AR069800A1 - Derivados 5- aminociclilmetil - oxazolidin-2- ona - Google Patents
Derivados 5- aminociclilmetil - oxazolidin-2- onaInfo
- Publication number
- AR069800A1 AR069800A1 ARP080105521A ARP080105521A AR069800A1 AR 069800 A1 AR069800 A1 AR 069800A1 AR P080105521 A ARP080105521 A AR P080105521A AR P080105521 A ARP080105521 A AR P080105521A AR 069800 A1 AR069800 A1 AR 069800A1
- Authority
- AR
- Argentina
- Prior art keywords
- represent
- aminociclilmetil
- oxazolidin
- ona
- derivatives
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 CH2N3 Chemical compound 0.000 abstract 2
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 abstract 2
- XXJGBENTLXFVFI-UHFFFAOYSA-N 1-amino-methylene Chemical compound N[CH2] XXJGBENTLXFVFI-UHFFFAOYSA-N 0.000 abstract 1
- 101100439662 Arabidopsis thaliana CHR5 gene Proteins 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Composiciones farmacéuticas que comprenden dichos compuestos y usos de los mismos para prevencion o tratamiento de infecciones bacteriales. Reivindicacion 1: Un compuesto de formula (1) en donde 1 o 2 de U, V, W, y X representan N, el resto representan CH o, en el caso de X, puede también representar CRa en donde Ra es F; R1 representa alcoxilo, halogeno o ciano; R2 representa H, CH2OH, CH2N3, CH2NH2, alquilcarbonilaminometilo o triazolo-1-ilmetilo; R3 representa H, o, cuando n es 1, R3 puede también representar OH, NH2, NHCOR6 o triazol-1-ilo; A representa CR4; K representa O, NH, OCH2, NHCO, NHCH2, CH2NH, CH2CH2, CH=CH, CHOHCHOH o CHR5; R4 representa H o en conjunto con R5 forma un enlace, también R4 puede representar OH cuando K no es O, NH, OCH2 o NHCO; R5 representa OH o en conjunto con R4 forma un enlace; R6 representa alquilo; m es 0 o 1 y n es 0 o 1; y G representa el grupo de formula (2) en el cual Z1 representa N, Z2 CH; o representa CH, y Z3 representa CH; o Z1 representa CH, Z2 representa N, y Z3 representa CH o N; o Z1 representa CH, Z2 representa CH, y Z3 representa CH o N; y el anillo P es seleccionado de entre los grupos de formulas (3), en donde Q es O o S; o una sal de un tal compuesto.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2007055194 | 2007-12-18 | ||
| IB2008054170 | 2008-10-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR069800A1 true AR069800A1 (es) | 2010-02-17 |
Family
ID=40471513
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080105521A AR069800A1 (es) | 2007-12-18 | 2008-12-18 | Derivados 5- aminociclilmetil - oxazolidin-2- ona |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9505750B2 (es) |
| EP (1) | EP2245028B1 (es) |
| JP (1) | JP5323088B2 (es) |
| KR (1) | KR101578234B1 (es) |
| CN (1) | CN101903380B (es) |
| AR (1) | AR069800A1 (es) |
| AT (1) | ATE546446T1 (es) |
| AU (1) | AU2008337096B2 (es) |
| BR (1) | BRPI0820985A2 (es) |
| CA (1) | CA2706837C (es) |
| ES (1) | ES2380398T3 (es) |
| MX (1) | MX2010006111A (es) |
| PL (1) | PL2245028T3 (es) |
| RU (1) | RU2492169C2 (es) |
| TW (1) | TWI441636B (es) |
| WO (1) | WO2009077989A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2411930T3 (es) | 2008-02-20 | 2013-07-09 | Actelion Pharmaceuticals Ltd. | Compuestos antibióticos azatricíclicos |
| CN104151315B (zh) | 2008-10-07 | 2017-01-11 | 埃科特莱茵药品有限公司 | 三环噁唑烷酮抗生素化合物 |
| JP2012505201A (ja) * | 2008-10-10 | 2012-03-01 | アクテリオン ファーマシューティカルズ リミテッド | ２−ベンゾチオフェニル−及び２−ナフチル−オキサゾリジノン、並びにそれらのアザアイソスター（ａｚａｉｓｏｓｔｅｒｅ）類似体 |
| US8507478B2 (en) | 2008-10-10 | 2013-08-13 | Actelion Pharmaceuticals Ltd. | Oxazolidinyl antibiotics |
| EP2674430A4 (en) | 2011-02-07 | 2014-07-02 | Daiichi Sankyo Co Ltd | AMINO-GROUP-PYRROLIDINONE DERIVATIVES |
| US9079922B2 (en) * | 2011-11-08 | 2015-07-14 | Actelion Pharmaceuticals Ltd | 2-oxo-oxazolidin-3,5-diyl antibiotic derivatives |
| WO2014024056A1 (en) | 2012-08-06 | 2014-02-13 | Daiichi Sankyo Company, Limited | Pyrrolidine derivatives with antibacterial properties |
| AR102256A1 (es) | 2014-10-15 | 2017-02-15 | Actelion Pharmaceuticals Ltd | Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxi |
| TW201833120A (zh) | 2017-02-17 | 2018-09-16 | 瑞士商愛杜西亞製藥有限公司 | 芳基噁唑啶酮抗生素化合物 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19707628A1 (de) * | 1997-02-26 | 1998-08-27 | Merck Patent Gmbh | Oxazolidinone |
| IT1297874B1 (it) | 1997-06-19 | 1999-12-20 | Ezio Pellegrinotti | Cerniera elastica per occhiali. |
| JP2002534411A (ja) | 1999-01-07 | 2002-10-15 | ワイス | 鬱病の処置のためのアリールピペラジニル−シクロヘキシルインドール誘導体 |
| MY145722A (en) | 2000-04-27 | 2012-03-30 | Abbott Lab | Diazabicyclic central nervous system active agents |
| GB0031086D0 (en) * | 2000-12-20 | 2001-01-31 | Smithkline Beecham Plc | Medicaments |
| JP2004535411A (ja) | 2001-05-25 | 2004-11-25 | ブリストルーマイヤーズ スクイブ カンパニー | マトリックスメタロプロテナーゼ及び／またはＴＮＦ−α転換酵素（ＴＡＣＥ）の阻害剤としてのヒダントイン及び関連複素環化合物 |
| GB0112834D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
| GB0112836D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
| TW200409637A (en) | 2002-06-26 | 2004-06-16 | Glaxo Group Ltd | Compounds |
| WO2004032856A2 (en) | 2002-10-07 | 2004-04-22 | Smithkline Beecham Corporation | Compounds |
| US7491714B2 (en) | 2002-12-04 | 2009-02-17 | Glaxo Group Limited | Quinolines and nitrogenated derivatives thereof and their use as antibacterial agents |
| DE10316081A1 (de) | 2003-04-08 | 2004-10-21 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Neue Verbindungen mit antibakterieller Aktivität |
| US7160888B2 (en) | 2003-08-22 | 2007-01-09 | Warner Lambert Company Llc | [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia |
| WO2006024741A2 (fr) | 2004-07-30 | 2006-03-09 | Palumed S.A. | Molecules hybrides qa ou q est une aminoquinoleine et a est un residu antibiotique, leur synthese et leurs utilisations en tant qu'agent antibacterien |
| DE102004041163A1 (de) | 2004-08-25 | 2006-03-02 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Neue Verbindungen mit antibakterieller Aktivität |
| JP4887297B2 (ja) | 2004-09-24 | 2012-02-29 | アクテリオン ファーマシューティカルズ リミテッド | 新規二環式抗生物質 |
| JP5314244B2 (ja) | 2004-10-27 | 2013-10-16 | 富山化学工業株式会社 | 新規な含窒素複素環化合物およびその塩 |
| WO2007012210A2 (de) | 2005-07-23 | 2007-02-01 | Schlittler & Co. Ag | Reiniger mit einweg-wischtasche |
| WO2007105154A2 (en) | 2006-03-10 | 2007-09-20 | Actelion Pharmaceuticals Ltd | Antibiotic compounds |
| DE602007006927D1 (en) | 2006-03-23 | 2010-07-15 | Actelion Pharmaceuticals Ltd | Antibiotische cyclohexyl- oder piperidinylcarboxamid-derivate |
| CL2008001002A1 (es) * | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
| CL2008001003A1 (es) | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
-
2008
- 2008-12-17 EP EP08861657A patent/EP2245028B1/en not_active Not-in-force
- 2008-12-17 PL PL08861657T patent/PL2245028T3/pl unknown
- 2008-12-17 BR BRPI0820985-5A patent/BRPI0820985A2/pt not_active IP Right Cessation
- 2008-12-17 AT AT08861657T patent/ATE546446T1/de active
- 2008-12-17 CN CN200880122170XA patent/CN101903380B/zh not_active Expired - Fee Related
- 2008-12-17 KR KR1020107014614A patent/KR101578234B1/ko not_active Expired - Fee Related
- 2008-12-17 US US12/809,555 patent/US9505750B2/en not_active Expired - Fee Related
- 2008-12-17 CA CA2706837A patent/CA2706837C/en not_active Expired - Fee Related
- 2008-12-17 WO PCT/IB2008/055374 patent/WO2009077989A1/en not_active Ceased
- 2008-12-17 RU RU2010129113/04A patent/RU2492169C2/ru not_active IP Right Cessation
- 2008-12-17 AU AU2008337096A patent/AU2008337096B2/en not_active Ceased
- 2008-12-17 MX MX2010006111A patent/MX2010006111A/es active IP Right Grant
- 2008-12-17 ES ES08861657T patent/ES2380398T3/es active Active
- 2008-12-17 JP JP2010539014A patent/JP5323088B2/ja not_active Expired - Fee Related
- 2008-12-18 AR ARP080105521A patent/AR069800A1/es unknown
- 2008-12-18 TW TW097149419A patent/TWI441636B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP5323088B2 (ja) | 2013-10-23 |
| WO2009077989A1 (en) | 2009-06-25 |
| CA2706837C (en) | 2016-05-03 |
| AU2008337096A1 (en) | 2009-06-25 |
| JP2011506593A (ja) | 2011-03-03 |
| CN101903380A (zh) | 2010-12-01 |
| TWI441636B (zh) | 2014-06-21 |
| CA2706837A1 (en) | 2009-06-25 |
| ATE546446T1 (de) | 2012-03-15 |
| US20110003789A1 (en) | 2011-01-06 |
| US9505750B2 (en) | 2016-11-29 |
| TW200932230A (en) | 2009-08-01 |
| EP2245028A1 (en) | 2010-11-03 |
| KR20100092965A (ko) | 2010-08-23 |
| ES2380398T3 (es) | 2012-05-11 |
| EP2245028B1 (en) | 2012-02-22 |
| AU2008337096B2 (en) | 2013-10-17 |
| RU2010129113A (ru) | 2012-01-27 |
| CN101903380B (zh) | 2013-04-17 |
| MX2010006111A (es) | 2010-06-25 |
| BRPI0820985A2 (pt) | 2015-06-16 |
| RU2492169C2 (ru) | 2013-09-10 |
| PL2245028T3 (pl) | 2012-07-31 |
| KR101578234B1 (ko) | 2015-12-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |