AR095601A1 - Diazilhidrazinas que contienen boro - Google Patents
Diazilhidrazinas que contienen boroInfo
- Publication number
- AR095601A1 AR095601A1 ARP140101226A ARP140101226A AR095601A1 AR 095601 A1 AR095601 A1 AR 095601A1 AR P140101226 A ARP140101226 A AR P140101226A AR P140101226 A ARP140101226 A AR P140101226A AR 095601 A1 AR095601 A1 AR 095601A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- optionally substituted
- alkyl
- hydrogen
- hydroxy
- Prior art date
Links
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 31
- 239000001257 hydrogen Substances 0.000 abstract 31
- 125000000217 alkyl group Chemical group 0.000 abstract 21
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 17
- 125000003545 alkoxy group Chemical group 0.000 abstract 15
- 150000002431 hydrogen Chemical class 0.000 abstract 14
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 14
- 125000001188 haloalkyl group Chemical group 0.000 abstract 12
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 12
- 125000001475 halogen functional group Chemical group 0.000 abstract 11
- -1 nitro, cyano, hydroxy, amino Chemical group 0.000 abstract 11
- 125000004414 alkyl thio group Chemical group 0.000 abstract 10
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 10
- 239000002253 acid Substances 0.000 abstract 6
- 150000001413 amino acids Chemical class 0.000 abstract 6
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 6
- 125000001072 heteroaryl group Chemical group 0.000 abstract 5
- 125000000623 heterocyclic group Chemical group 0.000 abstract 4
- 125000003107 substituted aryl group Chemical group 0.000 abstract 4
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 4
- 125000004104 aryloxy group Chemical group 0.000 abstract 3
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 3
- 125000005017 substituted alkenyl group Chemical group 0.000 abstract 3
- 125000004426 substituted alkynyl group Chemical group 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000005518 carboxamido group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 230000016784 immunoglobulin production Effects 0.000 abstract 1
- 238000002705 metabolomic analysis Methods 0.000 abstract 1
- 230000001431 metabolomic effect Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 238000007423 screening assay Methods 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
- 230000014616 translation Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/027—Organoboranes and organoborohydrides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
- A01N55/08—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing boron
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Es útil para aplicaciones tales como la terapia génica, el tratamiento de enfermedades, la producción a gran escala de proteínas y anticuerpos, los ensayos de cribado basados en células, la genómica funcional, la proteómica, la metabolómica y la regulación de los rasgos en organismos transgénicos, donde el control de gen los niveles de expresión es deseable. Reivindicación 1: Un compuesto que tiene la fórmula (1), donde: R¹ y R² se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno, alquilo opcionalmente sustituido y haloalquilo; o R¹ y R² tomados en conjunto con el átomo de carbono al cual están unidos forman un cicloalquilo de 4 a 8 miembros; R³ se selecciona del grupo que consiste de hidrógeno, alquilo opcionalmente sustituido, haloalquilo, cicloalquilo opcionalmente sustituido, alquenilo opcionalmente sustituido, arilo opcionalmente sustituido y heteroarilo opcionalmente sustituido; R⁴ se selecciona del grupo que consiste de los restos del grupo de fórmulas (2); X¹ se selecciona del grupo que consiste de -O- y -N(R⁸ᵃ)-; Y¹ es -(CR⁹ᵃR⁹ᵇ)ₘ-; Z¹ se selecciona del grupo que consiste de -O- y -N(R⁸ᵇ)- o Z¹ está ausente; R⁶ᵃ se selecciona del grupo que consiste de hidroxi, alquilo y alcoxi; o R⁶ᵃ forma un aducto de hidroxi ácido o un aducto de amino ácido; R⁷ᵃ y R⁷ᵇ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno, halo, nitro, ciano, hidroxi, amino, alquilo opcionalmente sustituido, haloalquilo, hidroxialquilo, alcoxi y alquiltio; R⁷ᵃ y R⁷ᵇ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno, halo, nitro, ciano, hidroxi, amino, alquilo opcionalmente sustituido, haloalquilo, hidroxialquilo, alcoxi y alquiltio; R⁸ᵃ y R⁸ᵇ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno y alquilo; R⁹ᵃ y R⁹ᵇ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno y alquilo; m es 1, 2, 3 ó 4; X² se selecciona del grupo que consiste de -O- y -N(R⁸ᶜ)-; Y² es -(CR⁹ᶜR⁹ᵈ)ₙ-; Z² se selecciona del grupo que consiste de -O- y -N(R⁸ᵈ)- o Z² está ausente; R⁶ᵇ se selecciona del grupo que consiste de hidroxi, alquilo y alcoxi; o R⁶ᵇ forma un aducto de hidroxi ácido o un aducto de amino ácido; R⁷ᶜ y R⁷ᵈ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno, halo, nitro, ciano, hidroxi, amino, alquilo opcionalmente sustituido, haloalquilo, hidroxialquilo, alcoxi y alquiltio; R⁸ᶜ y R⁸ᵈ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno y alquilo; R⁹ᶜ y R⁹ᵈ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno y alquilo; n es 1, 2, 3 ó 4; X se selecciona del grupo que consiste de -O- y -N(R⁸ᵉ)-; R⁶ᶜ se selecciona del grupo que consiste de hidroxi, alquilo y alcoxi; o R⁶ᶜ forma un aducto de hidroxi ácido o un aducto de amino ácido; R⁷ᵉ y R⁷ᶠ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno, halo, nitro, ciano, hidroxi, amino, alquilo opcionalmente sustituido, haloalquilo, hidroxialquilo, alcoxi y alquiltio; R⁸ᵉ se selecciona del grupo que consiste de hidrógeno y alquilo; R⁶ᵈ se selecciona del grupo que consiste de hidroxi, alquilo y alcoxi; o R⁶ᵈ forma un aducto de hidroxi ácido o un aducto de amino ácido; R⁶ᶠ se selecciona del grupo que consiste de hidrógeno, alquilo, amino e hidroxi; X⁵ se selecciona del grupo que consiste de -O- y -N(R⁸ᵏ)-; R⁷ᵍ y R⁷ʰ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno, halo, nitro, ciano, hidroxi, amino, alquilo opcionalmente sustituido, haloalquilo, hidroxialquilo, alcoxi y alquiltio; R⁸ᵏ se selecciona del grupo que consiste de hidrógeno y alquilo; X⁶ se selecciona del grupo que consiste de -O- y -N(R⁸ˡ)-; X⁷ se selecciona del grupo que consiste de -O- y -N(R⁸ⁿ)-; R⁸ˡ se selecciona del grupo que consiste de hidrógeno y alquilo; R⁸ᵐ se selecciona del grupo que consiste de hidrógeno y alquilo; R⁸ⁿ se selecciona del grupo que consiste de hidrógeno y alquilo; R¹⁰ᵃ se selecciona del grupo que consiste de hidrógeno y -(CR¹¹ᵃR¹¹ᵇ)ₒ-B(R¹²ᵃ)(R¹²ᵇ); y R¹⁰ᵇ, R¹⁰ᶜ, y R¹⁰ᵈ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno, halo, nitro, ciano, hidroxi, amino, -N(H)CHO, -N(H)CN, alquilo opcionalmente sustituido, haloalquilo, alcoxialquilo, hidroxialquilo, arilalquilo, cicloalquilo opcionalmente sustituido, alquenilo opcionalmente sustituido, alquinilo opcionalmente sustituido, arilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, heterociclo opcionalmente sustituido, alcoxi, ariloxi, arilalquiloxi, alquiltio, heteroalquilo, carboxamido, sulfonamido, -COR¹⁶, -SO₂R¹⁷, -N(R¹⁸)COR¹⁹, -N(R¹⁸)SO₂R²⁰ o N(R¹⁸)C=N(R²¹)-amino; o R¹⁰ᵇ se selecciona del grupo que consiste de hidrógeno, halo, nitro, ciano, hidroxi, -N(H)CHO, -N(H)CN, amino, alquilo opcionalmente sustituido, haloalquilo, hidroxialquilo, arilalquilo, cicloalquilo opcionalmente sustituido, alquenilo opcionalmente sustituido, alquinilo opcionalmente sustituido, arilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, heterociclo opcionalmente sustituido, alcoxi, ariloxi, arilalquiloxi, alquiltio, heteroalquilo, carboxamido, sulfonamido, -COR¹⁶, -SO₂R¹⁷, -N(R¹⁸)COR¹⁹, -N(R¹⁸)SO₂R²⁰ o -N(R¹⁸)C=N(R²¹)-amino; o R¹⁰ᶜ y R¹⁰ᵈ tomados en conjunto con dos átomos de carbono adyacentes forman un grupo cicloalquilo opcionalmente sustituido fusionado, heterociclo opcionalmente sustituido o heteroarilo opcionalmente sustituido; R¹¹ᵃ y R¹¹ᵇ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno y alquilo; R¹²ᵃ y R¹²ᵇ se seleccionan del grupo que consiste de hidroxi y alcoxi; o R¹²ᵃ y R¹²ᵇ tomados en conjunto forman una unión -O(CR¹³ᵃR¹³ᵇ)ₚO-; o -B(R¹²ᵃ)(R¹²ᵇ) forma un aducto de flúor; R¹³ᵃ y R¹³ᵇ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno y alquilo C₁₋₄; o es 0, 1, 2, 3, 4 ó 5; p es 2, 3 ó 4; R⁵ es un resto R⁴-3, R⁴-4, R⁴-8, R⁴-9 o R⁴-10 del grupo de fórmulas (2); o R⁵ se selecciona del grupo que consiste de los compuestos del grupo de fórmulas (3); X³ se selecciona del grupo que consiste de -O- y -N(R⁸ᶠ)-; Y³ es -(CR⁹ᵉR⁹ᶠ)q-; Z³ se selecciona del grupo que consiste de -O- y -N(R⁸ᵍ)- o Z³ está ausente; R⁶ᵉ se selecciona del grupo que consiste de hidroxi y alquilo; o R⁶ᵉ forma un aducto de hidroxi ácido o un aducto de amino ácido; R⁷ⁱ y R⁷ʲ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno, halo, nitro, ciano, hidroxi, amino, alquilo opcionalmente sustituido, haloalquilo, hidroxialquilo, alcoxi y alquiltio; R⁸ᶠ y R⁸ᵍ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno y alquilo; R⁹ᵉ y R⁹ᶠ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno y alquilo; q es 1, 2, 3 ó 4; X⁴ se selecciona del grupo que consiste de -O- y -N(R⁸ʰ)-; Y⁴ es -(CR⁹ᵍR⁹ʰ)ʳ-; Z⁴ se selecciona del grupo que consiste de -O- y -N(R⁸ⁱ)- o Z⁴ está ausente; R⁶ᵍ se selecciona del grupo que consiste de hidroxi y alquilo; o R⁶ᵍ forma un aducto de hidroxi ácido o un aducto de amino ácido; R⁷ᵏ y R⁷ˡ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno, halo, nitro, ciano, hidroxi, amino, alquilo opcionalmente sustituido, haloalquilo, hidroxialquilo, alcoxi y alquiltio; R⁸ʰ y R⁸ⁱ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno y alquilo; R⁹ᵍ y R⁹ʰ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno y alquilo; r es 1, 2, 3 ó 4; R¹⁰ᵉ se selecciona del grupo que consiste de hidrógeno y -(CR¹¹ᶜR¹¹ᵈ)ₛ-B(R¹²ᶜ)(R¹²ᵈ); y R¹⁰ᶠ, R¹⁰ᵍ, y R¹⁰ʰ se seleccionan -de manera independiente- del grupo que consiste de hidrógeno, halo, nitro, ciano, hidroxi, amino, -N(H)CHO, -N(H)CN, alquilo opcionalmente sustituido, haloalquilo, hidroxialquilo, arilalquilo, cicloalquilo opcionalmente sustituido, alquenilo opcionalmente sustituido, alquinilo opcionalmente sustituido, arilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, heterociclo opcionalmente sustituido, alcoxi, ariloxi, arilalquiloxi, alquiltio, carboxamido, sulfonamido, -COR¹⁶, -SO₂R¹⁷, -N(R¹⁸)COR¹⁹, -N(R¹⁸)SO₂R²⁰ o -N(R¹⁸)C=N(R²¹)-amino; o R¹⁰ᶠ se selecciona del grupo que consiste de hidrógeno, halo, nitro, ciano, hidroxi, amino, -N(H)CHO, -N(H)CN, alqu
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361792412P | 2013-03-15 | 2013-03-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR095601A1 true AR095601A1 (es) | 2015-10-28 |
Family
ID=51529908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140101226A AR095601A1 (es) | 2013-03-15 | 2014-03-17 | Diazilhidrazinas que contienen boro |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US9127024B2 (es) |
| EP (1) | EP2970106B1 (es) |
| JP (1) | JP6379173B2 (es) |
| KR (1) | KR20150129034A (es) |
| CN (1) | CN105283439B (es) |
| AR (1) | AR095601A1 (es) |
| AU (2) | AU2014227571B2 (es) |
| BR (1) | BR112015022994A2 (es) |
| CA (1) | CA2904436C (es) |
| DK (1) | DK2970106T3 (es) |
| ES (1) | ES2683329T3 (es) |
| IL (1) | IL241119B (es) |
| MX (1) | MX361717B (es) |
| NZ (1) | NZ712167A (es) |
| PH (1) | PH12015502099A1 (es) |
| RU (1) | RU2637946C2 (es) |
| SG (1) | SG11201506875YA (es) |
| TW (1) | TWI636986B (es) |
| WO (1) | WO2014144380A1 (es) |
| ZA (1) | ZA201506985B (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8617132B2 (en) | 2009-10-06 | 2013-12-31 | Regents Of The University Of Minnesota | Bioresorbable embolization microspheres |
| MY188960A (en) | 2010-08-10 | 2022-01-14 | Melinta Therapeutics Llc | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
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- 2015-07-22 US US14/805,837 patent/US9512148B2/en not_active Expired - Fee Related
- 2015-09-03 IL IL241119A patent/IL241119B/en not_active IP Right Cessation
- 2015-09-14 PH PH12015502099A patent/PH12015502099A1/en unknown
- 2015-09-18 ZA ZA2015/06985A patent/ZA201506985B/en unknown
-
2016
- 2016-11-17 US US15/354,239 patent/US10464951B2/en not_active Expired - Fee Related
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2017
- 2017-04-19 AU AU2017202580A patent/AU2017202580B2/en not_active Ceased
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2019
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