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AR075504A1 - Moleculas de anticuerpos que tienen especificidad para el ox40 humano - Google Patents

Moleculas de anticuerpos que tienen especificidad para el ox40 humano

Info

Publication number
AR075504A1
AR075504A1 ARP100100457A ARP100100457A AR075504A1 AR 075504 A1 AR075504 A1 AR 075504A1 AR P100100457 A ARP100100457 A AR P100100457A AR P100100457 A ARP100100457 A AR P100100457A AR 075504 A1 AR075504 A1 AR 075504A1
Authority
AR
Argentina
Prior art keywords
cdr
seq
heavy chain
sequence given
expression
Prior art date
Application number
ARP100100457A
Other languages
English (en)
Inventor
Andrew George Popplewell
Stephen Graham Shaw
Alastair David Griffiths Lawson
Andrew Malcolm Nesbitt
Diana Shpektor
Yi Zhang
Original Assignee
Ucb Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42634416&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR075504(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ucb Pharma Sa filed Critical Ucb Pharma Sa
Publication of AR075504A1 publication Critical patent/AR075504A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07K2317/55—Fab or Fab'
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
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Abstract

Reivindicacion 1: Un anticuerpo antagonista que enlaza OX40 humano caracterizado porque comprende una cadena pesada, en donde el dominio variable de la cadena pesada comprende al menos una de una CDR que tiene la secuencia dada en la SEQ ID NO:1 para la CDR-H1, una CDR que tiene la secuencia dada en la SEQ ID NO: 2 o la SEQ ID NO: 20 para la CDR-H2, y una CDR que tiene la secuencia dada en la SEQ ID NO: 3 para la CDR-H3. Reivindicacion 30: Una secuencia de ADN aislada caracterizado porque codifica la/s cadena/s pesadas/s y/o liviana/s de un anticuerpo de acuerdo con cualquiera de las reivindicaciones 1 a 28. Reivindicacion 31: Un vector de expresion o de donacion caracterizado porque comprende una o más secuencias de ADN de acuerdo con la reivindicacion 30. Reivindicacion 34: Una célula huésped caracterizado porque comprende uno o más vectores de expresion o de clonacion de acuerdo con la reivindicacion 31 o la reivindicacion 32 o la reivindicacion 33. Reivindicacion 36: Una composicion farmacéutica caracterizado porque comprende un anticuerpo de acuerdo con cualquiera de las reivindicaciones 1 a 28, en combinacion con uno o más de un excipiente, diluyente o portador farmacéuticamente aceptable.
ARP100100457A 2009-02-17 2010-02-17 Moleculas de anticuerpos que tienen especificidad para el ox40 humano AR075504A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15303809P 2009-02-17 2009-02-17

Publications (1)

Publication Number Publication Date
AR075504A1 true AR075504A1 (es) 2011-04-06

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ARP100100457A AR075504A1 (es) 2009-02-17 2010-02-17 Moleculas de anticuerpos que tienen especificidad para el ox40 humano

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US (3) US8614295B2 (es)
EP (1) EP2398498B1 (es)
JP (2) JP5782385B2 (es)
KR (1) KR101761929B1 (es)
CN (1) CN102741287B (es)
AR (1) AR075504A1 (es)
AU (1) AU2010216152B2 (es)
BR (1) BRPI1008692B8 (es)
CA (1) CA2751477C (es)
CL (1) CL2011001994A1 (es)
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MA (1) MA33122B1 (es)
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PE (1) PE20120211A1 (es)
PL (1) PL2398498T3 (es)
PT (1) PT2398498T (es)
SG (3) SG10201505038TA (es)
SI (1) SI2398498T1 (es)
TN (1) TN2011000374A1 (es)
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UY (1) UY32451A (es)
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Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201505038TA (en) * 2009-02-17 2015-07-30 Ucb Biopharma Sprl Antibody molecules having specificity for human ox40
GB0920127D0 (en) 2009-11-17 2009-12-30 Ucb Pharma Sa Antibodies
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