ATE207915T1 - Benzensulfonamidderivate als bradykinin antagonisten - Google Patents
Benzensulfonamidderivate als bradykinin antagonistenInfo
- Publication number
- ATE207915T1 ATE207915T1 AT96928492T AT96928492T ATE207915T1 AT E207915 T1 ATE207915 T1 AT E207915T1 AT 96928492 T AT96928492 T AT 96928492T AT 96928492 T AT96928492 T AT 96928492T AT E207915 T1 ATE207915 T1 AT E207915T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- branched
- alkyl
- linear
- nr3r4
- Prior art date
Links
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title 1
- 150000008331 benzenesulfonamides Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 101800004538 Bradykinin Proteins 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 abstract 1
- 102100035792 Kininogen-1 Human genes 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- -1 saturated heterocyclic radical Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9509885A FR2737892B1 (fr) | 1995-08-17 | 1995-08-17 | Nouveaux composes de benzenesulfonamide, procede de preparation et utilisation en therapeutique |
| PCT/FR1996/001262 WO1997007115A1 (fr) | 1995-08-17 | 1996-08-07 | Derives de benzenesulfonamide comme antagonistes de la bradykinine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE207915T1 true ATE207915T1 (de) | 2001-11-15 |
Family
ID=9481969
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96928492T ATE207915T1 (de) | 1995-08-17 | 1996-08-07 | Benzensulfonamidderivate als bradykinin antagonisten |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6080758A (de) |
| EP (1) | EP0787131B1 (de) |
| JP (1) | JPH10512285A (de) |
| AT (1) | ATE207915T1 (de) |
| DE (1) | DE69616502T2 (de) |
| DK (1) | DK0787131T3 (de) |
| ES (1) | ES2168501T3 (de) |
| FR (1) | FR2737892B1 (de) |
| PT (1) | PT787131E (de) |
| WO (1) | WO1997007115A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19609827A1 (de) * | 1996-03-13 | 1997-09-18 | Hoechst Ag | Aminoalkyl- und Acylaminoalkylether, Verfahren zu deren Herstellung und ihre Verwendung als Bradykinin-Rezeptorantagonisten |
| FR2751650B1 (fr) * | 1996-07-24 | 1998-10-09 | Fournier Ind & Sante | Nouveaux composes de n-benzenesulfonyl-l-proline, procede de preparation et utilisation en therapeutique |
| AU6422098A (en) * | 1997-03-24 | 1998-10-20 | Kyowa Hakko Kogyo Co. Ltd. | Benzene derivatives |
| DE19712960A1 (de) * | 1997-03-27 | 1998-10-01 | Hoechst Ag | Benzyloxy-substituierte, anellierte N-Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Bradykininrezeptorantagonisten |
| FR2765222B1 (fr) * | 1997-06-27 | 1999-12-31 | Fournier Ind & Sante | Nouveaux composes de n-benzenesulfonyl-l-proline, procede de preparation et utilisation en therapeutique |
| FR2790260B1 (fr) | 1999-02-26 | 2001-05-04 | Fournier Ind & Sante | Nouveaux composes de n-(benzenesulfonamide), procede de preparation et utilisation en therapeutique |
| US6699486B1 (en) | 1999-11-18 | 2004-03-02 | Bolla Corporation | Treatment or prevention of photoaging and skin cancer |
| US7105172B1 (en) | 1999-11-18 | 2006-09-12 | Bolla John D | Treatment of rosacea |
| EP1914236A1 (de) | 2002-04-10 | 2008-04-23 | Ortho-McNeil Pharmaceutical, Inc. | Neue Heteroaryl-Alkylamid-Derivate als Bradykininrezeptormodulatoren |
| DE60323631D1 (de) * | 2002-05-29 | 2008-10-30 | Dsm Ip Assets Bv | Verfahren zur reinigung einer rhizomucor aspartat-protease |
| TWI407960B (zh) | 2007-03-23 | 2013-09-11 | Jerini Ag | 小分子緩激肽ｂ２受體調節劑 |
| EP2185542A2 (de) * | 2007-08-15 | 2010-05-19 | Glaxo Group Limited | Substituierte chinolinderivate als antagonisten des h1-rezeptors |
| HUE058217T2 (hu) | 2017-11-24 | 2022-07-28 | Pharvaris Netherlands B V | Új bradikinin B2 receptor antagonisták |
| AR118983A1 (es) | 2019-05-23 | 2021-11-17 | Pharvaris Gmbh | Antagonistas cíclicos del receptor b2 de bradiquinina |
| AR118982A1 (es) | 2019-05-23 | 2021-11-17 | Pharvaris Gmbh | Antagonistas cíclicos del receptor b2 de bradiquinina |
| CN118076342B (zh) | 2021-08-05 | 2025-08-05 | 法瓦里斯有限责任公司 | 用于缓激肽b2受体拮抗剂的口服给药的脂质基组合物 |
| WO2023180575A1 (en) | 2022-03-25 | 2023-09-28 | Pharvaris Gmbh | Solid composition comprising solubilised bradykinin b2-receptor antagonists |
| US20250268887A1 (en) | 2022-03-25 | 2025-08-28 | Pharvaris Gmbh | Therapeutic uses of bradykinin b2-receptor antagonists |
| TW202345810A (zh) | 2022-03-25 | 2023-12-01 | 瑞士商帕法瑞斯有限責任公司 | 包含緩激肽ｂ２受體拮抗劑之固態延長釋放組成物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU686115B2 (en) * | 1992-11-02 | 1998-02-05 | Fujisawa Pharmaceutical Co., Ltd. | Imidazo (I,2-a) pyridine derivatives as bradykinin antagonists, pharmaceuticals and processes for their preparation |
| AU680870B2 (en) * | 1993-04-28 | 1997-08-14 | Astellas Pharma Inc. | New heterocyclic compounds |
-
1995
- 1995-08-17 FR FR9509885A patent/FR2737892B1/fr not_active Expired - Fee Related
-
1996
- 1996-08-07 WO PCT/FR1996/001262 patent/WO1997007115A1/fr not_active Ceased
- 1996-08-07 PT PT96928492T patent/PT787131E/pt unknown
- 1996-08-07 DE DE69616502T patent/DE69616502T2/de not_active Expired - Fee Related
- 1996-08-07 DK DK96928492T patent/DK0787131T3/da active
- 1996-08-07 AT AT96928492T patent/ATE207915T1/de not_active IP Right Cessation
- 1996-08-07 ES ES96928492T patent/ES2168501T3/es not_active Expired - Lifetime
- 1996-08-07 US US08/817,877 patent/US6080758A/en not_active Expired - Fee Related
- 1996-08-07 EP EP96928492A patent/EP0787131B1/de not_active Expired - Lifetime
- 1996-08-07 JP JP9508988A patent/JPH10512285A/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| FR2737892A1 (fr) | 1997-02-21 |
| US6080758A (en) | 2000-06-27 |
| EP0787131A1 (de) | 1997-08-06 |
| FR2737892B1 (fr) | 1997-10-24 |
| PT787131E (pt) | 2002-04-29 |
| DK0787131T3 (da) | 2002-02-18 |
| WO1997007115A1 (fr) | 1997-02-27 |
| EP0787131B1 (de) | 2001-10-31 |
| ES2168501T3 (es) | 2002-06-16 |
| JPH10512285A (ja) | 1998-11-24 |
| DE69616502D1 (de) | 2001-12-06 |
| DE69616502T2 (de) | 2002-06-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties | ||
| EEWE | Authorization for restitution | ||
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |