AR067475A1 - Antagonistas no basico s del receptor de la hormona concentradora de melanina 1 - Google Patents
Antagonistas no basico s del receptor de la hormona concentradora de melanina 1Info
- Publication number
- AR067475A1 AR067475A1 ARP080102936A ARP080102936A AR067475A1 AR 067475 A1 AR067475 A1 AR 067475A1 AR P080102936 A ARP080102936 A AR P080102936A AR P080102936 A ARP080102936 A AR P080102936A AR 067475 A1 AR067475 A1 AR 067475A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- ring
- cycloalkyl
- lower alkyl
- heteroaryl
- Prior art date
Links
- 241000343557 Melanina Species 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 229940088597 hormone Drugs 0.000 title 1
- 239000005556 hormone Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- -1 propanediyl Chemical group 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 2
- 229940002612 prodrug Drugs 0.000 abstract 2
- 239000000651 prodrug Substances 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 101150106280 Mchr1 gene Proteins 0.000 abstract 1
- 108700036626 Melanin-concentrating hormone receptor 1 Proteins 0.000 abstract 1
- 102100027375 Melanin-concentrating hormone receptor 1 Human genes 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 125000004858 cycloalkoxyalkyl group Chemical group 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000002483 medication Methods 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/18—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Psychology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuestos que incluyen todos los estereoisomeros, solvatos, profármacos y formas farmacéuticamente aceptables de los mismos de acuerdo con la formula (1). Además composiciones farmacéuticas que contienen al menos un compuesto de acuerdo con la formula (1) y opcionalmente al menos un agente terapéutico adicional y uso de dichos compuestos para preparar medicamentos utiles para tratar una enfermedad o trastorno modulado por MCHR-1 tal como, por ejemplo, obesidad, diabetes, depresion o ansiedad. Reivindicacion 1: Un compuesto de formula 1 o una sal farmacéuticamente aceptable del mismo caracterizado porque el anillo A es un anillo fenileno o un anillo heteroarilo que contiene uno o dos átomos de nitrogeno o un átomo de oxígeno; R1 es Z-Y-X-, donde X es O, S, >S(=O)-, o >S(=O)(=O); Y es un enlace, un cicloalquilo de 3 a 6 miembros o una cadena alquilo; y Z es arilo o heteroarilo; R2 es -E-G-(J)m, donde m es un numero entero de 1 a 3; E es O, S o un enlace; G es alquilo inferior, fenilalquilo, cicloalquilo, cicloalquilalquilo, alquilcicloalquilo, cicloalcoxi, alquilcicloalcoxi o cicloalcoxialquilo, y cada J es independientemente hidrogeno, hidroxilo, CN, -SO2R7, -SR7, -SOR7, alquilo inferior, alcoxi inferior, CF3, CF3O-, -COOR5 o CO-NR5aR6, donde cada uno de R5a y R6 se selecciona independientemente entre el grupo constituido por H, alquilo C1-3 y cicloalquilo, o R5a y R6 tomados juntos pueden ser propanodiilo, butanodiilo o pentanodiilo con el átomo de N al que están unidos para formar una amina cíclica de 4, 5 o 6 miembros que puede estar opcionalmente sustituida; R5 es H, alquilo C1-6 o cicloalquilo; R7 es alquilo inferior; y R3 es alquilo C1-6, cicloalquilo, alcoxi C1-6, halogeno, hidrogeno, -S-alquilo C1-6, CN, CF3O o CF3 y donde R2 y R3 pueden tomarse juntos para formar un anillo de 5 a 7 miembros que está saturado o parcialmente insaturado y puede incluir opcionalmente un heteroátomo E que es O o 0, 1 o 2 átomos de N, donde el anillo está sustituido con uno o dos grupos -O-G-(J)m, donde al menos un J es OH, y que puede estar opcionalmente sustituido con otros sustituyentes como los indicados para ôalquiloö o ôheteroariloö; con la condicion de que cuando el anillo A es un grupo fenileno, E-G y R3 no sean grupos alcoxi inferior no sustituidos iguales, y cuando G es alquilo inferior y J es H, R3 no sea hidrogeno; y cada uno de R8 y R9 es independientemente hidrogeno, halogeno o alquilo inferior, incluyendo ésteres de los mismos, profármacos de los mismos, solvatos de los mismos y todos los estereoisomeros de los mismos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94821307P | 2007-07-06 | 2007-07-06 | |
| US12/141,228 US20090011994A1 (en) | 2007-07-06 | 2008-06-18 | Non-basic melanin concentrating hormone receptor-1 antagonists and methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR067475A1 true AR067475A1 (es) | 2009-10-14 |
Family
ID=40221936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080102936A AR067475A1 (es) | 2007-07-06 | 2008-07-07 | Antagonistas no basico s del receptor de la hormona concentradora de melanina 1 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US20090011994A1 (es) |
| EP (1) | EP2173725A2 (es) |
| JP (1) | JP2010532791A (es) |
| KR (1) | KR20100044824A (es) |
| CN (1) | CN101801938A (es) |
| AR (1) | AR067475A1 (es) |
| AU (1) | AU2008275207A1 (es) |
| BR (1) | BRPI0813580A2 (es) |
| CA (1) | CA2692671A1 (es) |
| CL (1) | CL2008001994A1 (es) |
| CO (1) | CO6270360A2 (es) |
| EA (1) | EA201000157A1 (es) |
| PE (1) | PE20090437A1 (es) |
| TW (1) | TW200906413A (es) |
| WO (1) | WO2009009501A2 (es) |
| ZA (1) | ZA201000055B (es) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2069312T3 (da) * | 2006-07-25 | 2013-02-04 | Cephalon Inc | Pyridazinonderivater |
| DE102007007751A1 (de) * | 2007-02-16 | 2008-08-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| DE102007035333A1 (de) * | 2007-07-27 | 2009-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| JP5530370B2 (ja) | 2008-03-05 | 2014-06-25 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | インスリン分泌刺激剤としてのピラジノン誘導体、それらを得る方法および糖尿病を治療するためのそれらの使用 |
| EP2405913A1 (en) * | 2009-03-09 | 2012-01-18 | Bristol-Myers Squibb Company | Pyridone analogs useful as melanin concentrating hormone receptor-1 antagonists |
| US8278316B2 (en) | 2009-03-09 | 2012-10-02 | Bristol-Myers Squibb Company | Aza pyridone analogs useful as melanin concentrating hormone receptor-1 antagonists |
| JP2013506686A (ja) | 2009-09-30 | 2013-02-28 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | オートファジー阻害遺伝子産物の変調によりオートファジーを変調する方法 |
| EP2486004B1 (en) | 2009-10-09 | 2017-05-03 | Zafgen, Inc. | Sulphone compounds for use in the treatment of obesity |
| RS54945B1 (sr) | 2009-10-23 | 2016-11-30 | Janssen Pharmaceutica Nv | Disupstituisani oktahidropirolo[3,4-c]piroli kao oreksin receptor modulatori |
| CA2806221A1 (en) | 2010-07-22 | 2012-01-26 | Zafgen, Inc. | Tricyclic compounds and methods of making and using same |
| EP2668169B1 (en) | 2011-01-26 | 2017-11-15 | Zafgen, Inc. | Tetrazole compounds and methods of making and using same |
| BR112013028666A2 (pt) | 2011-05-06 | 2017-08-08 | Zafgen Inc | compostos de pirazolo sulfonamida tricícilos e métodos para fazer e usar o mesmo |
| EP2705030B1 (en) | 2011-05-06 | 2016-07-27 | Zafgen, Inc. | Partially saturated tricyclic compounds and methods of making and using same |
| MX343687B (es) | 2011-05-06 | 2016-11-16 | Zafgen Inc | Compuestos sulfonamida tricíclica y métodos para su fabricación y uso. |
| US9365540B2 (en) * | 2012-01-12 | 2016-06-14 | Takeda Pharmaceutical Company Limited | Benzimidazole derivatives as MCH receptor antagonists |
| WO2013109735A1 (en) | 2012-01-18 | 2013-07-25 | Zafgen, Inc. | Tricyclic sulfone compounds and methods of making and using same |
| BR112014017673A8 (pt) | 2012-01-18 | 2017-07-11 | Zafgen Inc | Compostos de sulfonamida tricíclicos e métodos para fazer e usar os mesmos |
| WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
| AU2013337287B2 (en) | 2012-11-05 | 2017-03-23 | Zafgen, Inc. | Methods of treating liver diseases |
| US10174009B2 (en) | 2012-11-05 | 2019-01-08 | Zafgen, Inc. | Tricyclic sulphonamide compounds and methods of making and using same |
| US9868717B2 (en) | 2012-11-05 | 2018-01-16 | Zafgen, Inc. | Tricyclic sulphonamide compounds and methods of making and using same |
| US20140206667A1 (en) | 2012-11-14 | 2014-07-24 | Michela Gallagher | Methods and compositions for treating schizophrenia |
| CN104403460B (zh) * | 2014-12-23 | 2016-06-15 | 江阴市天邦涂料股份有限公司 | 一种海水防污水性涂料 |
| HU230880B1 (hu) | 2015-04-15 | 2018-11-29 | Richter Gedeon Nyrt | Indol származékok |
| US10393856B2 (en) * | 2016-02-25 | 2019-08-27 | Honeywell International Inc. | Using bluetooth beacons to automatically update the location within a portable gas detector's logs |
| DK3426251T3 (da) | 2016-03-10 | 2022-06-20 | Janssen Pharmaceutica Nv | Fremgangsmåder til behandling af depression under anvendelse af orexin-2-receptorantagonister |
| MA45244A (fr) | 2016-06-13 | 2019-04-17 | Cancer Research Tech Ltd | Pyridines substituées utilisées en tant qu'inhibiteurs de dnmt1 |
| WO2020161610A2 (en) | 2019-02-04 | 2020-08-13 | Jungo Connectivity Ltd. | Adaptive monitoring of a vehicle using a camera |
| TW202409023A (zh) | 2022-07-14 | 2024-03-01 | 美商富曼西公司 | 除草苯并𠯤 |
| WO2025111184A1 (en) | 2023-11-21 | 2025-05-30 | Fmc Corporation | Substituted tetrahydroquinoline and tetrahydroquinoxaline herbicides |
| CN120081869A (zh) * | 2025-04-30 | 2025-06-03 | 西华大学 | 一种作用胆碱酯酶的药物前药及其制备方法与应用 |
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-
2008
- 2008-06-18 US US12/141,228 patent/US20090011994A1/en not_active Abandoned
- 2008-07-04 TW TW097125463A patent/TW200906413A/zh unknown
- 2008-07-04 PE PE2008001137A patent/PE20090437A1/es not_active Application Discontinuation
- 2008-07-04 CL CL200801994A patent/CL2008001994A1/es unknown
- 2008-07-07 EP EP20080772437 patent/EP2173725A2/en not_active Withdrawn
- 2008-07-07 CA CA 2692671 patent/CA2692671A1/en not_active Abandoned
- 2008-07-07 AU AU2008275207A patent/AU2008275207A1/en not_active Abandoned
- 2008-07-07 WO PCT/US2008/069361 patent/WO2009009501A2/en not_active Ceased
- 2008-07-07 AR ARP080102936A patent/AR067475A1/es not_active Application Discontinuation
- 2008-07-07 BR BRPI0813580-0A2A patent/BRPI0813580A2/pt not_active IP Right Cessation
- 2008-07-07 KR KR1020107002657A patent/KR20100044824A/ko not_active Withdrawn
- 2008-07-07 JP JP2010516181A patent/JP2010532791A/ja not_active Withdrawn
- 2008-07-07 EA EA201000157A patent/EA201000157A1/ru unknown
- 2008-07-07 CN CN200880106111A patent/CN101801938A/zh active Pending
-
2010
- 2010-01-04 ZA ZA2010/00055A patent/ZA201000055B/en unknown
- 2010-01-05 CO CO10000580A patent/CO6270360A2/es not_active Application Discontinuation
- 2010-09-14 US US12/881,234 patent/US8012984B2/en active Active
-
2011
- 2011-02-16 US US13/028,570 patent/US8067420B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009009501A4 (en) | 2009-06-11 |
| PE20090437A1 (es) | 2009-04-18 |
| US8012984B2 (en) | 2011-09-06 |
| CA2692671A1 (en) | 2009-01-15 |
| CN101801938A (zh) | 2010-08-11 |
| US20090011994A1 (en) | 2009-01-08 |
| US20110144060A1 (en) | 2011-06-16 |
| CO6270360A2 (es) | 2011-04-20 |
| BRPI0813580A2 (pt) | 2014-12-30 |
| US8067420B2 (en) | 2011-11-29 |
| JP2010532791A (ja) | 2010-10-14 |
| WO2009009501A3 (en) | 2009-04-02 |
| EP2173725A2 (en) | 2010-04-14 |
| EA201000157A1 (ru) | 2010-06-30 |
| WO2009009501A2 (en) | 2009-01-15 |
| CL2008001994A1 (es) | 2008-09-22 |
| US20110003759A1 (en) | 2011-01-06 |
| ZA201000055B (en) | 2011-05-25 |
| TW200906413A (en) | 2009-02-16 |
| KR20100044824A (ko) | 2010-04-30 |
| AU2008275207A1 (en) | 2009-01-15 |
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