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AR077366A1 - 2-carboxamida cicloaminoureas sustituidas inhibidoras de quinasas de fosfatidil inositol-3(pi3ks), composiciones farmaceuticas que las contienen y usos de las mismas en el tratamiento de enfermedades proliferativas. - Google Patents

2-carboxamida cicloaminoureas sustituidas inhibidoras de quinasas de fosfatidil inositol-3(pi3ks), composiciones farmaceuticas que las contienen y usos de las mismas en el tratamiento de enfermedades proliferativas.

Info

Publication number
AR077366A1
AR077366A1 ARP100102353A ARP100102353A AR077366A1 AR 077366 A1 AR077366 A1 AR 077366A1 AR P100102353 A ARP100102353 A AR P100102353A AR P100102353 A ARP100102353 A AR P100102353A AR 077366 A1 AR077366 A1 AR 077366A1
Authority
AR
Argentina
Prior art keywords
substituted
unsubstituted
phosfatidil
cyclaminoureas
pi3ks
Prior art date
Application number
ARP100102353A
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR077366A1 publication Critical patent/AR077366A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P11/00—Drugs for disorders of the respiratory system
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    • A—HUMAN NECESSITIES
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    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • A61P17/00—Drugs for dermatological disorders
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
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    • A61P27/02—Ophthalmic agents
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    • A61P27/06—Antiglaucoma agents or miotics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61P37/02—Immunomodulators
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    • A61P37/08—Antiallergic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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    • A61P7/06—Antianaemics
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Reproductive Health (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)

Abstract

Reivindicacion 1: Un compuesto de la formula (1) en donde A es un anillo de arilo insustituido o sustituido o un anillo heterocíclico insustituido o sustituido fusionado al resto de la molécula en las posiciones indicadas por el símbolo *; X-Y es (CH2)r u O(CH2)t o (CH2)tO en donde: r es 1, 2 o 3; t es 1 o 2; n es 0,1 o 2; q es 0, 1, 2, 3 o 4; R1 representa, independientemente en cada presentacion, halogeno; hidroxilo; arilo insustituido o sustituido; amino insustituido o sustituido; alquilo C1-7 insustituido; alquilo C1-7 que está sustituido una o más veces por hidroxilo, alcoxilo C1-7, amino insustituido o sustituido, arilo o heterociclilo, y en donde arilo puede estar mono- o poli-sustituido por halogeno; o dos sustituyentes R1 forman juntos un alcandi-ilo para formar una fraccion cíclica, opcionalmente sustituida por hidroxilo o halogeno, o una sal del mismo.
ARP100102353A 2009-07-02 2010-07-01 2-carboxamida cicloaminoureas sustituidas inhibidoras de quinasas de fosfatidil inositol-3(pi3ks), composiciones farmaceuticas que las contienen y usos de las mismas en el tratamiento de enfermedades proliferativas. AR077366A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27002809P 2009-07-02 2009-07-02

Publications (1)

Publication Number Publication Date
AR077366A1 true AR077366A1 (es) 2011-08-24

Family

ID=42357253

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100102353A AR077366A1 (es) 2009-07-02 2010-07-01 2-carboxamida cicloaminoureas sustituidas inhibidoras de quinasas de fosfatidil inositol-3(pi3ks), composiciones farmaceuticas que las contienen y usos de las mismas en el tratamiento de enfermedades proliferativas.

Country Status (15)

Country Link
US (1) US8357707B2 (es)
EP (1) EP2448946B1 (es)
JP (1) JP2012531454A (es)
KR (1) KR20120046723A (es)
CN (1) CN102471351A (es)
AR (1) AR077366A1 (es)
AU (1) AU2010268058A1 (es)
BR (1) BR112012000035A2 (es)
CA (1) CA2766853A1 (es)
EA (1) EA201200087A1 (es)
ES (1) ES2432671T3 (es)
MX (1) MX2012000178A (es)
TW (1) TW201103944A (es)
UY (1) UY32748A (es)
WO (1) WO2011000855A1 (es)

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CN104350144B (zh) 2012-05-23 2017-08-04 弗·哈夫曼-拉罗切有限公司 获得和使用内胚层和肝细胞的组合物和方法
EA202191009A1 (ru) * 2014-04-08 2021-08-31 Инсайт Корпорейшн Лечение b-клеточных злокачественных новообразований с применением комбинации ингибиторов jak и pi3k
KR20170084558A (ko) * 2016-01-12 2017-07-20 삼성전자주식회사 전자 장치 및 그의 동작 방법
CN106946669B (zh) * 2017-03-21 2020-09-15 国家电网公司 一种环保绝缘气体联产工艺及工业化生产装置
CN106986757B (zh) * 2017-04-24 2020-11-24 国家电网公司 一种环保绝缘气体生产工艺及工业生产装置
CN107935884B (zh) * 2017-11-30 2020-06-12 北京宇极科技发展有限公司 全氟腈的制备方法
CN108424375B (zh) * 2018-04-20 2020-06-02 北京宇极科技发展有限公司 全氟腈的制备方法

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Also Published As

Publication number Publication date
WO2011000855A1 (en) 2011-01-06
MX2012000178A (es) 2012-02-28
US20110003786A1 (en) 2011-01-06
CA2766853A1 (en) 2011-01-06
US8357707B2 (en) 2013-01-22
EA201200087A1 (ru) 2012-07-30
JP2012531454A (ja) 2012-12-10
AU2010268058A1 (en) 2012-01-19
BR112012000035A2 (pt) 2018-06-19
ES2432671T3 (es) 2013-12-04
EP2448946A1 (en) 2012-05-09
EP2448946B1 (en) 2013-07-24
KR20120046723A (ko) 2012-05-10
UY32748A (es) 2011-01-31
TW201103944A (en) 2011-02-01
CN102471351A (zh) 2012-05-23

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