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AR065506A1 - Anticuerpos antagonistas ox40 y su uso en el tratamiento de enfermedades - Google Patents

Anticuerpos antagonistas ox40 y su uso en el tratamiento de enfermedades

Info

Publication number
AR065506A1
AR065506A1 ARP080100818A ARP080100818A AR065506A1 AR 065506 A1 AR065506 A1 AR 065506A1 AR P080100818 A ARP080100818 A AR P080100818A AR P080100818 A ARP080100818 A AR P080100818A AR 065506 A1 AR065506 A1 AR 065506A1
Authority
AR
Argentina
Prior art keywords
amino acid
acid sequence
seq
antibodies
antibody
Prior art date
Application number
ARP080100818A
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English (en)
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39620235&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR065506(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of AR065506A1 publication Critical patent/AR065506A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P11/06—Antiasthmatics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Transplantation (AREA)
  • Endocrinology (AREA)
  • Otolaryngology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)

Abstract

Fragmentos de dichos anticuerpos que incluyen las secuencias de aminoácidos de los anticuerpos antagonistas y los ácidos nucleicos que codifican los anticuerpos. También se encuentran incluidos las regiones de union a antígeno (CDRs) derivadas delas regiones variables de cadena liviana y/o pesada de dichos anticuerpos. Además, el uso de anticuerpos antagonistas anti-OX40 en el tratamiento de enfermedades inflamatorias y autoinmunes. También secuencias humanizadas de un anticuerpoantagonista A10 y el mapeo de epítopo del sitio de union del anticuerpo. Reivindicacion 1: Un anticuerpo antagonista aislado que específicamente se une a un epítopo OX40 humano, caracterizado porque dicho anticuerpo comprende: a) una regionvariable de cadena pesada (VH) que comprende: (i) un VH CDR1 que tiene la secuencia de aminoácido de SEQ ID N°:17; (ii) un VH CDR2 que tiene la secuencia de aminoácido de SEQ ID N°:18; y/o (iii) un VH CDR3 que tiene la secuencia de aminoácido de SEQID N°:19; y/o b) una region variable de cadena liviana (VL) que comprende: (i) un VL CDR1 que tiene la secuencia de aminoácido de SEQ ID N°:12, 15 o 61; (ii) un VL CDR2 que tiene la secuencia de aminoácido de SEQ ID N°:13; y/o (iii) un VL CDR3 quetiene la secuencia de aminoácido de SEQ ID N°:14 o16.
ARP080100818A 2007-02-27 2008-02-27 Anticuerpos antagonistas ox40 y su uso en el tratamiento de enfermedades AR065506A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90369307P 2007-02-27 2007-02-27

Publications (1)

Publication Number Publication Date
AR065506A1 true AR065506A1 (es) 2009-06-10

Family

ID=39620235

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080100818A AR065506A1 (es) 2007-02-27 2008-02-27 Anticuerpos antagonistas ox40 y su uso en el tratamiento de enfermedades

Country Status (20)

Country Link
US (1) US20100136030A1 (es)
EP (1) EP2125891A2 (es)
JP (1) JP2010518873A (es)
KR (1) KR20100014588A (es)
CN (1) CN101668776A (es)
AR (1) AR065506A1 (es)
AU (1) AU2008219666A1 (es)
BR (1) BRPI0807269A2 (es)
CA (1) CA2679399A1 (es)
CL (1) CL2008000578A1 (es)
CO (1) CO6231009A2 (es)
CR (1) CR11042A (es)
EC (1) ECSP099656A (es)
IL (1) IL200572A0 (es)
MA (1) MA31246B1 (es)
MX (1) MX2009009194A (es)
PE (1) PE20090689A1 (es)
RU (1) RU2009135824A (es)
TW (1) TW200846367A (es)
WO (1) WO2008106116A2 (es)

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