AR075920A1 - Derivados de nicotinamida su preparacion y su aplicacion en terapeutica - Google Patents
Derivados de nicotinamida su preparacion y su aplicacion en terapeuticaInfo
- Publication number
- AR075920A1 AR075920A1 ARP100100920A ARP100100920A AR075920A1 AR 075920 A1 AR075920 A1 AR 075920A1 AR P100100920 A ARP100100920 A AR P100100920A AR P100100920 A ARP100100920 A AR P100100920A AR 075920 A1 AR075920 A1 AR 075920A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- alkyl
- hydrogen atom
- alkyl group
- therapeutics
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical class NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 229910003827 NRaRb Inorganic materials 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000005480 nicotinamides Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003222 pyridines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente se refiere a derivados de nicotinamida, composiciones que los contienen y su aplicacion en terapéutica, especialmente como anticancerosos. Reivindicacion 1: Compuesto de formula (1) en la que Z y Z' representan N o CH; x es un numero entero que vale 1 o 2, que representa el numero de átomos de fluor unidos al nucleo central de fenilo; L representa un grupo -CH=CH- o -(CH2)nNH- en el que el grupo NH está unido al C=O y n es un numero entero que vale 0, 1 o 2; R1 representa un átomo de hidrogeno, un grupo alquilo C1-6, cicloalquilo C3-6, fenilo; R'1 representa un átomo de hidrogeno o un grupo alquilo C1-6; R2 representa un grupo cicloalquilo C3-6; alquilo C1-6, opcionalmente sustituido con o uno o más grupos hidroxi o alcoxi C1-4; o un grupo -NRaRb en el que Ra y Rb representan independientemente uno del otro un átomo de hidrogeno o un grupo alquilo C1-6 o forman, junto con el átomo de nitrogeno al que están unidos, un grupo heterocicloalquilo C4-6 que comprende opcionalmente en el ciclo el grupo -S(O)q donde q= 0, 1 o 2 o el grupo -NH- o -N-alquilo C1-4- y que está opcionalmente sustituido con uno o más sustituyentes, iguales o diferentes entre sí cuando hay varios, elegidos entre un grupo -OH; alcoxi C1-4 o alquilo C1-4; R3 representa al menos un sustituyente en el nucleo de piridina elegido entre un átomo de hidrogeno o de fluor, un grupo alquilo C1-4 o -NRcRd en el que Rc y Rd representan un átomo de hidrogeno o un grupo alquilo C1-4.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0901365A FR2943669B1 (fr) | 2009-03-24 | 2009-03-24 | Derives de nicotinamide,leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR075920A1 true AR075920A1 (es) | 2011-05-04 |
Family
ID=40792887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100100920A AR075920A1 (es) | 2009-03-24 | 2010-03-23 | Derivados de nicotinamida su preparacion y su aplicacion en terapeutica |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20120053170A1 (es) |
| EP (1) | EP2411368A1 (es) |
| JP (1) | JP2012521396A (es) |
| KR (1) | KR20110133049A (es) |
| CN (1) | CN102448939A (es) |
| AR (1) | AR075920A1 (es) |
| AU (1) | AU2010227402A1 (es) |
| BR (1) | BRPI1013553A2 (es) |
| CA (1) | CA2756099A1 (es) |
| FR (1) | FR2943669B1 (es) |
| IL (1) | IL215285A0 (es) |
| MX (1) | MX2011010052A (es) |
| RU (1) | RU2011142753A (es) |
| SG (1) | SG174902A1 (es) |
| TW (1) | TW201038554A (es) |
| UY (1) | UY32517A (es) |
| WO (1) | WO2010109122A1 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG188367A1 (en) | 2010-09-03 | 2013-04-30 | Forma Tm Llc | Novel compounds and compositions for the inhibition of nampt |
| JP6038792B2 (ja) | 2010-09-03 | 2016-12-07 | フォーマ ティーエム， エルエルシー． | 癌などの疾患の治療のためのｎａｍｐｔ阻害剤としての４−｛［（ピリジン−３−イル−メチル）アミノカルボニル］アミノ｝ベンゼン−スルホン誘導体 |
| CN103717574B (zh) | 2011-05-04 | 2017-02-22 | 福马Tm有限责任公司 | 用于抑制nampt的新化合物和组合物 |
| WO2012177782A1 (en) * | 2011-06-20 | 2012-12-27 | Myrexis, Inc. | Compounds and therapeutic uses thereof |
| EP2712862A1 (en) * | 2012-09-28 | 2014-04-02 | Splicos | New anti-invasive compounds |
| EP2925750A1 (en) | 2012-11-29 | 2015-10-07 | Karyopharm Therapeutics, Inc. | Substituted 2,3-dihydrobenzofuranyl compounds and uses thereof |
| EA201690153A1 (ru) | 2013-07-03 | 2016-06-30 | Кариофарм Терапевтикс, Инк. | Замещенные бензофуранильные и бензоксазолильные соединения и их применения |
| WO2015042414A1 (en) | 2013-09-20 | 2015-03-26 | Karyopharm Therapeutics Inc. | Multicyclic compounds and methods of using same |
| EP4212148A1 (en) * | 2015-05-26 | 2023-07-19 | Plumb Pharmaceuticals, Inc. | Liposome loading |
| MX2018001979A (es) | 2015-08-18 | 2019-04-25 | Karyopharm Therapeutics Inc | (s,e) -3- (6-aminopiridin-3-il) -n- ( (5- (4- (3-fluoruro-3 metilpirrolidin-1-carbonil) fenil) -7- (4 fluorofenil) benzofuran-2-il)metil)acrilamida para el tratamiento del cancer. |
| WO2017117447A1 (en) * | 2015-12-31 | 2017-07-06 | Karyopharm Therapeutics Inc. | Multicyclic compounds and uses thereof |
| WO2023119230A1 (en) | 2021-12-22 | 2023-06-29 | L'oreal | Coagulation pathway and nicotinamide-adenine dinucleotide pathway modulating compositions and methods of their use |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1689376A2 (en) * | 2003-11-28 | 2006-08-16 | Novartis AG | Diaryl urea derivatives in the treatment of protein kinase dependent diseases |
| GB0327734D0 (en) * | 2003-11-28 | 2003-12-31 | Novartis Ag | Organic compounds |
| CA2579002C (en) * | 2004-09-02 | 2012-11-27 | Genentech, Inc. | Pyridyl inhibitors of hedgehog signalling |
| FR2921657A1 (fr) * | 2007-09-28 | 2009-04-03 | Sanofi Aventis Sa | Derives de nicotinamide, leur preparation et leur application en therapeutique |
-
2009
- 2009-03-24 FR FR0901365A patent/FR2943669B1/fr not_active Expired - Fee Related
-
2010
- 2010-03-22 SG SG2011068871A patent/SG174902A1/en unknown
- 2010-03-22 KR KR1020117024865A patent/KR20110133049A/ko not_active Withdrawn
- 2010-03-22 RU RU2011142753/04A patent/RU2011142753A/ru unknown
- 2010-03-22 CN CN2010800227689A patent/CN102448939A/zh active Pending
- 2010-03-22 CA CA2756099A patent/CA2756099A1/fr not_active Abandoned
- 2010-03-22 AU AU2010227402A patent/AU2010227402A1/en not_active Abandoned
- 2010-03-22 BR BRPI1013553A patent/BRPI1013553A2/pt not_active IP Right Cessation
- 2010-03-22 WO PCT/FR2010/050511 patent/WO2010109122A1/fr not_active Ceased
- 2010-03-22 US US13/258,220 patent/US20120053170A1/en not_active Abandoned
- 2010-03-22 EP EP10716566A patent/EP2411368A1/fr not_active Withdrawn
- 2010-03-22 JP JP2012501349A patent/JP2012521396A/ja not_active Withdrawn
- 2010-03-22 MX MX2011010052A patent/MX2011010052A/es not_active Application Discontinuation
- 2010-03-23 TW TW099108544A patent/TW201038554A/zh unknown
- 2010-03-23 AR ARP100100920A patent/AR075920A1/es unknown
- 2010-03-24 UY UY0001032517A patent/UY32517A/es not_active Application Discontinuation
-
2011
- 2011-09-21 IL IL215285A patent/IL215285A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2943669B1 (fr) | 2011-05-06 |
| MX2011010052A (es) | 2012-01-12 |
| SG174902A1 (en) | 2011-11-28 |
| KR20110133049A (ko) | 2011-12-09 |
| UY32517A (es) | 2010-10-29 |
| IL215285A0 (en) | 2011-11-30 |
| FR2943669A1 (fr) | 2010-10-01 |
| CN102448939A (zh) | 2012-05-09 |
| EP2411368A1 (fr) | 2012-02-01 |
| JP2012521396A (ja) | 2012-09-13 |
| RU2011142753A (ru) | 2013-04-27 |
| CA2756099A1 (fr) | 2010-09-30 |
| BRPI1013553A2 (pt) | 2016-04-12 |
| US20120053170A1 (en) | 2012-03-01 |
| AU2010227402A1 (en) | 2011-10-20 |
| WO2010109122A1 (fr) | 2010-09-30 |
| TW201038554A (en) | 2010-11-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |