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MX2025003150A - Metodo enzimatico para producir l-glufosinato y sus fosfoesteres - Google Patents

Metodo enzimatico para producir l-glufosinato y sus fosfoesteres

Info

Publication number
MX2025003150A
MX2025003150A MX2025003150A MX2025003150A MX2025003150A MX 2025003150 A MX2025003150 A MX 2025003150A MX 2025003150 A MX2025003150 A MX 2025003150A MX 2025003150 A MX2025003150 A MX 2025003150A MX 2025003150 A MX2025003150 A MX 2025003150A
Authority
MX
Mexico
Prior art keywords
glufosinate
phosphoesters
producing
enzymatic method
methylphosphinic acid
Prior art date
Application number
MX2025003150A
Other languages
English (en)
Inventor
Daniel Fischer
Ludger Lautenschütz
Steffen Schaffer
Markus Pötter
Original Assignee
Evonik Operations Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Operations Gmbh filed Critical Evonik Operations Gmbh
Publication of MX2025003150A publication Critical patent/MX2025003150A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01048—Cystathionine gamma-synthase (2.5.1.48)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01049—O-acetylhomoserine aminocarboxypropyltransferase (2.5.1.49)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se refiere a un método catalizado enzimáticamente para producir L-glufosinato o un fosfoéster del mismo. El método comprende una etapa en la que una L-homoserina HA activada se hace reaccionar con un sustrato S seleccionado de ácido metilfosfínico y los ésteres del ácido metilfosfínico. Para la catálisis enzimática se utilizan enzimas sulfhidrilasas E1. La invención hace accesibles nuevos sustratos en la producción enzimática de L glufosinato y sus fosfoésteres.
MX2025003150A 2022-09-21 2025-03-18 Metodo enzimatico para producir l-glufosinato y sus fosfoesteres MX2025003150A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2022/076215 WO2024061455A1 (en) 2022-09-21 2022-09-21 Enzymatic method for producing l-glufosinate and its phosphoesters

Publications (1)

Publication Number Publication Date
MX2025003150A true MX2025003150A (es) 2025-04-02

Family

ID=83995463

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2025003150A MX2025003150A (es) 2022-09-21 2025-03-18 Metodo enzimatico para producir l-glufosinato y sus fosfoesteres

Country Status (9)

Country Link
US (1) US20260002183A1 (es)
EP (1) EP4590846A1 (es)
JP (1) JP2025531377A (es)
CN (1) CN119907861A (es)
AR (1) AR130521A1 (es)
AU (1) AU2022479282A1 (es)
MX (1) MX2025003150A (es)
PE (1) PE20251258A1 (es)
WO (1) WO2024061455A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112023020035A2 (pt) 2021-04-01 2023-11-14 Evonik Operations Gmbh Método enzimático para produzir l-glufosinato e seus fosfoésteres
EP4105335A1 (en) 2021-06-16 2022-12-21 Evonik Operations GmbH Enzymatic method for the production of l-glufosinate p-alkyl esters

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5795776A (en) 1994-03-22 1998-08-18 Bio-Technology General Corp. Expression plasmids regulated by an OSMB promoter
DE10031999A1 (de) 1999-09-09 2001-04-19 Degussa Verfahren zur fermentativen Herstellung von D-Pantothensäure unter Verwendung coryneformer Bakterien
DE10109690A1 (de) 2000-09-02 2002-03-14 Degussa Neue für das metY-Gen kodierende Nukleotidsequenzen
US7445879B2 (en) 2005-08-23 2008-11-04 Nukote International, Inc. Preparation of suspension polymerized toners
KR100905381B1 (ko) 2006-07-28 2009-06-30 씨제이제일제당 (주) Ｌ-메치오닌 전구체 생산 균주 및 상기 ｌ-메치오닌전구체로부터의 ｌ-메치오닌 및 유기산의 생산방법
KR101048593B1 (ko) 2009-02-27 2011-07-12 씨제이제일제당 (주) 메칠머캅탄과 디메칠설파이드의 혼합물을 사용하여 메치오닌 생산능을 증가시키는 방법
NO2657250T3 (es) 2010-12-21 2018-02-03
US20170051323A1 (en) 2014-04-30 2017-02-23 Evonik Degussa Gmbh Method for Producing L-Amino Acids Using an Alkaliphilic Bacteria
US9834802B2 (en) 2016-03-02 2017-12-05 Agrimetis, Llc Methods for making L-glufosinate
CN106083922B (zh) 2016-08-23 2018-08-31 山东省农药科学研究院 一种精草铵膦的制备方法
AU2018304177B2 (en) 2017-07-18 2023-11-02 Basf Se Methods for the purification of L-glufosinate
CN108516991A (zh) 2018-05-28 2018-09-11 山东省农药科学研究院 一种精草铵膦的制备方法
CN112739822A (zh) 2018-09-05 2021-04-30 巴斯夫欧洲公司 改善l-草胺膦产率的方法
EP3909961B1 (en) 2019-01-11 2026-02-18 CJ CheilJedang Corporation L-glufosinate intermediate and l-glufosinate preparation method
KR102582675B1 (ko) 2019-01-11 2023-09-25 씨제이제일제당 주식회사 글루포시네이트 제조 방법
KR102182497B1 (ko) * 2019-12-20 2020-11-24 씨제이제일제당 주식회사 내막 단백질의 변이체 및 이를 이용한 목적 산물 생산 방법
BR112023020035A2 (pt) * 2021-04-01 2023-11-14 Evonik Operations Gmbh Método enzimático para produzir l-glufosinato e seus fosfoésteres

Also Published As

Publication number Publication date
CN119907861A (zh) 2025-04-29
EP4590846A1 (en) 2025-07-30
PE20251258A1 (es) 2025-05-06
AU2022479282A1 (en) 2025-05-01
US20260002183A1 (en) 2026-01-01
JP2025531377A (ja) 2025-09-19
WO2024061455A1 (en) 2024-03-28
AR130521A1 (es) 2024-12-11

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