AR067575A1 - Agentes citotoxicos que comprenden nuevos derivados de tomaimicina y su uso terapeutico - Google Patents
Agentes citotoxicos que comprenden nuevos derivados de tomaimicina y su uso terapeuticoInfo
- Publication number
- AR067575A1 AR067575A1 ARP080103068A ARP080103068A AR067575A1 AR 067575 A1 AR067575 A1 AR 067575A1 AR P080103068 A ARP080103068 A AR P080103068A AR P080103068 A ARP080103068 A AR P080103068A AR 067575 A1 AR067575 A1 AR 067575A1
- Authority
- AR
- Argentina
- Prior art keywords
- different
- same
- nrr
- hal
- aryl
- Prior art date
Links
- 229940127089 cytotoxic agent Drugs 0.000 title 1
- 239000002254 cytotoxic agent Substances 0.000 title 1
- 231100000599 cytotoxic agent Toxicity 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 239000011230 binding agent Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 cyclic amine Chemical class 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 206010007134 Candida infections Diseases 0.000 abstract 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- GNVMUORYQLCPJZ-UHFFFAOYSA-M Thiocarbamate Chemical compound NC([S-])=O GNVMUORYQLCPJZ-UHFFFAOYSA-M 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
La presente se refiere a nuevos derivados de tomaimicina que comprenden un ligante. También se refiere a las moléculas de conjugado que comprenden uno o más de dichos derivados de tomaimicina unidos mediante enlaces covalentes a un agente de union a la célula por un grupo de enlace que está presente en el ligante del derivado de tomaimicina. También se refiere a la preparacion de los derivados de tomaimicina y de las moléculas de conjugado. Composicion farmacéutica y uso para preparar medicamentos para tratar cáncer. Reivindicacion 1: Compuesto de formula (1) en la que: ----- representa un enlace sencillo opcional; ------ representa o un enlace sencillo o un doble enlace; siempre que cuando ------ represente un enlace sencillo, U y U', iguales o diferentes, representan independientemente H y W y W', iguales o diferentes, se seleccionan independientemente del grupo que consiste en: -OH, -OR, -OCOR, -COOR, -OCOOR, -OCONRR', un carbamato cíclico tal que N10 y C11 son una parte del ciclo, -NRCONRR', -OCSNHR, un tiocarbamato cíclico tal que N10 y C11 son una parte del ciclo, -SH, -SR, - SOR, -SOOR,-SO3, -NRSOOR', -NRR', una amina cíclica tal que N10 y C11 son una parte del ciclo, -NROR', -NRCOR', -N3, -CN, Hal, un trialquilo o triarilfosfonio y cuando ----- represente un doble enlace, U y U' están ausentes y W y W' representan H; R1, R2, R1', R2' son iguales. o diferentes y se eligen independientemente de: H, haluro o alquilo opcionalmente sustituido por uno o más Hal, CN, NRR', CF3, OR, arilo, Het; S(O)qR o R1 y R2 y R1' y R2' forman juntos un doble enlace que contiene grupo =B y =B' respectivamente; B y B' son iguales o diferentes y se eligen independientemente de: alquenilo que está opcionalmente sustituido por uno o más: Hal, CN, NRR', CF3, OR, SR, SOR, SO2R, arilo, Het o B y B' representan un átomo de oxígeno; X, X' son iguales o diferentes y se eligen independientemente de uno o más: -O-, -S-, -NR, -(C=O)-, -SO-, -SO2-, A, A' son iguales o diferentes y se eligen independientemente de alquilo o alquenilo, estando cada uno opcionalmente sustituido por uno o más: Hal, CN, NRR', CF3, OR, SR, SOR, SO2R, arilo, Het, alquilo, alquenilo; Y, Y' son iguales o diferentes y se eligen independientemente entre H, OR; T es -NR- o un arilo de 4 a 10 miembros, cicloalquilo, heterociclo, heteroarilo o un alquilo lineal o ramificado, estando cada uno sustituido por uno o más ligados no escindibles y opcionalmente sustituidos por uno o más de: Hal, CN, NRR', CF3, R, OR, SOR o SO2R; n, n', iguales o diferentes, son 0 o 1; q es 0,1 o 2; R, R' son iguales o diferentes y se eligen independientemente de: H, alquilo, arilo, estando cada uno opcionalmente sustituido por: Hal, CN, COOH, COOR, CONHR, CONRR', NRR', CF3, R, OR, SOR, SO2R, arilo, Het, o las sales farmacéuticamente aceptables, hidratos o sales hidratadas, las estructuras cristalinas polimorficas o sus isomeros opticos, racematos, diastereoisomeros o enantiomeros, de dichos compuestos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07290904.7A EP2019104B1 (en) | 2007-07-19 | 2007-07-19 | Cytotoxic agents comprising new tomaymycin derivatives and their therapeutic use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR067575A1 true AR067575A1 (es) | 2009-10-14 |
Family
ID=39048765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080103068A AR067575A1 (es) | 2007-07-19 | 2008-07-17 | Agentes citotoxicos que comprenden nuevos derivados de tomaimicina y su uso terapeutico |
Country Status (39)
| Country | Link |
|---|---|
| US (1) | US8404678B2 (es) |
| EP (2) | EP2019104B1 (es) |
| JP (1) | JP5551070B2 (es) |
| KR (1) | KR101627871B1 (es) |
| CN (1) | CN101784550B (es) |
| AR (1) | AR067575A1 (es) |
| AT (1) | ATE530553T1 (es) |
| AU (1) | AU2008281439B2 (es) |
| BR (1) | BRPI0814267A2 (es) |
| CA (1) | CA2693551C (es) |
| CL (1) | CL2008002139A1 (es) |
| CO (1) | CO6290692A2 (es) |
| CR (1) | CR11225A (es) |
| CY (2) | CY1112278T1 (es) |
| DK (2) | DK2019104T3 (es) |
| DO (1) | DOP2010000014A (es) |
| EA (1) | EA019938B1 (es) |
| EC (1) | ECSP109875A (es) |
| ES (2) | ES2435779T3 (es) |
| GT (1) | GT201000008A (es) |
| HR (1) | HRP20120067T1 (es) |
| IL (1) | IL203318A (es) |
| JO (1) | JO2744B1 (es) |
| MA (1) | MA31617B1 (es) |
| ME (1) | ME00969B (es) |
| MY (1) | MY151245A (es) |
| NI (1) | NI201000005A (es) |
| NZ (1) | NZ582679A (es) |
| PA (1) | PA8790201A1 (es) |
| PE (2) | PE20090889A1 (es) |
| PL (2) | PL2019104T3 (es) |
| PT (2) | PT2019104E (es) |
| RS (1) | RS52245B (es) |
| SI (2) | SI2019104T1 (es) |
| TN (1) | TN2010000002A1 (es) |
| TW (1) | TWI500618B (es) |
| UA (1) | UA98153C2 (es) |
| WO (1) | WO2009016516A2 (es) |
| ZA (1) | ZA201000389B (es) |
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