AR113772A1 - Biorreactor de perfusión y métodos de uso relacionados - Google Patents
Biorreactor de perfusión y métodos de uso relacionadosInfo
- Publication number
- AR113772A1 AR113772A1 ARP180103002A ARP180103002A AR113772A1 AR 113772 A1 AR113772 A1 AR 113772A1 AR P180103002 A ARP180103002 A AR P180103002A AR P180103002 A ARP180103002 A AR P180103002A AR 113772 A1 AR113772 A1 AR 113772A1
- Authority
- AR
- Argentina
- Prior art keywords
- bioreactor
- cell culture
- culture
- cell
- predetermined rate
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 230000010412 perfusion Effects 0.000 title 1
- 238000004113 cell culture Methods 0.000 abstract 5
- 235000015097 nutrients Nutrition 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 238000001069 Raman spectroscopy Methods 0.000 abstract 1
- 239000012737 fresh medium Substances 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M43/00—Combinations of bioreactors or fermenters with other apparatus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/14—Bioreactors or fermenters specially adapted for specific uses for producing enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/10—Perfusion
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
- C12M41/14—Incubators; Climatic chambers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/32—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of substances in solution
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/38—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of metabolites or enzymes in the cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/48—Automatic or computerized control
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Sustainable Development (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Computer Hardware Design (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Un método para controlar un sistema de biorreactor incluye proporcionar un cultivo celular en un biorreactor, en donde las condiciones en el biorreactor permiten que el cultivo celular produzca una proteína de interés (POI), medir parámetros del proceso (PP) del cultivo dentro del biorreactor mediante RAMAN, en donde los parámetros del proceso son seleccionados del grupo que consiste en concentración de nutrientes, concentración de células viables y atributos de la proteína, medir un peso predeterminado del biorreactor con el cultivo celular, extraer el medio agotado libre de células del cultivo celular empleando un primer conducto de salida a una primera tasa predeterminada, extraer las células del cultivo celular empleando un segundo conducto de salida a una segunda tasa predeterminada e introducir uno de medio fresco o nutrientes, o ambos, en el cultivo celular empleando un conducto de entrada a una tercera tasa predeterminada.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762572918P | 2017-10-16 | 2017-10-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR113772A1 true AR113772A1 (es) | 2020-06-10 |
Family
ID=64110133
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP180103002A AR113772A1 (es) | 2017-10-16 | 2018-10-16 | Biorreactor de perfusión y métodos de uso relacionados |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US11193103B2 (es) |
| EP (2) | EP4039786A1 (es) |
| JP (3) | JP7337784B2 (es) |
| KR (2) | KR102694992B1 (es) |
| CN (6) | CN118580924A (es) |
| AR (1) | AR113772A1 (es) |
| AU (2) | AU2018350898B9 (es) |
| CA (1) | CA3075679A1 (es) |
| DK (1) | DK3697887T3 (es) |
| EA (1) | EA202090740A1 (es) |
| ES (1) | ES2919850T3 (es) |
| HU (1) | HUE058924T2 (es) |
| IL (2) | IL315801A (es) |
| MX (1) | MX2020002851A (es) |
| PL (1) | PL3697887T3 (es) |
| SG (1) | SG11202002339XA (es) |
| TW (3) | TW202538049A (es) |
| WO (1) | WO2019079188A1 (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019071076A1 (en) | 2017-10-06 | 2019-04-11 | Lonza Ltd. | AUTOMATED CONTROL OF CELL CULTURE BY SPECTROSCOPY RAMAN |
| CN118580924A (zh) * | 2017-10-16 | 2024-09-03 | 里珍纳龙药品有限公司 | 灌注生物反应器及相关使用方法 |
| IL317123A (en) | 2018-08-27 | 2025-01-01 | Regeneron Pharma | Using Raman Spectroscopy for Downstream Purification |
| CN113924355B (zh) * | 2019-05-28 | 2024-04-02 | 上海药明生物技术有限公司 | 用于监测和自动控制灌流细胞培养的拉曼光谱集成灌流细胞培养系统 |
| CA3137494A1 (en) * | 2019-06-13 | 2020-12-17 | Amgen Inc. | Automated biomass-based perfusion control in the manufacturing of biologics |
| EP4055136A1 (en) * | 2019-11-07 | 2022-09-14 | Merck Patent GmbH | Methods and systems for performing perfusion cell culture |
| KR20220100934A (ko) | 2019-11-15 | 2022-07-18 | 론자 리미티드 | 접종물을 제조하기 위한 공정 및 시스템 |
| CA3164000A1 (en) | 2020-01-02 | 2021-07-08 | Christian SCHWALD | Single-use cell culture container with one or more in-situ online sensors |
| WO2021140002A1 (en) * | 2020-01-07 | 2021-07-15 | Cytiva Sweden Ab | Systems and method for controlling fluid flow in bioreactors |
| WO2021143699A1 (en) * | 2020-01-15 | 2021-07-22 | Wuxi Biologics (Shanghai) Co. Ltd. | An apparatus and a method for continuously harvesting a biological substance produced by a cultured cell |
| JP7681099B2 (ja) * | 2020-08-21 | 2025-05-21 | メルク パテント ゲーエムベーハー | バイオリアクタベースのクリーンミート生産用処理システム |
| KR102656244B1 (ko) | 2020-10-26 | 2024-04-09 | 성균관대학교산학협력단 | 바이오리액터 |
| AU2021392646A1 (en) * | 2020-12-01 | 2023-06-22 | The Brigham And Women's Hospital, Inc. | Spectrometry systems, methods, and applications |
| KR102590857B1 (ko) * | 2021-08-25 | 2023-10-19 | 재단법인 아산사회복지재단 | 세포 배양 장치 |
| CA3250278A1 (en) * | 2022-04-07 | 2023-10-12 | Mirror Biologics, Inc. | Artificial lymph node bioreator |
| JP2024030410A (ja) | 2022-08-24 | 2024-03-07 | 横河電機株式会社 | 細胞培養システム、及び細胞培養方法 |
| NL2033094B1 (en) * | 2022-09-21 | 2024-03-26 | Simabs Nv | Method for controlling a perfusion process in a bioreactor |
| JP2025064520A (ja) | 2023-10-06 | 2025-04-17 | 横河電機株式会社 | 装置、方法、コントローラ、細胞培養システム、およびプログラム |
| WO2025122785A1 (en) * | 2023-12-05 | 2025-06-12 | Massachusetts Institute Of Technology | Magnetic resonance relaxometry bioreactor monitoring |
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| EP0211241A3 (de) | 1985-07-06 | 1989-06-28 | Forschungszentrum Jülich Gmbh | Verfahren zur Exoenzymgewinnung durch Bakterienkultur |
| EP0567738A3 (en) * | 1992-05-01 | 1995-09-06 | American Cyanamid Co | Controlling perfusion rates in continuous bioreactor culture of animal cells |
| CA2238434A1 (en) | 1995-12-15 | 1997-06-19 | Systemix, Inc. | Method for obtaining retroviral vector supernatant having high transduction efficiency |
| US6544424B1 (en) | 1999-12-03 | 2003-04-08 | Refined Technology Company | Fluid filtration system |
| ITPD20030142A1 (it) | 2003-06-27 | 2004-12-28 | Livia Barenghi | Bioreattore, in particolare per spettroscopia nmr |
| JP2007535902A (ja) | 2003-07-17 | 2007-12-13 | グローバル セル ソリューションズ エルエルシー． | 自動細胞培養システムおよび方法 |
| ES2456015T3 (es) | 2004-03-05 | 2014-04-21 | Dsm Ip Assets B.V. | Procedimiento para cultivar células mediante perfusión continua y flujo tangencial alternante |
| WO2005084696A1 (en) | 2004-03-08 | 2005-09-15 | Universita'degli Studi Di Milano | Methods and agents for controlling intestinal inflammation and mucosal immunity using agents interacting with tir8/sigirr |
| CN101443444A (zh) * | 2004-12-29 | 2009-05-27 | 比奥根艾迪克Ma公司 | 生物反应器过程控制系统及方法 |
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| US8003408B2 (en) * | 2005-12-29 | 2011-08-23 | Intel Corporation | Modification of metal nanoparticles for improved analyte detection by surface enhanced Raman spectroscopy (SERS) |
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| EP3327132A3 (en) * | 2007-08-09 | 2018-07-18 | Wyeth LLC | Use of perfusion to enhance production of fed-batch cell culture in bioreactors |
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| US20120329151A1 (en) | 2009-07-06 | 2012-12-27 | F. Hoffmann-La Roche Ag | Method of culturing eukaryotic cells |
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| US10118149B2 (en) | 2011-01-13 | 2018-11-06 | Patheon Austria Gmbh & Co Kg | Oscillating flow minireactor |
| WO2013006479A2 (en) | 2011-07-01 | 2013-01-10 | Amgen Inc. | Mammalian cell culture |
| AU2012318963B2 (en) * | 2011-09-25 | 2016-02-11 | Labrador Diagnostics Llc | Systems and methods for multi-analysis |
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| SG10201705806YA (en) | 2012-10-10 | 2017-08-30 | Bayer Healthcare Llc | Methods and systems for optimizing perfusion cell culture system |
| CN105377874A (zh) * | 2013-03-08 | 2016-03-02 | 建新公司 | 治疗性蛋白药物物质的整合连续制造 |
| WO2014144999A1 (en) * | 2013-03-15 | 2014-09-18 | Biogen Idec Ma Inc. | Use of raman spectroscopy to monitor culture medium |
| US10214718B2 (en) * | 2013-07-01 | 2019-02-26 | University Of Massachusetts | Distributed perfusion bioreactor system for continuous culture of biological cells |
| HUE055888T2 (hu) * | 2013-09-16 | 2022-01-28 | Genzyme Corp | Eljárások és összeállítások sejttenyészet feldolgozására |
| PL3055409T3 (pl) | 2013-10-11 | 2018-10-31 | Regeneron Pharmaceuticals, Inc. | Metabolicznie zoptymalizowana hodowla komórkowa |
| US20160289633A1 (en) | 2013-12-20 | 2016-10-06 | Biogen Ma Inc. | Use of Perfusion Seed Cultures to Improve Biopharmaceutical Fed-Batch Production Capacity and Product Quality |
| WO2016004322A2 (en) | 2014-07-02 | 2016-01-07 | Biogen Ma Inc. | Cross-scale modeling of bioreactor cultures using raman spectroscopy |
| JP7340324B2 (ja) * | 2015-05-29 | 2023-09-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 連続培養における細胞コントロール灌流 |
| WO2016196315A2 (en) * | 2015-05-29 | 2016-12-08 | Biogen Ma Inc. | Cell culture methods and systems |
| CN106834117B (zh) * | 2015-10-27 | 2018-11-23 | 苏州迪欧益生物科技有限公司 | 用于解除动物细胞贴附的酶反应器及智能酶反应工作站 |
| WO2017076834A1 (en) | 2015-11-02 | 2017-05-11 | Ares Trading S.A. | Methods for modulating production profiles of recombinant proteins in perfusion mode |
| US11104875B2 (en) * | 2016-01-26 | 2021-08-31 | Boehringer Ingelheim International Gmbh | Linked perfusion to continuous-flow stirred-tank reactor cell culture system |
| CN205528832U (zh) * | 2016-02-26 | 2016-08-31 | 南京农业大学 | 一种体外灌流系统 |
| WO2019071076A1 (en) | 2017-10-06 | 2019-04-11 | Lonza Ltd. | AUTOMATED CONTROL OF CELL CULTURE BY SPECTROSCOPY RAMAN |
| CN118580924A (zh) * | 2017-10-16 | 2024-09-03 | 里珍纳龙药品有限公司 | 灌注生物反应器及相关使用方法 |
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2018
- 2018-10-15 CN CN202410761960.3A patent/CN118580924A/zh active Pending
- 2018-10-15 CN CN202410768516.4A patent/CN118580928A/zh active Pending
- 2018-10-15 PL PL18797333.4T patent/PL3697887T3/pl unknown
- 2018-10-15 US US16/160,465 patent/US11193103B2/en active Active
- 2018-10-15 CN CN202410761962.2A patent/CN118580925A/zh active Pending
- 2018-10-15 IL IL315801A patent/IL315801A/en unknown
- 2018-10-15 JP JP2020517855A patent/JP7337784B2/ja active Active
- 2018-10-15 CA CA3075679A patent/CA3075679A1/en active Pending
- 2018-10-15 TW TW114121002A patent/TW202538049A/zh unknown
- 2018-10-15 KR KR1020207010709A patent/KR102694992B1/ko active Active
- 2018-10-15 HU HUE18797333A patent/HUE058924T2/hu unknown
- 2018-10-15 SG SG11202002339XA patent/SG11202002339XA/en unknown
- 2018-10-15 ES ES18797333T patent/ES2919850T3/es active Active
- 2018-10-15 MX MX2020002851A patent/MX2020002851A/es unknown
- 2018-10-15 AU AU2018350898A patent/AU2018350898B9/en active Active
- 2018-10-15 CN CN202410768488.6A patent/CN118580927A/zh active Pending
- 2018-10-15 IL IL273150A patent/IL273150B2/en unknown
- 2018-10-15 TW TW107136209A patent/TWI827555B/zh active
- 2018-10-15 EA EA202090740A patent/EA202090740A1/ru unknown
- 2018-10-15 CN CN202410768485.2A patent/CN118580926A/zh active Pending
- 2018-10-15 DK DK18797333.4T patent/DK3697887T3/da active
- 2018-10-15 KR KR1020247026774A patent/KR20240125704A/ko active Pending
- 2018-10-15 CN CN201880066815.6A patent/CN111212899B/zh active Active
- 2018-10-15 WO PCT/US2018/055891 patent/WO2019079188A1/en not_active Ceased
- 2018-10-15 EP EP22160280.8A patent/EP4039786A1/en active Pending
- 2018-10-15 EP EP18797333.4A patent/EP3697887B1/en not_active Revoked
- 2018-10-15 TW TW112146996A patent/TWI889045B/zh active
- 2018-10-16 AR ARP180103002A patent/AR113772A1/es unknown
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2021
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