AR078517A1 - Composicion farmaceutica, forma de dosificacion farmaceutica, procedimiento para su preparacion, metodos para su tratamiento y sus usos - Google Patents
Composicion farmaceutica, forma de dosificacion farmaceutica, procedimiento para su preparacion, metodos para su tratamiento y sus usosInfo
- Publication number
- AR078517A1 AR078517A1 ARP100103599A ARP100103599A AR078517A1 AR 078517 A1 AR078517 A1 AR 078517A1 AR P100103599 A ARP100103599 A AR P100103599A AR P100103599 A ARP100103599 A AR P100103599A AR 078517 A1 AR078517 A1 AR 078517A1
- Authority
- AR
- Argentina
- Prior art keywords
- tablet
- pharmaceutical composition
- prevent
- diabetes mellitus
- composition according
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 9
- 239000002552 dosage form Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 239000003826 tablet Substances 0.000 abstract 10
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 5
- 239000003814 drug Substances 0.000 abstract 5
- 239000008103 glucose Substances 0.000 abstract 5
- 229940079593 drug Drugs 0.000 abstract 4
- 201000001421 hyperglycemia Diseases 0.000 abstract 4
- 210000002237 B-cell of pancreatic islet Anatomy 0.000 abstract 3
- 208000001145 Metabolic Syndrome Diseases 0.000 abstract 3
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 abstract 3
- 230000037396 body weight Effects 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 230000001771 impaired effect Effects 0.000 abstract 3
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 3
- 208000002705 Glucose Intolerance Diseases 0.000 abstract 2
- 206010022489 Insulin Resistance Diseases 0.000 abstract 2
- 208000008589 Obesity Diseases 0.000 abstract 2
- 206010033307 Overweight Diseases 0.000 abstract 2
- 229940123518 Sodium/glucose cotransporter 2 inhibitor Drugs 0.000 abstract 2
- 239000008280 blood Substances 0.000 abstract 2
- 210000004369 blood Anatomy 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000030159 metabolic disease Diseases 0.000 abstract 2
- 235000020824 obesity Nutrition 0.000 abstract 2
- 201000009104 prediabetes syndrome Diseases 0.000 abstract 2
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- 208000002177 Cataract Diseases 0.000 abstract 1
- 208000002249 Diabetes Complications Diseases 0.000 abstract 1
- 102000017011 Glycated Hemoglobin A Human genes 0.000 abstract 1
- 108010014663 Glycated Hemoglobin A Proteins 0.000 abstract 1
- 206010060378 Hyperinsulinaemia Diseases 0.000 abstract 1
- 206010061216 Infarction Diseases 0.000 abstract 1
- 208000031773 Insulin resistance syndrome Diseases 0.000 abstract 1
- 206010054805 Macroangiopathy Diseases 0.000 abstract 1
- 208000030831 Peripheral arterial occlusive disease Diseases 0.000 abstract 1
- 208000017442 Retinal disease Diseases 0.000 abstract 1
- 206010038923 Retinopathy Diseases 0.000 abstract 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 238000009825 accumulation Methods 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 229940000425 combination drug Drugs 0.000 abstract 1
- 230000006835 compression Effects 0.000 abstract 1
- 238000007906 compression Methods 0.000 abstract 1
- 230000007423 decrease Effects 0.000 abstract 1
- 230000007850 degeneration Effects 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000007888 film coating Substances 0.000 abstract 1
- 238000009501 film coating Methods 0.000 abstract 1
- 230000002641 glycemic effect Effects 0.000 abstract 1
- 230000003451 hyperinsulinaemic effect Effects 0.000 abstract 1
- 201000008980 hyperinsulinism Diseases 0.000 abstract 1
- 230000007574 infarction Effects 0.000 abstract 1
- 230000003914 insulin secretion Effects 0.000 abstract 1
- 208000028867 ischemia Diseases 0.000 abstract 1
- 208000017169 kidney disease Diseases 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 201000000083 maturity-onset diabetes of the young type 1 Diseases 0.000 abstract 1
- 229960004329 metformin hydrochloride Drugs 0.000 abstract 1
- OETHQSJEHLVLGH-UHFFFAOYSA-N metformin hydrochloride Chemical compound Cl.CN(C)C(=N)N=C(N)N OETHQSJEHLVLGH-UHFFFAOYSA-N 0.000 abstract 1
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin hydrochloride Natural products CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 abstract 1
- 210000004165 myocardium Anatomy 0.000 abstract 1
- 201000001119 neuropathy Diseases 0.000 abstract 1
- 230000007823 neuropathy Effects 0.000 abstract 1
- 208000033808 peripheral neuropathy Diseases 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 229940124531 pharmaceutical excipient Drugs 0.000 abstract 1
- 230000000291 postprandial effect Effects 0.000 abstract 1
- 229940121377 sodium-glucose co-transporter inhibitor Drugs 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Composiciones farmacéuticas que comprenden combinaciones en dosis fijas de un fármaco inhibidor de SGLT-2 y de un fármaco acompanante, procedimientos para la preparacion de las mismas y su utilizacion para tratar determinadas enfermedades Reivindicacion 1: Una composicion farmacéutica caracterizada porque comprende un inhibidor de SGLT-2, un fármaco acompanante, y uno o más excipientes farmacéuticos. Reivindicacion 3: La composicion farmacéutica de acuerdo con la reivindicacion 1 o 2, caracterizada porque el inhibidor de SGLT-2 está presente en un intervalo de dosificacion de aproximadamente 0,5 mg a aproximadamente 50 mg, particularmente de aproximadamente 1 mg a aproximadamente 25 mg. Reivindicacion 7: La composicion farmacéutica de acuerdo con la reivindicacion 6, caracterizada porque el clorhidrato de metformina está presente en un intervalo de dosificacion de aproximadamente 100 mg a aproximadamente 1500 mg. Reivindicacion 15: La composicion farmacéutica segun la reivindicacion 14, caracterizada porque el comprimido se selecciona entre un comprimido con una capa, un comprimido con dos capas, un comprimido recubierto por compresion (incluido un comprimido en comprimido y un comprimido en ojo de buey) y un comprimido que tiene un revestimiento pelicular para la carga del fármaco. Reivindicacion 16: La composicion farmacéutica segun la reivindicacion 14 o 15, caracterizada porque el comprimido comprende una cubierta pelicular. Reivindicacion 21: La forma de dosificacion farmacéutica segun la reivindicacion 20, caracterizada porque es una forma de dosificacion farmacéutica solida, cápsula o comprimido. Reivindicacion 24: Un método para prevenir, reducir la progresion, retrasar o tratar un trastorno metabolico seleccionado del grupo que consiste en diabetes mellitus tipo 1, diabetes mellitus tipo 2, alteracion de la tolerancia a la glucosa, alteracion de la glucosa sanguínea en ayunas, hiperglucemia, hiperglucemia posprandial, sobrepeso, obesidad y síndrome metabolico en un paciente que lo necesite, caracterizado porque se administra al paciente una composicion farmacéutica segun una o más de las reivindicaciones 1 a 19 o una forma de dosificacion farmacéutica segun una o más de las reivindicaciones 20 a 23. Reivindicacion 34: El uso de una composicion farmacéutica de acuerdo con una de las reivindicaciones 1 a 19, caracterizado porque es para la fabricacion de un medicamento para prevenir, frenar el avance, retrasar o tratar un trastorno metabolico seleccionado entre el grupo que consiste en diabetes mellitus de tipo 1, diabetes mellitus de tipo 2, alteracion de la tolerancia a la glucosa, alteracion de la glucosa sanguínea en ayunas, hiperglucemia, hiperglucemia posprandial, sobrepeso, obesidad y síndrome metabolico; o - mejorar el control glucémico y/o reducir la glucosa plasmática en ayunas, la glucosa plasmática posprandial y/o la hemoglobina glicosilada HbA1c; o - prevenir, frenar, retrasar o revertir el avance desde una alteracion de la tolerancia a la glucosa, la resistencia a la insulina y/o el síndrome metabolico hasta la diabetes mellitus de tipo 2; o - prevenir, frenar la progresion, retrasar o tratar una afeccion o trastorno seleccionado del grupo de complicaciones de la diabetes mellitus, tales como cataratas y enfermedades micro- y macrovasculares, tales como nefropatía, retinopatía, neuropatía, isquemia de tejidos, arteriosclerosis, infarto de miocardio, accidentes cerebrovasculares y enfermedad oclusiva arterial periférica; o - reducir el peso corporal o prevenir un aumento en el peso corporal o facilitar una reduccion en el peso corporal o prevenir, reducir, retrasar o tratar la degeneracion de las células beta pancreáticas y/o el declive de la funcionalidad de las células beta pancreáticas, y/o mejorar y/o restablecer la funcionalidad de las células beta pancreáticas y/o restablecer la funcionalidad de la secrecion de insulina pancreática; o - para prevenir, frenar, retrasar o tratar enfermedades o afecciones atribuidas a una acumulacion anormal de grasa en el hígado; o - mantener y/o mejorar la sensibilidad a la insulina y/o tratar o prevenir hiperinsulinemia y/o resistencia a la insulina; en un paciente que lo necesite.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09172081 | 2009-10-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR078517A1 true AR078517A1 (es) | 2011-11-16 |
Family
ID=43384552
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100103599A AR078517A1 (es) | 2009-10-02 | 2010-10-01 | Composicion farmaceutica, forma de dosificacion farmaceutica, procedimiento para su preparacion, metodos para su tratamiento y sus usos |
Country Status (38)
| Country | Link |
|---|---|
| US (3) | US10610489B2 (es) |
| EP (3) | EP3150200B1 (es) |
| JP (1) | JP5738300B2 (es) |
| KR (1) | KR101747152B1 (es) |
| CN (2) | CN102573808A (es) |
| AP (1) | AP3438A (es) |
| AR (1) | AR078517A1 (es) |
| AU (1) | AU2010302641B2 (es) |
| BR (1) | BR112012009376B8 (es) |
| CA (1) | CA2776288C (es) |
| CL (1) | CL2012000793A1 (es) |
| CY (1) | CY1118661T1 (es) |
| DK (2) | DK2482806T3 (es) |
| EA (1) | EA027181B1 (es) |
| EC (1) | ECSP12011834A (es) |
| ES (2) | ES2616606T3 (es) |
| FI (1) | FI3150200T3 (es) |
| HK (1) | HK1213498A1 (es) |
| HR (2) | HRP20170400T1 (es) |
| HU (2) | HUE067332T2 (es) |
| IL (1) | IL218257A (es) |
| IN (1) | IN2012DN02805A (es) |
| LT (2) | LT2482806T (es) |
| MA (1) | MA33608B1 (es) |
| ME (1) | ME02564B (es) |
| MX (1) | MX2012003102A (es) |
| NZ (1) | NZ598323A (es) |
| PE (1) | PE20120955A1 (es) |
| PH (1) | PH12012500646A1 (es) |
| PL (2) | PL2482806T3 (es) |
| PT (2) | PT2482806T (es) |
| RS (2) | RS55588B1 (es) |
| SI (2) | SI3150200T1 (es) |
| TN (1) | TN2012000143A1 (es) |
| TW (1) | TWI477509B (es) |
| UA (1) | UA106634C2 (es) |
| UY (1) | UY32919A (es) |
| WO (1) | WO2011039337A1 (es) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
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2017
- 2017-02-24 CY CY20171100258T patent/CY1118661T1/el unknown
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2020
- 2020-02-21 US US16/797,163 patent/US20200188306A1/en not_active Abandoned
-
2024
- 2024-01-16 US US18/413,822 patent/US20240148656A1/en active Pending
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