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AR132026A1 - Un proceso de preparación de l-metionina directamente a partir de l-homoserina - Google Patents

Un proceso de preparación de l-metionina directamente a partir de l-homoserina

Info

Publication number
AR132026A1
AR132026A1 ARP240100513A ARP240100513A AR132026A1 AR 132026 A1 AR132026 A1 AR 132026A1 AR P240100513 A ARP240100513 A AR P240100513A AR P240100513 A ARP240100513 A AR P240100513A AR 132026 A1 AR132026 A1 AR 132026A1
Authority
AR
Argentina
Prior art keywords
homoserine
methionine
preparing
amide
ester
Prior art date
Application number
ARP240100513A
Other languages
English (en)
Inventor
fan Lai
Qian Fan
Yonghua Dai
Pingping Yang
Jie Ren
Original Assignee
Hunan Lier Biotech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hunan Lier Biotech Co Ltd filed Critical Hunan Lier Biotech Co Ltd
Publication of AR132026A1 publication Critical patent/AR132026A1/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
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    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine
    • C—CHEMISTRY; METALLURGY
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    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
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    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01047—Cysteine synthase (2.5.1.47)
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    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01048—Cystathionine gamma-synthase (2.5.1.48)
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    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01049—O-acetylhomoserine aminocarboxypropyltransferase (2.5.1.49)
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    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01051—Beta-pyrazolylalanine synthase (2.5.1.51)
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    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01052—L-Mimosine synthase (2.5.1.52)
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    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01065—O-Phosphoserine sulfhydrylase (2.5.1.65)
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    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01076—Cysteate synthase (2.5.1.76)
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    • C12R2001/00—Microorganisms ; Processes using microorganisms
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    • C12R2001/185—Escherichia
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
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  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se provee un proceso de preparación de L-metionina mediante una reacción de catálisis enzimática de homoserina y metanotiol. El proceso de acuerdo con la presente descripción no comprende una etapa de generar O-acil-L-homoserina, y/o no se requiere O-acil-L-homoserina en el proceso. Reivindicación 1: Un proceso de preparación de L-metionina, que comprende las etapas de: a) proveer un medio de reacción, que comprende L-homoserina o una sal, un éster, una amida o un anhídrido de la misma, un donante de metiltio, y una enzima seleccionada del grupo que consiste en una transferasa que transfiere alquilo distinto de metilo o arilo, amoníaco liasa, y una liasa que cataliza la escisión de un enlace carbono-azufre; b) incubar el medio de reacción para producir un producto de reacción que comprende L-metionina o una sal, un éster, o una amida de la misma; y opcionalmente, c) recuperar la L-metionina o la sal, el éster o la amida de la misma a partir del medio de reacción.
ARP240100513A 2023-03-01 2024-02-29 Un proceso de preparación de l-metionina directamente a partir de l-homoserina AR132026A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202310186765 2023-03-01

Publications (1)

Publication Number Publication Date
AR132026A1 true AR132026A1 (es) 2025-05-21

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ID=92533835

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ARP240100513A AR132026A1 (es) 2023-03-01 2024-02-29 Un proceso de preparación de l-metionina directamente a partir de l-homoserina

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Country Link
EP (1) EP4647502A1 (es)
KR (1) KR20250155045A (es)
CN (2) CN118581171A (es)
AR (1) AR132026A1 (es)
TW (1) TWI884715B (es)
WO (1) WO2024179538A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120843473A (zh) * 2025-09-25 2025-10-28 山东天力药业有限公司 一种o-乙酰高丝氨酸硫化氢解酶突变体、表达该突变体的重组工程菌及其应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101223280B (zh) 2005-07-18 2013-05-15 赢创德固赛有限公司 二甲基二硫醚在微生物中用于甲硫氨酸生产
DE102006004063A1 (de) * 2006-01-28 2007-08-02 Degussa Gmbh Verfahren zur Herstellung von Methionin aus Homoserin
KR100905381B1 (ko) * 2006-07-28 2009-06-30 씨제이제일제당 (주) Ｌ-메치오닌 전구체 생산 균주 및 상기 ｌ-메치오닌전구체로부터의 ｌ-메치오닌 및 유기산의 생산방법
KR101048593B1 (ko) * 2009-02-27 2011-07-12 씨제이제일제당 (주) 메칠머캅탄과 디메칠설파이드의 혼합물을 사용하여 메치오닌 생산능을 증가시키는 방법
AR083468A1 (es) 2010-10-25 2013-02-27 Metabolic Explorer Sa Aumento de la disponibilidad de nadph para la produccion de metionina
AR086790A1 (es) 2011-06-29 2014-01-22 Metabolic Explorer Sa Un microorganismo para la produccion de metionina con importacion de glucosa mejorada
SG2014010441A (en) * 2011-09-02 2014-08-28 Arkema France Preparation process of l-methionine
BR112015007212B1 (pt) * 2012-10-26 2022-07-05 Adisseo France S.A.S. Método para produzir l-metionina, método para a produção de s-adenosilmetionina, método para a produção de cisteína, método para a produção de glutationa e método para a produção de 2-oxo-4-metiltiobutanoato
FR3041659B1 (fr) * 2015-09-30 2017-10-20 Arkema France Procede de production de l-methionine
KR101821050B1 (ko) * 2015-10-14 2018-03-09 씨제이제일제당 (주) 바이오-기반 n-아세틸-l-메티오닌 및 이의 용도
MY186059A (en) * 2015-11-27 2021-06-17 Evonik Operations Gmbh Method for producing l-methionine
CN105886449B (zh) 2016-04-14 2019-07-26 浙江工业大学 一种重组大肠杆菌及其生产l-甲硫氨酸的应用
KR102472559B1 (ko) 2019-06-28 2022-12-01 씨제이제일제당 주식회사 황 함유 아미노산 또는 그 유도체의 제조방법
CN113215124A (zh) 2021-04-27 2021-08-06 浙江工业大学 一种o-琥珀酰巯基转移酶在l-甲硫氨酸合成中的应用

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CN120769919A (zh) 2025-10-10
EP4647502A9 (en) 2025-12-24
KR20250155045A (ko) 2025-10-29
TWI884715B (zh) 2025-05-21
EP4647502A1 (en) 2025-11-12
WO2024179538A1 (zh) 2024-09-06
TW202440940A (zh) 2024-10-16
CN118581171A (zh) 2024-09-03

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