AR086790A1 - Un microorganismo para la produccion de metionina con importacion de glucosa mejorada - Google Patents
Un microorganismo para la produccion de metionina con importacion de glucosa mejoradaInfo
- Publication number
- AR086790A1 AR086790A1 ARP120102329A ARP120102329A AR086790A1 AR 086790 A1 AR086790 A1 AR 086790A1 AR P120102329 A ARP120102329 A AR P120102329A AR P120102329 A ARP120102329 A AR P120102329A AR 086790 A1 AR086790 A1 AR 086790A1
- Authority
- AR
- Argentina
- Prior art keywords
- methionine
- importation
- glucose
- microorganism
- production
- Prior art date
Links
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title abstract 5
- 239000008103 glucose Substances 0.000 title abstract 5
- 244000005700 microbiome Species 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 4
- 229930182817 methionine Natural products 0.000 abstract 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 238000000855 fermentation Methods 0.000 abstract 2
- 230000004151 fermentation Effects 0.000 abstract 2
- 239000001963 growth medium Substances 0.000 abstract 2
- 150000002741 methionine derivatives Chemical class 0.000 abstract 2
- 238000012986 modification Methods 0.000 abstract 2
- 230000004048 modification Effects 0.000 abstract 2
- 241000186031 Corynebacteriaceae Species 0.000 abstract 1
- 241000588921 Enterobacteriaceae Species 0.000 abstract 1
- 101100203163 Escherichia coli (strain K12) sgrT gene Proteins 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108010071189 phosphoenolpyruvate-glucose phosphotransferase Proteins 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/12—Methionine; Cysteine; Cystine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Microorganismo recombinante para la producción de metionina mejorada que comprende modificaciones para producir metionina a partir de glucosa como fuente principal de carbono por fermentación, y modificaciones para mejorar la importación de glucosa, en donde la importación de glucosa se mejora mediante la modificación de la expresión de al menos un gen seleccionado de ptsG, sgrT sgrS y dgsA, y donde el microorganismo es la familia bacteriana Enterobacteriaceae o Corynebacteriaceae. También se divulga con un método para la producción fermentativa de metionina o derivados de metionina que comprende las etapas de: el cultivo del microorganismo recombinante tal como se ha descrito anteriormente en un medio de cultivo adecuado que comprende una fuente fermentable de carbono que contiene glucosa y una fuente de azufre, y la recuperación de metionina o derivados de metionina del medio de cultivo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161502528P | 2011-06-29 | 2011-06-29 | |
| EP11305829 | 2011-06-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR086790A1 true AR086790A1 (es) | 2014-01-22 |
Family
ID=47423448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120102329A AR086790A1 (es) | 2011-06-29 | 2012-06-28 | Un microorganismo para la produccion de metionina con importacion de glucosa mejorada |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9506092B2 (es) |
| EP (1) | EP2726626B1 (es) |
| JP (1) | JP2014522642A (es) |
| KR (1) | KR102029819B1 (es) |
| CN (1) | CN103781913B (es) |
| AR (1) | AR086790A1 (es) |
| BR (1) | BR112013033675B1 (es) |
| ES (1) | ES2654589T3 (es) |
| MX (1) | MX347843B (es) |
| MY (1) | MY166543A (es) |
| PL (1) | PL2726626T3 (es) |
| WO (1) | WO2013001055A1 (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112014031425B1 (pt) | 2012-06-18 | 2022-01-18 | Evonik Operations Gmbh | Microrganismo recombinante para produção fermentativa de metionina |
| EP3039120B1 (en) * | 2013-08-30 | 2019-02-27 | Evonik Degussa GmbH | A microorganism for methionine production with enhanced methionine efflux |
| EP3039153B1 (en) | 2013-08-30 | 2018-08-22 | Evonik Degussa GmbH | Microorganism for methionine production with improved methionine synthase activity and methionine efflux |
| EP3189150A1 (en) | 2014-09-01 | 2017-07-12 | Metabolic Explorer | Method and microorganism for methionine production by fermentation with improved methionine efflux |
| EP3050970B1 (en) | 2015-01-28 | 2019-09-18 | Metabolic Explorer | Modified microorganism for optimized production of 1,4-butanediol |
| RU2017136561A (ru) * | 2015-03-18 | 2019-04-18 | Басф Се | Рекомбинантный микроорганизм для улучшенного получения химических продуктов тонкого органического синтеза |
| WO2016162712A1 (en) | 2015-04-07 | 2016-10-13 | Metabolic Explorer | Modified microorganism for the optimized production of 2,4-dihydroxyburyrate |
| US10858675B2 (en) | 2015-04-07 | 2020-12-08 | Metabolic Explorer | Modified microorganism for the optimized production of 2,4-dihydroxybutyrate with enhanced 2,4-dihydroxybutyrate efflux |
| MY184139A (en) | 2015-08-07 | 2021-03-22 | Evonik Operations Gmbh | Protein thiocarboxylate-dependent l-methionine production by fermentation |
| PL3380627T3 (pl) | 2015-11-27 | 2020-01-31 | Evonik Degussa Gmbh | Sposób wytwarzania L-metioniny |
| BR112018013873A2 (pt) | 2016-01-08 | 2018-12-18 | Evonik Degussa Gmbh | método para a produção fermentativa de l-metionina e/ou seus derivados |
| KR101853961B1 (ko) * | 2016-04-19 | 2018-06-20 | (주)휴맥스 | 포스 입력의 식별 서비스 제공 장치 및 방법 |
| EP3296404A1 (en) | 2016-09-15 | 2018-03-21 | Evonik Degussa GmbH | Modified microorganism for production of methionine |
| EP3354742A1 (en) | 2017-01-26 | 2018-08-01 | Metabolic Explorer | Methods and microorganisms for the production of glycolic acid and/or glyoxylic acid |
| MY200267A (en) | 2017-07-11 | 2023-12-18 | Adisseo France Sas | Methionine-producing yeast |
| EP3470512A1 (en) | 2017-10-10 | 2019-04-17 | Metabolic Explorer | Mutant phosphoserine aminotransferase for the conversion of homoserine into 4-hydroxy-2-ketobutyrate |
| KR102221040B1 (ko) * | 2019-05-09 | 2021-03-03 | 씨제이제일제당 주식회사 | L-아미노산을 생산하는 미생물 및 이를 이용한 l-아미노산을 생산하는 방법 |
| EP4392551A1 (en) | 2021-08-25 | 2024-07-03 | Metabolic Explorer | Dehydrogenase mutants and applications thereof in amino acid synthesis |
| US20250027124A1 (en) | 2021-11-17 | 2025-01-23 | Metabolic Explorer | Microorganism and method for the improved production of valine |
| EP4486760A1 (en) | 2022-03-01 | 2025-01-08 | Metabolic Explorer | Microorganism and method for the improved production of leucine and/or isoleucine |
| CA3225234A1 (en) | 2022-08-04 | 2024-02-08 | Metabolic Explorer | Microorganism and method for the improved production of serine and/or cysteine |
| KR20250155045A (ko) | 2023-03-01 | 2025-10-29 | 후난 라이어 바이오테크 씨오., 엘티디. | L-호모세린으로부터 직접적으로 l-메티오닌을 제조하는 공정 |
| EP4467640A1 (en) | 2023-05-23 | 2024-11-27 | Metabolic Explorer | Microorganism and method for the improved production of cysteine and/or derivatives thereof |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4110641B2 (ja) | 1998-11-17 | 2008-07-02 | 味の素株式会社 | 発酵法によるｌ−メチオニンの製造法 |
| JP2000157267A (ja) | 1998-11-24 | 2000-06-13 | Ajinomoto Co Inc | 変異型ｍｅｔＪ遺伝子及びＬ−メチオニンの製造法 |
| AU2001285844A1 (en) | 2000-08-02 | 2002-02-13 | Degussa A.G. | Nucleotide sequences which code for the meth gene |
| DE10116518A1 (de) | 2001-04-03 | 2002-10-17 | Degussa | Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung von Stämmen der Familie Enterobacteriaceae |
| ES2336655T3 (es) * | 2001-07-06 | 2010-04-15 | Evonik Degussa Gmbh | Proceso para la preparacion de l-aminoacidos que utiliza cepas de la familia enterobacteriaceas. |
| RU2245919C2 (ru) | 2002-09-06 | 2005-02-10 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | Способ получения l-аминокислоты, штамм escherichia coli tdh7δ mlc::cat/pprt614-продуцент l-треонина |
| DE10303571A1 (de) * | 2003-01-30 | 2004-08-12 | Degussa Ag | Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung von Stämmen der Familie Enterobacteriaceae |
| US20060270013A1 (en) | 2003-02-18 | 2006-11-30 | Michel Chateau | Method for the production of evolved microorganisms which permit the generation or modification of metabolic pathways |
| DE10314618A1 (de) * | 2003-04-01 | 2004-10-14 | Degussa Ag | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von Stämmen der Familie Enterobacteriaceae |
| DE10359594A1 (de) | 2003-12-18 | 2005-07-28 | Basf Ag | PEF-TU-Expressionseinheiten |
| DE102004003411A1 (de) * | 2004-01-23 | 2005-09-01 | Degussa Ag | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von Stämmen der Familie Enterobacteriaceae |
| DE102004005836A1 (de) * | 2004-02-06 | 2005-09-15 | Degussa Ag | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von Stämmen der Familie Enterobacteriaceae |
| KR100651220B1 (ko) | 2004-06-29 | 2006-11-29 | 씨제이 주식회사 | Ｌ-메씨오닌 생산 균주 및 상기 균주를 이용한ｌ-메씨오닌의 생산방법 |
| DE102004035065A1 (de) | 2004-07-20 | 2006-02-16 | Basf Ag | P-ET-TS-Expressionseinheiten |
| ES2459617T3 (es) | 2006-01-04 | 2014-05-12 | Metabolic Explorer | Procedimiento para la preparación de metionina y sus precursores homoserina o succinilhomoserina que utiliza un microorganismo |
| WO2007119576A1 (en) * | 2006-03-23 | 2007-10-25 | Ajinomoto Co., Inc. | A method for producing an l-amino acid using a bacterium of the enterobacteriaceae family |
| WO2009043372A1 (en) * | 2007-10-02 | 2009-04-09 | Metabolic Explorer | Increasing methionine yield |
| BRPI0819509A2 (pt) | 2007-12-18 | 2014-10-14 | Korea Advanced Inst Sci & Tech | MICROORGANISMO E VETOR RECOMBINANTE, SACAROSE FOSFOTRANSFERASE, GENE (ptsG), BETA-FRUTOFURANOSIDASE E MÉTODO PARA PRODUZIR METABÓLITOCOS, POLÍMEROS BIODEGRADÁVEIS OU PROTEÍNAS RECOMBINANTES |
| WO2010020290A1 (en) * | 2008-08-22 | 2010-02-25 | Metabolic Explorer | Producing methionine without n-acetyl methionine |
| AR083468A1 (es) | 2010-10-25 | 2013-02-27 | Metabolic Explorer Sa | Aumento de la disponibilidad de nadph para la produccion de metionina |
| WO2012090021A1 (en) * | 2010-12-30 | 2012-07-05 | Metabolic Explorer | Recombinant microorganism for the fermentative production of methionine |
-
2012
- 2012-06-28 AR ARP120102329A patent/AR086790A1/es unknown
- 2012-06-29 MX MX2013015202A patent/MX347843B/es active IP Right Grant
- 2012-06-29 KR KR1020147002040A patent/KR102029819B1/ko active Active
- 2012-06-29 BR BR112013033675-7A patent/BR112013033675B1/pt active IP Right Grant
- 2012-06-29 WO PCT/EP2012/062674 patent/WO2013001055A1/en not_active Ceased
- 2012-06-29 MY MYPI2013004653A patent/MY166543A/en unknown
- 2012-06-29 JP JP2014517728A patent/JP2014522642A/ja not_active Ceased
- 2012-06-29 CN CN201280042510.4A patent/CN103781913B/zh active Active
- 2012-06-29 PL PL12730555T patent/PL2726626T3/pl unknown
- 2012-06-29 US US14/128,715 patent/US9506092B2/en active Active
- 2012-06-29 EP EP12730555.5A patent/EP2726626B1/en not_active Not-in-force
- 2012-06-29 ES ES12730555.5T patent/ES2654589T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| MX2013015202A (es) | 2014-02-17 |
| WO2013001055A1 (en) | 2013-01-03 |
| EP2726626A1 (en) | 2014-05-07 |
| BR112013033675A2 (pt) | 2018-06-19 |
| JP2014522642A (ja) | 2014-09-08 |
| US20140134680A1 (en) | 2014-05-15 |
| US9506092B2 (en) | 2016-11-29 |
| KR102029819B1 (ko) | 2019-10-08 |
| EP2726626B1 (en) | 2017-11-15 |
| CN103781913B (zh) | 2016-02-24 |
| BR112013033675B1 (pt) | 2021-06-29 |
| KR20140043804A (ko) | 2014-04-10 |
| MX347843B (es) | 2017-05-16 |
| MY166543A (en) | 2018-07-16 |
| ES2654589T3 (es) | 2018-02-14 |
| CN103781913A (zh) | 2014-05-07 |
| PL2726626T3 (pl) | 2018-05-30 |
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Legal Events
| Date | Code | Title | Description |
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| FB | Suspension of granting procedure |