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PE20130774A1 - Compuestos heterociclicos activadores de ampk y metodos para emplearlos - Google Patents

Compuestos heterociclicos activadores de ampk y metodos para emplearlos

Info

Publication number
PE20130774A1
PE20130774A1 PE2013000118A PE2013000118A PE20130774A1 PE 20130774 A1 PE20130774 A1 PE 20130774A1 PE 2013000118 A PE2013000118 A PE 2013000118A PE 2013000118 A PE2013000118 A PE 2013000118A PE 20130774 A1 PE20130774 A1 PE 20130774A1
Authority
PE
Peru
Prior art keywords
alkyl
heterocyclic compounds
methods
ampk activating
compounds
Prior art date
Application number
PE2013000118A
Other languages
English (en)
Inventor
Dane Goff
Donald Payan
Rajinder Singh
Simon Shaw
David Carroll
Original Assignee
Rigel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44504240&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20130774(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rigel Pharmaceuticals Inc filed Critical Rigel Pharmaceuticals Inc
Publication of PE20130774A1 publication Critical patent/PE20130774A1/es

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Abstract

SE REFIERE COMPUESTOS HETEROCICLICOS ACTIVADORES DE AMPKDE FORMULA (I) DONDE: E ES -R2, -C(O)NR1R2, -NR1R2, ENTRE OTROS; EN DONDE R1 ES H; -(ALQUILO C1-C4), ENTRE OTROS; R2 ES -C(O)HCA, -(ALQUIL C0-C3)-AR, (ALQUIL C0-C3)-HET ENTRE OTROS; R3 SE SELECCIONA DE (ALQUILO C1-C6), -(HALOALQUILO C1-C6), -(ALQUIL C0-C6) ENTRE OTROS; W ES 0-3; R4 SE SELECCIONA DE (ALQUILO C1-C6),-(HALOALQUILO C1-C6; HALOGENO; ENTRE OTROS; X ES 0-4; J ES -C(O)-, -NR13-, DONDE R13 SE SELECCIONA ENTRE -H, -(ALQUILO C1-C4), -C(O)-(ALQUILO C1-C4), ENTRE OTROS; B ES HETEROARILENO, ARILENO, ENTRE OTROS; D1, D2 Y D3 CADA UNO SON CH, C SUSTITUIDO CON UNO DE LOS W GRUPOS R3, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-(4-(4-CIANOBENCIL)PIPERIDIN-4-IL)-6-(4-(4-FLUOROBENCIL)PIPERAZIN-1-CARBONIL)PICOLINAMIDA; N-(1-(4-CIANOBENCIL)PIPERIDIN-4-IL)-5-(PIPERAZIN-1-CARBONIL)PICOLINAMIDA, ENTRE OTROS. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE TRASTORNOS Y AFECCIONES RELACIONADOS CON EL METABOLISMO.
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US10941134B2 (en) 2021-03-09
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