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HN2009000504A - Derivados de pirrolizina, indolizina y quinolizina su preparacion y su aplicacion en terapeutica. - Google Patents

Derivados de pirrolizina, indolizina y quinolizina su preparacion y su aplicacion en terapeutica.

Info

Publication number
HN2009000504A
HN2009000504A HN2009000504A HN2009000504A HN2009000504A HN 2009000504 A HN2009000504 A HN 2009000504A HN 2009000504 A HN2009000504 A HN 2009000504A HN 2009000504 A HN2009000504 A HN 2009000504A HN 2009000504 A HN2009000504 A HN 2009000504A
Authority
HN
Honduras
Prior art keywords
ilo
alcoxy
mono
therapeutics
application
Prior art date
Application number
HN2009000504A
Other languages
English (en)
Inventor
Dargazanli Gihad
Estenne-Bouhtou Genevieve
Medaisko Florence
Carmen Renones Maria
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of HN2009000504A publication Critical patent/HN2009000504A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Indole Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A COMPUESTO QUE RESPONDE A LA FORMULA GENERAL EN LA QUE M Y N REPRESENTAN CADA UNO EL NUMERO 1Ó 2 AR REPRESENTA UN GRUPO ELEGIDO ENTRE GRUPOS FENILO, NAFTILO- 2- PIRRIDIN-2-ILO, PIRIDIN-3-ILO, PIRIDIN- 4-ILO, FURAN-2-ILO, FGURAN 3-ILO, TIEN-2-ILO, TIEN-3-ILO, TIAZOL-2-ILO, Y OXAZOL-2-ILO, PUDIENDO ESTAR ESTE GRUPO AE SUSTITUIDO OPCIONALMENTE; R REPRESENTA BIEN UN ATOMO DE HIDROGENO, BIEN UNO O VARIOS SUSTITUYENTES IDENTICOS O DIFERENTES EL UNO DEL OTRO ELEGIDOS ENTRE LOS ATOMOS DE HALOGENOS Y LOS GRUPOS MONO O POLIFLUOROALQUILO (C1-C6) Y MONO O POLIFLUROALQUILOXI (C3-C7), CICLOALQUIL (C1-C6) LINEALES ALQUILOS (C3-C7) RAMIFICADOS O CICLICOS COCLOALQUIL (C3-C7) ALQUILO (C1-C6) ALCOXI (C1-C6) ALCOXI (C1-C6), CICLOALQUILOXI (C3-C7) ALQUILOXI (C1-C6) ALQUILITO (C1-C6), CIANO, AMINO, FENILO, ACETILO,BENZOILO, ALQUISULFONILICO (C1-C6), CARBOXI ALCOXI- CARNONILO (C1-C6) Y PENTAFLUOROSULFANILO. APLICACION EN TERAPEUTICA
HN2009000504A 2006-09-22 2009-03-18 Derivados de pirrolizina, indolizina y quinolizina su preparacion y su aplicacion en terapeutica. HN2009000504A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0608348A FR2906251B1 (fr) 2006-09-22 2006-09-22 Derives de pyrrolizine, indolizine et quinolizine, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
HN2009000504A true HN2009000504A (es) 2011-10-20

Family

ID=37897398

Family Applications (1)

Application Number Title Priority Date Filing Date
HN2009000504A HN2009000504A (es) 2006-09-22 2009-03-18 Derivados de pirrolizina, indolizina y quinolizina su preparacion y su aplicacion en terapeutica.

Country Status (29)

Country Link
US (2) US7776880B2 (es)
EP (1) EP2077837A2 (es)
JP (1) JP2010504311A (es)
KR (1) KR20090080947A (es)
CN (1) CN101573113A (es)
AR (1) AR062896A1 (es)
AU (1) AU2007301880A1 (es)
BR (1) BRPI0717100A2 (es)
CA (1) CA2663080A1 (es)
CL (1) CL2007002732A1 (es)
CO (1) CO6160309A2 (es)
CR (1) CR10658A (es)
EA (1) EA015974B1 (es)
FR (1) FR2906251B1 (es)
GT (1) GT200900061A (es)
HN (1) HN2009000504A (es)
IL (1) IL197500A0 (es)
MA (1) MA30790B1 (es)
ME (1) MEP10109A (es)
MX (1) MX2009003083A (es)
NO (1) NO20091351L (es)
NZ (1) NZ575573A (es)
PE (1) PE20081376A1 (es)
SV (1) SV2009003191A (es)
TN (1) TN2009000082A1 (es)
TW (1) TW200819455A (es)
UY (1) UY30604A1 (es)
WO (1) WO2008037881A2 (es)
ZA (1) ZA200901850B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2842804B1 (fr) 2002-07-29 2004-09-03 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
FR2861074B1 (fr) * 2003-10-17 2006-04-07 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
UY32397A (es) * 2009-01-28 2010-08-31 Astrazeneca Ab Compuestos de 2-aza-biciclo [2,2,1] heptano y sus usos
WO2010087761A1 (en) * 2009-01-28 2010-08-05 Astrazeneca Ab 2-aza-bicyclo[2.2.2]octane compounds and uses thereof
US8338441B2 (en) 2009-05-15 2012-12-25 Gilead Sciences, Inc. Inhibitors of human immunodeficiency virus replication
US8143273B2 (en) * 2010-06-22 2012-03-27 Hoffman-La Roche Inc. Quinolizidine and indolizidine derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3801636A (en) 1971-08-13 1974-04-02 Abbott Lab 3,4,5-tri-substituted cinnamides
US4409225A (en) * 1981-03-16 1983-10-11 Beecham Group Limited Substituted benzamides
AU2491092A (en) * 1991-09-12 1993-04-05 Smithkline Beecham Plc Azabicyclic compounds as 5-ht4 receptor antagonists
CZ284456B6 (cs) 1992-02-15 1998-12-16 Hoechst Aktiengesellschaft Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje
WO2002024695A2 (en) * 2000-09-22 2002-03-28 Ortho Mcneil Pharmaceutical, Inc. Octahydro-indolizines and quinolizines and hexahydro-pyrrolizines
FR2861073B1 (fr) 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-[heteroaryl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
FR2861076B1 (fr) 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
GT200900061A (es) 2010-06-21
BRPI0717100A2 (pt) 2013-10-15
CO6160309A2 (es) 2010-05-20
CN101573113A (zh) 2009-11-04
MA30790B1 (fr) 2009-10-01
SV2009003191A (es) 2009-10-27
EP2077837A2 (fr) 2009-07-15
AR062896A1 (es) 2008-12-10
US7776880B2 (en) 2010-08-17
US20100267766A1 (en) 2010-10-21
UY30604A1 (es) 2008-05-02
ZA200901850B (en) 2010-06-30
WO2008037881A2 (fr) 2008-04-03
WO2008037881A3 (fr) 2008-05-22
PE20081376A1 (es) 2008-11-07
US20090258899A1 (en) 2009-10-15
MX2009003083A (es) 2009-04-02
IL197500A0 (en) 2009-12-24
KR20090080947A (ko) 2009-07-27
FR2906251B1 (fr) 2008-11-07
TW200819455A (en) 2008-05-01
CR10658A (es) 2009-06-24
MEP10109A (en) 2011-12-20
EA200970312A1 (ru) 2009-12-30
NZ575573A (en) 2011-12-22
EA015974B1 (ru) 2012-01-30
JP2010504311A (ja) 2010-02-12
CA2663080A1 (fr) 2008-04-03
TN2009000082A1 (en) 2010-08-19
CL2007002732A1 (es) 2008-04-18
NO20091351L (no) 2009-06-22
FR2906251A1 (fr) 2008-03-28
AU2007301880A1 (en) 2008-04-03

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