AR086200A1 - Hongos filamentosos que tienen un fenotipo de viscosidad alterado - Google Patents
Hongos filamentosos que tienen un fenotipo de viscosidad alteradoInfo
- Publication number
- AR086200A1 AR086200A1 ARP120101366A ARP120101366A AR086200A1 AR 086200 A1 AR086200 A1 AR 086200A1 AR P120101366 A ARP120101366 A AR P120101366A AR P120101366 A ARP120101366 A AR P120101366A AR 086200 A1 AR086200 A1 AR 086200A1
- Authority
- AR
- Argentina
- Prior art keywords
- cells
- strain
- compared
- parental strain
- variant
- Prior art date
Links
- 241000233866 Fungi Species 0.000 abstract 4
- 238000013019 agitation Methods 0.000 abstract 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 4
- 229910052760 oxygen Inorganic materials 0.000 abstract 4
- 239000001301 oxygen Substances 0.000 abstract 4
- 230000004077 genetic alteration Effects 0.000 abstract 3
- 231100000118 genetic alteration Toxicity 0.000 abstract 3
- 101100351303 Caenorhabditis elegans pdfr-1 gene Proteins 0.000 abstract 2
- 238000010564 aerobic fermentation Methods 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/36—Adaptation or attenuation of cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/07—Nucleotidyltransferases (2.7.7)
- C12Y207/07013—Mannose-1-phosphate guanylyltransferase (2.7.7.13)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Botany (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Dichas variantes son adecuadas para el crecimiento en cultivos sumergidos, por ej., para la producción a gran escala de enzimas y otras proteínas para aplicaciones comerciales.Reivindicación 1: Una cepa variante de hongo filamentoso derivada de una cepa parental, comprendiendo la cepa variante una alteración genética que hace que las células de la cepa variante produzcan una cantidad alterada de proteína Seb1 funcional en comparación con células de la cepa parental, donde las células de la cepa variante producen durante la fermentación aeróbica en cultivo sumergido un caldo celular que (i) requiere una cantidad alterada de agitación para mantener un contenido preseleccionado de oxígeno disuelto en comparación con las células de la cepa parental, y/o (ii) mantiene un contenido de oxígeno disuelto alterado en una cantidad preseleccionada de agitación, en comparación con las células de la cepa parental. Reivindicación 18: Un método para producir una cepa variante de células de hongo filamentoso que comprende: introducir una alteración genética en una cepa parental de células de hongo filamentoso, alteración genética la cual altera la producción de la proteína Seb1 funcional en comparación con las células de la cepa parental, produciendo de ese modo una célula de hongo filamentoso variante que produce durante la fermentación aeróbica en cultivo sumergido un caldo celular que (i) requiere una cantidad alterada de agitación para mantener un contenido de oxígeno disuelto preseleccionado, en comparación con las células de la cepa parental, y/o (ii) mantiene un contenido de oxígeno disuelto alterado en una cantidad preseleccionada de agitación, en comparación con las células de la cepa parental.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161478162P | 2011-04-22 | 2011-04-22 | |
| US201161478160P | 2011-04-22 | 2011-04-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR086200A1 true AR086200A1 (es) | 2013-11-27 |
Family
ID=46018123
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120101366A AR086200A1 (es) | 2011-04-22 | 2012-04-20 | Hongos filamentosos que tienen un fenotipo de viscosidad alterado |
| ARP120101367A AR086201A1 (es) | 2011-04-22 | 2012-04-20 | Hongos filamentosos que tienen un fenotipo de viscosidad alterado |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120101367A AR086201A1 (es) | 2011-04-22 | 2012-04-20 | Hongos filamentosos que tienen un fenotipo de viscosidad alterado |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9725726B2 (es) |
| EP (3) | EP2699588B1 (es) |
| JP (2) | JP6042866B2 (es) |
| KR (2) | KR101952470B1 (es) |
| CN (2) | CN103517916B (es) |
| AR (2) | AR086200A1 (es) |
| AU (3) | AU2012245402B2 (es) |
| BR (2) | BR112013025430A2 (es) |
| CA (2) | CA2833541C (es) |
| DK (3) | DK2699588T3 (es) |
| WO (2) | WO2012145595A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2699588B1 (en) * | 2011-04-22 | 2016-11-30 | Danisco US Inc. | Filamentous fungi having an altered viscosity phenotype |
| WO2012145592A1 (en) * | 2011-04-22 | 2012-10-26 | Danisco Us Inc. | Filamentous fungi having an altered viscosity phenotype |
| WO2017025586A1 (en) * | 2015-08-13 | 2017-02-16 | Glykos Finland Oy | Regulatory protein deficient trichoderma cells and methods of use thereof |
| JP7376505B2 (ja) * | 2018-04-24 | 2023-11-08 | ダニスコ・ユーエス・インク | 粘性が低下した表現型を含む糸状菌株 |
| CA3108045A1 (en) | 2018-07-30 | 2020-02-06 | Toray Industries, Inc. | Mutant of trichoderma filamentous fungus and method for producing protein |
| JP2021532775A (ja) * | 2018-07-30 | 2021-12-02 | ダニスコ・ユーエス・インク | タンパク質生産性が強化された表現型を含む突然変異及び遺伝子改変糸状菌株並びにそれらの方法 |
| EP4055177B1 (en) | 2019-11-08 | 2024-07-31 | Danisco US Inc. | Fungal strains comprising enhanced protein productivity phenotypes and methods thereof |
| FR3104169B1 (fr) * | 2019-12-04 | 2022-10-21 | Ifp Energies Now | Souche de champignon ayant une viscosite diminuee |
| CN113881586B (zh) * | 2021-09-27 | 2023-03-10 | 四川大学 | 耐高温、耐高糖、耐高盐酿酒酵母菌株及构建方法和应用 |
| CN118109437B (zh) * | 2024-04-29 | 2024-07-09 | 北京中医药大学深圳医院(龙岗) | 一种来自菌类中药的gdp-甘露糖焦磷酸化酶及其编码基因和应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI972909A0 (fi) * | 1997-07-09 | 1997-07-09 | Valtion Teknillinen | Oekad produktion av avsoendrade proteiner genom rekombinatjaestceller |
| US7189538B2 (en) | 1999-03-24 | 2007-03-13 | Genencor International, Inc. | Hyphal growth in fungi |
| BR0012856A (pt) * | 1999-07-30 | 2002-06-11 | Tno | Aspergillus sojae recombinante, métodos para introduzir uma sequência de ácido nucleico em aspergillus sojae, para selecionar aspergillus sojae transformado ou transfectado, para produzir aspergillus sojae recombinante, aspergillus sojae mutante ou recombinante, fungo recombinante processos de expressão de uma sequência de ácido, nucleico introduzida, para a expressão de uma proteìna ou polipeptìdeo, para a produção de uma proteìna ou polipeptìdeo, e, para produzir uma fitase ou uma proteìna tendo atividade fitase |
| DE60127661T2 (de) | 2000-04-13 | 2007-12-06 | Mark Aaron Jupiter Emalfarb | Expression regulierende sequenzen von schimmelpilz chrysosporium |
| EP2368904A1 (en) | 2001-03-14 | 2011-09-28 | Genencor International, Inc. | Regulatable growth of filamentous fungi |
| US20050042738A1 (en) * | 2001-05-25 | 2005-02-24 | Anita Swarnakar | Carbohydrate-associated proteins |
| US6902921B2 (en) * | 2001-10-30 | 2005-06-07 | 454 Corporation | Sulfurylase-luciferase fusion proteins and thermostable sulfurylase |
| ATE542895T1 (de) | 2003-05-29 | 2012-02-15 | Danisco Us Inc | Neue trichoderma-gene |
| US9180998B2 (en) | 2007-09-11 | 2015-11-10 | Cold Chain Technologies, Inc. | Insulated pallet shipper and methods of making and using the same |
| AU2009223508B2 (en) * | 2008-03-07 | 2013-08-01 | Danisco Us Inc. | Expression of catalase in Trichoderma |
| US10266832B2 (en) * | 2010-08-25 | 2019-04-23 | Danisco Us Inc | Filamentous fungi having an altered viscosity phenotype |
| WO2012145592A1 (en) * | 2011-04-22 | 2012-10-26 | Danisco Us Inc. | Filamentous fungi having an altered viscosity phenotype |
| EP2699588B1 (en) * | 2011-04-22 | 2016-11-30 | Danisco US Inc. | Filamentous fungi having an altered viscosity phenotype |
-
2012
- 2012-04-20 EP EP12718831.6A patent/EP2699588B1/en active Active
- 2012-04-20 KR KR1020137030769A patent/KR101952470B1/ko active Active
- 2012-04-20 JP JP2014506563A patent/JP6042866B2/ja active Active
- 2012-04-20 EP EP15189224.7A patent/EP3000870B1/en active Active
- 2012-04-20 DK DK12718831.6T patent/DK2699588T3/en active
- 2012-04-20 KR KR1020137030514A patent/KR101993939B1/ko active Active
- 2012-04-20 CN CN201280019757.4A patent/CN103517916B/zh active Active
- 2012-04-20 JP JP2014506565A patent/JP6042868B2/ja active Active
- 2012-04-20 US US14/111,615 patent/US9725726B2/en active Active
- 2012-04-20 DK DK12717559.4T patent/DK2663633T3/en active
- 2012-04-20 EP EP12717559.4A patent/EP2663633B1/en active Active
- 2012-04-20 CA CA2833541A patent/CA2833541C/en active Active
- 2012-04-20 AR ARP120101366A patent/AR086200A1/es unknown
- 2012-04-20 US US14/112,879 patent/US9725727B2/en active Active
- 2012-04-20 WO PCT/US2012/034403 patent/WO2012145595A1/en not_active Ceased
- 2012-04-20 DK DK15189224.7T patent/DK3000870T3/en active
- 2012-04-20 BR BR112013025430A patent/BR112013025430A2/pt not_active Application Discontinuation
- 2012-04-20 AU AU2012245402A patent/AU2012245402B2/en active Active
- 2012-04-20 BR BR112013025203A patent/BR112013025203A2/pt not_active Application Discontinuation
- 2012-04-20 CN CN201280019678.3A patent/CN103502431B/zh active Active
- 2012-04-20 CA CA2833660A patent/CA2833660C/en active Active
- 2012-04-20 WO PCT/US2012/034379 patent/WO2012145584A1/en not_active Ceased
- 2012-04-20 AU AU2012245322A patent/AU2012245322A1/en not_active Abandoned
- 2012-04-20 AR ARP120101367A patent/AR086201A1/es unknown
-
2017
- 2017-04-26 AU AU2017202753A patent/AU2017202753A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |