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AR067182A1 - Moduladores del receptor 7 tipo toll - Google Patents

Moduladores del receptor 7 tipo toll

Info

Publication number
AR067182A1
AR067182A1 ARP080102756A ARP080102756A AR067182A1 AR 067182 A1 AR067182 A1 AR 067182A1 AR P080102756 A ARP080102756 A AR P080102756A AR P080102756 A ARP080102756 A AR P080102756A AR 067182 A1 AR067182 A1 AR 067182A1
Authority
AR
Argentina
Prior art keywords
substituted
alkyl
carbocyclyl
heterocyclyl
heteroalkyl
Prior art date
Application number
ARP080102756A
Other languages
English (en)
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39789972&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR067182(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of AR067182A1 publication Critical patent/AR067182A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Composiciones farmacéuticas que contienen tales compuestos y uso del compuesto para fabricar medicamentos antivirales. Reivindicacion 1: Un compuesto de Formula (1) o (2): o una sal farmacéuticamente aceptable de la misma, en donde: X1 es -NH-, -O-, alquileno, alquileno sustituido, alquenileno, alquenileno sustituido, alquinileno, alquinileno sustituido, carbociclileno, carbociclileno sustituido, heterociclileno, o heterociclileno sustituido; D es carbociclileno o heterociclileno; cada L1 es independientemente alquileno o alquileno sustituido; cada R1 es independientemente -NR4R5; m es 1 o 2; L2 es una ligadura covalente, -NH-, -O-, o -S-; R2 es H, halo, alquilo, alquilo sustituido, alquenilo, alquenilo sustituido, carbociclilo, carbociclilo sustituido, carbociclilalquilo, carbociclilalquilo sustituido, arilalquilo, arilalquilo sustituido, heterociclilalquilo, heterociclilalquilo sustituido, -C(O)R6, -C(O)OR6, -C(O)NR7R8, -S(O)OR7, -S(O)NR7R8, -S(O)2R7, -S(O)R7, -S(O)2OR7, o -S(O)2NR7R8; L3 es -NH-, -O-, -S-, -N(R9)C(O)-, -S(O)2-, -S(O)-, o una ligadura covalente; R3 es alquilo, alquilo sustituido, alquenilo, alquenilo sustituido, alquinilo, alquinilo sustituido, heteroalquilo, heteroalquilo sustituido, carbociclilo, carbociclilo sustituido, carbociclilalquilo, carbociclilalquilo sustituido, heterociclilo, heterociclilo sustituido, heterociclilalquilo, o heterociclilalquilo sustituido; R4 y R5 son cada uno independientemente H, alquilo, alquilo sustituido, carbociclilo, carbociclilo sustituido, carbociclilalquilo, carbociclilalquilo sustituido, heterociclilo, heterociclilo sustituido, heterociclilalquilo, heterociclilalquilo sustituido, -C(O)H, -C(O)R3, -S(O)R3, -S(O)2R3, -C(O)OR3, o -C(O)NR7R8; o R4 y R5, tomados junto con el nitrogeno al cual ambos están unidos, forman un heterociclo sustituido o no sustituido; R6 es alquilo, alquilo sustituido, alquenilo, alquenilo sustituido, alquinilo, alquinilo sustituido, heteroalquilo, heteroalquilo sustituido, carbociclilo, carbociclilo sustituido, carbociclilalquilo, carbociclilalquilo sustituido, heterociclo, heterociclilo sustituido, heterociclilalquilo, o heterociclilalquilo sustituido; R7 y R8 son cada uno independientemente H, alquilo, alquilo sustituido, carbociclilo, carbociclilo sustituido, carbociclilalquilo, carbociclilalquilo sustituido, heterociclilo, heterociclilo sustituido, heterociclilalquilo, o heterociclilalquilo sustituido; o R7 y R8, tomados junta con el nitrogeno al cual ambos están ligados, forman un heterociclo sustituido o no sustituido; R9 es H, alquilo, alquilo sustituido, carbociclilo, carbociclilo sustituido, carbociclilalquilo, carbociclilalquilo sustituido, heterociclilo, heterociclilo sustituido, heterociclilalquilo, o heterociclilalquilo sustituido; R10 es halogeno, ciano, azido, nitro, alquilo, alquilo sustituido, hidroxilo, amino, heteroalquilo, o heteroalquilo sustituido; n es un numero entero de 0 a 5; y con las siguientes estipulaciones: (a) Cuando X1 es -CH2-, D es 1,4-fenileno, R3-L3- es CH3CH2CH2CH2O- o CH3-O-CH2CH2-O, n=0, m=1, luego NR4R5 no es: (1) una 4,4-piperazina o peperidina disustituida (2) o 4-sustituida -NHCH3; (b) Cuando X1 es -CH2-, D es 1,4-fenileno o 1,4-piperidinileno, R3-L3- es CH3CH2CH2CH2O- o CH3-O-CH2CH2-O, n=O, m=1, luego ni R4 ni R5 son alquilo sustituido, heterociclilo sustituido, benzilo sustituido; y (c) Cuando X1 es -CH2, D es 2,5-piridileno, R3-L3- es CH3CH2CH2CH2O- o CH3-O-CH2CH2-O, n=O, m=1, luego NR4R5 no es pirrolilo, piperazil, N(CH3)2.
ARP080102756A 2007-06-29 2008-06-26 Moduladores del receptor 7 tipo toll AR067182A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93772607P 2007-06-29 2007-06-29
US95971407P 2007-07-16 2007-07-16

Publications (1)

Publication Number Publication Date
AR067182A1 true AR067182A1 (es) 2009-09-30

Family

ID=39789972

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080102756A AR067182A1 (es) 2007-06-29 2008-06-26 Moduladores del receptor 7 tipo toll

Country Status (22)

Country Link
US (5) US7968544B2 (es)
EP (1) EP2170888B1 (es)
JP (2) JP5395068B2 (es)
KR (1) KR101561710B1 (es)
CN (1) CN101784548B (es)
AP (1) AP2706A (es)
AR (1) AR067182A1 (es)
AU (1) AU2008271127C1 (es)
BR (1) BRPI0813952A2 (es)
CA (1) CA2691444C (es)
CO (1) CO6251258A2 (es)
EA (2) EA021463B1 (es)
EC (1) ECSP109905A (es)
ES (1) ES2541434T3 (es)
IL (1) IL202622A (es)
MX (1) MX2009013832A (es)
NZ (1) NZ582090A (es)
PL (1) PL2170888T3 (es)
PT (1) PT2170888E (es)
SI (1) SI2170888T1 (es)
TW (1) TWI434849B (es)
WO (1) WO2009005687A1 (es)

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