciacion de traduccion eucariotica 4e (eif4e) y sus usos.
|
|
CA3171258A1
(en)
|
2020-03-19 |
2021-09-23 |
Nan JI |
Mdm2 degraders and uses thereof
|
|
US20230250110A1
(en)
|
2020-06-03 |
2023-08-10 |
Kymera Therapeutics, Inc. |
Deuterated irak degraders and uses thereof
|
|
TW202210483A
(zh)
|
2020-06-03 |
2022-03-16 |
美商凱麥拉醫療公司 |
Irak降解劑之結晶型
|
|
CN114057724B
(zh)
*
|
2020-07-29 |
2025-01-03 |
鲁南制药集团股份有限公司 |
一种btk抑制剂
|
|
KR20230074721A
(ko)
|
2020-08-17 |
2023-05-31 |
바이사이클티엑스 리미티드 |
Nectin-4에 특이적인 이환 콘쥬게이트 및 이의 용도
|
|
US20230320990A1
(en)
|
2020-08-28 |
2023-10-12 |
Synthon B.V. |
Pharmaceutical composition comprising ibrutinib
|
|
US20240024325A1
(en)
*
|
2020-08-28 |
2024-01-25 |
Emory University |
Methods of Managing Cocaine or Other Drug Addictions
|
|
CN114105990A
(zh)
*
|
2020-08-31 |
2022-03-01 |
北京四环制药有限公司 |
一种伊布替尼的合成方法
|
|
CN114105991A
(zh)
*
|
2020-08-31 |
2022-03-01 |
北京四环制药有限公司 |
一种伊布替尼中间体的制备方法
|
|
WO2022083745A1
(zh)
*
|
2020-10-23 |
2022-04-28 |
中国科学院上海药物研究所 |
一种布鲁顿酪氨酸激酶抑制剂的用途
|
|
WO2022087634A1
(en)
|
2020-10-23 |
2022-04-28 |
Nimbus Clotho, Inc. |
Ctps1 inhibitors and uses thereof
|
|
AU2021392040A1
(en)
|
2020-12-02 |
2023-06-29 |
Ikena Oncology, Inc. |
Tead inhibitors and uses thereof
|
|
WO2022120353A1
(en)
|
2020-12-02 |
2022-06-09 |
Ikena Oncology, Inc. |
Tead inhibitors and uses thereof
|
|
CN118434732A
(zh)
|
2020-12-10 |
2024-08-02 |
建新公司 |
Tolebrutinib的晶型及其制备方法和用途
|
|
CN112574216B
(zh)
*
|
2020-12-16 |
2022-03-08 |
天津济坤医药科技有限公司 |
一种化合物及其制备方法以及其在制备治疗抗癌药物中的应用
|
|
CN116867758A
(zh)
|
2020-12-30 |
2023-10-10 |
凯麦拉医疗公司 |
Irak降解剂和其用途
|
|
US20240092785A1
(en)
|
2021-01-21 |
2024-03-21 |
Synthon B.V. |
Process for making ibrutinib
|
|
MX2023009060A
(es)
|
2021-02-02 |
2023-09-29 |
Liminal Biosciences Ltd |
Antagonistas de gpr84 y usos de estos.
|
|
AU2022215844A1
(en)
|
2021-02-02 |
2023-09-14 |
Liminal Biosciences Limited |
Gpr84 antagonists and uses thereof
|
|
JP2024506909A
(ja)
|
2021-02-12 |
2024-02-15 |
ニンバス サターン, インコーポレイテッド |
Hpk1アンタゴニスト及びその使用
|
|
CA3207380A1
(en)
|
2021-02-15 |
2022-08-18 |
Haojing RONG |
Irak4 degraders and uses thereof
|
|
AU2022220043A1
(en)
|
2021-02-15 |
2023-08-31 |
Kymera Therapeutics, Inc. |
Irak4 degraders and uses thereof
|
|
US11926625B2
(en)
|
2021-03-05 |
2024-03-12 |
Nimbus Saturn, Inc. |
HPK1 antagonists and uses thereof
|
|
WO2022213062A1
(en)
|
2021-03-29 |
2022-10-06 |
Nimbus Saturn, Inc. |
Hpk1 antagonists and uses thereof
|
|
CN115160319B
(zh)
*
|
2021-04-01 |
2023-12-26 |
西安新通药物研究股份有限公司 |
含1,3-苯并二氧戊环结构的化合物及其制备方法与用途
|
|
BR112023020781A2
(pt)
|
2021-04-09 |
2023-12-19 |
Nimbus Clio Inc |
Moduladores de cbl-b e usos dos mesmos
|
|
IL307673A
(en)
|
2021-04-16 |
2023-12-01 |
Ikena Oncology Inc |
MEK inhibitors and their use
|
|
IL308314A
(en)
|
2021-05-07 |
2024-01-01 |
Kymera Therapeutics Inc |
CDK2 compounds and their uses
|
|
CA3220269A1
(en)
*
|
2021-06-01 |
2022-12-08 |
Manijeh N. Goldberg |
Enhanced two-stage microparticle-based localized therapeutic delivery system
|
|
US11433072B1
(en)
|
2021-06-10 |
2022-09-06 |
Hikma Pharmaceuticals USA, Inc. |
Oral dosage forms of ibrutinib
|
|
TN2023000295A1
(en)
|
2021-06-10 |
2025-07-02 |
Hikma Pharmaceuticals Usa Inc |
Oral dosage forms of ibrutinib
|
|
CN113583001A
(zh)
*
|
2021-07-13 |
2021-11-02 |
江苏君若药业有限公司 |
依鲁替尼的制备
|
|
WO2023014817A1
(en)
|
2021-08-03 |
2023-02-09 |
Syros Pharmaceuticals, Inc. |
Compositions and methods for treating lymphomas with a cdk7 inhibitor in combination with a btk inhibitor
|
|
CN115702898B
(zh)
*
|
2021-08-04 |
2024-02-09 |
成都倍特药业股份有限公司 |
一种btk抑制剂固体制剂及其制备方法
|
|
CN118019739A
(zh)
|
2021-08-25 |
2024-05-10 |
皮克医疗公司 |
Eif4e抑制剂及其用途
|
|
WO2023028235A1
(en)
|
2021-08-25 |
2023-03-02 |
PIC Therapeutics, Inc. |
Eif4e inhibitors and uses thereof
|
|
CN113845521B
(zh)
*
|
2021-08-31 |
2024-06-18 |
中原工学院 |
水相中光催化一锅法合成咪唑并含氮杂环肼类衍生物的方法
|
|
CN114940678B
(zh)
*
|
2021-09-26 |
2023-02-07 |
上海贵之言医药科技有限公司 |
一种吡唑并嘧啶酯类化合物
|
|
WO2023071973A1
(en)
*
|
2021-10-26 |
2023-05-04 |
Shenzhen Targetrx, Inc. |
Fused bicyclic compound for inhibiting activity of tyrosine kinase
|
|
WO2023076556A1
(en)
|
2021-10-29 |
2023-05-04 |
Kymera Therapeutics, Inc. |
Irak4 degraders and synthesis thereof
|
|
WO2023104808A1
(en)
|
2021-12-10 |
2023-06-15 |
Synthon B.V. |
Pharmaceutical composition comprising ibrutinib
|
|
WO2023114984A1
(en)
|
2021-12-17 |
2023-06-22 |
Ikena Oncology, Inc. |
Tead inhibitors and uses thereof
|
|
WO2023147594A2
(en)
|
2022-01-31 |
2023-08-03 |
Kymera Therapeutics, Inc. |
Irak degraders and uses thereof
|
|
WO2023173057A1
(en)
|
2022-03-10 |
2023-09-14 |
Ikena Oncology, Inc. |
Mek inhibitors and uses thereof
|
|
WO2023173053A1
(en)
|
2022-03-10 |
2023-09-14 |
Ikena Oncology, Inc. |
Mek inhibitors and uses thereof
|
|
CN114605418B
(zh)
*
|
2022-03-15 |
2023-09-05 |
广东医科大学附属医院 |
一类具有抗肿瘤活性的依鲁替尼丙烯酰胺类衍生物及其合成方法与应用
|
|
WO2023211889A1
(en)
|
2022-04-25 |
2023-11-02 |
Ikena Oncology, Inc. |
Polymorphic compounds and uses thereof
|
|
US20250302954A1
(en)
|
2022-05-11 |
2025-10-02 |
Celgene Corporation |
Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy
|
|
KR20250040894A
(ko)
|
2022-05-25 |
2025-03-25 |
이케나 온콜로지, 인코포레이티드 |
Mek 억제제 및 이의 용도
|
|
US11807689B1
(en)
|
2022-06-01 |
2023-11-07 |
Tg Therapeutics, Inc. |
Anti-CD20 antibody compositions
|
|
US11884740B1
(en)
|
2022-06-01 |
2024-01-30 |
Tg Therapeutics, Inc. |
Anti-CD20 antibody compositions
|
|
US11965032B1
(en)
|
2022-06-01 |
2024-04-23 |
Tg Therapeutics, Inc. |
Anti-CD20 antibody compositions
|
|
US11814439B1
(en)
|
2022-06-01 |
2023-11-14 |
Tg Therapeutics, Inc. |
Anti-CD20 antibody compositions
|
|
US11786531B1
(en)
|
2022-06-08 |
2023-10-17 |
Beigene Switzerland Gmbh |
Methods of treating B-cell proliferative disorder
|
|
WO2023242384A1
(en)
|
2022-06-17 |
2023-12-21 |
Krka, D.D., Novo Mesto |
Crystalline form of ibrutinib
|
|
CN119343340A
(zh)
*
|
2022-06-22 |
2025-01-21 |
普林斯匹亚生物制药公司 |
制备修饰的btk抑制剂的方法
|
|
AU2023317742A1
(en)
|
2022-08-02 |
2025-03-20 |
Liminal Biosciences Limited |
Substituted pyridone gpr84 antagonists and uses thereof
|
|
EP4565568A1
(en)
|
2022-08-02 |
2025-06-11 |
Liminal Biosciences Limited |
Heteroaryl carboxamide and related gpr84 antagonists and uses thereof
|
|
WO2024028364A1
(en)
|
2022-08-02 |
2024-02-08 |
Liminal Biosciences Limited |
Aryl-triazolyl and related gpr84 antagonists and uses thereof
|
|
CN115417827B
(zh)
*
|
2022-09-30 |
2023-05-26 |
中国药科大学 |
6-氨基-1,3,5-三嗪类化合物及其合成方法和应用
|
|
CN120302975A
(zh)
|
2022-10-31 |
2025-07-11 |
住友制药美国公司 |
治疗骨髓增生性肿瘤的pim1抑制剂
|
|
TW202430148A
(zh)
|
2022-11-22 |
2024-08-01 |
美商皮克醫療公司 |
eIF4E抑制劑及其用途
|
|
CN118924759A
(zh)
*
|
2023-05-12 |
2024-11-12 |
武汉人福创新药物研发中心有限公司 |
含有btk抑制剂的组合物及其用途
|
|
CN118987211B
(zh)
*
|
2023-05-22 |
2025-09-19 |
无锡瓴方生物医药科技有限公司 |
一种联合用药物组合物及其应用
|
|
IL321489A
(en)
|
2023-06-23 |
2025-08-01 |
Kymera Therapeutics Inc |
IRAQ joints and their uses
|
|
TW202529769A
(zh)
|
2023-09-21 |
2025-08-01 |
日商武田藥品工業股份有限公司 |
Tyk2抑制劑及其用途
|
|
WO2025264860A2
(en)
|
2024-06-18 |
2025-12-26 |
Yale University |
Methods of treating post-covid airway disease
|