[go: up one dir, main page]

PE20190653A1 - Nuevos derivados de pirrol, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen - Google Patents

Nuevos derivados de pirrol, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen

Info

Publication number
PE20190653A1
PE20190653A1 PE2019000414A PE2019000414A PE20190653A1 PE 20190653 A1 PE20190653 A1 PE 20190653A1 PE 2019000414 A PE2019000414 A PE 2019000414A PE 2019000414 A PE2019000414 A PE 2019000414A PE 20190653 A1 PE20190653 A1 PE 20190653A1
Authority
PE
Peru
Prior art keywords
pharmaceutical compositions
methyl
preparation procedure
pirrol
compositions containing
Prior art date
Application number
PE2019000414A
Other languages
English (en)
Inventor
Tiran Amaud Le
Jerôme-Benoît Starck
Anne-Françoise Guillouzic
Olivier Geneste
Janos Tatai
James Edward Paul Davidson
I-Jen Chen
Thierry Le-Diguarher
Jean-Michel Henlin
Nanteuil Guillaume De
Imre Fejes
Miklos Nyerges
James Brooke Murray
Didier Durand
Original Assignee
Servier Lab
Vernalis Randd Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50023639&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20190653(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Servier Lab, Vernalis Randd Ltd filed Critical Servier Lab
Publication of PE20190653A1 publication Critical patent/PE20190653A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Referido a compuestos de formula I, en donde A1 y A2 es cada uno, metilo, T es metilo, (morfolin-4-il)metilo, o 3-(morfolin-4-il)propilo; R3 es arilo o heteroarilo; R4 es 4-hidroxifenilo; R5 es H; Ra y Rd es H, y (Rb, Rc), junto con los atomos que lo portan, forman 1,3-dioxolano o un grupo 1,4-dioxano, entre otros. Donde estos compuestos son derivados de pirrol, siendo un compuesto seleccionado 5-(5-cloro-2-{[(3S)-3-(morfolin-4-ilmetil)-3,4-dihidroisoquinolin-2(1H)-il]-carbonil}fenil)-N-(4-hidroxifenil)-1,2-dimetil-N-(1-metil-1H-pirazol-4-il)-1H-pirrol-3-carboxamida. Tambien se refiere a su procedimiento de preparacion, las composiciones farmaceuticas que los contienen y su uso en el tratamiento del cancer.
PE2019000414A 2013-07-23 2014-06-26 Nuevos derivados de pirrol, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen PE20190653A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1357258A FR3008975A1 (fr) 2013-07-23 2013-07-23 Nouveaux derives de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
PE20190653A1 true PE20190653A1 (es) 2019-05-08

Family

ID=50023639

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2014001034A PE20150399A1 (es) 2013-07-23 2014-06-26 Nuevos derivados de pirrol, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen
PE2019000414A PE20190653A1 (es) 2013-07-23 2014-06-26 Nuevos derivados de pirrol, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PE2014001034A PE20150399A1 (es) 2013-07-23 2014-06-26 Nuevos derivados de pirrol, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen

Country Status (48)

Country Link
US (7) US9108983B2 (es)
EP (1) EP2829539B1 (es)
JP (1) JP5923560B2 (es)
KR (2) KR101712111B1 (es)
CN (3) CN106674196A (es)
AR (1) AR096979A1 (es)
AU (1) AU2014203521B2 (es)
BR (1) BR102014017950B1 (es)
CA (1) CA2856505C (es)
CL (1) CL2014001853A1 (es)
CR (1) CR20140307A (es)
CU (1) CU24315B1 (es)
CY (1) CY1118756T1 (es)
DK (1) DK2829539T3 (es)
DO (1) DOP2014000154A (es)
EA (1) EA026906B1 (es)
ES (1) ES2620515T3 (es)
FR (1) FR3008975A1 (es)
GE (1) GEP201706686B (es)
GT (1) GT201400144A (es)
HK (1) HK1203506A1 (es)
HR (1) HRP20170349T1 (es)
HU (1) HUE033361T2 (es)
IL (1) IL233343A (es)
JO (1) JO3275B1 (es)
LT (1) LT2829539T (es)
MA (1) MA37206B1 (es)
MD (1) MD4575C1 (es)
ME (1) ME02635B (es)
MX (1) MX348370B (es)
MY (1) MY173259A (es)
NI (1) NI201400079A (es)
PE (2) PE20150399A1 (es)
PH (1) PH12014000179A1 (es)
PL (1) PL2829539T3 (es)
PT (1) PT2829539T (es)
RS (1) RS55838B1 (es)
RU (1) RU2607788C2 (es)
SA (1) SA114350670B1 (es)
SG (1) SG10201403750UA (es)
SI (1) SI2829539T1 (es)
SV (1) SV2014004770A (es)
TN (1) TN2014000278A1 (es)
TW (1) TWI549948B (es)
UA (1) UA115773C2 (es)
UY (1) UY35639A (es)
WO (1) WO2015011400A1 (es)
ZA (1) ZA201405323B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3008975A1 (fr) * 2013-07-23 2015-01-30 Servier Lab Nouveaux derives de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
SG10202013206TA (en) * 2016-07-22 2021-02-25 Servier Lab Combination of a bcl-2 inhibitor and a mcl-1 inhibitor, uses and pharmaceutical compositions thereof
UY37342A (es) 2016-07-22 2018-01-31 Servier Lab Combinación de un inhibidor de bcl-2 y un inhibidor de mcl1, usos y composiciones farmacéuticas de éstos
WO2018158225A1 (en) 2017-02-28 2018-09-07 Les Laboratoires Servier Combination of a bcl-2 inhibitor and a mdm2 inhibitor, uses and pharmaceutical compositions thereof
FR3072679B1 (fr) * 2017-10-25 2020-10-30 Servier Lab Nouveaux derives macrocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP7478142B2 (ja) 2018-06-07 2024-05-02 ディスアーム セラピューティクス， インコーポレイテッド Ｓａｒｍ１阻害剤
BR112021007194A2 (pt) 2018-10-31 2021-07-20 Les Laboratoires Servier sal de um inibidor de bcl-2, forma cristalina relacionada, método para preparação da mesma e composições farmacêuticas contendo a mesma
UY38431A (es) * 2018-10-31 2020-05-29 Servier Lab Formulación basada en ciclodextrina de un inhibidor de bcl-2
RS65047B1 (sr) * 2018-12-06 2024-02-29 Servier Lab Novi kristalni oblici tienopirimidina kao inhibitori mcl-1
WO2020132045A1 (en) 2018-12-19 2020-06-25 Disarm Therapeutics, Inc. Inhibitors of sarm1 in combination with neuroprotective agents
WO2020139044A1 (ko) * 2018-12-27 2020-07-02 홀로스메딕 주식회사 신규한 화합물 및 이를 포함하는 항암 활성 증진용 약학 조성물
KR102468480B1 (ko) 2018-12-27 2022-11-18 홀로스메딕 주식회사 신규한 화합물 및 이를 포함하는 항암 활성 증진용 약학 조성물
JP2022532335A (ja) * 2019-05-14 2022-07-14 レ ラボラトワール セルヴィエ ＧＬＹ１０１ＶＡＬ突然変異を有するＢＣＬ－２媒介性ガンの処置に使用するためのＢｃｌ－２阻害剤
AU2020279979A1 (en) 2019-05-20 2021-11-25 Les Laboratoires Servier Mcl-1 inhibitor antibody-drug conjugates and methods of use
CN116390735A (zh) 2020-07-31 2023-07-04 法国施维雅药厂 治疗癌症的Bcl-2抑制剂和低甲基化剂的组合、其用途和药物组合物
WO2022090443A1 (en) 2020-10-30 2022-05-05 Les Laboratoires Servier Administration and dose regimen for a combination of a bcl-2 inhibitor and a mcl1 inhibitor
CN117136076A (zh) 2020-11-24 2023-11-28 诺华股份有限公司 Mcl-1抑制剂抗体药物缀合物和使用方法
CA3206906A1 (en) 2021-02-02 2022-08-11 Andras Herner Selective bcl-xl protac compounds and methods of use
CN113129644B (zh) * 2021-03-05 2022-03-08 中国人民解放军国防科技大学 基于球面扫描线的船舶三维特征航线提取方法
US20240208926A1 (en) * 2021-03-24 2024-06-27 Les Laboratoires Servier New process for the synthesis of 5-{5-chloro-2-[(3s)-3-[(morpholin-4-yl)methyl]-3,4-dihydroisoquinoline-2(1h)- carbonyl]phenyl}-1,2-dimethyl-1h-pyrrole-3-carboxylic acid derivatives and its application for the production of pharmaceutical compounds
US20240239746A1 (en) * 2021-04-26 2024-07-18 Sunshine Lake Pharma Co., Ltd. Preparation method for pyrrole amide compound
AU2022429802A1 (en) * 2021-12-29 2024-06-20 Eil Therapeutics, Inc. Bcl-2 inhibitors
CN114736156B (zh) * 2022-05-18 2024-03-19 中捷四方生物科技股份有限公司 一种白叶藤碱简化衍生物的制备方法及用途
KR20250027281A (ko) 2022-05-20 2025-02-25 노파르티스 아게 Epha2 bcl-xl 억제제 항체-약물 접합체 및 그의 사용 방법
AU2023273734A1 (en) 2022-05-20 2024-12-12 Les Laboratoires Servier Met bcl-xl inhibitor antibody-drug conjugates and methods of use thereof
IL317101A (en) 2022-05-20 2025-01-01 Novartis Ag Antibody-drug conjugates of anticancer compounds and methods of using them
CN115960121B (zh) * 2022-10-27 2025-09-12 南通药明康德医药科技有限公司 一种合成1-(3-氧杂丁环烷基)-1h-吡唑-4-硼酸频哪醇酯的方法
CN120752058A (zh) 2023-03-10 2025-10-03 诺华股份有限公司 panRAS抑制剂抗体-药物缀合物及其使用方法
WO2025111431A1 (en) * 2023-11-22 2025-05-30 Les Laboratoires Servier Anti-cd7 antibody-drug conjugates and methods of use thereof
WO2025111450A1 (en) 2023-11-22 2025-05-30 Les Laboratoires Servier Anti-cd74 antibody-drug conjugates and methods of use thereof
WO2025215536A1 (en) 2024-04-10 2025-10-16 Novartis Ag Macrocyclic panras inhibitors for the treatment of cancer

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL121432A (en) 1995-12-01 2000-09-28 Suntory Ltd Pyrrolo [3,2-C]azepine-4-one derivatives and pyrrolo [3,4-C]azepine-4-one derivatives their preparation and pharmaceutical compositions containing them
US7122544B2 (en) 2000-12-06 2006-10-17 Signal Pharmaceuticals, Llc Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto
BRPI0514504A (pt) * 2004-08-20 2008-06-10 Univ Michigan pequenas moléculas inibidoras de membros da famìlia bcl-2 anti-apoptóticos e os usos das mesmas
WO2006052568A2 (en) 2004-11-10 2006-05-18 Eli Lilly And Company Tgf-beta inhibitors
KR20070107000A (ko) * 2005-02-15 2007-11-06 노보 노르디스크 에이/에스 3,4-디히드로-1ｈ-이소퀴놀린-2-카르복실산5-아미노피리딘-2-일 에스테르
US20080269214A1 (en) * 2005-03-04 2008-10-30 Astrazeneca Ab Pyrrole Derivatives as Dna Gyrase and Topoisomerase Inhibitors
SE531110C2 (sv) 2006-07-14 2008-12-23 Vaelinge Innovation Ab Låssystem omfattande ett kombinationslås för paneler
US7706888B2 (en) 2006-07-14 2010-04-27 Med-El Elektromedizinische Geraete Gmbh Bi-planar electrode with shunting gates
WO2008008907A2 (en) 2006-07-14 2008-01-17 Genelabs Technologies, Inc. Antiviral agents
WO2009073545A2 (en) 2007-11-30 2009-06-11 Maxthera, Inc. Tetrahydro-isoquinoline ppat inhibitors as antibacterial agents
PE20120334A1 (es) 2008-12-19 2012-04-16 Abbott Lab COMPUESTOS HETEROCICLICOS INHIBIDORES DE LAS PROTEINAS ANTI-APOPTOTICAS Bcl2
US8557612B2 (en) 2009-06-26 2013-10-15 California Institute Of Technology Method for fabricating micro and nanostructures in a material
EP2714681B1 (en) * 2011-05-25 2015-06-24 Bristol-Myers Squibb Company Substituted sulfonamides useful as antiapoptotic bcl inhibitors
EA201491265A1 (ru) * 2011-12-23 2014-11-28 Новартис Аг Соединения для ингибирования взаимодействия bcl-2 с партнерами по связыванию
US20140357633A1 (en) 2011-12-23 2014-12-04 Novartis Ag Compounds for inhibiting the interaction of bcl2 with binding partners
FR2986002B1 (fr) * 2012-01-24 2014-02-21 Servier Lab Nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3008975A1 (fr) * 2013-07-23 2015-01-30 Servier Lab Nouveaux derives de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
US10688101B2 (en) 2020-06-23
CL2014001853A1 (es) 2015-06-26
NI201400079A (es) 2014-10-24
KR20150011786A (ko) 2015-02-02
MX2014008867A (es) 2015-05-28
US20150031673A1 (en) 2015-01-29
US20200261464A1 (en) 2020-08-20
JP2015028018A (ja) 2015-02-12
GEP201706686B (en) 2017-06-26
FR3008975A1 (fr) 2015-01-30
EP2829539B1 (fr) 2016-12-21
US20210290631A1 (en) 2021-09-23
HUE033361T2 (hu) 2017-11-28
ME02635B (me) 2017-06-20
TN2014000278A1 (fr) 2015-09-30
MD4575B1 (ro) 2018-06-30
US20170202851A1 (en) 2017-07-20
ES2620515T3 (es) 2017-06-28
CU20140081A7 (es) 2016-02-29
UA115773C2 (uk) 2017-12-26
US9598427B2 (en) 2017-03-21
PT2829539T (pt) 2017-01-27
CN106674201A (zh) 2017-05-17
CU24315B1 (es) 2018-02-08
ZA201405323B (en) 2015-09-30
SG10201403750UA (en) 2015-02-27
BR102014017950B1 (pt) 2020-05-19
GT201400144A (es) 2015-11-24
HK1201529A1 (en) 2015-09-04
EA026906B1 (ru) 2017-05-31
HRP20170349T1 (hr) 2017-04-21
EP2829539A1 (fr) 2015-01-28
US20150313907A1 (en) 2015-11-05
PE20150399A1 (es) 2015-04-11
US20240245699A1 (en) 2024-07-25
MY173259A (en) 2020-01-09
AU2014203521B2 (en) 2018-09-27
CN106674196A (zh) 2017-05-17
PH12014000179B1 (en) 2016-01-18
CN104341395B (zh) 2017-07-04
BR102014017950A2 (pt) 2015-11-17
KR101712111B1 (ko) 2017-03-03
CA2856505C (fr) 2017-06-27
US20190192528A1 (en) 2019-06-27
CR20140307A (es) 2014-11-17
RU2607788C2 (ru) 2017-01-10
JP5923560B2 (ja) 2016-05-24
HK1203506A1 (en) 2015-10-30
JO3275B1 (ar) 2018-09-16
MX348370B (es) 2017-06-08
CN104341395A (zh) 2015-02-11
IL233343A (en) 2017-06-29
MD20140072A2 (ro) 2015-01-31
RU2014130125A (ru) 2016-02-20
SV2014004770A (es) 2015-01-28
TW201512186A (zh) 2015-04-01
US9108983B2 (en) 2015-08-18
LT2829539T (lt) 2017-02-27
NZ626623A (en) 2016-01-29
AR096979A1 (es) 2016-02-10
WO2015011400A1 (fr) 2015-01-29
PH12014000179A1 (en) 2016-01-18
RS55838B1 (sr) 2017-08-31
DK2829539T3 (en) 2017-04-03
US11058689B2 (en) 2021-07-13
DOP2014000154A (es) 2014-10-15
EA201400753A1 (ru) 2015-03-31
MA37206B1 (fr) 2018-09-28
SI2829539T1 (sl) 2017-04-26
AU2014203521A1 (en) 2015-02-12
US10265323B2 (en) 2019-04-23
UY35639A (es) 2015-02-27
CA2856505A1 (fr) 2015-01-23
KR20170001695A (ko) 2017-01-04
SA114350670B1 (ar) 2016-02-09
MD4575C1 (ro) 2019-01-31
TWI549948B (zh) 2016-09-21
PL2829539T3 (pl) 2017-08-31
CY1118756T1 (el) 2017-07-12

Similar Documents

Publication Publication Date Title
PE20190653A1 (es) Nuevos derivados de pirrol, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen
PE20150218A1 (es) Nuevos derivados fosfatos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen
DOP2018000187A (es) Derivados de pirazolo[1,5-a]pirazin-4-ilo
PE20191245A1 (es) Compuestos de tiazolcarboxamidas y piridinacarboxamida utiles como inhibidores de quinasa pim
PE20121815A1 (es) Compuestos de pirrolo-pirimidina como inhibidores de cdk4/6
EA201891861A1 (ru) 2-(морфолин-4-ил)-1,7-нафтиридины
PE20160875A1 (es) Compuestos de biaril-amida como inhibidores de cinasa
AR091285A1 (es) Inhibidores de bromodominio y sus usos
AR095311A1 (es) 3-pirimidin-4-il-oxazolidin-2-onas como inhibidores de idh mutante
PE20171177A1 (es) Compuestos aminopirimidinilo inhibidores de jak
PE20160608A1 (es) Compuestos de quinolina selectivamente sustituida
PE20191613A1 (es) Compuestos de pirazolo[1,5-a]piridina sustituidos como inhibidores de la quinasa ret
EA201992884A2 (ru) Арильные, гетероарильные и гетероциклические соединения для лечения заболеваний
MX373846B (es) Nuevos derivados de pirazolo pirimidina y su uso como inhibidores de malt1.
RU2016152470A (ru) Применение замещенных оксадиазолов для борьбы с фитопатогенными грибами
PE20140302A1 (es) Inhibidores del virus de la hepatitis c
PE20171307A1 (es) Compuestos de triazolopirimidina y usos de los mismos
EA201790661A3 (ru) Ингибиторы вируса гепатита c
MX376271B (es) Compuestos heterocíclicos y usos de los mismos.
AR080785A1 (es) Derivados de imidazo[1,2-a]pirimidina ,proceso para prepararlos e intermediarios de dicha sintesis, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de patologias del sistema nervioso central,tales como esquizofrenia y parkinson, entre otros.
AR094452A1 (es) COMPUESTOS HETEROCÍCLICOS SUSTITUIDOS CON AMIDA ÚTILES COMO MODULADORES DE LAS RESPUESTAS DE IL-12, IL-23 Y/O INFa
AR111494A1 (es) Compuestos de anilinoquinazolina c₅ y su uso en el tratamiento del cáncer
AR080467A1 (es) Derivados tetrazolicos moduladores selectivos de receptores cb2, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del dolor y otras enfermedades
AR099640A1 (es) Derivados de pirrolopiridina o pirazolopiridina
AR089781A1 (es) Fluorometil-5,6-dihidro-4h-[1,3]oxazinas