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PE20080144A1 - Compuestos de tetrahidropiridotienopirimidina con actividad antiproliferativa - Google Patents

Compuestos de tetrahidropiridotienopirimidina con actividad antiproliferativa

Info

Publication number
PE20080144A1
PE20080144A1 PE2007000292A PE2007000292A PE20080144A1 PE 20080144 A1 PE20080144 A1 PE 20080144A1 PE 2007000292 A PE2007000292 A PE 2007000292A PE 2007000292 A PE2007000292 A PE 2007000292A PE 20080144 A1 PE20080144 A1 PE 20080144A1
Authority
PE
Peru
Prior art keywords
halo
compounds
alkyl
tetrahydropyridotienopyrimidine
antiproliferative activity
Prior art date
Application number
PE2007000292A
Other languages
English (en)
Inventor
Chengzhi Zhang
Kanwar Sidhu
Mario Lobell
Gaetan Ladouceur
Qian Zhao
Zheng Liu
Kristen Allegue
Chetan Darne
Jason Newcom
Original Assignee
Bayer Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharmaceuticals Corp filed Critical Bayer Pharmaceuticals Corp
Publication of PE20080144A1 publication Critical patent/PE20080144A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE REFIERE A COMPUESTOS TETRAHIDROPIRIDOTIENOPIRIMIDINA DE FORMULA (I), DONDE m ES DE 0 A 2; n ES DE 0 A 3; q ES 0 O 1; R1 ES H, ALQUILO(C1-C4) O HALO; R2 ES H, CN, HALO, ENTRE OTROS; R3 ES H, CN, HALO, ALQUILO(C1-C4), *-O(CH2)pAr, ENTRE OTROS; O R2 Y R3 JUNTOS PUEDEN FORMAR UN CARBO O HETEROCICLO; R4 ES CN, ALQUENILO(C2-C4), HALO, ENTRE OTROS; R5 ES H O HALO; R9 ES H O CH2-Y; O R10 ES H; R9 Y R10 JUNTOS PUEDEN FORMAR UN LIGAMIENTO ACETILENICO, R8 ES HALO, HIDROXILO O ALQUILO(C1-C4); R7 ES UN GRUPO MONO- O DI-(ALQUILO(CI-C4))AMINO. SON SELECCIONADOS: N-[3-CLORO-4(PIRIDIN-2-ILMETOXI)FENIL]-7[(2E)-4-(DIETILAMINO)BUT-2-ENOIL]-5,6,7,8-TETRAHIDROPIRIDO[4',3':4,5]TIENO[2,3-d]PIRIMIDIN-4-AMINA, N-[3-CLORO-4(PIRIDIN-2-ILMETOXI)FENIL]-7[(2E)-4-(DIMETILAMINO)BUT-2-ENOIL]-5,6,7,8-TETRAHIDROPIRIDO[4',3':4,5]TIENO[2,3-d]PIRIMIDIN-4-AMINA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION Y UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS TIENE ACTIVIDAD ANTIPROLIFERATIVA Y SON UTILES EN EL TRATAMIENTO DE TRASTORNOS ASOCIADOS A HIPERPROLIFERACION Y TRATAMIENTO DEL CANCER
PE2007000292A 2006-03-20 2007-03-19 Compuestos de tetrahidropiridotienopirimidina con actividad antiproliferativa PE20080144A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US78414606P 2006-03-20 2006-03-20

Publications (1)

Publication Number Publication Date
PE20080144A1 true PE20080144A1 (es) 2008-04-06

Family

ID=38523058

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000292A PE20080144A1 (es) 2006-03-20 2007-03-19 Compuestos de tetrahidropiridotienopirimidina con actividad antiproliferativa

Country Status (29)

Country Link
US (1) US8501755B2 (es)
EP (1) EP2001890B1 (es)
JP (1) JP5282026B2 (es)
KR (1) KR20080110834A (es)
CN (1) CN101448840B (es)
AR (1) AR059901A1 (es)
AT (1) ATE495179T1 (es)
AU (1) AU2007227317A1 (es)
BR (1) BRPI0711045A2 (es)
CA (1) CA2647036C (es)
CR (1) CR10304A (es)
DE (1) DE602007011906D1 (es)
DO (1) DOP2007000053A (es)
EC (1) ECSP088749A (es)
ES (1) ES2357654T3 (es)
GT (1) GT200800187A (es)
IL (1) IL194028A0 (es)
MA (1) MA30351B1 (es)
MX (1) MX2008012006A (es)
NZ (1) NZ571326A (es)
PA (1) PA8719401A1 (es)
PE (1) PE20080144A1 (es)
RU (1) RU2008141239A (es)
SV (1) SV2008003032A (es)
TN (1) TNSN08370A1 (es)
TW (1) TW200804397A (es)
UY (1) UY30220A1 (es)
WO (1) WO2007109279A2 (es)
ZA (1) ZA200808017B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2431927B (en) 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en) 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
EP2212332B1 (en) * 2007-09-14 2012-10-24 Bayer Intellectual Property GmbH Substituted tricyclic compounds and methods of use thereof
CN102264745B (zh) * 2008-11-10 2015-07-22 财团法人卫生研究院 作为酪胺酸激酶抑制剂的稠合双环及多环嘧啶化合物
EP2806876A4 (en) * 2012-01-25 2016-03-02 Proteostasis Therapeutics Inc Proteasome activity enhancing compounds
JP2017519737A (ja) * 2014-05-26 2017-07-20 バイエル・ファルマ・アクティエンゲゼルシャフト 置換テトラヒドロピリドチエノピリミジン
US10561749B2 (en) 2015-07-03 2020-02-18 Kyoto University Nuclear medicine diagnostic imaging agent
EP4186910A1 (en) 2016-06-22 2023-05-31 Vanderbilt University Positive allosteric modulators of the muscarinic acetylcholine receptor m4
CN109890388B (zh) 2016-11-07 2023-03-28 范德比尔特大学 毒蕈碱型乙酰胆碱受体m4的正向别构调节剂
JP7097623B2 (ja) 2016-11-07 2022-07-08 ヴァンダービルト ユニヴァーシティ ムスカリン性アセチルコリンレセプターｍ４のポジティブアロステリック調節因子
US10961253B2 (en) 2016-11-07 2021-03-30 Vanderbilt University Positive allosteric modulators of the muscarinic acetylcholine receptor M4
US11376254B2 (en) 2017-12-05 2022-07-05 Vanderbilt University Positive allosteric modulators of the muscarinic acetylcholine receptor M4
TW201930311A (zh) 2017-12-05 2019-08-01 泛德比爾特大學 蕈毒鹼型乙醯膽鹼受體m4之正向別構調節劑
US12398151B2 (en) 2019-03-19 2025-08-26 Suvalent Therapeutics, Inc. Sumo inhibitor compounds and uses thereof
KR20240044458A (ko) * 2021-08-05 2024-04-04 브리스톨-마이어스 스큅 컴퍼니 Her2 억제제로서 사용하기 위한 트리시클릭 융합된 피리미딘 화합물
CN114736154B (zh) * 2022-03-15 2023-07-21 安庆朗坤药业有限公司 N-（3-氯-4-（2-吡啶甲氧基）苯基）-2-氰基乙酰胺的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3453900A (en) * 1999-03-30 2000-10-23 Nippon Soda Co., Ltd. Thienopyrimidine compounds and salts thereof and process for the preparation of the same
DE19944604A1 (de) 1999-09-17 2001-03-22 Merck Patent Gmbh Aminderivate
US6608053B2 (en) * 2000-04-27 2003-08-19 Yamanouchi Pharmaceutical Co., Ltd. Fused heteroaryl derivatives
JPWO2003035653A1 (ja) * 2001-10-26 2005-02-10 日本曹達株式会社 ピリドチエノピリミジン化合物およびその塩
WO2005010008A1 (en) * 2003-07-24 2005-02-03 Bayer Pharmaceuticals Corporation Substituted tetrahydrobenzothienopyrimidinamine compounds useful for treating hyper-proliferative disorders

Also Published As

Publication number Publication date
WO2007109279A3 (en) 2007-12-21
WO2007109279A2 (en) 2007-09-27
KR20080110834A (ko) 2008-12-19
MX2008012006A (es) 2008-10-03
PA8719401A1 (es) 2009-02-09
MA30351B1 (fr) 2009-04-01
CN101448840B (zh) 2011-12-14
CA2647036A1 (en) 2007-09-27
CA2647036C (en) 2015-06-23
AR059901A1 (es) 2008-05-07
DOP2007000053A (es) 2007-09-30
TW200804397A (en) 2008-01-16
EP2001890B1 (en) 2011-01-12
IL194028A0 (en) 2009-09-22
RU2008141239A (ru) 2010-04-27
EP2001890A2 (en) 2008-12-17
BRPI0711045A2 (pt) 2012-06-26
SV2008003032A (es) 2009-11-26
ATE495179T1 (de) 2011-01-15
CN101448840A (zh) 2009-06-03
ES2357654T3 (es) 2011-04-28
US20100298297A1 (en) 2010-11-25
ECSP088749A (es) 2008-10-31
NZ571326A (en) 2011-07-29
AU2007227317A1 (en) 2007-09-27
JP2009530387A (ja) 2009-08-27
ZA200808017B (en) 2009-11-25
US8501755B2 (en) 2013-08-06
DE602007011906D1 (de) 2011-02-24
JP5282026B2 (ja) 2013-09-04
UY30220A1 (es) 2007-10-31
GT200800187A (es) 2009-04-07
CR10304A (es) 2009-01-27
TNSN08370A1 (en) 2009-12-29

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Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed