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MX2022006713A - Anticuerpos que interrumpen la interaccion entre gal3 y receptor de insulina o integrinas y metodos de uso de los mismos. - Google Patents

Anticuerpos que interrumpen la interaccion entre gal3 y receptor de insulina o integrinas y metodos de uso de los mismos.

Info

Publication number
MX2022006713A
MX2022006713A MX2022006713A MX2022006713A MX2022006713A MX 2022006713 A MX2022006713 A MX 2022006713A MX 2022006713 A MX2022006713 A MX 2022006713A MX 2022006713 A MX2022006713 A MX 2022006713A MX 2022006713 A MX2022006713 A MX 2022006713A
Authority
MX
Mexico
Prior art keywords
methods
integrins
interaction
insulin receptor
gal3
Prior art date
Application number
MX2022006713A
Other languages
English (en)
Inventor
Jing Zhang
Ksenya Shchors
Dongxu Sun
Maja Bonacorsi
Yinan Wu
Yadong Yu
Catherine A Gordon
Tsung- Huang Tsai
Samuel A F William
Original Assignee
Truebinding Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Truebinding Inc filed Critical Truebinding Inc
Publication of MX2022006713A publication Critical patent/MX2022006713A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
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    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K—PEPTIDES
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
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    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

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Abstract

En la presente se describen métodos y composiciones para interrumpir una interacción entre Galectina-3 y el receptor de insulina o integrinas. En la presente se describen además métodos y composiciones para el tratamiento de una enfermedad o un trastorno en un sujeto, tal como el tratamiento de diabetes mellitus, síndrome inflamatorio intestinal, enfermedad hepática grasa no alcohólica y esteatohepatitis no alcohólica.
MX2022006713A 2019-12-06 2020-12-03 Anticuerpos que interrumpen la interaccion entre gal3 y receptor de insulina o integrinas y metodos de uso de los mismos. MX2022006713A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962944833P 2019-12-06 2019-12-06
PCT/US2020/063134 WO2021113527A1 (en) 2019-12-06 2020-12-03 Antibodies that disrupt the interaction of gal3 and insulin receptor or integrins and methods of use thereof

Publications (1)

Publication Number Publication Date
MX2022006713A true MX2022006713A (es) 2022-07-12

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MX2022006713A MX2022006713A (es) 2019-12-06 2020-12-03 Anticuerpos que interrumpen la interaccion entre gal3 y receptor de insulina o integrinas y metodos de uso de los mismos.

Country Status (9)

Country Link
US (1) US20230094463A1 (es)
EP (2) EP4684799A2 (es)
JP (1) JP2023504199A (es)
KR (1) KR20220112261A (es)
CN (1) CN115279789A (es)
AU (1) AU2020396539A1 (es)
CA (1) CA3164060A1 (es)
MX (1) MX2022006713A (es)
WO (1) WO2021113527A1 (es)

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Publication number Priority date Publication date Assignee Title
WO2019023247A1 (en) 2017-07-25 2019-01-31 Immutics, Inc. TREATMENT OF CANCER BY BLOCKING THE INTERACTION OF TIM-3 AND ITS LIGAND
JP2022523333A (ja) 2019-01-30 2022-04-22 トゥルーバインディング，インコーポレイテッド 抗ｇａｌ３抗体およびその使用
EP4157338A4 (en) 2020-05-26 2024-11-13 TrueBinding, Inc. METHOD FOR TREATING INFLAMMATORY DISEASES BY GALECTIN-3 BLOCKING
JP2024526764A (ja) * 2021-07-13 2024-07-19 トゥルーバインディング，インコーポレイテッド タンパク質凝集を防止する方法

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