[go: up one dir, main page]

MXPA03007493A - Nuevo sistema de expresion genetica inducible a base de receptor de ecdisona/receptor x retinoide de invertebrado. - Google Patents

Nuevo sistema de expresion genetica inducible a base de receptor de ecdisona/receptor x retinoide de invertebrado.

Info

Publication number
MXPA03007493A
MXPA03007493A MXPA03007493A MXPA03007493A MXPA03007493A MX PA03007493 A MXPA03007493 A MX PA03007493A MX PA03007493 A MXPA03007493 A MX PA03007493A MX PA03007493 A MXPA03007493 A MX PA03007493A MX PA03007493 A MXPA03007493 A MX PA03007493A
Authority
MX
Mexico
Prior art keywords
receptor
gene expression
expression system
inducible gene
based inducible
Prior art date
Application number
MXPA03007493A
Other languages
English (en)
Inventor
Reddy Palli Subba
Original Assignee
Rheogene Holdings Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26953897&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MXPA03007493(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rheogene Holdings Inc filed Critical Rheogene Holdings Inc
Publication of MXPA03007493A publication Critical patent/MXPA03007493A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Wood Science & Technology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Esta invencion se refiere al campo de la biotecnologia o ingenieria genetica. Especificamente, esta invencion se refiere al campo de la expresion genetica. Mas especificamente, esta invencion se refiere a un nuevo sistema de expresion genetica inducible a base del receptor de ecdisona/receptor X retinoide de invertebrado y metodos para modular la expresion genetica en una celula huesped para aplicaciones tales como terapia genetica, produccion a gran escala de proteinas y anticuerpos, analisis de seleccion de alto rendimiento a base de celulas, genomicos funcionales y regulacion de caracteristicas en organismos transgenicos.
MXPA03007493A 2001-02-20 2002-02-20 Nuevo sistema de expresion genetica inducible a base de receptor de ecdisona/receptor x retinoide de invertebrado. MXPA03007493A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26979901P 2001-02-20 2001-02-20
US29481401P 2001-05-31 2001-05-31
PCT/US2002/005235 WO2002066613A2 (en) 2001-02-20 2002-02-20 Novel ecdysone receptor/invertebrate retinoid x receptor-based inducible gene expression system

Publications (1)

Publication Number Publication Date
MXPA03007493A true MXPA03007493A (es) 2004-10-15

Family

ID=26953897

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03007493A MXPA03007493A (es) 2001-02-20 2002-02-20 Nuevo sistema de expresion genetica inducible a base de receptor de ecdisona/receptor x retinoide de invertebrado.

Country Status (11)

Country Link
US (2) US9493540B2 (es)
EP (1) EP1456346B1 (es)
JP (3) JP4955904B2 (es)
AT (1) ATE545705T1 (es)
AU (2) AU2002247184B2 (es)
CA (1) CA2441444C (es)
DK (1) DK1456346T3 (es)
ES (1) ES2385598T3 (es)
MX (1) MXPA03007493A (es)
PT (1) PT1456346E (es)
WO (1) WO2002066613A2 (es)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040033600A1 (en) * 2001-03-21 2004-02-19 Palli Subba Reddy Ecdysone receptor-based inducible gene expression system
US8105825B2 (en) 2000-10-03 2012-01-31 Intrexon Corporation Multiple inducible gene regulation system
WO2002066614A2 (en) 2001-02-20 2002-08-29 Rheogene Holdings, Inc. Chimeric retinoid x receptors and their use in a novel ecdysone receptor-based inducible gene expression system
DK1373470T3 (da) 2001-02-20 2013-07-29 Intrexon Corp Hidtil ukendte substitutionsmutantreceptorer og deres anvendelse i et cellekernereceptorbaseret inducerbart genekspressionssystem
ES2385598T3 (es) 2001-02-20 2012-07-27 Intrexon Corporation Sistema novedoso de expresión génica inducible basado en el receptor de ecdisona/receptor X retinoide de invertebrado
AU2002248500B2 (en) 2001-02-20 2007-12-13 Intrexon Corporation Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
WO2003027289A1 (en) * 2001-09-26 2003-04-03 Rheo Gene Holdings, Inc. Leafhopper ecdysone receptor nucleic acids, polypeptides, and uses thereof
CA2930389A1 (en) 2001-09-26 2003-04-03 Intrexon Corporation Whitefly ecdysone receptor nucleic acids, polypeptides, and uses thereof
US7304161B2 (en) * 2003-02-10 2007-12-04 Intrexon Corporation Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
US7456315B2 (en) 2003-02-28 2008-11-25 Intrexon Corporation Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US7935510B2 (en) 2004-04-30 2011-05-03 Intrexon Corporation Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
AU2007332980A1 (en) 2006-07-26 2008-06-19 Intrexon Corporation Methods and compositions for treating disease
WO2008153801A1 (en) 2007-05-29 2008-12-18 Intrexon Corporation Chiral diachylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
KR20100049084A (ko) * 2007-08-23 2010-05-11 인트렉손 코포레이션 질병 진단을 위한 방법 및 조성물
BRPI0817233A2 (pt) 2007-09-28 2012-11-06 Intrexon Corp construções terapêuticas de gene de trca e bireatores para a expressão de moléculas bioterapêuticas, e usos das mesmas
NZ585190A (en) 2007-10-08 2012-11-30 Intrexon Corp Engineered dendritic cells and uses for the treatment of cancer
WO2009114201A2 (en) 2008-03-14 2009-09-17 Intrexon Corporation Steroidal ligands and their use in gene switch modulation
JP5272898B2 (ja) 2009-05-29 2013-08-28 ソニー株式会社 信号処理装置、信号処理方法、および受信システム
WO2011119773A1 (en) 2010-03-23 2011-09-29 Roeth Jeremiah F Vectors conditionally expressing therapeutic proteins, host cells comprising the vectors, and uses thereof
CA2828411A1 (en) 2011-03-04 2012-09-13 Intrexon Corporation Vectors conditionally expressing protein
EP2699688A1 (en) 2011-04-20 2014-02-26 The Trustees Of The University Of Pennsylvania Regimens and compositions for aav-mediated passive immunization of airborne pathogens
ES2683329T3 (es) 2013-03-15 2018-09-26 Intrexon Corporation Diacilhidrazinas que contienen boro
US9719106B2 (en) 2013-04-29 2017-08-01 The Trustees Of The University Of Pennsylvania Tissue preferential codon modified expression cassettes, vectors containing same, and uses thereof
EP3988649B1 (en) 2013-09-18 2024-11-27 Kymab Limited Methods, cells and organisms
CA2961738A1 (en) 2014-09-17 2016-03-24 Intrexon Corporation Boron-containing diacylhydrazine compounds
WO2016200543A2 (en) 2015-05-13 2016-12-15 The Trustees Of The University Of Pennsylvania Aav-mediated expression of anti-inluenza antibodies and methods of use thereof
SG11201802912PA (en) 2015-10-10 2018-05-30 Intrexon Corp Improved therapeutic control of proteolytically sensitive, destabilized forms of interleukin-12
KR20180069081A (ko) 2015-11-11 2018-06-22 인트렉손 코포레이션 심장 이상 및 기타 병리 이상의 치료를 위한 복수의 생물학적으로 활성화된 폴리펩티드를 단일 벡터로부터 발현하기 위한 조성물 및 방법
KR102652827B1 (ko) 2016-06-08 2024-04-01 프레시전 인코포레이티드 Cd33 특이적 키메라 항원 수용체
UY37343A (es) 2016-07-25 2018-02-28 Intrexon Corp Control del fenotipo en plantas
MX2019005235A (es) 2016-11-09 2019-12-05 Intrexon Corp Constructos de expresion de frataxina.
CN110462040A (zh) 2017-01-10 2019-11-15 英特拉克森公司 通过新基因开关表达系统调节多肽的表达
CA3052487A1 (en) 2017-02-28 2018-09-07 The Trustees Of The University Of Pennsylvania Influenza vaccines based on aav vectors
JOP20190200A1 (ar) 2017-02-28 2019-08-27 Univ Pennsylvania تركيبات نافعة في معالجة ضمور العضل النخاعي
SG10201912973XA (en) 2017-02-28 2020-03-30 Univ Pennsylvania Adeno-associated virus (aav) clade f vector and uses therefor
EP4681734A2 (en) 2017-06-07 2026-01-21 Precigen, Inc. Expression of novel cell tags
US12404306B2 (en) 2018-03-06 2025-09-02 Precigen, Inc. Human papillomavirus vaccines and uses of the same
IL277128B2 (en) 2018-03-06 2025-11-01 Precigen Inc Hepatitis b vaccines and uses of the same
JP7575273B2 (ja) 2018-04-16 2024-10-29 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア デュシェンヌ型筋ジストロフィーを治療するための組成物及び方法
WO2020206056A1 (en) 2019-04-04 2020-10-08 Greenvenus Llc Peptides and methods of plant protection
CA3200014A1 (en) 2020-12-01 2022-06-09 James M. Wilson Novel compositions with tissue-specific targeting motifs and compositions containing same
AU2022262771A1 (en) 2021-04-23 2023-11-02 The Trustees Of The University Of Pennsylvania Novel compositions with brain-specific targeting motifs and compositions containing same
EP4409010A1 (en) 2021-10-02 2024-08-07 The Trustees of The University of Pennsylvania Novel aav capsids and compositions containing same
EP4469584A1 (en) 2022-01-25 2024-12-04 The Trustees of The University of Pennsylvania Aav capsids for improved heart transduction and detargeting of liver
JP2026500351A (ja) 2022-12-17 2026-01-06 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア 心筋および骨格筋特異的標的化モチーフを有する組換えａａｖ変異体ベクターおよびそれを含む組成物
WO2024130070A2 (en) 2022-12-17 2024-06-20 The Trustees Of The University Of Pennsylvania Recombinant aav capsids with cardiac- and skeletal muscle- specific targeting motifs and uses thereof
WO2025007046A1 (en) 2023-06-29 2025-01-02 The Trustees Of The University Of Pennsylvania Mutant aav with central nervous system targeting motifs and compositions containing same
WO2025102034A1 (en) 2023-11-10 2025-05-15 The Trustees Of The University Of Pennsylvania Gene therapy for barth syndrome
WO2025106661A1 (en) 2023-11-14 2025-05-22 The Trustees Of The University Of Pennsylvania Compositions with cardiac and skeletal musclespecific targeting motifs and uses thereof

Family Cites Families (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4631211A (en) 1985-03-25 1986-12-23 Scripps Clinic & Research Foundation Means for sequential solid phase organic synthesis and methods using the same
US4985461A (en) 1985-10-21 1991-01-15 Rohm And Haas Company Insecticidal N'-substituted-N,N'-diacylhydrazines
US5117057A (en) 1985-10-21 1992-05-26 Rohm And Haas Company Insecticidal N' substituted-N-N'-disubstituted-hydrazines
US5424333A (en) 1985-10-21 1995-06-13 Rohm And Haas Company Anthelmintic N'-substituted-N,N'-disubstitutedhydrazines
FR2593630B1 (fr) 1986-01-27 1988-03-18 Maurice Francois Ecran d'affichage a matrice active a resistance de drain et procedes de fabrication de cet ecran
US4859609A (en) 1986-04-30 1989-08-22 Genentech, Inc. Novel receptors for efficient determination of ligands and their antagonists or agonists
US5225443A (en) 1986-05-01 1993-07-06 Rohm And Haas Company Insecticidal N'-substituted-N'-substituted N,N'-diacylhydrazines
US5071773A (en) 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays
US4981784A (en) 1987-12-02 1991-01-01 The Salk Institute For Biological Studies Retinoic acid receptor method
US5171671A (en) 1987-12-02 1992-12-15 The Salk Institute For Biological Studies Retinoic acid receptor composition
US5429952A (en) 1988-02-02 1995-07-04 Biocode, Inc. Marking of products to establish identity and source
US5010175A (en) 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
EP0413763B1 (en) 1988-06-13 1996-11-06 American Biogenetic Sciences, Inc. Method for the production of monoclonal antibodies utilizing a germfree animal
US4954655A (en) 1989-03-31 1990-09-04 Rohm And Haas Company Preparation of alkylhydrazines
US5283173A (en) 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
WO1991012258A1 (en) 1990-02-09 1991-08-22 The Salk Institute For Biological Studies Retinoid receptor compositions and methods
JP3949711B2 (ja) 1990-02-26 2007-07-25 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ 昆虫ステロイドレセプターｄｎａ配列の同定及び発現
EP0522054A4 (en) 1990-03-22 1993-02-10 The Salk Institute For Biological Studies Insect retinoid receptor compositions and methods
US7119077B1 (en) 1990-03-22 2006-10-10 The Salk Institute For Biological Studies Multimeric forms of members of the steroid/thyroid superfamily of receptors with the ultraspiracle receptor
US5688691A (en) 1990-03-22 1997-11-18 The Salk Institute For Biological Studies Insect retinoid-like receptor compositions and methods
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
CA2043775A1 (en) 1990-06-14 1991-12-15 Dat P. Le Dibenzoylakylcyanohydrazines
US5139749A (en) 1990-06-22 1992-08-18 Tas, Inc. Fluidized calcining process
IL100643A (en) 1991-01-25 1996-10-31 Nippon Kayaku Kk History of hydrazine and pesticides containing these histories as an active ingredient
WO1993003713A1 (en) 1991-08-23 1993-03-04 The Salk Institute For Biological Studies Use of selective ligands for treatment of disease states responsive to steroid or steroid-like hormones
US5668175A (en) 1991-08-23 1997-09-16 The Salk Institute For Biological Studies Use of selective ligands for treatment of disease states responsive to steroid or steroid-like retinoids
EP0609240B1 (en) 1991-09-17 2002-04-03 The Salk Institute For Biological Studies Receptors of the thyroid/steroid hormone receptor superfamily
EP1396541A3 (en) 1991-12-06 2004-11-24 The Salk Institute For Biological Studies Multimeric forms of members of the steroid/thyroid superfamily of receptors
JPH06510206A (ja) 1992-01-24 1994-11-17 アンスティテュー・ナシオナル・ドゥ・ラ・サンテ・エ・ドゥ・ラ・ルシェルシュ・メディカル 新規ヘテロダイマー核レセプタータンパク質、それをコードする遺伝子、およびその使用
US5530028A (en) 1992-11-23 1996-06-25 Rohm And Haas Company Insecticidal N'-substituted-N,N'-diacylhydrazines
US6013836A (en) 1992-02-28 2000-01-11 Rohm And Haas Company Insecticidal N'-substituted-N,N'-disubstitutedhydrazines
EP0705279B1 (en) 1993-05-27 2003-02-19 Selectide Corporation Topologically segregated, encoded solid phase libraries
AU1173995A (en) 1993-11-10 1995-05-29 Arch Development Corporation Ubiquitous nuclear receptor: compositions and methods
FR2714830B1 (fr) 1994-01-10 1996-03-22 Rhone Poulenc Rorer Sa Composition contenant des acides nucléiques, préparation et utilisations.
FR2715847B1 (fr) 1994-02-08 1996-04-12 Rhone Poulenc Rorer Sa Composition contenant des acides nucléiques, préparation et utilisations.
FR2727679B1 (fr) 1994-12-05 1997-01-03 Rhone Poulenc Rorer Sa Nouveaux agents de transfection et leurs applications pharmaceutiques
US6326166B1 (en) 1995-12-29 2001-12-04 Massachusetts Institute Of Technology Chimeric DNA-binding proteins
EP0809509A4 (en) 1995-01-13 2000-02-02 Salk Inst For Biological Studi ALLOSTERIC REGULATION OF NUCLEAR HORMONE RECEPTORS
FR2730637B1 (fr) 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
JPH11500922A (ja) 1995-03-03 1999-01-26 ノバルティス・アクチエンゲゼルシャフト 化学リガンドの存在下での受容体媒介トランス活性化による植物における遺伝子発現の制御
TR199701436T1 (xx) 1995-05-26 1998-03-21 Zeneca Limited Bir ekdison resept�r�n� i�eren bir gen anahtar�.
US5939442A (en) 1995-06-07 1999-08-17 The Salk Institute For Biological Studies Modulations of peroxisome proliferator activated receptor-γ, and methods for the use thereof
US6266622B1 (en) 1995-12-13 2001-07-24 Regents Of The University Of California Nuclear receptor ligands and ligand binding domains
GB9606126D0 (en) 1996-03-22 1996-05-22 British Biotech Pharm Biosensors
CA2200423C (en) 1996-03-26 2006-12-19 Sietse Mosselman Novel estrogen receptor
US6723531B2 (en) 1996-04-05 2004-04-20 The Salk Institute For Biological Studies Method for modulating expression of exogenous genes in mammalian systems, and products related thereto
EP0910652B1 (en) 1996-04-05 2014-10-08 The Salk Institute For Biological Studies Hormone-mediated methods for modulating expression of exogenous genes in mammalian systems, and products related thereto
US6610828B1 (en) 1996-05-24 2003-08-26 Syngenta Limited Heliothis ecdysone receptor
US6025483A (en) 1996-06-05 2000-02-15 The Regents Of The University Of California Maize and cauliflower apetalai gene products and nucleic acid molecules encoding same
US5919667A (en) 1996-06-20 1999-07-06 The Salk Institute For Biological Studies Modular assembly retroviral vectors and uses thereof
WO1998035550A2 (en) 1997-02-14 1998-08-20 New Zealand Pastoral Agriculture Research Institute Limited Insect ecdysteroid receptors
EP0998560A1 (en) 1997-07-10 2000-05-10 The Salk Institute For Biological Studies Modified lepidopteran receptors and hybrid multifunctional proteins for use in regulation of transgene expression
US6300488B1 (en) 1997-07-10 2001-10-09 The Salk Institute For Biological Studies Modified lepidopteran receptors and hybrid multifunctional proteins for use in transcription and regulation of transgene expression
WO1999010510A2 (en) 1997-08-26 1999-03-04 Ariad Gene Therapeutics, Inc. Fusion proteins comprising a dimerization, trimerization or tetramerization domain and an additional heterologous transcription activation, transcription repression, dna binding or ligand binding domain
US7101681B1 (en) 1997-11-21 2006-09-05 Amgen, Inc. Nuclear hormone receptor drug screens
US6756491B2 (en) 1998-01-09 2004-06-29 The Salk Institute For Biological Studies Steroid-activated nuclear receptors and uses therefor
AUPP135698A0 (en) 1998-01-15 1998-02-05 Commonwealth Scientific And Industrial Research Organisation Insectical modalities
US6410245B1 (en) 1998-04-01 2002-06-25 Affymax, Inc. Compositions and methods for detecting ligand-dependent nuclear receptor and coactivator interactions
JP2002510790A (ja) 1998-04-06 2002-04-09 ブンセン ラッシュ ラボラトリーズ インコーポレーテッド 指向的進化バイオセンサ
US6333318B1 (en) 1998-05-14 2001-12-25 The Salk Institute For Biological Studies Formulations useful for modulating expression of exogenous genes in mammalian systems, and products related thereto
US6258603B1 (en) * 1998-06-17 2001-07-10 Rohm And Haas Company Ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US6117639A (en) 1998-08-31 2000-09-12 Vertex Pharmaceuticals Incorporated Fusion proteins, DNA molecules, vectors, and host cells useful for measuring protease activity
HUP0103993A3 (en) 1998-09-10 2003-10-28 Pioneer Hi Bred Internat Inc D Ecdysone receptors and methods for their use
AU6501499A (en) 1998-09-29 2000-04-17 Johns Hopkins University, The Inducible genetic suppression of cellular excitability
US5989863A (en) 1998-10-14 1999-11-23 Incyte Pharmaceuticals, Inc. Human ankyrin family protein
WO2000071743A1 (fr) 1999-05-25 2000-11-30 Eisai Co., Ltd. Methode bihybride dans une cellule de mammifere
US6591884B1 (en) 1999-05-25 2003-07-15 Silverbrook Research Pty Ltd Printed media production
EP1203022A4 (en) 1999-07-01 2004-09-08 Commw Scient Ind Res Org NOVEL GENETIC SEQUENCES ENCODING THE STEROID HORMONE AND NEOTININ RECEPTORS AND USES THEREOF
US7057015B1 (en) 1999-10-20 2006-06-06 The Salk Institute For Biological Studies Hormone receptor functional dimers and methods of their use
AU2001241682A1 (en) * 2000-02-24 2001-09-03 The Salk Institute For Biological Studies Gene expression system based on chimeric receptors
US20040033600A1 (en) 2001-03-21 2004-02-19 Palli Subba Reddy Ecdysone receptor-based inducible gene expression system
JP5031967B2 (ja) 2000-03-22 2012-09-26 イントレキソン コーポレーション 新規エクジソン受容体ベースの誘導性遺伝子発現系
US20020037514A1 (en) * 2000-03-24 2002-03-28 Klein Elliott S. Identification of nuclear receptor-dependent coregulator recruitment
US8105825B2 (en) 2000-10-03 2012-01-31 Intrexon Corporation Multiple inducible gene regulation system
DK1373470T3 (da) 2001-02-20 2013-07-29 Intrexon Corp Hidtil ukendte substitutionsmutantreceptorer og deres anvendelse i et cellekernereceptorbaseret inducerbart genekspressionssystem
WO2002066614A2 (en) 2001-02-20 2002-08-29 Rheogene Holdings, Inc. Chimeric retinoid x receptors and their use in a novel ecdysone receptor-based inducible gene expression system
ES2385598T3 (es) * 2001-02-20 2012-07-27 Intrexon Corporation Sistema novedoso de expresión génica inducible basado en el receptor de ecdisona/receptor X retinoide de invertebrado
AU2002248500B2 (en) 2001-02-20 2007-12-13 Intrexon Corporation Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
WO2003027289A1 (en) 2001-09-26 2003-04-03 Rheo Gene Holdings, Inc. Leafhopper ecdysone receptor nucleic acids, polypeptides, and uses thereof
CA2930389A1 (en) 2001-09-26 2003-04-03 Intrexon Corporation Whitefly ecdysone receptor nucleic acids, polypeptides, and uses thereof
WO2003105489A1 (en) 2002-06-07 2003-12-18 The Trustees Of Columbia University Method and device for online dynamic semantic video compression and video indexing
US20050228016A1 (en) 2002-06-13 2005-10-13 Enrique Michelotti Tetrahydroquinolines for modulating the expression of exogenous genes via an ecdysone receptor complex
US7375093B2 (en) 2002-07-05 2008-05-20 Intrexon Corporation Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US7304161B2 (en) 2003-02-10 2007-12-04 Intrexon Corporation Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
US7304162B2 (en) 2003-02-21 2007-12-04 Intrexon Corporation Oxadiazoline ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US7456315B2 (en) 2003-02-28 2008-11-25 Intrexon Corporation Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US7935510B2 (en) 2004-04-30 2011-05-03 Intrexon Corporation Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
US9034650B2 (en) 2005-02-02 2015-05-19 Intrexon Corporation Site-specific serine recombinases and methods of their use
US8115059B1 (en) 2005-07-22 2012-02-14 University Of Kentucky Research Foundation Gene expression modulation system for use in plants and method for modulating gene expression in plants
US8471890B1 (en) 2009-12-30 2013-06-25 Insors Integrated Communications Adaptive video communication channel

Also Published As

Publication number Publication date
EP1456346B1 (en) 2012-02-15
AU2002247184B2 (en) 2008-06-19
US9493540B2 (en) 2016-11-15
AU2008221578B2 (en) 2012-05-03
JP2013236634A (ja) 2013-11-28
US20120167239A1 (en) 2012-06-28
WO2002066613A2 (en) 2002-08-29
JP5887301B2 (ja) 2016-03-16
EP1456346A4 (en) 2006-12-20
CA2441444C (en) 2013-09-03
JP4955904B2 (ja) 2012-06-20
JP2004533214A (ja) 2004-11-04
DK1456346T3 (da) 2012-05-29
JP2009131259A (ja) 2009-06-18
ES2385598T3 (es) 2012-07-27
EP1456346A2 (en) 2004-09-15
ATE545705T1 (de) 2012-03-15
US20170096672A1 (en) 2017-04-06
PT1456346E (pt) 2012-05-02
CA2441444A1 (en) 2002-08-29
AU2008221578A1 (en) 2008-10-16
JP5345372B2 (ja) 2013-11-20
WO2002066613A3 (en) 2004-07-15

Similar Documents

Publication Publication Date Title
MXPA03007493A (es) Nuevo sistema de expresion genetica inducible a base de receptor de ecdisona/receptor x retinoide de invertebrado.
MXPA03007492A (es) Receptores de retinoide x quimerico y su uso en un sistema de expresion de gen inducible basado en receptor de ecdisona novedoso.
MXPA03007496A (es) Nuevos receptores mutantes de sustitucion y su uso en un sistema de expresion genetica inducible a base de receptores nucleares.
MXPA02009157A (es) Nuevo sistema de expresion genetica inducible a base del receptor de ecdisona.
WO2002066615A3 (en) Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
WO2005108617A3 (en) Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
Guisbert et al. Convergence of molecular, modeling, and systems approaches for an understanding of the Escherichia coli heat shock response
Hennig et al. Large-scale low-cost NGS library preparation using a robust Tn5 purification and tagmentation protocol
Lartigue et al. Genome transplantation in bacteria: changing one species to another
Vo et al. Unbiased profiling of CRISPR RNA-guided transposition products by long-read sequencing
Ronda et al. Accelerating genome editing in CHO cells using CRISPR Cas9 and CRISPy, a web‐based target finding tool
ATE400651T1 (de) Verwendung von grünem fluoreszenzprotein
TWI319008B (en) Multiple inducible gene regulation system
Jayaraman et al. Cell-free optogenetic gene expression system
Tenhaef et al. Automated rational strain construction based on high-throughput conjugation
BR9607300A (pt) Polinucleotídeo transcrito de rna cdna vetor de dna biologicamente funcional célula hospedeira processo para produzir um polipeptídeo polipeptídeo produto de anticorpo hibridoma e linhagem de célula de hibridoma
Abdulsalam et al. Deciphering the genetic code: Mechanisms, evolution, and implications for biotechnology
Arakawa A method to convert mRNA into a gRNA library for CRISPR/Cas9 editing of any organism
Prabhakar et al. Uncovering translation roadblocks during the development of a synthetic tRNA
Kuchmina et al. Ethylene production in Synechocystis sp. PCC 6803 promotes phototactic movement
Rousseau et al. The helix–turn–helix motif of bacterial insertion sequence IS 911 transposase is required for DNA binding
Pohlschroder et al. Haloferax volcanii: a versatile model for studying archaeal biology
Kiel et al. Ribosome recycling: an essential process of protein synthesis
Schmitt et al. Archimedes’ principle for characterisation of recombinant whole cell biocatalysts
Koh et al. Regulation of DNA replication initiation by ParA is independent of parS location in Bacillus subtilis

Legal Events

Date Code Title Description
GB Transfer or assignment
FG Grant or registration