AR078515A1 - Moleculas de union biespecificas de union a vegf (factor de crecimiento endotelial vascular) y a dll4 (ligando 4 de tipo delta) para la terapia anti-angiogenesis - Google Patents
Moleculas de union biespecificas de union a vegf (factor de crecimiento endotelial vascular) y a dll4 (ligando 4 de tipo delta) para la terapia anti-angiogenesisInfo
- Publication number
- AR078515A1 AR078515A1 ARP100103596A ARP100103596A AR078515A1 AR 078515 A1 AR078515 A1 AR 078515A1 AR P100103596 A ARP100103596 A AR P100103596A AR P100103596 A ARP100103596 A AR P100103596A AR 078515 A1 AR078515 A1 AR 078515A1
- Authority
- AR
- Argentina
- Prior art keywords
- xaa
- tyr
- vegf
- immunoglobulin
- ala
- Prior art date
Links
- 102100033553 Delta-like protein 4 Human genes 0.000 title 1
- 101000872077 Homo sapiens Delta-like protein 4 Proteins 0.000 title 1
- 230000003527 anti-angiogenesis Effects 0.000 title 1
- 239000003102 growth factor Substances 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 230000002792 vascular Effects 0.000 title 1
- 108060003951 Immunoglobulin Proteins 0.000 abstract 7
- 102000018358 immunoglobulin Human genes 0.000 abstract 7
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 abstract 6
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 abstract 6
- 150000001413 amino acids Chemical group 0.000 abstract 2
- BJHCYTJNPVGSBZ-YXSASFKJSA-N 1-[4-[6-amino-5-[(Z)-methoxyiminomethyl]pyrimidin-4-yl]oxy-2-chlorophenyl]-3-ethylurea Chemical compound CCNC(=O)Nc1ccc(Oc2ncnc(N)c2\C=N/OC)cc1Cl BJHCYTJNPVGSBZ-YXSASFKJSA-N 0.000 abstract 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
- DBKNLHKEVPZVQC-LPEHRKFASA-N Arg-Ala-Pro Chemical compound NC(N)=NCCC[C@H](N)C(=O)N[C@@H](C)C(=O)N1CCC[C@@H]1C(O)=O DBKNLHKEVPZVQC-LPEHRKFASA-N 0.000 abstract 1
- ZDBWKBCKYJGKGP-DCAQKATOSA-N Arg-Leu-Ala Chemical compound [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(O)=O ZDBWKBCKYJGKGP-DCAQKATOSA-N 0.000 abstract 1
- ILJQISGMGXRZQQ-IHRRRGAJSA-N Asp-Arg-Tyr Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O ILJQISGMGXRZQQ-IHRRRGAJSA-N 0.000 abstract 1
- MJJIHRWNWSQTOI-VEVYYDQMSA-N Asp-Thr-Arg Chemical compound OC(=O)C[C@H](N)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O MJJIHRWNWSQTOI-VEVYYDQMSA-N 0.000 abstract 1
- JDDYEZGPYBBPBN-JRQIVUDYSA-N Asp-Thr-Tyr Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O JDDYEZGPYBBPBN-JRQIVUDYSA-N 0.000 abstract 1
- NALWOULWGHTVDA-UWVGGRQHSA-N Asp-Tyr Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 NALWOULWGHTVDA-UWVGGRQHSA-N 0.000 abstract 1
- CUYLIWAAAYJKJH-RYUDHWBXSA-N Gly-Glu-Tyr Chemical compound NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 CUYLIWAAAYJKJH-RYUDHWBXSA-N 0.000 abstract 1
- 101000808011 Homo sapiens Vascular endothelial growth factor A Proteins 0.000 abstract 1
- JTBFQNHKNRZJDS-SYWGBEHUSA-N Ile-Trp-Ala Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](C)C(=O)O)N JTBFQNHKNRZJDS-SYWGBEHUSA-N 0.000 abstract 1
- SENJXOPIZNYLHU-UHFFFAOYSA-N L-leucyl-L-arginine Natural products CC(C)CC(N)C(=O)NC(C(O)=O)CCCN=C(N)N SENJXOPIZNYLHU-UHFFFAOYSA-N 0.000 abstract 1
- OIDKVWTWGDWMHY-RYUDHWBXSA-N Pro-Tyr Chemical compound C([C@@H](C(=O)O)NC(=O)[C@H]1NCCC1)C1=CC=C(O)C=C1 OIDKVWTWGDWMHY-RYUDHWBXSA-N 0.000 abstract 1
- GXXTUIUYTWGPMV-FXQIFTODSA-N Ser-Arg-Ala Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(O)=O GXXTUIUYTWGPMV-FXQIFTODSA-N 0.000 abstract 1
- WDXYVIIVDIDOSX-DCAQKATOSA-N Ser-Arg-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)CCCN=C(N)N WDXYVIIVDIDOSX-DCAQKATOSA-N 0.000 abstract 1
- FEZASNVQLJQBHW-CABZTGNLSA-N Trp-Gly-Ala Chemical compound C1=CC=C2C(C[C@H](N)C(=O)NCC(=O)N[C@@H](C)C(O)=O)=CNC2=C1 FEZASNVQLJQBHW-CABZTGNLSA-N 0.000 abstract 1
- QZOSVNLXLSNHQK-UWVGGRQHSA-N Tyr-Asp Chemical compound OC(=O)C[C@@H](C(O)=O)NC(=O)[C@@H](N)CC1=CC=C(O)C=C1 QZOSVNLXLSNHQK-UWVGGRQHSA-N 0.000 abstract 1
- AZGZDDNKFFUDEH-QWRGUYRKSA-N Tyr-Gly-Ser Chemical compound OC[C@@H](C(O)=O)NC(=O)CNC(=O)[C@@H](N)CC1=CC=C(O)C=C1 AZGZDDNKFFUDEH-QWRGUYRKSA-N 0.000 abstract 1
- 102000016549 Vascular Endothelial Growth Factor Receptor-2 Human genes 0.000 abstract 1
- 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 abstract 1
- 108010041407 alanylaspartic acid Proteins 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 108010068265 aspartyltyrosine Proteins 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 102000058223 human VEGFA Human genes 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 108010000761 leucylarginine Proteins 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 108010079317 prolyl-tyrosine Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Abstract
Moléculas de union biespecíficas, en particular dominios variables sencillos de inmunoglobulina tales como VHH y anticuerpos de dominio, que comprenden un componente de union a VEGF y un componente de union a DII4 en una molécula. Composiciones farmacéuticas que contienen los mismos y su uso en el tratamiento de enfermedades que están asociadas con efectos mediados por VEGF y DII4 sobre la angiogénesis. Ácidos nucleicos que codifican las moléculas de union biespecificas, células hospedadoras y métodos para prepararlas. Reivindicacion 5: Una molécula de union biespecífica de una cualquiera de las reivindicaciones 2 a 4, caracterizada porque dicho componente de union a DII4 y dicho componente de union a VEGF comprende al menos un dominio variable sencillo de inmunoglobulina de union a VEGF y al menos un domino variable sencillo de inmunoglobulina de union a DII4, respectivamente, en el que dicho dominio variable sencillo de inmunoglobulina tiene cuatro regiones flanqueantes y tres regiones determinantes de la complementariedad CDR1, CDR2 y CDR3, respectivamente, en las que a) una CDR de dicho al menos un dominio variable sencillo de inmunoglobulina de union a DII4 tiene una secuencia de aminoácidos seleccionada de i. Arg Ala Pro Asp Thr Arg Leu Xaa Pro Tyr Xaa Tyr Asp Xaa se muestra la SEC ID N°: 1, en la que Xaa en la posicion 8 es Arg, Ala o Glu; Xaa en la posicion 11 es Leu o Glu; y Xaa en la posicion 14 es Tyr o His; y ii. Asp Arg Tyr Ile Trp Ala Arg GIn Gly Glu Tyr Trp Gly Ala Tyr Xaa AspTyr como se muestra en la SEC ID N°: 2, en la que Xaa es GIn, Ala o Tyr; y en la que b) una CDR de dicho dominio al menos un dominio variable sencillo de inmunoglobulina de union a VEGF tiene la secuencia de aminoácidos Ser Arg Ala Tyr Gly Ser Ser Arg Leu Arg Leu Ala Asp Thr Tyr Xaa Tyr, mostrada en la SEC ID N°: 3, en la que Xaa es Asp o Glu, en la que dicho dominio variable sencillo de inmunoglobulina de union a VEGF es capaz de bloquear la interaccion de VEGF165 recombinante humano con el VEGFR-2 recombinante humano con una velocidad de inhibicion >= 60%.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09172137 | 2009-10-02 | ||
| EP10175316 | 2010-09-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR078515A1 true AR078515A1 (es) | 2011-11-16 |
Family
ID=43431796
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100103596A AR078515A1 (es) | 2009-10-02 | 2010-10-01 | Moleculas de union biespecificas de union a vegf (factor de crecimiento endotelial vascular) y a dll4 (ligando 4 de tipo delta) para la terapia anti-angiogenesis |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US20110172398A1 (es) |
| EP (1) | EP2483314A1 (es) |
| JP (2) | JP5833009B2 (es) |
| KR (1) | KR20120101375A (es) |
| CN (2) | CN105037542A (es) |
| AP (1) | AP2012006188A0 (es) |
| AR (1) | AR078515A1 (es) |
| AU (1) | AU2010302589A1 (es) |
| BR (1) | BR112012007239A2 (es) |
| CA (1) | CA2775422A1 (es) |
| CL (1) | CL2012000826A1 (es) |
| EA (1) | EA201200548A1 (es) |
| EC (1) | ECSP12011835A (es) |
| IL (1) | IL218542A0 (es) |
| IN (1) | IN2012DN02752A (es) |
| MA (1) | MA33607B1 (es) |
| MX (1) | MX2012003897A (es) |
| NZ (2) | NZ626302A (es) |
| PE (1) | PE20121024A1 (es) |
| PH (1) | PH12012500525A1 (es) |
| TN (1) | TN2012000145A1 (es) |
| TW (1) | TW201124533A (es) |
| UY (1) | UY32920A (es) |
| WO (1) | WO2011039370A1 (es) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7750124B2 (en) * | 2006-09-29 | 2010-07-06 | Oncomed Pharmaceuticals, Inc. | Anti-human DLL4 antibodies and compositions |
| BRPI0910482A2 (pt) | 2008-04-29 | 2019-09-24 | Abbott Lab | imunoglobinas de domínio variável duplo e usos das mesmas |
| NZ589436A (en) | 2008-06-03 | 2012-12-21 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| TW201008580A (en) | 2008-06-03 | 2010-03-01 | Abbott Lab | Dual variable domain immunoglobulin and uses thereof |
| US8268314B2 (en) | 2008-10-08 | 2012-09-18 | Hoffmann-La Roche Inc. | Bispecific anti-VEGF/anti-ANG-2 antibodies |
| EP3243835B1 (en) | 2009-02-11 | 2024-04-10 | Albumedix Ltd | Albumin variants and conjugates |
| WO2010129304A2 (en) | 2009-04-27 | 2010-11-11 | Oncomed Pharmaceuticals, Inc. | Method for making heteromultimeric molecules |
| WO2011025964A2 (en) | 2009-08-29 | 2011-03-03 | Abbott Laboratories | Therapeutic dll4 binding proteins |
| UY32920A (es) * | 2009-10-02 | 2011-04-29 | Boehringer Ingelheim Int | Moleculas de unión biespecíficas para la terapia anti-angiogénesis |
| US8883145B2 (en) | 2009-10-16 | 2014-11-11 | Oncomed Pharmaceuticals, Inc. | Methods of treatment with DLL4 antagonists and an anti-hypertensive agent |
| ES2700230T3 (es) | 2009-10-30 | 2019-02-14 | Albumedix Ltd | Variantes de albúmina |
| UA112743C2 (uk) | 2010-03-02 | 2016-10-25 | Еббві Інк. | Терапевтичний dll4-зв'язувальний білок |
| PE20130207A1 (es) | 2010-05-06 | 2013-02-28 | Novartis Ag | Anticuerpos antagonistas de lrp6 (proteina relacionada con lipoproteinas de baja densidad 6) y composiciones |
| EA201291181A1 (ru) | 2010-05-06 | 2013-05-30 | Новартис Аг | Композиции и способы применения терапевтических поливалентных антител против белка, родственного рецептору липопротеинов низкой плотности 6 (lrp6) |
| WO2012010550A1 (en) | 2010-07-19 | 2012-01-26 | F. Hoffmann-La Roche Ag | Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy |
| KR20130126576A (ko) | 2010-07-19 | 2013-11-20 | 에프. 호프만-라 로슈 아게 | 항암요법에 반응할 가능성이 증가된 환자를 확인하는 방법 |
| NZ607480A (en) | 2010-08-03 | 2014-10-31 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| JP2013539364A (ja) | 2010-08-26 | 2013-10-24 | アッヴィ・インコーポレイテッド | 二重可変ドメイン免疫グロブリンおよびその使用 |
| US20120225081A1 (en) * | 2010-09-03 | 2012-09-06 | Boehringer Ingelheim International Gmbh | Vegf-binding molecules |
| US8551479B2 (en) | 2010-09-10 | 2013-10-08 | Oncomed Pharmaceuticals, Inc. | Methods for treating melanoma |
| WO2012068098A1 (en) * | 2010-11-15 | 2012-05-24 | Oncomed Pharmaceuticals, Inc. | Methods for treating cancer with dll4 antagonists |
| US9527925B2 (en) | 2011-04-01 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to VEGF and ANG2 |
| US20130078247A1 (en) * | 2011-04-01 | 2013-03-28 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to dii4 and ang2 |
| AU2015268749B2 (en) * | 2011-09-23 | 2017-05-25 | Oncomed Pharmaceuticals, Inc. | VEGF/DLL4 binding agents and uses thereof |
| LT3485903T (lt) * | 2011-09-23 | 2023-02-27 | Mereo Biopharma 5, Inc. | Vegf/ dll4 surišantys agentai ir jų panaudojimas |
| AR088633A1 (es) | 2011-11-04 | 2014-06-25 | Novartis Ag | Constructos extensores de vida media de lrp6 (proteina relacionada con lipoproteinas de baja densidad 6) |
| WO2013075066A2 (en) | 2011-11-18 | 2013-05-23 | Eleven Biotherapeutics, Inc. | Proteins with improved half-life and other properties |
| JP2015508994A (ja) | 2011-12-30 | 2015-03-26 | アッヴィ・インコーポレイテッド | Ｉｌ−１３および／またはｉｌ−１７に対する二重可変ドメイン免疫グロブリン |
| MX2014010278A (es) | 2012-03-16 | 2015-03-05 | Novozymes Biopharma Dk As | Variantes de albumina. |
| CN104428315B (zh) | 2012-07-13 | 2017-09-29 | 罗氏格黎卡特股份公司 | 双特异性抗‑vegf/抗‑ang‑2抗体及其在治疗眼血管疾病中的应用 |
| MX2015003894A (es) * | 2012-09-28 | 2015-07-17 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden aglutinantes duales de angiopoyetina-2 / dll4 agentes anti-vegf. |
| EP2900261A1 (en) * | 2012-09-28 | 2015-08-05 | Boehringer Ingelheim International GmbH | Pharmaceutical combinations comprising dual angiopoietin-2 / dll4 binders and anti-vegf-r agents |
| US20150368329A1 (en) * | 2012-10-15 | 2015-12-24 | Oncomed Pharmaceuticals, Inc. | Methods of Treating Ocular Diseases |
| US9599620B2 (en) | 2012-10-31 | 2017-03-21 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with a DLL4 antagonist |
| MY194330A (en) | 2012-11-01 | 2022-11-28 | Abbvie Inc | Anti-dll4/vegf dual variable domain immunoglobulin and uses thereof |
| EP3466973A1 (en) * | 2012-11-01 | 2019-04-10 | AbbVie Inc. | Stable dual variable domain immunoglobulin protein formulations |
| EP2917233A1 (en) | 2012-11-08 | 2015-09-16 | Novozymes Biopharma DK A/S | Albumin variants |
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- 2010-09-30 US US12/894,989 patent/US20110172398A1/en not_active Abandoned
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- 2010-10-01 TW TW099133632A patent/TW201124533A/zh unknown
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- 2010-10-01 MX MX2012003897A patent/MX2012003897A/es not_active Application Discontinuation
- 2010-10-01 EP EP10768428A patent/EP2483314A1/en not_active Withdrawn
- 2010-10-01 EA EA201200548A patent/EA201200548A1/ru unknown
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- 2010-10-01 PH PH1/2012/500525A patent/PH12012500525A1/en unknown
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- 2010-10-01 AR ARP100103596A patent/AR078515A1/es unknown
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| NZ598956A (en) | 2014-07-25 |
| UY32920A (es) | 2011-04-29 |
| KR20120101375A (ko) | 2012-09-13 |
| MA33607B1 (fr) | 2012-09-01 |
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| CN102639566A (zh) | 2012-08-15 |
| IN2012DN02752A (es) | 2015-09-18 |
| CL2012000826A1 (es) | 2012-10-19 |
| BR112012007239A2 (pt) | 2019-09-24 |
| EP2483314A1 (en) | 2012-08-08 |
| IL218542A0 (en) | 2012-05-31 |
| JP2013506411A (ja) | 2013-02-28 |
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| ECSP12011835A (es) | 2012-06-29 |
| CN102639566B (zh) | 2015-07-22 |
| TW201124533A (en) | 2011-07-16 |
| MX2012003897A (es) | 2012-05-08 |
| NZ626302A (en) | 2015-09-25 |
| TN2012000145A1 (en) | 2013-09-19 |
| PE20121024A1 (es) | 2012-08-10 |
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