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AR066846A1 - Anticuerpos anti- notcchh1 nrr y sus metodos de uso - Google Patents

Anticuerpos anti- notcchh1 nrr y sus metodos de uso

Info

Publication number
AR066846A1
AR066846A1 ARP080102361A ARP080102361A AR066846A1 AR 066846 A1 AR066846 A1 AR 066846A1 AR P080102361 A ARP080102361 A AR P080102361A AR P080102361 A ARP080102361 A AR P080102361A AR 066846 A1 AR066846 A1 AR 066846A1
Authority
AR
Argentina
Prior art keywords
antibody
notcchh1
methods
nrr
notch1
Prior art date
Application number
ARP080102361A
Other languages
English (en)
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39735560&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR066846(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of AR066846A1 publication Critical patent/AR066846A1/es

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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Abstract

Reivindicacion 1: Un anticuerpo de la region regulatoria negativa (NRR) anti-Notch1 aislado, en donde dicho anticuerpo se une a un Notch1 NRR con una kd de 1 x 10-7 o mayor y en donde dicho anticuerpo, cuando se une a dicho Notch1 NRR, disminuye la senalizacion de Notch1. Asimismo se proporciona un polinucleotido que codifica a dicho anticuerpo, un vector que comprende dicho polinucleotido, células huéspedes que comprenden el vector y composiciones que comprenden el anticuerpo o el vector.
ARP080102361A 2007-06-04 2008-06-04 Anticuerpos anti- notcchh1 nrr y sus metodos de uso AR066846A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93307207P 2007-06-04 2007-06-04
US99464607P 2007-09-20 2007-09-20

Publications (1)

Publication Number Publication Date
AR066846A1 true AR066846A1 (es) 2009-09-16

Family

ID=39735560

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080102361A AR066846A1 (es) 2007-06-04 2008-06-04 Anticuerpos anti- notcchh1 nrr y sus metodos de uso

Country Status (28)

Country Link
US (5) US8846871B2 (es)
EP (1) EP2152748B1 (es)
JP (4) JP5623272B2 (es)
KR (2) KR20100021581A (es)
CN (1) CN101796074B (es)
AR (1) AR066846A1 (es)
BR (1) BRPI0811382A2 (es)
CA (1) CA2687866C (es)
CL (1) CL2008001634A1 (es)
CO (1) CO6150200A2 (es)
CR (2) CR11139A (es)
CY (1) CY1114690T1 (es)
DK (1) DK2152748T3 (es)
EC (1) ECSP099785A (es)
ES (1) ES2432798T3 (es)
HR (1) HRP20131107T1 (es)
IL (3) IL202183A0 (es)
MA (1) MA31502B1 (es)
MX (1) MX2009013199A (es)
NZ (1) NZ581303A (es)
PE (1) PE20090321A1 (es)
PH (1) PH12015500550A1 (es)
PL (1) PL2152748T3 (es)
PT (1) PT2152748E (es)
RU (1) RU2476443C2 (es)
SI (1) SI2152748T1 (es)
TW (1) TWI458737B (es)
WO (1) WO2008150525A1 (es)

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US6984522B2 (en) * 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
WO2007145840A2 (en) 2006-06-13 2007-12-21 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
EP2087006B1 (en) 2006-10-19 2016-06-08 Genentech, Inc. Anti-notch3 agonist antibodies and their use in the treatment of notch3-related diseases
WO2008136848A2 (en) 2006-10-19 2008-11-13 Genentech Inc. Novel anti-notch3 antibodies and their use in the detection and diagnosis of disease
CA2670992C (en) 2006-12-18 2017-11-21 Genentech, Inc. Antagonist anti-notch3 antibodies and their use in the prevention and treatment of notch3-related diseases
JP5618544B2 (ja) 2007-01-24 2014-11-05 オンコメッドファーマシューティカルズ インコーポレイテッド 癌の診断および処置のための組成物および方法
PE20090321A1 (es) 2007-06-04 2009-04-20 Genentech Inc Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica
NZ590127A (en) 2008-07-08 2012-11-30 Oncomed Pharm Inc Notch1 receptor binding agents and methods of use thereof
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
BRPI0913827A2 (pt) 2008-10-01 2020-12-29 Genentech, Inc Anticorpo monoclonal, método para inibir a atividade de notch2, método para tratar uma doença, método para tratar uma malignidade, método para tratar um melanoma, usos de um anticorpo e anticorpo nrr anti-notch2
CN102686610A (zh) * 2009-06-18 2012-09-19 辉瑞公司 抗刻缺蛋白-1抗体
US20120129189A1 (en) * 2009-07-17 2012-05-24 Chulan Kwon Methods of Controlling Cell Proliferation
CA2775880A1 (en) * 2009-09-30 2011-04-07 Genentech, Inc. Anti-notch3 antagonist antibodies to treat gamma secretase inhibitor responsive and anti-notch1 antagonist antibody unresponsive t-cell leukemias
WO2011063237A2 (en) 2009-11-19 2011-05-26 Oncomed Pharmaceuticals, Inc. Jagged-binding agents and uses thereof
AU2011205316B2 (en) * 2010-01-13 2015-05-28 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
BR112012020102A2 (pt) 2010-02-10 2016-11-29 Immunogen Inc anticorpos cd20 e usos dos mesmos.
WO2012080891A1 (en) * 2010-12-15 2012-06-21 Rinat Neuroscience Corp. Anti-notch-1 antibodies
JP6016800B2 (ja) * 2010-12-15 2016-10-26 ワイス・エルエルシー 抗ノッチ１抗体
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