AR070458A1 - Derivados de oxazolidina, una composicion farmaceutica que los contiene y su uso en la preparacion de un medicamento para el tratamiento de una infeccion bacteriana. - Google Patents
Derivados de oxazolidina, una composicion farmaceutica que los contiene y su uso en la preparacion de un medicamento para el tratamiento de una infeccion bacteriana.Info
- Publication number
- AR070458A1 AR070458A1 ARP090100598A ARP090100598A AR070458A1 AR 070458 A1 AR070458 A1 AR 070458A1 AR P090100598 A ARP090100598 A AR P090100598A AR P090100598 A ARP090100598 A AR P090100598A AR 070458 A1 AR070458 A1 AR 070458A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- treatment
- bacterial infection
- group
- oxazolidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Uso de estos compuestos en la elaboracion de un medicamento para la prevencion o tratamiento de una infeccion bacteriana y en composiciones farmacéuticas. Reivindicacion 1: Un compuesto de la formula (1) en donde ô-------ô es un enlace, o está ausente; R1 representa a alcoxi C1-4 o halogeno; R1b representa a H o alquilo C1-3; U y V representan cada uno independientemente a CH o N; W representa a CH o N, o, en caso de que ô----ô esté ausente, W representa a CH2 o NH; con la condicion de que por lo menos uno de U, V y W represente a CH o CH2; A representa a -CH2-CH(R2)-B-NH-* o CH(R3)-CH2-N(R4)-[CH2]m-*; donde los asteriscos indican el enlace que está unido a través del grupo CH2- a la porcion oxazolidinona; B representa a CH2 o CO; y R2 representa a hidrogeno, OH o NH2; R3 y R4 representan ambos a hidrogeno, o R3 y R4 juntos forman un puente metileno; m representa al entero 0, 1 o 2; y G representa a fenilo que es monosustituido en la posicion 3 o 4, o disustituido en las posiciones 3 y 4, en donde cada substituyente es seleccionado independientemente del grupo constituido por alquilo C1-4, alcoxi C1-3 y halogeno; o G representa a un grupo seleccionado del grupo constituido por los grupos G1, G2, G3, G4, G5 y G6 donde M representa a CH o N; Q y Q' representan independientemente a S u O; ò Z1 representa a N, Z2 representa a CH, y Z3 representa a CH; o ò Z1 representa a CH, Z2 representa a N, y Z3 representa a CH o N; o ò Z1 representa a CH, Z2 representa a CR5, y Z3 representa a CH; o ò Z1 representa a CH, Z2 representa a CH, y Z3 representa a N; y R5 representa a hidrogeno o fluor; o una sal de tal compuesto.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2008050651 | 2008-02-22 | ||
| IB2008054095 | 2008-10-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR070458A1 true AR070458A1 (es) | 2010-04-07 |
Family
ID=40578768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090100598A AR070458A1 (es) | 2008-02-22 | 2009-02-20 | Derivados de oxazolidina, una composicion farmaceutica que los contiene y su uso en la preparacion de un medicamento para el tratamiento de una infeccion bacteriana. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8349826B2 (es) |
| EP (1) | EP2254887B9 (es) |
| JP (1) | JP5404652B2 (es) |
| KR (1) | KR101592046B1 (es) |
| CN (1) | CN102015698B (es) |
| AR (1) | AR070458A1 (es) |
| BR (1) | BRPI0908208A2 (es) |
| CA (1) | CA2713187C (es) |
| ES (1) | ES2398939T3 (es) |
| MX (1) | MX2010008921A (es) |
| PL (1) | PL2254887T3 (es) |
| RU (1) | RU2501799C2 (es) |
| TW (1) | TWI429643B (es) |
| WO (1) | WO2009104159A1 (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2411930T3 (es) | 2008-02-20 | 2013-07-09 | Actelion Pharmaceuticals Ltd. | Compuestos antibióticos azatricíclicos |
| CN104151315B (zh) | 2008-10-07 | 2017-01-11 | 埃科特莱茵药品有限公司 | 三环噁唑烷酮抗生素化合物 |
| JP2012505201A (ja) * | 2008-10-10 | 2012-03-01 | アクテリオン ファーマシューティカルズ リミテッド | ２−ベンゾチオフェニル−及び２−ナフチル−オキサゾリジノン、並びにそれらのアザアイソスター（ａｚａｉｓｏｓｔｅｒｅ）類似体 |
| US8507478B2 (en) | 2008-10-10 | 2013-08-13 | Actelion Pharmaceuticals Ltd. | Oxazolidinyl antibiotics |
| AR076222A1 (es) | 2009-04-09 | 2011-05-26 | Actelion Pharmaceuticals Ltd | Derivados 2-hidroxietil-1h-quinolin-ona y sus analogos azaisotericos con actividad antibacteriana y composiciones farmaceuticas que los contienen |
| EP2674430A4 (en) | 2011-02-07 | 2014-07-02 | Daiichi Sankyo Co Ltd | AMINO-GROUP-PYRROLIDINONE DERIVATIVES |
| US8916573B2 (en) | 2011-08-11 | 2014-12-23 | Actelion Pharmaceuticals Ltd. | Quinazoline-2,4-dione derivatives |
| US9079922B2 (en) * | 2011-11-08 | 2015-07-14 | Actelion Pharmaceuticals Ltd | 2-oxo-oxazolidin-3,5-diyl antibiotic derivatives |
| WO2013080156A1 (en) | 2011-11-30 | 2013-06-06 | Actelion Pharmaceuticals Ltd | 3,7-disubstituted octahydro-2h-pyrido[4,3-e][1,3]oxazin-2-one antibiotics |
| WO2014024056A1 (en) | 2012-08-06 | 2014-02-13 | Daiichi Sankyo Company, Limited | Pyrrolidine derivatives with antibacterial properties |
| EP2943492A1 (en) | 2013-01-09 | 2015-11-18 | Actelion Pharmaceuticals Ltd. | Antibacterial oxadiazolone derivatives |
| PL2986607T3 (pl) | 2013-04-16 | 2017-11-30 | Idorsia Pharmaceuticals Ltd | Przeciwbakteryjne pochodne biaromatyczne |
| CA2910177A1 (en) | 2013-05-08 | 2014-11-13 | Actelion Pharmaceuticals Ltd | Antibacterial phthalide derivatives |
| AR102256A1 (es) | 2014-10-15 | 2017-02-15 | Actelion Pharmaceuticals Ltd | Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxi |
| EP3413976A1 (en) * | 2016-02-08 | 2018-12-19 | Redx Pharma PLC | Heterocyclic compounds, in particular 2-oxo-4,4,5,5,6,6,7,7-octahydrobenzoxazole derivatives, and their use as antibacterial compounds |
| GB201602235D0 (en) * | 2016-02-08 | 2016-03-23 | Redx Pharma Plc | Antibacterial compounds |
| WO2017137743A1 (en) * | 2016-02-08 | 2017-08-17 | Redx Pharma Plc | Antibacterial compounds |
| TW201833120A (zh) | 2017-02-17 | 2018-09-16 | 瑞士商愛杜西亞製藥有限公司 | 芳基噁唑啶酮抗生素化合物 |
| ES2942761T3 (es) * | 2017-06-08 | 2023-06-06 | Bugworks Res Inc | Compuestos heterocíclicos útiles como agentes antibacterianos y método para la producción de los mismos |
| EP3717490B1 (en) * | 2017-11-29 | 2023-05-24 | Bugworks Research, Inc. | Anti-bacterial heterocyclic compounds and their synthesis |
| SMT202300130T1 (it) * | 2018-03-28 | 2023-05-12 | Bugworks Research Inc | Composti antibiotici ossazolidinone e processo di preparazione |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2168696B (en) | 1984-12-21 | 1989-01-11 | Boehringer Biochemia Srl | Fluoro coumarins as antilymphoedema agents |
| CA2012681A1 (en) | 1989-03-31 | 1990-09-30 | Masayasu Okuhira | Quinolone derivatives, preparation processes thereof, and antibacterial agents containing the same |
| DE19514313A1 (de) * | 1994-08-03 | 1996-02-08 | Bayer Ag | Benzoxazolyl- und Benzothiazolyloxazolidinone |
| CN1163892A (zh) * | 1996-01-16 | 1997-11-05 | 拜尔公司 | 2-氧代-和2-硫代-1，2-二氢喹啉基-噁唑烷酮类化合物 |
| DE19601265A1 (de) * | 1996-01-16 | 1997-07-17 | Bayer Ag | 2-Oxo- und 2-Thio-1,2-dihydrochinolinyl-oxazolidinone |
| DE19604223A1 (de) | 1996-02-06 | 1997-08-07 | Bayer Ag | Neue substituierte Oxazolidinone |
| WO2001030782A2 (en) | 1999-10-29 | 2001-05-03 | Syngenta Participations Ag | Novel herbicides |
| GB0031086D0 (en) | 2000-12-20 | 2001-01-31 | Smithkline Beecham Plc | Medicaments |
| GB0101577D0 (en) | 2001-01-22 | 2001-03-07 | Smithkline Beecham Plc | Compounds |
| GB0112834D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
| FR2852954B1 (fr) * | 2003-03-28 | 2006-07-14 | Aventis Pharma Sa | Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent |
| CN1898238A (zh) * | 2003-12-18 | 2007-01-17 | 莫弗凯姆联合化学股份公司 | 噁唑烷酮－喹诺酮杂化物抗生素 |
| WO2006024741A2 (fr) * | 2004-07-30 | 2006-03-09 | Palumed S.A. | Molecules hybrides qa ou q est une aminoquinoleine et a est un residu antibiotique, leur synthese et leurs utilisations en tant qu'agent antibacterien |
| TWI320783B (en) | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
| MY150958A (en) * | 2005-06-16 | 2014-03-31 | Astrazeneca Ab | Compounds for the treatment of multi-drug resistant bacterial infections |
| DE602006013878D1 (de) | 2005-12-22 | 2010-06-02 | Glaxo Group Ltd | Heterocyclische verbindungen, ihre herstellung und ihre verwendung als antibakterielle mittel |
| EP1987025B1 (en) * | 2006-02-14 | 2009-09-16 | Pfizer Products Inc. | Benzoxazinone and benzoxazepinone oxazolidinones as antibacterial agents |
| KR101409261B1 (ko) | 2006-05-26 | 2014-06-18 | 다이쇼 세이야꾸 가부시끼가이샤 | 신규의 복소환 화합물 또는 그 염 및 그 중간체 |
| EP2404913A3 (en) | 2006-06-16 | 2012-06-06 | Pharma Mar S.A. | Process and intermediates for the preparation of antitumoral dihydropyran-2-one compounds |
| DE602007012133D1 (de) | 2006-12-01 | 2011-03-03 | Andrew Burritt | Triazolopyridinverbindungen zur behandlung von degenerations- und entzündungskrankheiten |
| CL2008001002A1 (es) | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
| CL2008001003A1 (es) | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
-
2009
- 2009-02-20 MX MX2010008921A patent/MX2010008921A/es active IP Right Grant
- 2009-02-20 CA CA2713187A patent/CA2713187C/en not_active Expired - Fee Related
- 2009-02-20 US US12/918,779 patent/US8349826B2/en not_active Expired - Fee Related
- 2009-02-20 AR ARP090100598A patent/AR070458A1/es unknown
- 2009-02-20 KR KR1020107020126A patent/KR101592046B1/ko not_active Expired - Fee Related
- 2009-02-20 CN CN200980106053.9A patent/CN102015698B/zh not_active Expired - Fee Related
- 2009-02-20 RU RU2010138840/04A patent/RU2501799C2/ru not_active IP Right Cessation
- 2009-02-20 WO PCT/IB2009/050702 patent/WO2009104159A1/en not_active Ceased
- 2009-02-20 PL PL09711588T patent/PL2254887T3/pl unknown
- 2009-02-20 ES ES09711588T patent/ES2398939T3/es active Active
- 2009-02-20 JP JP2010547295A patent/JP5404652B2/ja not_active Expired - Fee Related
- 2009-02-20 BR BRPI0908208-5A patent/BRPI0908208A2/pt not_active IP Right Cessation
- 2009-02-20 EP EP09711588.5A patent/EP2254887B9/en not_active Not-in-force
- 2009-02-20 TW TW098105507A patent/TWI429643B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011512401A (ja) | 2011-04-21 |
| US8349826B2 (en) | 2013-01-08 |
| WO2009104159A1 (en) | 2009-08-27 |
| TWI429643B (zh) | 2014-03-11 |
| US20100331308A1 (en) | 2010-12-30 |
| CA2713187A1 (en) | 2009-08-27 |
| TW200940534A (en) | 2009-10-01 |
| RU2010138840A (ru) | 2012-03-27 |
| AU2009215247A1 (en) | 2009-08-27 |
| JP5404652B2 (ja) | 2014-02-05 |
| RU2501799C2 (ru) | 2013-12-20 |
| CN102015698A (zh) | 2011-04-13 |
| ES2398939T3 (es) | 2013-03-22 |
| EP2254887B9 (en) | 2013-05-29 |
| EP2254887B1 (en) | 2012-12-19 |
| EP2254887A1 (en) | 2010-12-01 |
| MX2010008921A (es) | 2010-09-07 |
| ES2398939T9 (es) | 2013-07-24 |
| CN102015698B (zh) | 2014-08-27 |
| KR20100124282A (ko) | 2010-11-26 |
| CA2713187C (en) | 2016-06-07 |
| KR101592046B1 (ko) | 2016-02-05 |
| PL2254887T3 (pl) | 2013-05-31 |
| BRPI0908208A2 (pt) | 2015-08-25 |
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Legal Events
| Date | Code | Title | Description |
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| FB | Suspension of granting procedure |