[go: up one dir, main page]

AR122601A2 - Composiciones parasiticidas que comprenden múltiples agentes activos, métodos y usos de las mismas - Google Patents

Composiciones parasiticidas que comprenden múltiples agentes activos, métodos y usos de las mismas

Info

Publication number
AR122601A2
AR122601A2 ARP210101597A ARP210101597A AR122601A2 AR 122601 A2 AR122601 A2 AR 122601A2 AR P210101597 A ARP210101597 A AR P210101597A AR P210101597 A ARP210101597 A AR P210101597A AR 122601 A2 AR122601 A2 AR 122601A2
Authority
AR
Argentina
Prior art keywords
haloalkyl
alkyl
halogen
alkoxy
hydrogen
Prior art date
Application number
ARP210101597A
Other languages
English (en)
Inventor
Joseph Rosenthal
Monica Tejwani
Arima Das-Nandy
Original Assignee
Merial Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44009983&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR122601(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merial Inc filed Critical Merial Inc
Publication of AR122601A2 publication Critical patent/AR122601A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/60—1,4-Diazines; Hydrogenated 1,4-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/02—Acyclic compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N49/00—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds containing the group, wherein m+n>=1, both X together may also mean —Y— or a direct carbon-to-carbon bond, and the carbon atoms marked with an asterisk are not part of any ring system other than that which may be formed by the atoms X, the carbon atoms in square brackets being part of any acyclic or cyclic structure, or the group, wherein A means a carbon atom or Y, n>=0, and not more than one of these carbon atoms being a member of the same ring system, e.g. juvenile insect hormones or mimics thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/231—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having one or two double bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N2300/00—Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Pest Control & Pesticides (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Insects & Arthropods (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pretreatment Of Seeds And Plants (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Composiciones para combatir los ectoparásitos y los endoparásitos en los animales, que comprenden al menos un 1-arilpirazol, al menos una lactona macrocíclica, al menos un regulador del crecimiento de los insectos y al menos un compuesto antihelmíntico, en combinación con un vehículo farmacéuticamente aceptable. Métodos mejorados para erradicar, controlar y prevenir las infecciones y las infestaciones de parásitos en un animal, que comprenden administrarle las composiciones de la invención al animal que lo necesita. Reivindicación 1: Una composición veterinaria tópica en forma de una formulación de aplicación puntual o para verter, para tratar o prevenir una infección o una infestación de parásitos en un animal, caracterizada porque comprende (a) una combinación de al menos un agente activo de 1-arilpirazol, de fórmula (1) donde: R¹ es hidrógeno, ciano, nitro, halógeno, R³, R⁸, formilo, -C(O)R⁸, -C(O)OR⁸, -C(O)NR⁹R¹⁰, -C(=NOH)NH₂, -C(=NNH₂)R⁹, o -C(S)NH₂; R² es R⁸, halógeno, ciano, nitro, -SCN, 4-5-dicianoimidazol-2-ilo, o -S(O)ₘR¹¹; R³ es hidrógeno, halógeno, alquilo, haloalquilo, OH, OR⁸, S(O)ₘR¹¹, -C(O)R⁸, -C(O)OR⁸, NR⁹R¹⁰, -N=C(R⁹)(R¹⁴), -N=C(R¹⁰)-Z-(R⁹), -N=C(R¹⁰)-NR⁹R¹⁰, -N(R⁸)-C(R¹⁰)=NR⁹, -N(R¹¹)C(O)CR¹⁵R¹⁰R¹¹, -N(R¹¹)C(O)arilo, -N(R¹¹)C(O)heteroarilo o -N(R¹¹)C(O)OR¹⁰; R⁴, R⁵ y R⁷ son independientemente hidrógeno, halógeno, alquilo, haloalquilo, ciano o nitro; R⁶ es halógeno, alquilo, haloalquilo, alcoxi, haloalquiloxi, ciano, nitro, -C(O)R¹², -S(O)ₙR¹² o SF₅; X es un átomo de nitrógeno o C-R¹³; Z es O, S(O)ₘ o NR⁹; R⁸ es alquilo o haloalquilo; R⁹ es hidrógeno, alquilo, haloalquilo o alcoxi; R¹⁰ es hidrógeno, alquilo, haloalquilo, alcoxi, o -C(O)R⁸; R¹¹ es alquilo, haloalquilo, alquenilo, haloalquenilo, alquinilo, haloalquinilo, alcoxialquilo, o haloalcoxialquilo; R¹² es alquilo o haloalquilo; R¹³ es hidrógeno, halógeno, ciano, nitro, alquilo, haloalquilo, alcoxi o haloalcoxi; R¹⁴ se sustituye opcionalmente arilo u opcionalmente heteroarilo sustituido; R¹⁵ es hidrógeno, halógeno, alcoxi, haloalcoxi, alcoxialquilo, haloalcoxialquilo, formiloxi, alquilcarboniloxi, haloalquilcarboniloxi, alquiltio, haloalquiltio, alquilsulfinilo, haloalquilsulfinilo, alquilsulfonilo, haloalquilsulfonilo, alquilamino, dialquilamino, haloalquilamino, di(haloalquil)amino, ariloxi o arilalcoxi; donde dichos grupos alquilo, haloalquilo, alcoxi, se sustituyen opcionalmente con alquilo, haloalquilo, alcoxi, arilo, o heteroarilo; dichos grupos arilo o heteroarilo se sustituyen opcionalmente con uno o más de alquilo, haloalquilo, arilo, halógeno, C(O)R⁸, -C(O)OR⁸, -C(O)NR⁹R¹⁰, -C(S)NH₂, o -S(O)ₘR¹¹ m es 0, 1 ó 2; y n es 0, 1 ó 2; o una sal aceptable farmacéuticamente, hidrato o solvato del mismo; al menos un agente activo que es una lactona macrocíclica que es una avermectina o una milbemicina; al menos un agente activo que es un regulador del crecimiento de los insectos que se selecciona de (S)-metopreno, piriproxifeno, hidropreno, ciromazina, fluazurón, lufenurón y novalurón; y al menos un agente activo antihelmíntico que se selecciona de tiabendazol, oxibendazol, mebendazol, fenbendazol, oxfendazol, albendazol, triclabendazol, febantel, levamisol, pirantel, morantel, praziquantel, closantel, clorsulón, un agente activo de amino acetonitrilo o un agente activo de arilazol-2-il cianoetilamino; (b) un vehículo farmacéuticamente aceptable que comprende glicerol formal y dimetil isosorbide; y (c) opcionalmente un inhibidor de la cristalización. Reivindicación 8: Una composición de acuerdo con la reivindicación 1, caracterizada porque comprende: aproximadamente 5% a aproximadamente 15% (p/v) de fipronil; aproximadamente 0.01 a 2% (p/v) de al menos uno de eprinomectina, ivermectina, oxima de milbemicina o moxidectina; aproximadamente 5 a aproximadamente 15% (p/v) de al menos uno de (S)-metopreno, piriproxifeno; y aproximadamente 5 a 15% (p/v) de al menos uno de febantel, levamisol, pirantel, o praziquantel. Reivindicación 10: La composición de la reivindicación 1, caracterizada porque el al menos un 1-arilpirazol es fipronil, la al menos una lactona macrocíclica es eprinomectina, el al menos un IGR es (S)-metopreno y el al menos un antihelmíntico es praziquantel.
ARP210101597A 2010-04-02 2021-06-11 Composiciones parasiticidas que comprenden múltiples agentes activos, métodos y usos de las mismas AR122601A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32055910P 2010-04-02 2010-04-02

Publications (1)

Publication Number Publication Date
AR122601A2 true AR122601A2 (es) 2022-09-21

Family

ID=44009983

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP110101108A AR081754A1 (es) 2010-04-02 2011-04-01 Composiciones parasiticidas que comprenden multiples agentes activos, metodos y usos de las mismas
ARP210101597A AR122601A2 (es) 2010-04-02 2021-06-11 Composiciones parasiticidas que comprenden múltiples agentes activos, métodos y usos de las mismas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP110101108A AR081754A1 (es) 2010-04-02 2011-04-01 Composiciones parasiticidas que comprenden multiples agentes activos, metodos y usos de las mismas

Country Status (37)

Country Link
US (2) US9173403B2 (es)
EP (2) EP2552201B1 (es)
JP (2) JP6060360B2 (es)
KR (2) KR101936557B1 (es)
CN (2) CN102869253B (es)
AP (2) AP2014008017A0 (es)
AR (2) AR081754A1 (es)
AU (1) AU2011234984B2 (es)
BR (1) BR112012025203B1 (es)
CA (1) CA2793880C (es)
CL (1) CL2012002764A1 (es)
CO (1) CO6630175A2 (es)
CR (1) CR20120483A (es)
CY (2) CY1118622T1 (es)
DK (2) DK3175711T3 (es)
EA (1) EA022068B1 (es)
ES (2) ES2619255T3 (es)
HR (2) HRP20170385T1 (es)
HU (2) HUE052270T2 (es)
IL (2) IL222063A (es)
LT (2) LT3175711T (es)
ME (1) ME02605B (es)
MX (2) MX351637B (es)
MY (1) MY161635A (es)
NZ (3) NZ602721A (es)
PH (1) PH12012501894A1 (es)
PL (2) PL226804B1 (es)
PT (2) PT3175711T (es)
RS (2) RS61147B1 (es)
RU (1) RU2633751C1 (es)
SG (1) SG184171A1 (es)
SI (2) SI3175711T1 (es)
SM (2) SMT201700151T1 (es)
TW (2) TWI574623B (es)
UA (1) UA108641C2 (es)
WO (1) WO2011123773A1 (es)
ZA (2) ZA201207073B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3788874A1 (en) * 2011-09-12 2021-03-10 Boehringer Ingelheim Animal Health USA Inc. Parasiticidal compositions comprising an isoxazoline active agent, method and uses thereof
AU2012227241C1 (en) * 2011-09-23 2017-01-19 Virbac (Australia) Pty Limited Veterinary Topical Formulation
JP5800669B2 (ja) * 2011-10-18 2015-10-28 大阪化成株式会社 抗菌・抗カビ性付与剤、繊維類加工剤及び抗菌・抗カビ性繊維類の製造方法
CA2852607C (en) 2011-10-18 2021-05-04 Institut National De La Recherche Agronomique Use of avermectin derivative for increasing bioavailability and efficacy of macrocylic lactones
NZ712345A (en) * 2013-04-12 2016-04-29 Zoetis Services Llc Composition of macrocyclic lactones, levamisole, an amino sugar and an additional antiparasitic agent
AU2013204176B2 (en) * 2013-04-12 2016-06-02 Zoetis Services Llc Stable veterinary combination formulations of macrocyclic lactones and imidazothiazoles
US20160081986A1 (en) * 2013-05-20 2016-03-24 Zoetis Services Llc Long-acting spiro-isoxazoline antiparasitic compositions
WO2016112317A1 (en) * 2015-01-09 2016-07-14 Abbvie Inc. Treatment of filarial diseases
FR3039400B1 (fr) * 2015-07-27 2017-08-18 Virbac Nouvelles compositions veterinaires pour la prevention et le traitement simultane des endoparasites et ectoparasites
DE202015103926U1 (de) 2015-07-27 2015-09-15 Virbac Neue veterinärmedizinische Zusammensetzungen für die gleichzeitige Vorbeugung und Behandlung von Endoparasiten und Ektoparasiten
WO2017017091A1 (fr) * 2015-07-27 2017-02-02 Virbac Nouvelles compositions vétérinaires pour la prévention et le traitement simultané des endoparasites et ectoparasites
EP3373898A1 (en) 2015-11-09 2018-09-19 Merial, Inc. Pet care compositions
GB201520724D0 (en) 2015-11-24 2016-01-06 Merial Inc Veterinary formulations
JP6666433B2 (ja) * 2016-04-26 2020-03-13 オルガノ株式会社 水処理剤組成物および水処理方法
US11160867B2 (en) * 2017-05-11 2021-11-02 Auburn University Anti-protozoal compounds and uses thereof
WO2019005700A1 (en) * 2017-06-26 2019-01-03 Merial, Inc. DOUBLE-ACTING PARASITICIDE GRANULATE COMPOSITIONS, METHODS AND USES THEREOF
RU2659174C1 (ru) * 2017-08-31 2018-06-28 Общество с ограниченной ответственностью "Научно-внедренческий центр Агроветзащита" (ООО "НВЦ Агроветзащита") Противопаразитарная композиция для защиты сельскохозяйственных животных
US11583545B2 (en) * 2018-02-08 2023-02-21 Boehringer Ingelheim Animal Health USA Inc. Parasiticidal compositions comprising eprinomectin and praziquantel, methods and uses thereof
RU2692620C1 (ru) * 2018-04-13 2019-06-25 Федеральное государственное бюджетное учреждение науки Федеральный исследовательский центр Тюменский научный центр Сибирского отделения Российской академии наук (ТюмНЦ СО РАН) Способ снижения численности мух на объектах ветеринарно-санитарного надзора
DK3846786T3 (da) * 2018-09-05 2024-12-02 Zoetis Services Llc Velsmagende antiparasitære formuleringer
KR102188378B1 (ko) * 2018-11-02 2020-12-08 녹십자수의약품(주) 셀라멕틴을 포함하는 구충제 조성물
WO2020112374A1 (en) * 2018-11-20 2020-06-04 Boehringer Ingelheim Animal Health USA Inc. Indazolylcyanoethylamino compound, compositions of same, method of making, and methods of using thereof
RU2709019C1 (ru) * 2019-01-29 2019-12-13 Федеральное государственное бюджетное научное учреждение "Федеральный научный центр - Всероссийский научно-исследовательский институт экспериментальной ветеринарии имени К.И. Скрябина и Я.Р. Коваленко Российской академии наук" Антигельминтное средство
BR112021016196A2 (pt) * 2019-03-01 2021-10-05 Boehringer Ingelheim Animal Health USA Inc. Composições injetáveis de clorsulon, métodos e usos das mesmas
EP4013388A1 (en) 2019-08-14 2022-06-22 Vetoquinol SA Compositions comprising tigolaner for controlling parasites
CN111587861A (zh) * 2020-05-21 2020-08-28 广州市穗升有害生物防治中心 引诱箱
CN112006981B (zh) * 2020-07-30 2023-01-10 瑞普（天津）生物药业有限公司 一种长效复方驱虫药物液体制剂及其制备方法与应用
US12342828B2 (en) 2020-09-14 2025-07-01 Insight Pharmaceuticals Corporation Repellant formulation and method
CN113662917B (zh) * 2021-09-15 2023-01-10 谢彩华 一种莫奈太尔乳剂及其制备方法
CN114042065B (zh) * 2021-11-26 2024-03-15 长沙拜特生物科技研究所有限公司 一种复方甲苯咪唑透皮溶液剂及其制备方法
US20240423959A1 (en) * 2022-06-21 2024-12-26 Jjr&D, Llc Topical benzimidazole formulations and methods for use in treating inflammatory dermatoses

Family Cites Families (125)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6426333B1 (en) 1996-09-19 2002-07-30 Merial Spot-on formulations for combating parasites
FR2753377B1 (fr) 1996-09-19 1999-09-24 Rhone Merieux Nouvelle association parasiticide a base de 1-n-phenylpyra- zoles et de lactones macrocycliques endectocides
US3318769A (en) 1963-05-31 1967-05-09 Shell Oil Co Resin compositions comprising organo-phosphorus pesticides
NL160809C (nl) 1970-05-15 1979-12-17 Duphar Int Res Werkwijze ter bereiding van benzoylureumverbindingen, alsmede werkwijze ter bereiding van insekticide prepara- ten op basis van benzoylureumverbindingen.
US4001441A (en) 1970-12-21 1977-01-04 The Procter & Gamble Company Meat analog
US3852416A (en) 1971-05-27 1974-12-03 L Grubb Tick and flea collar of solid solution plasticized vinylic resin-carbamate insecticide
US3950360A (en) 1972-06-08 1976-04-13 Sankyo Company Limited Antibiotic substances
JPS4914624A (es) 1972-06-08 1974-02-08
US3818047A (en) 1972-08-07 1974-06-18 C Henrick Substituted pyrones
US4150109A (en) 1974-05-07 1979-04-17 Dick Pierre R G Devices for protecting animals from ectoparasites
SE434277B (sv) 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
CH604517A5 (es) 1976-08-19 1978-09-15 Ciba Geigy Ag
US4256108A (en) 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4134973A (en) 1977-04-11 1979-01-16 Merck & Co., Inc. Carbohydrate derivatives of milbemycin and processes therefor
US4199569A (en) 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
US4144352A (en) 1977-12-19 1979-03-13 Merck & Co., Inc. Milbemycin compounds as anthelmintic agents
US4203976A (en) 1978-08-02 1980-05-20 Merck & Co., Inc. Sugar derivatives of C-076 compounds
US4265874A (en) 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
JPS57139012A (en) 1981-02-23 1982-08-27 Sankyo Co Ltd Anthelmintic composition
US4427663A (en) 1982-03-16 1984-01-24 Merck & Co., Inc. 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof
DE3235931A1 (de) 1982-09-29 1984-03-29 Bayer Ag, 5090 Leverkusen Koeder zur bekaempfung von ungeziefer
JPS59199673A (ja) 1983-04-25 1984-11-12 Sumitomo Chem Co Ltd 含窒素複素環化合物、その製造法およびそれを有効成分とする有害生物防除剤
IL76708A (en) 1984-10-18 1990-01-18 Ciba Geigy Ag Substituted n-benzoyl-n'-(2,5-dichloro-4(1,1,2,3,3,3-hexafluoropropyloxy)-phenyl)ureas,their preparation and pesticidal compositions containing them
EP0192060B1 (de) 1985-02-04 1991-09-18 Nihon Bayer Agrochem K.K. Heterocyclische Verbindungen
US5547974A (en) 1985-12-20 1996-08-20 Rhone-Poulenc Agriculture Ltd. Derivatives of N-phenylpyrazoles
US6372774B1 (en) 1985-12-20 2002-04-16 Rhone-Poulenc Agriculture Ltd. Derivatives of N-phenylpyrazoles
GB8531485D0 (en) 1985-12-20 1986-02-05 May & Baker Ltd Compositions of matter
GB8713768D0 (en) 1987-06-12 1987-07-15 May & Baker Ltd Compositions of matter
US5232940A (en) 1985-12-20 1993-08-03 Hatton Leslie R Derivatives of N-phenylpyrazoles
EP0237482A1 (de) 1986-03-06 1987-09-16 Ciba-Geigy Ag C(29)-Carbonyloxi-milbemycin-Derivate zur Bekämpfung von tier- und pflanzenparasitären Schädlingen
EP0246739B1 (en) 1986-03-25 1991-01-23 Sankyo Company Limited Macrolide compounds, their preparation and their use
GB8613914D0 (en) 1986-06-07 1986-07-09 Coopers Animal Health Liquid formulations
ATE75745T1 (de) 1986-07-02 1992-05-15 Ciba Geigy Ag Pestizide.
US4855317A (en) 1987-03-06 1989-08-08 Ciba-Geigy Corporation Insecticides and parasiticides
US4871719A (en) 1987-03-24 1989-10-03 Ciba-Geigy Corporation Composition for controlling parasites in productive livestock
US4874749A (en) 1987-07-31 1989-10-17 Merck & Co., Inc. 4"-Deoxy-4-N-methylamino avermectin Bla/Blb
DE3888936T2 (de) 1987-11-03 1994-07-21 Beecham Group Plc Zwischenprodukte für die Herstellung makrolider Antibiotika mit anthelmintischer Wirkung.
SE8802173D0 (sv) 1988-06-10 1988-06-10 Astra Ab Pyrimidine derivatives
GB8816915D0 (en) 1988-07-15 1988-08-17 May & Baker Ltd New compositions of matter
NZ232422A (en) 1989-02-16 1992-11-25 Merck & Co Inc 13-ketal milbemycin derivatives and parasiticides
IE904606A1 (en) 1989-12-21 1991-07-03 Beecham Group Plc Novel products
CA2036147A1 (en) 1990-06-29 1991-12-30 Hiroki Tomioka A 1-pyridylimidazole derivative and its production and use
NO179282C (no) 1991-01-18 1996-09-11 Rhone Poulenc Agrochimie Nye 1-(2-pyridyl)pyrazolforbindelser til kontroll av skadeinsekter
NZ247278A (en) 1991-02-12 1995-03-28 Ancare Distributors Veterinary anthelmintic drench comprising a suspension of praziquantel in a liquid carrier
US5236938A (en) 1991-04-30 1993-08-17 Rhone-Poulenc Inc. Pesticidal 1-aryl-5-(substituted alkylideneimino)pyrazoles
WO1992022555A1 (en) 1991-06-17 1992-12-23 Beecham Group Plc Paraherquamide derivatives, precursor thereof, processes for their preparation, microorganism used and their use as antiparasitic agents
US5246255A (en) 1991-06-24 1993-09-21 Forbes Christopher B Repair flange
US5411737A (en) 1991-10-15 1995-05-02 Merck & Co., Inc. Slow release syneresing polymeric drug delivery device
MX9206034A (es) 1991-10-24 1993-05-01 Roussel Uclaf Sistema para el control de plagas.
US5345377A (en) 1992-10-30 1994-09-06 Electric Power Research Institute, Inc. Harmonic controller for an active power line conditioner
GB9300883D0 (en) 1993-01-18 1993-03-10 Pfizer Ltd Antiparasitic agents
US5399582A (en) 1993-11-01 1995-03-21 Merck & Co., Inc. Antiparasitic agents
JP3715994B2 (ja) 1993-12-21 2005-11-16 住友化学株式会社 害虫防除剤
AUPM969994A0 (en) 1994-11-28 1994-12-22 Virbac S.A. Equine anthelmintic formulations
DE4443888A1 (de) 1994-12-09 1996-06-13 Bayer Ag Dermal applizierbare Formulierungen von Parasitiziden
US5962499A (en) 1995-03-20 1999-10-05 Merck & Co., Inc. Nodulisporic acid derivatives
US6221894B1 (en) 1995-03-20 2001-04-24 Merck & Co., Inc. Nodulisporic acid derivatives
TW334436B (en) 1995-07-21 1998-06-21 Upjohn Co Antiparasitic marcfortines and paraherquamides
FR2739255B1 (fr) 1995-09-29 1998-09-04 Rhone Merieux Composition antiparasitaire pour le traitement et la protection des animaux de compagnie
US5817688A (en) 1995-12-19 1998-10-06 Rhone-Poulenc Inc. Pesticidal 1-arylpyrazole derivatives
EP0780378B1 (en) 1995-12-19 2003-04-09 Bayer CropScience S.A. New 1-aryl pyrazole derivatives and their use as pesticides
US5922885A (en) 1995-12-19 1999-07-13 Rhone-Poulenc Inc. Pesticidal 1-arylpyrazole derivatives
SE517612C2 (sv) 1995-12-20 2002-06-25 Rhone Poulenc Agrochimie Användning av 5-amino-4-etylsulfinyl-1-arylpyrazol föreningar som pesticider
FR2752525B1 (fr) 1996-08-20 2000-05-05 Rhone Merieux Procede de lutte contre les myiases des cheptels bovins et ovins et compositions pour la mise en oeuvre de ce procede
US6413542B1 (en) 1996-03-29 2002-07-02 Merial Direct pour-on antiparasitic skin solution and methods for treating, preventing and controlling myasis
US6010710A (en) 1996-03-29 2000-01-04 Merial Direct pour-on skin solution for antiparasitic use in cattle and sheep
IE80657B1 (en) 1996-03-29 1998-11-04 Merial Sas Insecticidal combination to control mammal fleas in particular fleas on cats and dogs
US5885607A (en) 1996-03-29 1999-03-23 Rhone Merieux N-phenylpyrazole-based anti-flea and anti-tick external device for cats and dogs
US5958888A (en) * 1996-07-02 1999-09-28 Merial, Inc. Water miscible macrolide solutions
US20050192319A1 (en) 1996-09-19 2005-09-01 Albert Boeckh Spot-on formulations for combating parasites
US6998131B2 (en) 1996-09-19 2006-02-14 Merial Limited Spot-on formulations for combating parasites
EP0836851A1 (en) 1996-10-21 1998-04-22 Virbac S.A. Amidine compounds for use in treating ecto or endo parasitic diseases and systemic parasite control compositions
GB9625045D0 (en) 1996-11-30 1997-01-22 Pfizer Ltd Parasiticidal compounds
US6069157A (en) 1997-11-25 2000-05-30 Pfizer Inc. Parasiticidal compounds
US6350771B1 (en) 1996-12-24 2002-02-26 Rhone-Poulenc, Inc. Pesticidal 1-arylpyrazoles
WO1998045274A1 (en) 1997-04-07 1998-10-15 Mitsubishi Chemical Corporation Pyrazole derivatives, process for preparing the same, intermediates, and pest control agent containing the same as active ingredient
US6207647B1 (en) 1997-07-18 2001-03-27 Smithkline Beecham Corporation RatA
US6057355A (en) 1997-08-05 2000-05-02 Rhone-Poulenc Inc. Pesticidal combination
US6090751A (en) 1998-06-10 2000-07-18 Rhone-Poulenc Agro Emulsifiable concentrate comprising an insecticidal 1-arylpyrazole
GB9825402D0 (en) 1998-11-19 1999-01-13 Pfizer Ltd Antiparasitic formulations
DE60025198D1 (de) 1999-06-04 2006-02-02 Nufarm Ltd Stabile biozidale zusammensetzung
CO5261614A1 (es) 1999-12-02 2003-03-31 Aventis Cropsience S A Control de artropodos en animales
US6787342B2 (en) 2000-02-16 2004-09-07 Merial Limited Paste formulations
PE20011289A1 (es) 2000-04-07 2001-12-21 Upjohn Co Composiciones antihelminticas que comprenden lactonas macrociclicas y espirodioxepinoindoles
CA2311881C (en) 2000-06-16 2007-08-28 Gary O. Maupin Control of arthropods in rodents
US6399786B1 (en) 2000-07-14 2002-06-04 Merck & Co., Inc. Nonacyclic nodulisporic acid derivatives
DK1197215T3 (da) 2000-10-10 2006-07-10 Wyeth Corp Anthelmintiske sammensætninger
GB0108485D0 (en) 2001-04-04 2001-05-23 Pfizer Ltd Combination therapy
DE10117676A1 (de) 2001-04-09 2002-10-10 Bayer Ag Dermal applizierbare flüssige Formulierungen zur Bekämpfung von parasitierenden Insekten an Tieren
WO2002094233A1 (en) 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Delivery of antiemetics through an inhalation route
JP2003201204A (ja) * 2001-10-25 2003-07-18 Sankyo Co Ltd 寄生虫駆除組成物
MXPA04003854A (es) 2001-10-25 2005-02-17 Sankyo Lifetech Company Ltd Composicion antihelmintica.
US7517877B2 (en) 2002-03-05 2009-04-14 Merial Limited 5-substituted-alkylaminopyrazole derivatives as pesticides
US7001889B2 (en) 2002-06-21 2006-02-21 Merial Limited Anthelmintic oral homogeneous veterinary pastes
NZ520295A (en) 2002-07-19 2005-04-29 Ashmont Holdings Ltd Anthelmintic formulations comprising levamisole and either an avermectin or milbemycin
US20040037869A1 (en) * 2002-08-16 2004-02-26 Douglas Cleverly Non-animal product containing veterinary formulations
TW200409760A (en) 2002-09-11 2004-06-16 Novartis Ag Organic compounds
EA011505B1 (ru) 2002-12-03 2009-04-28 Мириэл Лимитид Пестициды на основе производных 5-(ациламино)пиразола
US7262214B2 (en) * 2003-02-26 2007-08-28 Merial Limited 1-N-arylpyrazole derivatives in prevention of arthropod-borne and mosquito-borne diseases
LT1610613T (lt) * 2003-04-04 2017-03-27 Merial, Inc. Vietinio taikymo antihelmintinės veterinarinės kompozicijos
US7531186B2 (en) 2003-12-17 2009-05-12 Merial Limited Topical formulations comprising 1-N-arylpyrazole derivatives and amitraz
AU2005219788B2 (en) 2004-03-05 2010-06-03 Nissan Chemical Corporation Isoxazoline-substituted benzamide compound and noxious organism control agent
BRPI0403620A (pt) 2004-08-13 2006-03-28 Gladstone Santos De Souza cestoticida transdérmico , isolado ou associado a anti-helmintìco e ou ectoparasiticidas e ou inibidor de crescimento insetos ou inibidor de desenvolvimento de insetos para tratamento de cães, gatos e equideos
CN101133033B (zh) 2004-12-07 2013-01-23 梅瑞尔有限公司 作为杀虫化合物的5-氨基吡唑衍生物
DE102005011779A1 (de) 2005-03-11 2006-09-14 Bayer Healthcare Ag Endoparasitizide Mittel
US20060293260A1 (en) 2005-05-24 2006-12-28 Wyeth Useful high load concentrate compositions for control of ecto-and endo-parasites
EP1965645A2 (en) 2005-12-14 2008-09-10 E.I. Du Pont De Nemours And Company Isoxazolines for controlling invertebrate pests
TW200803740A (en) 2005-12-16 2008-01-16 Du Pont 5-aryl isoxazolines for controlling invertebrate pests
TWI412322B (zh) 2005-12-30 2013-10-21 Du Pont 控制無脊椎害蟲之異唑啉
CN101511795B (zh) 2006-07-05 2013-09-18 安万特农业公司 1-芳基-5-烷基吡唑衍生化合物、其制备方法和使用方法
EP2687093B1 (en) 2006-09-01 2020-07-22 FMC Corporation Local topical administration formulations containing indoxacarb
CA2683180A1 (en) 2007-04-10 2008-10-16 Bayer Cropscience Ag Insecticidal aryl isoxazoline derivatives
EP2155755B1 (en) 2007-05-03 2016-07-06 Merial, Inc. Compositions comprising c-13 alkoxyether macrolide compounds and phenylpyrazole compounds
ME03373B (me) 2007-05-15 2020-01-20 Merial Inc Ariloazol-2-il cijanoetilamino jedinjenja, postupci dobijanja i postupci njihove primene
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
SI2182945T1 (sl) 2007-06-27 2015-12-31 E.I. Du Pont De Nemours And Company Metoda za zatiranje škodljivcev pri živalih
PT2170321E (pt) 2007-06-29 2013-08-01 Zoetis Llc Combinação anti-helmíntica
EP2170308A1 (en) 2007-07-31 2010-04-07 Wyeth a Corporation of the State of Delaware Endoparasiticidal topical compositions
TWI556741B (zh) 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
TW200924647A (en) 2007-08-30 2009-06-16 Schering Plough Ltd Local topical administration formulations containing fipronil
GB2457734A (en) 2008-02-25 2009-08-26 Norbrook Lab Ltd Topical phenyl pyrazole insecticide composition
GB0804619D0 (en) 2008-03-12 2008-04-16 Norbrook Lab Ltd A topical ectoparasiticide composition
GB2464449B (en) 2008-09-05 2011-10-12 Norbrook Lab Ltd A topical ectoparasticide composition
GB0905365D0 (en) * 2009-03-27 2009-05-13 Norbrook Lab Ltd A topical parasiticide composition

Also Published As

Publication number Publication date
EA201201371A1 (ru) 2013-03-29
BR112012025203B1 (pt) 2019-11-26
EA022068B1 (ru) 2015-10-30
JP6272977B2 (ja) 2018-01-31
KR101936557B1 (ko) 2019-01-08
LT2552201T (lt) 2017-03-10
NZ714074A (en) 2017-05-26
NZ602721A (en) 2014-08-29
RU2012146731A (ru) 2014-05-10
NZ628874A (en) 2015-12-24
KR20180030952A (ko) 2018-03-26
MY161635A (en) 2017-04-28
IL249141B (en) 2019-03-31
EP2552201B1 (en) 2016-12-14
EP2552201A1 (en) 2013-02-06
US9173403B2 (en) 2015-11-03
CN102869253A (zh) 2013-01-09
PL2552201T3 (pl) 2017-06-30
SI2552201T1 (sl) 2017-02-28
CY1118622T1 (el) 2017-07-12
TWI574623B (zh) 2017-03-21
DK2552201T3 (en) 2017-02-27
RS61147B1 (sr) 2020-12-31
SI3175711T1 (sl) 2021-01-29
AR081754A1 (es) 2012-10-17
WO2011123773A1 (en) 2011-10-06
AP3233A (en) 2015-04-30
DK3175711T3 (da) 2020-09-28
JP6060360B2 (ja) 2017-01-18
AP2014008017A0 (en) 2014-10-31
MX351637B (es) 2017-10-23
TW201138629A (en) 2011-11-16
ZA201406719B (en) 2016-06-29
KR20130025396A (ko) 2013-03-11
BR112012025203A2 (pt) 2015-09-08
JP2013523773A (ja) 2013-06-17
PL226804B1 (pl) 2017-09-29
RU2633751C1 (ru) 2017-10-17
US20110245191A1 (en) 2011-10-06
CY1123668T1 (el) 2022-03-24
EP3175711A1 (en) 2017-06-07
PH12012501894A1 (en) 2013-01-14
IL249141A0 (en) 2017-01-31
TWI670011B (zh) 2019-09-01
RS55655B1 (sr) 2017-06-30
CN104757004B (zh) 2017-10-13
PT2552201T (pt) 2017-03-17
CR20120483A (es) 2013-01-11
KR101841302B1 (ko) 2018-03-22
LT3175711T (lt) 2020-11-25
IL222063A (en) 2016-12-29
PL402539A1 (pl) 2013-09-30
CL2012002764A1 (es) 2013-01-25
US20160220566A1 (en) 2016-08-04
AU2011234984B2 (en) 2015-03-26
CN104757004A (zh) 2015-07-08
MX2012011360A (es) 2012-11-12
HRP20170385T1 (hr) 2017-05-05
ES2619255T3 (es) 2017-06-23
CO6630175A2 (es) 2013-03-01
JP2017036332A (ja) 2017-02-16
CN102869253B (zh) 2015-08-19
HRP20201765T1 (hr) 2020-12-25
TW201639456A (zh) 2016-11-16
ZA201207073B (en) 2014-12-23
HUE031537T2 (en) 2017-07-28
UA108641C2 (uk) 2015-05-25
ME02605B (me) 2017-06-20
SG184171A1 (en) 2012-10-30
US9770449B2 (en) 2017-09-26
CA2793880A1 (en) 2011-10-06
CA2793880C (en) 2018-02-13
AP2012006489A0 (en) 2012-10-31
MX339968B (es) 2016-06-20
HUE052270T2 (hu) 2021-04-28
AU2011234984A1 (en) 2012-10-25
PT3175711T (pt) 2020-11-23
SMT202000662T1 (it) 2021-01-05
EP3175711B1 (en) 2020-09-16
ES2843631T3 (es) 2021-07-19
SMT201700151T1 (it) 2017-05-08

Similar Documents

Publication Publication Date Title
AR122601A2 (es) Composiciones parasiticidas que comprenden múltiples agentes activos, métodos y usos de las mismas
AR124687A2 (es) Composiciones veterinarias orales parasiticidas que comprenden agentes activos de acción sistémica, métodos y usos de las mismas
HRP20201745T1 (hr) Paraziticidni pripravci koji sadrže djelatno sredstvo izoksazolina, postupak za njih i njihove uporabe
RU2007146113A (ru) Замещенные арилпиразолы в качестве агентов для уничтожения паразитов
RU2013139630A (ru) Спироциклические производные изоксазолина в качестве противопаразитарных агентов
PT2379537E (pt) Compostos orgânicos
JP2012521978A (ja) 局所用殺寄生虫組成物
UY28671A1 (es) Pirido(2.3-d)pirimidina-2,4-diaminas como inhibidores de pde 2
AR084509A1 (es) Combinaciones de compuestos activos ectoparasiticidas
DE60214401D1 (de) Hetero-bicyclische crf antagonisten
JP6049866B2 (ja) 駆虫剤としてのアゼチジン誘導体
RU2747149C1 (ru) Анти-эндопаразитарные депсипептиды
RU2014131951A (ru) Производные дигидрофуран азетидина в качестве противопаразитарных агентов
MX2022013890A (es) Sintesis y derivados de acido boronico, formas polimorficas y usos terapeuticos de los mismos.
CO6592097A2 (es) Composiciones endoparasiticidas
ES3030701T3 (en) Endoparasitic depsipeptides
JP2013087120A (ja) 内部寄生虫に対するアミノアセトニトリル誘導体の使用
WO2023230217A1 (en) Antileishmanial compounds, compositions and use thereof
RU2008106057A (ru) Производные бензимидазола для лечения воспалитнльных заболеваний
AU2016247183B2 (en) Parasiticidal compositions comprising multiple active agents, methods and uses thereof
TH117393A (th) องค์ประกอบซึ่งประกอบรวมด้วยแอริลไพราโซล และ/หรือ ฟอร์มามิดีน, วิธีและการใช้ขององค์ประกอบนี้
NZ736374A (en) Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof
AR046145A1 (es) Composicion farmaceutica que contiene al menos un compuesto con actividad de receptor de cb1, o un profarmaco, tautomero o sal del mismo, como componente activo adecuado para el tratamiento y/o profilaxis de enfermedades relacionadas con receptor cb1 en pacientes juveniles y/o para el tratamiento y/