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AR084903A1 - Derivados de aminodihidrotiazina fusionada - Google Patents

Derivados de aminodihidrotiazina fusionada

Info

Publication number
AR084903A1
AR084903A1 ARP120100191A ARP120100191A AR084903A1 AR 084903 A1 AR084903 A1 AR 084903A1 AR P120100191 A ARP120100191 A AR P120100191A AR P120100191 A ARP120100191 A AR P120100191A AR 084903 A1 AR084903 A1 AR 084903A1
Authority
AR
Argentina
Prior art keywords
aminodihydrotiazine
fused
derivatives
inhibitory effect
bace1
Prior art date
Application number
ARP120100191A
Other languages
English (en)
Inventor
Adrian Hall
Christopher Neil Farthing
Pineiro Jose Luis Castro
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43769479&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR084903(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of AR084903A1 publication Critical patent/AR084903A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente se refiere a un derivado de aminodihidrotiazina fusionado de fórmula (1) donde: X es hidrógeno o flúor; A es CH o N; Y es metilo, etilo, monofluorometilo, difluorometilo, trifluorometilo, difluoroetilo, metoxi, etoxi, metoximetilo -CºN; y sus sales farmacéuticamente aceptables; tal compuesto tiene un efecto inhibidor de la producción de Ab o un efecto inhibidor de BACE1 y es útil como un agente profiláctico o terapéutico para una enfermedad neurodegenerativa causada por Ab y tipificado por demencia tipo Alzheimer.
ARP120100191A 2011-01-21 2012-01-20 Derivados de aminodihidrotiazina fusionada AR084903A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1101140.0A GB201101140D0 (en) 2011-01-21 2011-01-21 Fused aminodihydrothiazine derivatives

Publications (1)

Publication Number Publication Date
AR084903A1 true AR084903A1 (es) 2013-07-10

Family

ID=43769479

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120100191A AR084903A1 (es) 2011-01-21 2012-01-20 Derivados de aminodihidrotiazina fusionada

Country Status (22)

Country Link
US (3) US8338407B2 (es)
EP (1) EP2665732B1 (es)
JP (1) JP5947815B2 (es)
KR (1) KR101906466B1 (es)
CN (1) CN103328486B (es)
AR (1) AR084903A1 (es)
AU (1) AU2012208526B2 (es)
BR (1) BR112013018602A2 (es)
CA (1) CA2828738A1 (es)
CL (1) CL2013002083A1 (es)
ES (1) ES2575914T3 (es)
GB (1) GB201101140D0 (es)
IL (1) IL226596A (es)
MX (1) MX2013007917A (es)
PE (1) PE20141182A1 (es)
PH (1) PH12013501085A1 (es)
RU (1) RU2593756C2 (es)
SG (1) SG190908A1 (es)
TW (1) TW201309710A (es)
UA (1) UA109927C2 (es)
WO (1) WO2012098213A1 (es)
ZA (1) ZA201303801B (es)

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GB201101140D0 (en) 2011-01-21 2011-03-09 Eisai Ltd Fused aminodihydrothiazine derivatives
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AR103680A1 (es) * 2015-02-23 2017-05-24 Lilly Co Eli Inhibidores selectivos de bace1
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TWI675034B (zh) * 2016-05-20 2019-10-21 美商美國禮來大藥廠 四氫呋喃并<img align="absmiddle" height="18px" width="27px" file="d10999.TIF" alt="其他非圖式 ed10999.png" img-content="tif" orientation="portrait" inline="yes" giffile="ed10999.png"></img>化合物及其作為選擇性ＢＡＣＥ１抑制劑之用途
JP2019530647A (ja) * 2016-08-18 2019-10-24 イーライ リリー アンド カンパニー Ｂａｃｅ−１阻害剤と抗ｎ３ｐｇｌｕ ａベータ抗体の併用療法
TWI669119B (zh) 2016-10-21 2019-08-21 美國禮來大藥廠 組合療法
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Also Published As

Publication number Publication date
KR20140002724A (ko) 2014-01-08
AU2012208526A1 (en) 2013-05-02
CA2828738A1 (en) 2012-07-26
IL226596A (en) 2016-04-21
JP2014502987A (ja) 2014-02-06
EP2665732A1 (en) 2013-11-27
US20130203740A1 (en) 2013-08-08
ZA201303801B (en) 2014-07-30
WO2012098213A1 (en) 2012-07-26
US8338407B2 (en) 2012-12-25
EP2665732B1 (en) 2016-03-30
RU2593756C2 (ru) 2016-08-10
CL2013002083A1 (es) 2013-12-06
SG190908A1 (en) 2013-07-31
ES2575914T3 (es) 2016-07-04
US20120190672A1 (en) 2012-07-26
US20140142091A1 (en) 2014-05-22
GB201101140D0 (en) 2011-03-09
CN103328486B (zh) 2016-08-17
UA109927C2 (ru) 2015-10-26
CN103328486A (zh) 2013-09-25
RU2013138717A (ru) 2015-02-27
US8592408B2 (en) 2013-11-26
PH12013501085A1 (en) 2017-10-25
US8940734B2 (en) 2015-01-27
BR112013018602A2 (pt) 2020-09-01
AU2012208526B2 (en) 2015-09-24
JP5947815B2 (ja) 2016-07-06
TW201309710A (zh) 2013-03-01
KR101906466B1 (ko) 2018-10-10
PE20141182A1 (es) 2014-09-14
MX2013007917A (es) 2013-08-29
NZ611365A (en) 2015-04-24

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