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CL2008001634A1 - Anticuerpo de la region regulatoria negativa anti-notch1 aislado; polinucleotido que lo codifica; vector y celula huesped; metodo de produccion; composicion que lo comprende; y su uso para preparar un medicamento para tratar un trastorno asociado con un aumento en la señalizacion o expresion de notch1 en un individuo. - Google Patents

Anticuerpo de la region regulatoria negativa anti-notch1 aislado; polinucleotido que lo codifica; vector y celula huesped; metodo de produccion; composicion que lo comprende; y su uso para preparar un medicamento para tratar un trastorno asociado con un aumento en la señalizacion o expresion de notch1 en un individuo.

Info

Publication number
CL2008001634A1
CL2008001634A1 CL2008001634A CL2008001634A CL2008001634A1 CL 2008001634 A1 CL2008001634 A1 CL 2008001634A1 CL 2008001634 A CL2008001634 A CL 2008001634A CL 2008001634 A CL2008001634 A CL 2008001634A CL 2008001634 A1 CL2008001634 A1 CL 2008001634A1
Authority
CL
Chile
Prior art keywords
notch1
antibody
vector
hvr
polynucleotide
Prior art date
Application number
CL2008001634A
Other languages
English (en)
Inventor
Yan Wu
Christian W Siebel
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39735560&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2008001634(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of CL2008001634A1 publication Critical patent/CL2008001634A1/es

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Abstract

UN ANTICUERPO DE LA REGIÓN REGULATORIA NEGATIVA (NRR) ANTI-NOTCHL AISLADO, SE UNE A UN NOTCH1 NRR CON UNA KD DE 1 X 10-7 O MAYOR, DONDE DICHO ANTICUERPO, CUANDO SE UNE A DICHO NOTCHL NRR, DISMINUYE LA SEÑALIZACIÓN DE NOTCH1, Y DONDE EL ANTICUERPO COMPRENDE HVR•L1, HVR•L2, HVR•L3, HVR•HL. HVR•H2 Y HVR•H3, DONDE CADA UNO, EN ORDEN, COMPRENDE: (I) SEA ID NO: 7, 8, 9, 1, 2, 6; (II)SEO ID NO: 7, 8, LA, 1, 3, 6; (III) SEA ID NO: 7, 8,11,1,4,6; O (IV) SEA ID NO: 7, 8, 12, 1, 5, 6. UN POLINUCLEÓTIDO QUE LO CODIFICA. UN VECTOR QUE COMPRENDE DICHO POLINUCLEÓTIDO. UNA CÉLULA HUÉSPED QUE COMPRENDE DICHO VECTOR. UN MÉTODO PARA PREPARAR UN ANTICUERPO ANTI-NOTCH1 NRR, DONDE DICHO MÉTODO COMPRENDE (A) EXPRESAR DICHO VECTOR EN UNA CÉLULA HUÉSPED ADECUADA Y (B) RECUPERAR EL ANTICUERPO. UNA COMPOSICIÓN QUE COMPRENDE UN ANTICUERPO ANTI-NOTCH1 NRR. USO DE UNA CANTIDAD EFECTIVA DE UN ANTICUERPO ANTI-NOTCH1 NRR, PARA PREPARAR UN MEDICAMENTO ÚTIL PARA TRATAR TRASTORNOS ASOCIADOS CON AUMENTO DE LA SEÑALIZACIÓN O EXPRESIÓN DE NOTCH1 O CON UNA MUTACIÓN EN UNA SECUENCIA DE AMINOÁCIDOS DE NOTCH1 EN UN INDIVIDUO, PARA TRATAR CÁNCER, UN TUMOR Y/O UN TRASTORNO PROLIFERATIVO CELULAR EN UN INDIVIDUO, ENTRE OTROS.
CL2008001634A 2007-06-04 2008-06-04 Anticuerpo de la region regulatoria negativa anti-notch1 aislado; polinucleotido que lo codifica; vector y celula huesped; metodo de produccion; composicion que lo comprende; y su uso para preparar un medicamento para tratar un trastorno asociado con un aumento en la señalizacion o expresion de notch1 en un individuo. CL2008001634A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93307207P 2007-06-04 2007-06-04
US99464607P 2007-09-20 2007-09-20

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CL2008001634A1 true CL2008001634A1 (es) 2009-05-22

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CL2008001634A CL2008001634A1 (es) 2007-06-04 2008-06-04 Anticuerpo de la region regulatoria negativa anti-notch1 aislado; polinucleotido que lo codifica; vector y celula huesped; metodo de produccion; composicion que lo comprende; y su uso para preparar un medicamento para tratar un trastorno asociado con un aumento en la señalizacion o expresion de notch1 en un individuo.

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US6984522B2 (en) * 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
WO2007145840A2 (en) 2006-06-13 2007-12-21 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
EP2087006B1 (en) 2006-10-19 2016-06-08 Genentech, Inc. Anti-notch3 agonist antibodies and their use in the treatment of notch3-related diseases
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