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FI970246A7 - Dihydrobentsofuraanit - Google Patents

Dihydrobentsofuraanit Download PDF

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Publication number
FI970246A7
FI970246A7 FI970246A FI970246A FI970246A7 FI 970246 A7 FI970246 A7 FI 970246A7 FI 970246 A FI970246 A FI 970246A FI 970246 A FI970246 A FI 970246A FI 970246 A7 FI970246 A7 FI 970246A7
Authority
FI
Finland
Prior art keywords
dihydrobenzofurans
compounds
formula
description
relates
Prior art date
Application number
FI970246A
Other languages
English (en)
Swedish (sv)
Other versions
FI970246A0 (fi
FI970246L (fi
Inventor
Christian Schudt
Armin Hatzelmann
Dieter Flockerzi
Hermann Amschler
Rolf Beume
Dietrich Häfner
Beate Gutterer
Wolf-Rüdiger Ulrich
Ulrich Thibaut
Hans-Peter Kley
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of FI970246A0 publication Critical patent/FI970246A0/fi
Publication of FI970246A7 publication Critical patent/FI970246A7/fi
Publication of FI970246L publication Critical patent/FI970246L/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Keksintö koskee kaavan (I) mukaisia yhdisteitä, joissa R1, R2, R3 ja R4 ovat kuvauksessa määritellyt, jotka yhdisteet ovat uusia tehokkaita PDE:n estäjiä.
FI970246A 1994-07-22 1995-07-19 Dihydrobentsofuraanit FI970246L (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH232394 1994-07-22
PCT/EP1995/002841 WO1996003399A1 (de) 1994-07-22 1995-07-19 Dihydrobenzofurane

Publications (3)

Publication Number Publication Date
FI970246A0 FI970246A0 (fi) 1997-01-21
FI970246A7 true FI970246A7 (fi) 1997-01-21
FI970246L FI970246L (fi) 1997-01-21

Family

ID=4231132

Family Applications (1)

Application Number Title Priority Date Filing Date
FI970246A FI970246L (fi) 1994-07-22 1995-07-19 Dihydrobentsofuraanit

Country Status (22)

Country Link
US (1) US6121274A (fi)
EP (1) EP0772610B9 (fi)
JP (1) JP4146894B2 (fi)
KR (1) KR100381584B1 (fi)
CN (1) CN1068879C (fi)
AT (1) ATE196765T1 (fi)
AU (1) AU702346B2 (fi)
CZ (1) CZ291758B6 (fi)
DE (1) DE59508773D1 (fi)
DK (1) DK0772610T3 (fi)
ES (1) ES2152414T3 (fi)
FI (1) FI970246L (fi)
GR (1) GR3034991T3 (fi)
HU (1) HU221504B (fi)
MX (1) MX9700557A (fi)
NO (1) NO311221B1 (fi)
NZ (1) NZ290420A (fi)
PL (1) PL185683B1 (fi)
PT (1) PT772610E (fi)
RU (1) RU2138498C1 (fi)
SK (1) SK281857B6 (fi)
WO (1) WO1996003399A1 (fi)

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PL329912A1 (en) * 1996-05-20 1999-04-26 Darwin Discovery Ltd Benzofurane carboxyamides and their therapeutic applications
DE19628622A1 (de) * 1996-07-16 1998-01-22 Byk Gulden Lomberg Chem Fab Neue 5-substituierte [2H] Chromene
DE19628621A1 (de) * 1996-07-16 1998-01-22 Byk Gulden Lomberg Chem Fab Neue 4-substituierte Benzofurane
AU4454597A (en) * 1996-08-19 1998-03-06 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel benzofuran-4-carboxamides
AU5652698A (en) * 1996-11-12 1998-06-03 Byk Gulden Lomberg Chemische Fabrik Gmbh (2,3-dihydrobenzofuranyl)-thiazoles as phosphodiesterase inhibitors
CN1114604C (zh) * 1996-11-15 2003-07-16 达尔文发现有限公司 双环芳基甲酰胺及其治疗应用
ES2193414T3 (es) * 1996-11-20 2003-11-01 Altana Pharma Ag Dihidrobenzofuranos sustituidos como inhibidores de la pde.
ATE258930T1 (de) * 1997-12-15 2004-02-15 Altana Pharma Ag Dihydrobenzifurane
GB2333041A (en) * 1998-01-13 1999-07-14 Johnson & Johnson Medical Ltd Wound Composition
SI1075476T1 (en) 1998-05-05 2003-10-31 Altana Pharma Ag Novel benzimidazoles and benzoxazoles
DE59906365D1 (de) * 1998-06-10 2003-08-28 Altana Pharma Ag Benzamide mit tetrahydrofuranyloxy-substituenten als inhibitoren der phosphodiesterase 4
SK287231B6 (sk) 1999-08-21 2010-04-07 Nycomed Gmbh Liečivo zahŕňajúce PDE inhibítor a agonistu beta2 adrenoreceptora
GB0003257D0 (en) * 2000-02-11 2000-04-05 Darwin Discovery Ltd Heterocyclic compounds and their therapeutic use
JP2005521711A (ja) * 2002-03-29 2005-07-21 中外製薬株式会社 呼吸器疾病の予防または治療のための医薬組成物
RU2368604C2 (ru) * 2002-07-19 2009-09-27 Мемори Фармасьютиклз Корпорейшн Ингибиторы фосфодиэстеразы 4, включающие n-замещенные аналоги анилина и дифениламина
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
AU2004226353A1 (en) 2003-04-01 2004-10-14 Laboratoires Serono Sa Inhibitors of phosphodiesterases in infertility
EP2270004A1 (en) * 2004-02-27 2011-01-05 Vertex Pharmceuticals Incorporated Caspase inhibitors and uses thereof
DE102004024504A1 (de) * 2004-05-18 2006-02-16 Bayer Healthcare Ag Neue Cylopenta[b]benzofuran-Derivate und ihre Verwendung
CA2615760A1 (en) * 2005-08-08 2007-02-15 Pfizer Inc. Salts and polymorphs of n,2-dimethyl-6-[7-(2-morpholinoethoxy)quinolin-4-yloxy]benzofuran-3-carboxamide
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US7842713B2 (en) * 2006-04-20 2010-11-30 Pfizer Inc Fused phenyl amido heterocyclic compounds
MX2009012062A (es) 2007-05-16 2009-11-19 Nycomed Gmbh Derivados de pirazolona como inhibidores de pde4.
US7879802B2 (en) 2007-06-04 2011-02-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
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Also Published As

Publication number Publication date
CN1068879C (zh) 2001-07-25
NO311221B1 (no) 2001-10-29
HUT77925A (hu) 1998-11-30
ES2152414T3 (es) 2001-02-01
KR100381584B1 (ko) 2003-08-21
PL318297A1 (en) 1997-06-09
SK297A3 (en) 1997-08-06
EP0772610B9 (de) 2001-07-25
ATE196765T1 (de) 2000-10-15
CN1159804A (zh) 1997-09-17
MX9700557A (es) 1997-12-31
CZ291758B6 (cs) 2003-05-14
SK281857B6 (sk) 2001-08-06
JP4146894B2 (ja) 2008-09-10
NZ290420A (en) 1999-01-28
DE59508773D1 (de) 2000-11-09
PL185683B1 (pl) 2003-07-31
WO1996003399A1 (de) 1996-02-08
FI970246A0 (fi) 1997-01-21
EP0772610B1 (de) 2000-10-04
DK0772610T3 (da) 2001-01-29
AU702346B2 (en) 1999-02-18
PT772610E (pt) 2001-03-30
NO970092L (no) 1997-01-09
HU9700022D0 (en) 1997-02-28
JPH10503484A (ja) 1998-03-31
FI970246L (fi) 1997-01-21
AU3115395A (en) 1996-02-22
US6121274A (en) 2000-09-19
RU2138498C1 (ru) 1999-09-27
HU221504B (en) 2002-10-28
GR3034991T3 (en) 2001-03-30
NO970092D0 (no) 1997-01-09
CZ18897A3 (en) 1997-09-17
EP0772610A1 (de) 1997-05-14

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