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AR132464A1 - Régimen de dosificación de inhibidor de la cápside - Google Patents

Régimen de dosificación de inhibidor de la cápside

Info

Publication number
AR132464A1
AR132464A1 ARP240100984A ARP240100984A AR132464A1 AR 132464 A1 AR132464 A1 AR 132464A1 AR P240100984 A ARP240100984 A AR P240100984A AR P240100984 A ARP240100984 A AR P240100984A AR 132464 A1 AR132464 A1 AR 132464A1
Authority
AR
Argentina
Prior art keywords
patient
compound
formula
pharmaceutically acceptable
acceptable salt
Prior art date
Application number
ARP240100984A
Other languages
English (en)
Inventor
Rebecca R Begley
Polina German
Justin Lutz
Rameshraja Palaparthy
Abdul Naveed Shaik
Martin S Rhee
Renu Singh
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of AR132464A1 publication Critical patent/AR132464A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La presente descripción se relaciona con regímenes de dosificación de un inhibidor de la cápside del VIH y métodos para el tratamiento o prevención de una infección por el virus de la inmunodeficiencia humana (VIH) en un paciente. Reivindicación 1: Un método para tratar o prevenir el VIH en un paciente, que comprende administrar al paciente un compuesto de la fórmula (1a) o una sal farmacéuticamente aceptable de este, el método comprende: (a) administrar al paciente una dosis de inicio del compuesto de la fórmula (1a), o una sal farmacéuticamente aceptable de este, durante un primer período; y (b) administrar al paciente una o más dosis de mantenimiento del compuesto de la fórmula (1a), o una sal farmacéuticamente aceptable de este, durante un segundo período, en donde el segundo período se produce después del primer período; y en donde si el paciente omite u omitirá una dosis de mantenimiento, el método comprende además administrar por vía oral al paciente una dosis puente de aproximadamente 250 mg a aproximadamente 650 mg del compuesto de la fórmula (1a), o una sal farmacéuticamente aceptable de este, una vez por semana hasta que el paciente reanude la administración de la una o más dosis de mantenimiento.
ARP240100984A 2023-04-19 2024-04-18 Régimen de dosificación de inhibidor de la cápside AR132464A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202363497168P 2023-04-19 2023-04-19

Publications (1)

Publication Number Publication Date
AR132464A1 true AR132464A1 (es) 2025-07-02

Family

ID=91029870

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP240100984A AR132464A1 (es) 2023-04-19 2024-04-18 Régimen de dosificación de inhibidor de la cápside

Country Status (7)

Country Link
US (1) US20240390349A1 (es)
KR (1) KR20250172591A (es)
CN (1) CN121358478A (es)
AR (1) AR132464A1 (es)
AU (1) AU2024259111A1 (es)
TW (1) TW202444363A (es)
WO (1) WO2024220624A1 (es)

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WO2025264995A1 (en) * 2024-06-21 2025-12-26 Gilead Sciences, Inc. Formulations of an hiv capsid inhibitor

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Also Published As

Publication number Publication date
AU2024259111A1 (en) 2025-10-16
WO2024220624A1 (en) 2024-10-24
TW202444363A (zh) 2024-11-16
KR20250172591A (ko) 2025-12-09
US20240390349A1 (en) 2024-11-28
CN121358478A (zh) 2026-01-16

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