[go: up one dir, main page]

PE20020906A1 - Inhibidores de peptido-deformilasa - Google Patents

Inhibidores de peptido-deformilasa

Info

Publication number
PE20020906A1
PE20020906A1 PE2002000170A PE2002000170A PE20020906A1 PE 20020906 A1 PE20020906 A1 PE 20020906A1 PE 2002000170 A PE2002000170 A PE 2002000170A PE 2002000170 A PE2002000170 A PE 2002000170A PE 20020906 A1 PE20020906 A1 PE 20020906A1
Authority
PE
Peru
Prior art keywords
alkyl
compounds
heptanoil
carbocycle
hydrazine
Prior art date
Application number
PE2002000170A
Other languages
English (en)
Inventor
Jia-Ning Xiang
Iv Siegfried B Christensen
Jinhwa Lee
Daniel J Mercer
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of PE20020906A1 publication Critical patent/PE20020906A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C243/34—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a carbon skeleton further substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C243/30—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
    • C07C243/32—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/38—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/02—Compounds containing any of the groups, e.g. carbazates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/06—Compounds containing any of the groups, e.g. semicarbazides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

SE REFIERE A COMPUESTOS DE FORMULA IIDONDE R ES ALQUILO C2-C6, ALQUENILO C2-C6, ALQUINILO C2-C6, (CH2)n-CARBOCICLO C3-C6, ENTRE OTROS; R1 ES H, ALQUILO C1-C6, OH, (CH2)n-CARBOCICLO C3-C7; R2 ES H (CON LA CONDICION DE QUE X NO ES O) ALQUILO C1-C3, ALQUENILO C2-C3, ALQUINILO C2-C3, ENTRE OTROS; R3 ES H, ALQUILO C1-C3, FENILO; R2 JUNTO A N FORMAN UN ANILLO HETEROCICLICO QUE PUEDE ESTAR OPCIONALMENTE CONDENSADO A UN ANILLO DE ARILO, HETEROARILO; X ES O, NR3, ENLACE COVALENTE; Y ES O, CH2, ENLACE COVALENTE; n ES 0-2. SON COMPUESTOS PREFERIDOS N-BUTIL-N-(t-BUTOXICARBONILO)-N'-{(2R)-[(FORMILHIDROXIAMINO)METIL]HEPTANOIL}-HIDRAZINA, N-BUTIL-N-FENOXICARBONIL-N'-{(2R)-[(FORMILHIDROXIAMINO)METIL]HEPTANOIL}-HIDRAZINA, ENTRE OTROS. LOS COMPUESTOS MENCIONADOS SON INHIBIDORES DE PEPTIDO-DEFORMILASA Y SON UTILES PARA EL TRATAMIENTO DE INFECCIONES BACTERIANAS
PE2002000170A 2001-03-01 2002-03-01 Inhibidores de peptido-deformilasa PE20020906A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27257001P 2001-03-01 2001-03-01

Publications (1)

Publication Number Publication Date
PE20020906A1 true PE20020906A1 (es) 2002-12-08

Family

ID=23040368

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000170A PE20020906A1 (es) 2001-03-01 2002-03-01 Inhibidores de peptido-deformilasa

Country Status (20)

Country Link
US (1) US7019003B2 (es)
EP (1) EP1363873B1 (es)
JP (1) JP4266638B2 (es)
KR (1) KR20030092008A (es)
CN (1) CN1505607A (es)
AR (1) AR032920A1 (es)
AU (1) AU2002335490B2 (es)
BR (1) BR0207810A (es)
CA (1) CA2439827A1 (es)
CZ (1) CZ20032342A3 (es)
EG (1) EG24516A (es)
HU (1) HUP0303308A2 (es)
IL (1) IL157643A0 (es)
MX (1) MXPA03007869A (es)
NO (1) NO20033828L (es)
NZ (1) NZ527728A (es)
PE (1) PE20020906A1 (es)
PL (1) PL364563A1 (es)
UY (1) UY27192A1 (es)
WO (1) WO2002070541A2 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY27813A1 (es) 2002-05-31 2003-12-31 Smithkline Beecham Corp Inhibidores de la peptido-desformilasa
JP2005532358A (ja) * 2002-06-06 2005-10-27 スミスクライン・ビーチャム・コーポレイション ペプチドデホルミラーゼ阻害剤
NZ538833A (en) * 2002-09-19 2008-05-30 Novartis Ag Process for preparing intermediates
GB0229673D0 (en) * 2002-12-19 2003-01-29 British Biotech Pharm Antibacterial agents
US7332485B2 (en) * 2003-07-08 2008-02-19 Smithkline Beecham Corp Peptide deformylase inhibitors
US7507726B2 (en) * 2003-08-15 2009-03-24 Smithklinebeecham Corporation Peptide deformylase inhibitors
WO2006055663A2 (en) 2004-11-17 2006-05-26 Smithkline Beecham Corporation The use of novel antibacterial compounds
US7982053B2 (en) * 2005-07-29 2011-07-19 Glaxosmithkline Llc Peptide deformylase inhibitors
US7622492B2 (en) 2005-08-31 2009-11-24 Hoffmann-La Roche Inc. Pyrazolones as inhibitors of 11β-hydroxysteroid dehydrogenase
CA2626641A1 (en) * 2005-10-21 2007-07-19 Glaxo Group Limited Compounds
KR100753796B1 (ko) * 2006-07-28 2007-08-31 주식회사 프로메디텍 데포르밀라제 저해제, 이의 제조방법, 및 이를 포함하는조성물
GB0707706D0 (en) * 2007-04-20 2007-05-30 Glaxo Group Ltd Compounds
UA108596C2 (xx) * 2007-11-09 2015-05-25 Інгібітори пептиддеформілази
US8466151B2 (en) 2007-12-26 2013-06-18 Critical Outcome Technologies, Inc. Compounds and method for treatment of cancer
EP2318406B1 (en) 2008-07-17 2016-01-27 Critical Outcome Technologies, Inc. Thiosemicarbazone inhibitor compounds and cancer treatment methods
US8987272B2 (en) 2010-04-01 2015-03-24 Critical Outcome Technologies Inc. Compounds and method for treatment of HIV
JP2015500238A (ja) * 2011-12-02 2015-01-05 グラクソスミスクライン、インテレクチュアル、プロパティー、ナンバー２、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｎｏ．２ Ｌｉｍｉｔｅｄ ペプチドデホルミラーゼ阻害剤
CN116375698B (zh) * 2023-06-05 2023-08-01 中国林业科学研究院林产化学工业研究所 具有靶向抗肿瘤活性的漆酚基异羟肟酸型hdac抑制剂及其制备方法和应用
CN119462779B (zh) * 2024-11-06 2025-12-26 中国船舶集团有限公司第七一八研究所 一种光引发剂fmt的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK77487A (da) * 1986-03-11 1987-09-12 Hoffmann La Roche Hydroxylaminderivater
GB9223904D0 (en) * 1992-11-13 1993-01-06 British Bio Technology Inhibition of cytokine production
US6013792A (en) * 1993-08-05 2000-01-11 Syntex (U.S.A.), Inc. Matrix metalloprotease inhibitors
US6037472A (en) * 1993-11-04 2000-03-14 Syntex (U.S.A.) Inc. Matrix metalloprotease inhibitors
EP0763012B1 (en) * 1994-05-28 1999-06-09 British Biotech Pharmaceuticals Limited Succinyl hydroxamic acid, n-formyl-n-hydroxy amino carboxylic acid and succinic acid amide derivatives as metalloprotease inhibitors
GB9827805D0 (en) 1998-12-16 1999-02-10 British Biotech Pharm Antibacterial agents
WO2001042431A2 (en) 1999-12-08 2001-06-14 Bayer Aktiengesellschaft Regulation of human mitochondrial deformylase

Also Published As

Publication number Publication date
AR032920A1 (es) 2003-12-03
NO20033828D0 (no) 2003-08-28
MXPA03007869A (es) 2003-12-04
EP1363873A2 (en) 2003-11-26
AU2002335490B2 (en) 2005-10-20
JP2004537507A (ja) 2004-12-16
EP1363873A4 (en) 2006-01-04
EP1363873B1 (en) 2016-04-20
US7019003B2 (en) 2006-03-28
US20040087585A1 (en) 2004-05-06
IL157643A0 (en) 2004-03-28
CA2439827A1 (en) 2002-09-12
NZ527728A (en) 2004-09-24
HUP0303308A2 (hu) 2004-01-28
NO20033828L (no) 2003-10-06
KR20030092008A (ko) 2003-12-03
PL364563A1 (en) 2004-12-13
WO2002070541A3 (en) 2002-12-19
JP4266638B2 (ja) 2009-05-20
BR0207810A (pt) 2008-04-15
WO2002070541A2 (en) 2002-09-12
UY27192A1 (es) 2002-09-30
EG24516A (en) 2009-08-19
CN1505607A (zh) 2004-06-16
CZ20032342A3 (cs) 2004-04-14

Similar Documents

Publication Publication Date Title
PE20020906A1 (es) Inhibidores de peptido-deformilasa
PE20010632A1 (es) Derivados de ter-butil-(7-metil-imidazol[1,2-a]piridin-3-il)-amina, procedimiento para su preparacion, medicamentos y composiciones farmaceuticas que los contienen
UY26727A1 (es) Derivados de tropano útiles en terapia
NO20054195D0 (no) Isoksazolforbindelser som inhibitorer for varmesjokkproteiner
AR038536A1 (es) N-aril-2-oxazolidinona-5- carboxamidas y sus derivados
BRPI0506817A (pt) inibidores seletivos de quinase
ES2193990T3 (es) Derivados de purina.
PE20010634A1 (es) Imidazo-3-il-aminas biciclicas, procedimiento para su preparacion y medicamentos que las contienen
EA200300333A1 (ru) Новые тиадиазолы и оксадиазолы и их применение в качестве ингибиторов фосфодиэстеразы-7
DK1485377T3 (da) Pyranoner egnede som ATM-inhibitorer
AR047085A1 (es) Derivados de (3-oxo-3,4-dihidro-quinoxalina-2-il-amino)benzamida y compuestos relacionados como inhibidores de glucogeno fosforilasa para el tratamiento de diabetes y obesidad
AR049578A1 (es) Derivados de hidantoina, procesos de obtencion y composiciones farmaceuticas
CL2004001167A1 (es) Compuestos derivados de tiazolidindionas; procedimiento de elaboracion: composicion farmaceutica que los contiene; y su uso en el tratamiento de la diabetes.
MXPA04009476A (es) Compuestos de (tiazol-4,2-disustituidos-5-il)amina como inhibidores de la pde7.
DE69414019D1 (de) Bicyclische Stichstoff enthaltende Derivate als Prolyl-Endopeptidase Inhibitoren
DE60330758D1 (de) Bestimmte pharmazeutisch wertvolle substituierte aminoalkyl-heterocyclen
PE20050160A1 (es) 3-aminopirrolidinas como inhibidores de la captacion de monoaminas
ATE374750T1 (de) Serotoninwiederaufnahme-inhibitoren
MY143245A (en) 4- 2-(cycloalkylamino)pyrimidin-4-yl-(phenyl)-imidazolin-2-one derivatives as p38 map-kinase inhibitors for the treatment of inflammatory diseases
FI934045A0 (fi) Pyridin- och imidazolderivat foer kardiovaskulaera sjukdomar
HU911992D0 (en) 2-(amino-alkyl)-5-(aryl-alkyl)-1,3-dioxanes, and process for the production of the medical preparations containing them
ATE445619T1 (de) Pyridinylpyrazolopyrimidinon-derivate als pde 7 inhibitoren
AR044175A1 (es) Compuestos de cefemo
CO5680413A2 (es) Aminoacidos con afinidad por la proteina c2 delta
AR057558A1 (es) Compuestos de cinolincarboxamida y composicion farmaceutica

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed