AR061561A1 - Derivados amino de b- homoandrostanos y b- heteroandrostanos. procesos de obtencion y composiciones farmaceuticas - Google Patents
Derivados amino de b- homoandrostanos y b- heteroandrostanos. procesos de obtencion y composiciones farmaceuticasInfo
- Publication number
- AR061561A1 AR061561A1 ARP070102730A ARP070102730A AR061561A1 AR 061561 A1 AR061561 A1 AR 061561A1 AR P070102730 A ARP070102730 A AR P070102730A AR P070102730 A ARP070102730 A AR P070102730A AR 061561 A1 AR061561 A1 AR 061561A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- branched
- linear
- oxygen
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000001412 amines Chemical class 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 7
- 229910052760 oxygen Inorganic materials 0.000 abstract 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 3
- 239000001301 oxygen Substances 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 2
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 101100240516 Caenorhabditis elegans nhr-10 gene Proteins 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- QZLYKIGBANMMBK-UGCZWRCOSA-N androstane group Chemical group [C@@H]12CCC[C@@]1(C)CC[C@H]1[C@H]2CC[C@H]2CCCC[C@]12C QZLYKIGBANMMBK-UGCZWRCOSA-N 0.000 abstract 2
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- -1 hydroxy, methoxy, ethoxy groups Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 239000011593 sulfur Chemical group 0.000 abstract 2
- 125000001963 4 membered heterocyclic group Chemical group 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-N anhydrous guanidine Natural products NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002993 cycloalkylene group Chemical group 0.000 abstract 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/004—Expansion of ring B by one atom, e.g. B homo steroids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/003—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by oxygen as hetero atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Procedimientos para su preparacion y composiciones farmacéuticas que los contienen para el tratamiento de trastornos cardiovasculares tales como insuficiencia cardíaca e hipertension. Reivindicacion 1: Un compuesto que tiene la formula general (1) en la cual: A es un grupo divalente seleccionado entre -CH2CH2CH2-, -CH(OR3)CH2CH2-, -CH2CH(OR3)CH2-, -C(=X)CH2CH2-, -CH2C(=X)CH2-, -BCH2CH2-, -CH2BCH2-, -BCH2-, -BC(=X)CH2-, -C(=X)BCH2-, -BC(=X)-, donde el símbolo ô -ô indica enlaces individuales alfa o beta que conectan el grupo A con el esqueleto de androstano en la posicion 5 u 8; B es oxígeno o NR4; R3 es H o alquilo C1-6; X es oxígeno, azufre o NOR5; R4 es H, alquilo C1-6 o formilo cuando A es -BCH2CH2-, -CH2BCH2-, o -BCH2-, en la cual B es NR4; R5 es H o alquilo C1-6; R1 es H, alquilo C1-6 o acilo C2-6, cuando el enlace ---- en la posicion 17 del esqueleto de androstano es un unico enlace; o R1 no está presente cuando el enlace ---- en la posicion 17 es un enlace doble; R2 es DNR6R7 o el grupo de formula (2) con los grupos D o Z unidos al átomo de oxígeno; D es alquileno C2-6 lineal o ramificado o un cicloalquileno C3-6 que opcionalmente contiene un anillo de fenilo; R6 y R7, que son iguales o diferentes y son H, alquilo C1-6, fenilalquilo C1-4 o cuando R6 es hidrogeno; o R7 es C(=NR9)NHR10; o R6 y R7, conjuntamente con el átomo de nitrogeno al cual están unidos, forman un anillo de 4, 5 o 6 miembros mono heterocíclico saturado o insaturado, substituido o no substituido, que opcionalmente contiene otro heteroátomo seleccionado entre el grupo que comprende oxigeno, azufre o nitrogeno; R6 y R7 están opcionalmente substituidos por uno o más grupos hidroxi, metoxi, etoxi; R8 es H, alquilo C1-6 lineal o ramificado, opcionalmente substituido por uno o más hidroxi, metoxi, etoxi o C(=NR9)NHR10; R9 y R10, que pueden ser iguales o diferentes y que son H, alquilo lineal o ramificado C1-6; o R9 y R10, conjuntamente con los átomos de N y el átomo de C guanidínico, forman un anillo de 5 o 6 miembros mono heterocíclico saturado o insaturado, substituido o no substituido, que opcionalmente contiene otro heteroátomo seleccionado entre el grupo que comprende O, S o N; Z es alquileno C1-4 lineal o ramificado o un enlace individual; Y es CH2, O, S o NR11; R11 es H, alquilo C1-6; n es el numero 0, 1, 2, o 3; m es el numero 0, 1, 2, o 3; el símbolo ---- en las posiciones 17, es independientemente un enlace simple o doble y cuando es un enlace exocíclico simple en las posiciones 17, es un enlace simple alfa o beta.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06116001 | 2006-06-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR061561A1 true AR061561A1 (es) | 2008-09-03 |
Family
ID=37603055
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070102730A AR061561A1 (es) | 2006-06-23 | 2007-06-21 | Derivados amino de b- homoandrostanos y b- heteroandrostanos. procesos de obtencion y composiciones farmaceuticas |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8022203B2 (es) |
| EP (1) | EP2032593B1 (es) |
| JP (1) | JP4664433B2 (es) |
| KR (1) | KR101446166B1 (es) |
| CN (1) | CN101479291B (es) |
| AR (1) | AR061561A1 (es) |
| AT (1) | ATE497504T1 (es) |
| AU (1) | AU2007263117B2 (es) |
| BR (1) | BRPI0713439A2 (es) |
| CA (1) | CA2654354C (es) |
| CY (1) | CY1112012T1 (es) |
| DE (1) | DE602007012348D1 (es) |
| DK (1) | DK2032593T3 (es) |
| EA (1) | EA014333B1 (es) |
| ES (1) | ES2359544T3 (es) |
| MX (1) | MX2008016425A (es) |
| PL (1) | PL2032593T3 (es) |
| SI (1) | SI2032593T1 (es) |
| TW (1) | TWI372762B (es) |
| WO (1) | WO2007147713A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2422603T3 (es) | 2007-05-31 | 2013-09-12 | Shionogi & Co | Compuestos oxiimino y el uso de estos |
| CN101983187A (zh) * | 2008-04-02 | 2011-03-02 | 株式会社钟化 | (s)-3-(1-氰基-1，1-二苯基甲基)吡咯烷的制备方法 |
| ES2408159T3 (es) | 2008-06-11 | 2013-06-18 | Shionogi & Co., Ltd. | Compuestos de oxicarbamoilo y su utilización |
| SG2014010912A (en) * | 2009-03-23 | 2014-06-27 | Sigma Tau Ind Farmaceuti | 5-ß, 14-ß-ANDROSTANE DERIVATIVES USEFUL FOR THE TREATMENT OF PROTEINURIA, GLOMERULOSCLEROSIS AND RENAL FAILURE |
| GB201104199D0 (en) | 2011-03-11 | 2011-04-27 | Syngenta Participations Ag | Plant growth regulator compounds |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2806029A (en) * | 1956-07-16 | 1957-09-10 | Searle & Co | 3-oxygenated 12a-aza-c-homopregnane-12, 20-diones and congeners |
| US3136584A (en) * | 1963-01-25 | 1964-06-09 | Whitlock Associates Inc | Bulk material hopper unloader |
| US3328408A (en) * | 1964-01-30 | 1967-06-27 | Smith | 6-azaestranes, intermediates and process |
| DE19633349A1 (de) * | 1996-08-19 | 1998-02-26 | Sigma Tau Ind Farmaceuti | Neue 6-Hydroxy- und 6-Oxo-androstan-Derivate, die auf das kardiovaskuläre System wirken und pharmazeutische Zusammensetzungen, die diese enthalten |
| US6825208B2 (en) * | 2001-08-20 | 2004-11-30 | Bristol-Myers Squibb Pharma Company | Tetrahydroquinoline derivatives as antithrombotic agents |
| US7053076B2 (en) * | 2001-08-29 | 2006-05-30 | Xenoport, Inc. | Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs |
| JP5065019B2 (ja) * | 2004-06-24 | 2012-10-31 | ウィスコンシン アルムニ リサーチ ファンデイション | 新生糖ランダム化及びジギトキシン類似体 |
-
2007
- 2007-05-28 TW TW096118972A patent/TWI372762B/zh not_active IP Right Cessation
- 2007-05-31 AT AT07729767T patent/ATE497504T1/de active
- 2007-05-31 AU AU2007263117A patent/AU2007263117B2/en not_active Ceased
- 2007-05-31 SI SI200730552T patent/SI2032593T1/sl unknown
- 2007-05-31 PL PL07729767T patent/PL2032593T3/pl unknown
- 2007-05-31 JP JP2009517074A patent/JP4664433B2/ja not_active Expired - Fee Related
- 2007-05-31 EA EA200970046A patent/EA014333B1/ru not_active IP Right Cessation
- 2007-05-31 MX MX2008016425A patent/MX2008016425A/es active IP Right Grant
- 2007-05-31 WO PCT/EP2007/055366 patent/WO2007147713A1/en not_active Ceased
- 2007-05-31 EP EP07729767A patent/EP2032593B1/en not_active Not-in-force
- 2007-05-31 DE DE602007012348T patent/DE602007012348D1/de active Active
- 2007-05-31 DK DK07729767.9T patent/DK2032593T3/da active
- 2007-05-31 KR KR1020097001487A patent/KR101446166B1/ko not_active Expired - Fee Related
- 2007-05-31 CA CA2654354A patent/CA2654354C/en not_active Expired - Fee Related
- 2007-05-31 ES ES07729767T patent/ES2359544T3/es active Active
- 2007-05-31 CN CN2007800235240A patent/CN101479291B/zh not_active Expired - Fee Related
- 2007-05-31 BR BRPI0713439-8A patent/BRPI0713439A2/pt not_active IP Right Cessation
- 2007-05-31 US US12/305,571 patent/US8022203B2/en not_active Expired - Fee Related
- 2007-06-21 AR ARP070102730A patent/AR061561A1/es unknown
-
2011
- 2011-04-26 CY CY20111100412T patent/CY1112012T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2654354C (en) | 2014-12-23 |
| ATE497504T1 (de) | 2011-02-15 |
| TW200817427A (en) | 2008-04-16 |
| JP4664433B2 (ja) | 2011-04-06 |
| CY1112012T1 (el) | 2015-11-04 |
| KR20090023730A (ko) | 2009-03-05 |
| AU2007263117A1 (en) | 2007-12-27 |
| US8022203B2 (en) | 2011-09-20 |
| CN101479291B (zh) | 2012-09-19 |
| TWI372762B (en) | 2012-09-21 |
| PL2032593T3 (pl) | 2011-05-31 |
| JP2009541410A (ja) | 2009-11-26 |
| CA2654354A1 (en) | 2007-12-27 |
| MX2008016425A (es) | 2009-01-21 |
| WO2007147713A1 (en) | 2007-12-27 |
| BRPI0713439A2 (pt) | 2012-03-06 |
| KR101446166B1 (ko) | 2014-10-01 |
| CN101479291A (zh) | 2009-07-08 |
| ES2359544T3 (es) | 2011-05-24 |
| EP2032593A1 (en) | 2009-03-11 |
| EA014333B1 (ru) | 2010-10-29 |
| US20090209506A1 (en) | 2009-08-20 |
| EA200970046A1 (ru) | 2009-06-30 |
| DE602007012348D1 (de) | 2011-03-17 |
| DK2032593T3 (da) | 2011-05-16 |
| AU2007263117A2 (en) | 2009-03-12 |
| EP2032593B1 (en) | 2011-02-02 |
| AU2007263117B2 (en) | 2012-05-24 |
| HK1134097A1 (en) | 2010-04-16 |
| SI2032593T1 (sl) | 2011-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |